Clinical outcomes and contributors to weight loss in a cancer cachexia clinic

Journal of Palliative Medicine

Volumn 14, Issue 9, 2011, Pages 1004-1008

  Del Fabbro, Egidio ^a   Hui, David ^a   Dalal, Shalini ^a   Dev, Rony ^a   Noorhuddin, Zohra ^a   Bruera, Eduardo ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT; CORTICOSTEROID; CYANOCOBALAMIN; HYDROCORTISONE; LAXATIVE; MELATONIN; METOCLOPRAMIDE; MIRTAZAPINE; MOUTHWASH; OPIATE; TESTOSTERONE; THALIDOMIDE; THYROID HORMONE; THYROTROPIN; ZINC;

ADRENAL INSUFFICIENCY; ADULT; AGED; ANOREXIA; APPETITE; BODY MASS; BODY WEIGHT; CACHEXIA; CALORIMETRY; CANCER CENTER; CONSTIPATION; CYANOCOBALAMIN DEFICIENCY; DYSGEUSIA; DYSPHAGIA; ENERGY EXPENDITURE; EXERCISE; FEMALE; FOLLOW UP; HORMONE SUBSTITUTION; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYPERMETABOLISM; HYPOGONADISM; HYPOTHYROIDISM; MAJOR CLINICAL STUDY; MALE; MOOD CHANGE; MOOD DISORDER; MUCOSA INFLAMMATION; NAUSEA; NUTRITIONAL COUNSELING; OUTCOME ASSESSMENT; PATIENT REFERRAL; REST; RETROSPECTIVE STUDY; REVIEW; SATIETY; SPEECH THERAPY; TESTOSTERONE BLOOD LEVEL; THYROTROPIN BLOOD LEVEL; TOOTH PAIN; VITAMIN BLOOD LEVEL; VOMITING; WEIGHT REDUCTION;

ADULT; AGED; AGED, 80 AND OVER; AMBULATORY CARE FACILITIES; CACHEXIA; FEMALE; HORMONE REPLACEMENT THERAPY; HUMANS; MALE; MIDDLE AGED; NEOPLASMS; OUTCOME ASSESSMENT (HEALTH CARE); YOUNG ADULT;

EID: 80052692183     PISSN: 10966218     EISSN: 15577740     Source Type: Journal    
DOI: 10.1089/jpm.2011.0098     Document Type: Review

References (25)

1. Suarez-Almazor ME, Newman C, Hanson J, Bruera E: Attitudes of terminally ill cancer patients about euthanasia and assisted suicide: Predominance of psychosocial determinants and beliefs over symptom distress and subsequent survival. J Clin Oncol 2002;20:2134-2141.
2. Tong H, Isenring E, Yates P: The prevalence of nutrition impact symptoms and their relationship to quality of life and clinical outcomes in medical oncology patients. Support Care Cancer 2009;17:83-90.
3. Dewys WD, Begg C, Lavin PT, Band PR, Bennett JM, Bertino JR, Cohen MH, Douglass HO Jr, Engstrom PF, Ezdinli EZ, Horton J, Johnson GJ, Moertel CG, Oken MM, Perlia C, Rosenbaum C, Silverstein MN, Skeel RT, Sponzo RW, Tormey DC: Prognostic effect of weight loss prior to chemotherapy in cancer patients. Eastern Cooperative Oncology Group. Am J Med 1980;69491-497.
4. Ross PJ, Ashley S, Norton A, Priest K, Waters JS, Eisen T, Smith IE, O'Brien ME: Do patients with weight loss have a worse outcome when undergoing chemotherapy for lung cancers? Br J Cancer 2004;90:1905-1911.
5. Fein R, Kelsen DP, Geller N, Bains M, McCormack P, Brennan MF: Adenocarcinoma of the esophagus and gastroesophageal junction. Prognostic factors and results of therapy. Cancer 1985;56:2512-2518.
6. Andreyev HJ, Norman AR, Oates J, Cunningham D: Why do patients with weight loss have a worse outcome when undergoing chemotherapy for gastrointestinal malignancies? Eur J Cancer 1998;34:503-509.
7. Evans WJ, Morley JE, Argiles J, Bales C, Baracos V, Guttridge D, Jatoi A, Kalantar-Zadeh K, Lochs H, Mantovani G, Marks D, Mitch WE, Muscaritoli M, Najand A, Ponikowski P, Rossi Fanelli F, Schambelan M, Schols A, Schuster M, Thomas D, Wolfe R, Anker SD: Cachexia: A new definition. Clin Nutr 2008;27:793-799.
8. Blum D, Omlin A, Fearon K, Baracos V, Radbruch L, Kaasa S, Strasser F; European Palliative Care Research Collaborative: Evolving classification systems for cancer cachexia: Ready for clinical practice? Support Care Cancer 2010;18:273-279.
9. Andrew I, Kirkpatrick G, Holden K, Hawkins C: Audit of symptoms and prescribing in patients with the anorexiacachexia syndrome. Pharm World Sci 2008;30:489-496.
10. LasheenW,D.Walsh: The cancer anorexia-cachexia syndrome: Myth or reality? Support Care Cancer 2010;18:265-272.
11. Khalid U, Spiro A, Baldwin C, Sharma B, McGough C, Norman AR, Eisen T, O'Brien ME, Cunnigham D, Andreyev HJ: Symptoms and weight loss in patients with gastrointestinal and lung cancer at presentation. Support Care Cancer 2007;15:39-46.
12. Kubrak C, Olson K, Jha N, Jensen L, McCargar L, Seikaly H, Harris J, Scrimger R, Parliament M, Baracos VE: Nutrition impact symptoms: Key determinants of reduced dietary intake, weight loss, and reduced functional capacity of patients with head and neck cancer before treatment. Head Neck 2010;32:290-300.
13. Ravasco P, Monteiro-Grillo I, Marques Vidal P, Camilo ME: Impact of nutrition on outcome: A prospective randomized controlled trial in patients with head and neck cancer undergoing radiotherapy. Head Neck 2005;27:659-668.
14. Strasser F, Palmer JL, Schover LR, Yusuf SW, Pisters K, Vassilopoulou-Sellin R, DeGracia B, Willey JS, Bruera E: The impact of hypogonadism and autonomic dysfunction on fatigue, emotional function, and sexual desire in male patients with advanced cancer: A pilot study. Cancer 2006;107:2949-2957.
15. Jereczek-Fossa BA, Alterio D, Jassem J, Gibelli B, Tradati N, Orecchia R: Radiotherapy-induced thyroid disorders. Cancer Treat Rev 2004;30:369-384.
16. Ottery FD: Definition of standardized nutritional assessment and interventional pathways in oncology. Nutrition 1996;12 (1 Suppl):S15-S19.
17. Yavuzsen T, Walsh D, Davis MP, Kirkova J, Jin T, LeGrand S, Lagman R, Bicanovsky L, Estfan B, Cheema B, Haddad A: Components of the anorexia-cachexia syndrome: Gastrointestinal symptom correlates of cancer anorexia. Support Care Cancer 2009;17:1531-41.
18. Grosvenor M, Bulcavage L, Chlebowski RT: Symptoms potentially influencing weight loss in a cancer population. Correlations with primary site, nutritional status, and chemotherapy administration. Cancer 1989;63:330-334.
19. Sarhill N, Mahmoud F, Walsh D, Nelson KA, Komurcu S, Davis M, LeGrand S, Abdullah O, Rybicki L: Evaluation of nutritional status in advanced metastatic cancer. Support Care Cancer 2003;11:652-659.
20. Prado CM, Lieffers JR, McCargar LJ, Reiman T, Sawyer MB, Martin L, Baracos VE: Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: A population-based study. Lancet Oncol 2008;9:629-635.
21. Dev R, Del Fabbro E, Bruera E: Association between megestrol acetate treatment and symptomatic adrenal insufficiency with hypogonadism in male patients with cancer. Cancer 2007;110:1173-1177.
22. Cannabis-In-Cachexia-Study-Group, Strasser F, Luftner D, Possinger K, Ernst G, Ruhstaller T, Meissner W, Ko YD, Schnelle M, Reif M, Cerny T: Comparison of orally administered cannabis extract and delta-9- tetrahydrocannabinol in treating patients with cancer-related anorexia-cachexia syndrome: A multicenter, phase III, randomized, double-blind, placebo-controlled clinical trial from the Cannabis-In-Cachexia- Study-Group. J Clin Oncol 2006;24:3394-3400.
23. Holick MF: Vitamin D deficiency. N Engl JMed 2007;357:266-281.
24. Bosaeus I, Daneryd P, Svanberg E, Lundholm K: Dietary intake and resting energy expenditure in relation to weight loss in unselected cancer patients. Int J Cancer 2001;93:380-383.
25. Hyltander A, Daneryd P, Sandstrom R, Korner U, Lundholm K: Beta-adrenoceptor activity and resting energy metabolism in weight losing cancer patients. Eur J Cancer 2000;36:330-334.