New coumarin-based fluorescent melatonin ligands. Design, synthesis and pharmacological characterization

European Journal of Medicinal Chemistry

Volumn 103, Issue , 2015, Pages 370-373

  De La Fuente Revenga, Mario ^a   Herrera Arozamena, Clara ^a   Fernández Sáez, Nerea ^a   Barco, Gema ^a   García Orue, Itxaso ^a   Sugden, David ^b   Rivara, Silvia ^c   Rodríguez Franco, María Isabel ^a  

^a INSTITUTO DE QUÍMICA MÉDICA   (Spain)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF PARMA   (Italy)

Author keywords

Bioisosterism; Coumarins; GPCRs fluorescent probes; Melatonin

Indexed keywords

COUMARIN DERIVATIVE; FLUORESCENT DYE; HORMONE RECEPTOR BLOCKING AGENT; INDOLE; MELATONIN; MELATONIN 1 RECEPTOR; MELATONIN 2 RECEPTOR; N [ 2 (6 METHOXY 2 OXO 2H CHROMEN 4 YL)ETHYL]ACETAMIDE; RADIOLIGAND; UNCLASSIFIED DRUG; COUMARIN; LIGAND;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CYCLIZATION; DRUG DESIGN; DRUG SYNTHESIS; HUMAN; MELANOPHORE; NONHUMAN; PROTEIN EXPRESSION; ROOM TEMPERATURE; XENOPUS LAEVIS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; METABOLISM; MOLECULAR IMAGING; PROCEDURES; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

COUMARINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; FLUORESCENT DYES; HUMANS; LIGANDS; MELATONIN; MOLECULAR IMAGING; MOLECULAR STRUCTURE; RECEPTOR, MELATONIN, MT1; RECEPTOR, MELATONIN, MT2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84941646552     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2015.09.003     Document Type: Article

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