Modeling the energetic cost of cancer as a result of altered energy metabolism: Implications for cachexia

Theoretical Biology and Medical Modelling

Volumn 12, Issue 1, 2015, Pages

  Friesen, Douglas E ^a   Baracos, Vickie E ^a   Tuszynski, Jack A ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE;

AEROBIC METABOLISM; ANAEROBIC GROWTH; BIOLOGICAL MODEL; CACHEXIA; ENERGY METABOLISM; HUMAN; METABOLISM; NEOPLASM;

AEROBIOSIS; ANAEROBIOSIS; CACHEXIA; ENERGY METABOLISM; GLUCOSE; HUMANS; METABOLIC NETWORKS AND PATHWAYS; MODELS, BIOLOGICAL; NEOPLASMS;

EID: 84941650046     PISSN: None     EISSN: 17424682     Source Type: Journal    
DOI: 10.1186/s12976-015-0015-0     Document Type: Article

References (63)

1. Sharma R, Anker S. First Cachexia Symposium, Berlin, Germany, 1st-2nd December, 2000. Eur J Heart Fail. 2001;3:751-4.
2. Fearon K, Strasser F, Anker SD, Bosaeus I, Bruera E, Fainsinger RL, et al. Definition and classification of cancer cachexia: an international consensus. Lancet Oncol. 2011;12:489-95.
3. Evans WJ, Morley JE, Argilés J, Bales C, Baracos V, Guttridge D, et al. Cachexia: A new definition. Clin Nutr. 2008;27:793-9.
4. Dodson S, Baracos VE, Jatoi A, Evans WJ, Cella D, Dalton JT, et al. Muscle wasting in cancer cachexia: clinical implications, diagnosis, and emerging treatment strategies. Annu Rev Med. 2011;62:265-79.
5. Johns N, Stephens NA, Fearon KCH. Muscle wasting in cancer. Int J Biochem Cell Biol. 2013;45:2215-29.
6. Fearon KCH, Moses AGW. Cancer cachexia. Int J Cardiol. 2002;85:73-81.
7. Bosaeus I, Daneryd P, Svanberg E, Lundholm K. Dietary intake and resting energy expenditure in relation to weight loss in unselected cancer patients. Int J Cancer. 2001;93:380-3.
8. Cao D-x, Wu G-h, Zhang B, Quan Y-j, Wei J, Jin H, et al. Resting energy expenditure and body composition in patients with newly detected cancer. Clin Nutr. 2010;29:72-7.
9. Del Fabbro E, Hui D, Dalal S, Dev R, Nooruddin ZI, Noorhuddin Z, et al. Clinical outcomes and contributors to weight loss in a cancer cachexia clinic. J Palliat Med. 2011;14:1004-8.
10. Xu WP, Cao DX, Lin ZM, Wu GH, Chen L, Zhang JP, et al. Analysis of energy utilization and body composition in kidney, bladder, and adrenal cancer patients. Urol Oncol. 2012;30:711-8.
11. Boroughs LK, DeBerardinis RJ. Metabolic pathways promoting cancer cell survival and growth. Nat Cell Biol. 2015;17:351-9.
12. Bensinger SJ, Christofk HR. New aspects of the Warburg effect in cancer cell biology. Semin Cell Dev Biol. 2012;23:352-61.
13. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144:646-74.
14. Moreno-Sanchez R, Rodriguez-Enriquez S, Saavedra E, Marin-Hernandez A, Gallardo-Perez JC. The bioenergetics of cancer: is glycolysis the main ATP supplier in all tumor cells? Biofactors. 2009;35:209-25.
15. Warburg O. On the origin of cancer cells. Science. 1956;123:309-14.
16. Zu XL, Guppy M. Cancer metabolism: facts, fantasy, and fiction. Biochem Biophys Res Commun. 2004;313:459-65.
17. Rodríguez-Enríquez S, Gallardo-Pérez JC, Avilés-Salas A, Marín-Hernández A, Carreño-Fuentes L, Maldonado-Lagunas V, et al. Energy metabolism transition in multi-cellular human tumor spheroids. J Cell Physiol. 2008;216:189-97.
18. Kiebish MA, Han X, Cheng H, Seyfried TN. In vitro growth environment produces lipidomic and electron transport chain abnormalities in mitochondria from non-tumorigenic astrocytes and brain tumours. ASN Neuro. 2009;1:art:e00011.
19. Maher EA, Marin-Valencia I, Bachoo RM, Mashimo T, Raisanen J, Hatanpaa KJ, et al. Metabolism of [U-13 C]glucose in human brain tumors in vivo. NMR Biomed. 2012;25:1234-44.
20. Fan TWM, Lane AN, Higashi RM, Farag MA, Gao H, Bousamra M, et al. Altered regulation of metabolic pathways in human lung cancer discerned by (13)C stable isotope-resolved metabolomics (SIRM). Mol Cancer. 2009;8:41.
21. Edén E, Edström S, Bennegård K, Scherstén T, Lundholm K. Glucose flux in relation to energy expenditure in malnourished patients with and without cancer during periods of fasting and feeding. Cancer Res. 1984;44:1718-24.
22. Holroyde CP, Skutches CL, Boden G, Reichard GA. Glucose Metabolism in Cachectic Patients with Colorectal Cancer. Cancer Res. 1984;44:5910-3.
23. Holroyde CP, Gabuzda TG, Putnam RC, Paul P, Reichard GA. Altered glucose metabolism in metastatic carcinoma. Cancer Res. 1975;35:3710-4.
24. Lundholm K, Edström S, Karlberg I, Ekman L, Scherstén T. Glucose turnover, gluconeogenesis from glycerol, and estimation of net glucose cycling in cancer patients. Cancer. 1982;50:1142-50.
25. Tayek JA, Katz J. Glucose production, recycling, Cori cycle, and gluconeogenesis in humans: relationship to serum cortisol. Am J Physiol Endocrinol Metab. 1997;272:E476-84.
26. Kallerhoff M, Karnebogen M, Singer D, Dettenbach A, Gralher U, Ringert RH. Microcalorimetric measurements carried out on isolated tumorous and nontumorous tissue samples from organs in the urogenital tract in comparison to histological and impulse-cytophotometric investigations. Urol Res. 1996;24:83-91.
27. DeBerardinis RJ, Mancuso A, Daikhin E, Nissim I, Yudkoff M, Wehrli S, et al. Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc Natl Acad Sci U S A. 2007;104:19345-50.
28. Ferrannini E. The theoretical bases of indirect calorimetry: a review. Metabolism. 1988;37:287-301.
29. Douglas RG, Shaw JHF. Metabolic effects of cancer. Br J Surg. 1990;77:246-54.
30. Gold J. Cancer cachexia and gluconeogenesis. Ann N Y Acad Sci. 1974;230:103-10.
31. Hall KD, Baracos VE. Computational modeling of cancer cachexia. Curr Opin Clin Nutr Metab Care. 2008;11:214-21.
32. Koea JB, Shaw JH. The effect of tumor bulk on the metabolic response to cancer. Ann Surg. 1992;215:282-8.
33. Straub RH, Cutolo M, Buttgereit F, Pongratz G. Energy regulation and neuroendocrine-immune control in chronic inflammatory diseases. J Intern Med. 2010;267:543-60.
34. Rich PR. The molecular machinery of Keilin's respiratory chain. Biochem Soc Trans. 2003;31:1095-105.
35. Lieffers JR, Mourtzakis M, Hall KD, McCargar LJ, Prado CM, Baracos VE. A viscerally driven cachexia syndrome in patients with advanced colorectal cancer: contributions of organ and tumor mass to whole-body energy demands. Am J Clin Nutr. 2009;89:1173-9.
36. Dempsey DT, Feurer ID, Knox LS, Crosby LO, Buzby GP, Mullen JL. Energy expenditure in malnourished gastrointestinal cancer patients. Cancer. 1984;53:1265-73.
37. Cunningham JJ. Body composition as a determinant of energy expenditure: a synthetic review and a proposed general prediction equation. Am J Clin Nutr. 1991;54:963-9.
38. Heymsfield SB, Müller MJ, Bosy-Westphal A, Thomas D, Shen W. Human brain mass: similar body composition associations as observed across mammals. Am J Hum Biol. 2012;24:479-85.
39. Elia M. Organ and tissue contribution to metabolic rate. In: Kinney J, Tucker HN, editors. Energy metabolism: tissue determinants and cellular corollaries. New York: Raven; 1992. p. 61-79.
40. Fanciulli M, Bruno T, Castiglione S, Del Carlo C, Paggi MG, Floridi A. Glucose metabolism in adriamycin-sensitive and -resistant LoVo human colon carcinoma cells. Oncol Res. 1993;5:357-62.
41. Moreno-Sanchez R, Rodriguez-Enriquez S, Marin-Hernandez A, Saavedra E. Energy metabolism in tumor cells. FEBS J. 2007;274:1393-418.
42. Busk M, Horsman MR, Kristjansen PEG, van der Kogel AJ, Bussink J, Overgaard J. Aerobic glycolysis in cancers: implications for the usability of oxygen-responsive genes and fluorodeoxyglucose-PET as markers of tissue hypoxia. Int J Cancer. 2008;122:2726-34.
43. Guppy M, Leedman P, Zu X, Russell V. Contribution by different fuels and metabolic pathways to the total ATP turnover of proliferating MCF-7 breast cancer cells. Biochem J. 2002;364:309-15.
44. Scott CB. Contribution of anaerobic energy expenditure to whole body thermogenesis. Nutr Metab. 2005;2:14.
45. Jebb SA, Osborne RJ, Dixon AK, Bleehen NM, Elia M. Measurements of resting energy expenditure and body composition before and after treatment of small cell lung cancer. Ann Oncol. 1994;5:915-9.
46. Reichard GA, Moury NF, Hochella NJ, Patterson AL, Weinhouse S. Quantitative Estimation of the Cori Cycle in the Human. J Biol Chem. 1963;238:495-501.
47. Hirai K, Ishiko O, Tisdale M. Mechanism of Depletion of Liver Glycogen in Cancer Cachexia. Biochem Biophys Res Commun. 1997;241:49-52.
48. Kleiber M. Body size and metabolism. Hilgardia. 1932;6:315-53.
49. Gatenby RA, Gillies RJ. Why do cancers have high aerobic glycolysis? Nat Rev Cancer. 2004;4:891-9.
50. Ptitsyn AA, Weil MM, Thamm DH. Systems biology approach to identification of biomarkers for metastatic progression in cancer. BMC Bioinformatics. 2008;9:S8.
51. Mandrekar SJ, An M-W, Meyers J, Grothey A, Bogaerts J, Sargent DJ. Evaluation of Alternate Categorical Tumor Metrics and Cut Points for Response Categorization Using the RECIST 1.1 Data Warehouse. J Clin Oncol. 2014;32:841-50.
52. Tateishi U, Tatsumi M, Terauchi T, Ando K, Niitsu N, Kim WS, et al. Prognostic significance of metabolic tumor burden by positron emission tomography/computed tomography in patients with relapsed/refractory diffuse large B-cell lymphoma. Cancer Sci. 2015;106:186-93.
53. Zhao Y, Butler EB, Tan M. Targeting cellular metabolism to improve cancer therapeutics. Cell Death Dis. 2013;4:e532.
54. Brand K. Aerobic glycolysis by proliferating cells: protection against oxidative stress at the expense of energy yield. J Bioenerg Biomembr. 1997;29:355-64.
55. Medina MÁ. Glutamine and Cancer. J Nutr. 2001;131:25395-425.
56. Vasseur S, Tomasini R, Tournaire R, Iovanna JL. Hypoxia induced tumor metabolic switch contributes to pancreatic cancer aggressiveness. Cancers. 2010;2:2138-52.
57. Brennan MF. Uncomplicated starvation versus cancer cachexia. Cancer Res. 1977;37:2359-64.
58. Barber MD, Ross JA, Fearon KCH. Cancer cachexia. Surg Oncol. 1999;8:133-41.
59. Fearon KCH, von Meyenfeldt MF, Moses AGW, Van Geenen R, Roy A, Gouma DJ, et al. Effect of a protein and energy dense N-3 fatty acid enriched oral supplement on loss of weight and lean tissue in cancer cachexia: a randomised double blind trial. Gut. 2003;52:1479-86.
60. Ravasco P. Dietary Counseling Improves Patient Outcomes: A Prospective, Randomized, Controlled Trial in Colorectal Cancer Patients Undergoing Radiotherapy. J Clin Oncol. 2005;23:1431-8.
61. Bozzetti F, Arends J, Lundholm K, Micklewright A, Zurcher G, Muscaritoli M, et al. ESPEN Guidelines on Parenteral Nutrition: non-surgical oncology. Clin Nutr. 2009;28:445-54.
62. Arends J, Bodoky G, Bozzetti F, Fearon K, Muscaritoli M, Selga G, et al. ESPEN Guidelines on Enteral Nutrition: Non-surgical oncology. Clin Nutr. 2006;25:245-59.
63. Dev R, Hui D, Chisholm G, Delgado-Guay M, Dalal S, Del Fabbro E, et al. Hypermetabolism and symptom burden in advanced cancer patients evaluated in a cachexia clinic. J Cachex Sarcopenia Muscle. 2015;6:95-8.