-
2
-
-
77649337140
-
Nonalcoholic fatty liver disease. Pathology and pathogenesis
-
Tiniakos, D. G., Vos, M. B. & Brunt, E. M. Nonalcoholic fatty liver disease. pathology and pathogenesis. Annu Rev Pathol 5, 145-171 (2010).
-
(2010)
Annu Rev Pathol
, vol.5
, pp. 145-171
-
-
Tiniakos, D.G.1
Vos, M.B.2
Brunt, E.M.3
-
3
-
-
0031947715
-
Steatohepatitis. A tale of two hits?
-
Day, C. P. & James, O. F. Steatohepatitis. a tale of two hits? Gastroenterology 114, 842-845 (1998).
-
(1998)
Gastroenterology
, vol.114
, pp. 842-845
-
-
Day, C.P.1
James, O.F.2
-
4
-
-
79959517565
-
Human fatty liver disease. Old questions and new insights
-
Cohen, J. C., Horton, J. D. & Hobbs, H. H. Human fatty liver disease. old questions and new insights. Science 332, 1519-1523 (2011).
-
(2011)
Science
, vol.332
, pp. 1519-1523
-
-
Cohen, J.C.1
Horton, J.D.2
Hobbs, H.H.3
-
5
-
-
77950323927
-
Pathogenesis of non-alcoholic fatty liver disease
-
Dowman, J. K., Tomlinson, J. W. & Newsome, P. N. Pathogenesis of non-alcoholic fatty liver disease. QJM 103, 71-83 (2010).
-
(2010)
QJM
, vol.103
, pp. 71-83
-
-
Dowman, J.K.1
Tomlinson, J.W.2
Newsome, P.N.3
-
6
-
-
78049522194
-
Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis
-
Tilg, H. & Moschen, A. R. Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis. Hepatology 52, 1836-1846 (2010).
-
(2010)
Hepatology
, vol.52
, pp. 1836-1846
-
-
Tilg, H.1
Moschen, A.R.2
-
7
-
-
84884984539
-
Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease
-
Begriche, K., Massart, J., Robin, M. A., Bonnet, F. & Fromenty, B. Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease. Hepatology 58, 1497-1507 (2013).
-
(2013)
Hepatology
, vol.58
, pp. 1497-1507
-
-
Begriche, K.1
Massart, J.2
Robin, M.A.3
Bonnet, F.4
Fromenty, B.5
-
8
-
-
80052940689
-
Iron in fatty liver and in the metabolic syndrome: A promising therapeutic target
-
Dongiovanni, P., Fracanzani, A. L., Fargion, S. & Valenti, L. Iron in fatty liver and in the metabolic syndrome: a promising therapeutic target. J Hepatol 55, 920-932 (2011).
-
(2011)
J Hepatol
, vol.55
, pp. 920-932
-
-
Dongiovanni, P.1
Fracanzani, A.L.2
Fargion, S.3
Valenti, L.4
-
9
-
-
84855931616
-
ADH4 intronic variations are associated with alcohol dependence: Results from an Italian case-control association study
-
Turchi, C. et al. ADH4 intronic variations are associated with alcohol dependence: results from an Italian case-control association study. Pharmacogenet Genomics 22, 79-94 (2012).
-
(2012)
Pharmacogenet Genomics
, vol.22
, pp. 79-94
-
-
Turchi, C.1
-
10
-
-
84866421262
-
Critical role of cytochrome P450 2E1 (CYP2E1) in the development of high fat-induced non-alcoholic steatohepatitis
-
Abdelmegeed, M. A. et al. Critical role of cytochrome P450 2E1 (CYP2E1) in the development of high fat-induced non-alcoholic steatohepatitis. J Hepatol 57, 860-866 (2012).
-
(2012)
J Hepatol
, vol.57
, pp. 860-866
-
-
Abdelmegeed, M.A.1
-
11
-
-
84891737631
-
Molecular interplay between Delta5/Delta6 desaturases and long-chain fatty acids in the pathogenesis of non-alcoholic steatohepatitis
-
Lopez-Vicario, C. et al. Molecular interplay between Delta5/Delta6 desaturases and long-chain fatty acids in the pathogenesis of non-alcoholic steatohepatitis. Gut 63, 344-355 (2014).
-
(2014)
Gut
, vol.63
, pp. 344-355
-
-
Lopez-Vicario, C.1
-
12
-
-
39149104311
-
Molecular basis and mechanisms of progression of nonalcoholic steatohepatitis
-
Marra, F., Gastaldelli, A., Svegliati Baroni, G., Tell, G. & Tiribelli, C. Molecular basis and mechanisms of progression of nonalcoholic steatohepatitis. Trends Mol Med 14, 72-81 (2008).
-
(2008)
Trends Mol Med
, vol.14
, pp. 72-81
-
-
Marra, F.1
Gastaldelli, A.2
Svegliati Baroni, G.3
Tell, G.4
Tiribelli, C.5
-
13
-
-
78651089694
-
Animal models of nonalcoholic fatty liver disease
-
Hebbard, L. & George, J. Animal models of nonalcoholic fatty liver disease. Nat Rev Gastroenterol Hepatol 8, 35-44 (2011).
-
(2011)
Nat Rev Gastroenterol Hepatol
, vol.8
, pp. 35-44
-
-
Hebbard, L.1
George, J.2
-
14
-
-
80052947518
-
NASH animal models: Are we there yet?
-
Kohli, R. & Feldstein, A. E. NASH animal models: are we there yet? J Hepatol 55, 941-943 (2011).
-
(2011)
J Hepatol
, vol.55
, pp. 941-943
-
-
Kohli, R.1
Feldstein, A.E.2
-
15
-
-
77949311823
-
Nonalcoholic fatty liver disease: A review and update
-
Lewis, J. R. & Mohanty, S. R. Nonalcoholic fatty liver disease: a review and update. Dig Dis Sci 55, 560-578 (2010).
-
(2010)
Dig Dis Sci
, vol.55
, pp. 560-578
-
-
Lewis, J.R.1
Mohanty, S.R.2
-
16
-
-
38949085542
-
The development of porcine models of obesity and the metabolic syndrome
-
Spurlock, M. E. & Gabler, N. K. The development of porcine models of obesity and the metabolic syndrome. J Nutr 138, 397-402 (2008).
-
(2008)
J Nutr
, vol.138
, pp. 397-402
-
-
Spurlock, M.E.1
Gabler, N.K.2
-
17
-
-
77954562869
-
Porcine models for the metabolic syndrome, digestive and bone disorders: A general overview
-
Litten-Brown, J. C., Corson, A. M. & Clarke, L. Porcine models for the metabolic syndrome, digestive and bone disorders: a general overview. Animal 4, 899-920 (2010).
-
(2010)
Animal
, vol.4
, pp. 899-920
-
-
Litten-Brown, J.C.1
Corson, A.M.2
Clarke, L.3
-
18
-
-
84869003221
-
Analyses of pig genomes provide insight into porcine demography and evolution
-
Groenen, M. A. M. et al. Analyses of pig genomes provide insight into porcine demography and evolution. Nature 491, 393-398 (2012).
-
(2012)
Nature
, vol.491
, pp. 393-398
-
-
Groenen, M.A.M.1
-
19
-
-
0036291432
-
High-fat high-energy feeding impairs fasting glucose and increases fasting insulin levels in the Gottingen minipig - Results from a pilot study
-
Larsen, M. O., Rolin, B., Wilken, M., Carr, R. D. & Svendsen, O. High-fat high-energy feeding impairs fasting glucose and increases fasting insulin levels in the Gottingen minipig - Results from a pilot study. Ann Ny Acad Sci 967, 414-423 (2002).
-
(2002)
Ann Ny Acad Sci
, vol.967
, pp. 414-423
-
-
Larsen, M.O.1
Rolin, B.2
Wilken, M.3
Carr, R.D.4
Svendsen, O.5
-
20
-
-
25444470246
-
Obesity induced during sexual maturation is linked to LDL-triacylglycerols in Yucatan miniature swine
-
Sebert, S. P. et al. Obesity induced during sexual maturation is linked to LDL-triacylglycerols in Yucatan miniature swine. Brit J Nutr 94, 282-289 (2005).
-
(2005)
Brit J Nutr
, vol.94
, pp. 282-289
-
-
Sebert, S.P.1
-
21
-
-
33646479329
-
Components of metabolic syndrome and coronary artery disease in female ossabaw swine fed excess atherogenic diet
-
Dyson, M. C., Alloosh, M., Vuchetich, J. P., Mokelke, E. A. & Sturek, M. Components of metabolic syndrome and coronary artery disease in female ossabaw swine fed excess atherogenic diet. Comparative Med 56, 35-45 (2006).
-
(2006)
Comparative Med
, vol.56
, pp. 35-45
-
-
Dyson, M.C.1
Alloosh, M.2
Vuchetich, J.P.3
Mokelke, E.A.4
Sturek, M.5
-
22
-
-
67651146952
-
Nutritional Model of Steatohepatitis and Metabolic Syndrome in the Ossabaw Miniature Swine
-
Lee, L. et al. Nutritional Model of Steatohepatitis and Metabolic Syndrome in the Ossabaw Miniature Swine. Hepatology 50, 56-67 (2009).
-
(2009)
Hepatology
, vol.50
, pp. 56-67
-
-
Lee, L.1
-
23
-
-
70350341897
-
The susceptibility of three strains of Chinese minipigs to diet-induced type 2 diabetes mellitus
-
Chen, H., Liu, Y. Q., Li, C. H., Guo, X. M. & Huang, L. J. The susceptibility of three strains of chinese minipigs to diet-induced type 2 diabetes mellitus. Lab Animal 38, 355-363 (2009).
-
(2009)
Lab Animal
, vol.38
, pp. 355-363
-
-
Chen, H.1
Liu, Y.Q.2
Li, C.H.3
Guo, X.M.4
Huang, L.J.5
-
24
-
-
20044374023
-
Design and validation of a histological scoring system for nonalcoholic fatty liver disease
-
Kleiner, D. E. et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 41, 1313-1321 (2005).
-
(2005)
Hepatology
, vol.41
, pp. 1313-1321
-
-
Kleiner, D.E.1
-
25
-
-
84941562556
-
Aquaporins and glycerol metabolism in health and disease. Translational value in liver steatosis and obesity
-
Calamita, G. et al. Aquaporins and glycerol metabolism in health and disease. Translational value in liver steatosis and obesity. European Journal of Clinical Investigation 44, 76-76 (2014).
-
(2014)
European Journal of Clinical Investigation
, vol.44
, pp. 76-76
-
-
Calamita, G.1
-
26
-
-
84865451683
-
Implications of aquaglyceroporins 7 and 9 in glycerol metabolism and metabolic syndrome
-
Maeda, N. Implications of aquaglyceroporins 7 and 9 in glycerol metabolism and metabolic syndrome. Molecular Aspects of Medicine 33, 665-675 (2012).
-
(2012)
Molecular Aspects of Medicine
, vol.33
, pp. 665-675
-
-
Maeda, N.1
-
27
-
-
43049172157
-
Acetyl-coenzyme A acyltransferase 2 attenuates the apoptotic effects of BNIP3 in two human cell lines
-
Cao, W. et al. Acetyl-coenzyme A acyltransferase 2 attenuates the apoptotic effects of BNIP3 in two human cell lines. Bba-Gen Subjects 1780, 873-880 (2008).
-
(2008)
Bba-Gen Subjects
, vol.1780
, pp. 873-880
-
-
Cao, W.1
-
28
-
-
77951923438
-
Crystal Structures of Human HMG-CoA Synthase Isoforms Provide Insights into Inherited Ketogenesis Disorders and Inhibitor Design
-
Shafqat, N., Turnbull, A., Zschocke, J., Oppermann, U. & Yue, W. W. Crystal Structures of Human HMG-CoA Synthase Isoforms Provide Insights into Inherited Ketogenesis Disorders and Inhibitor Design. Journal of Molecular Biology 398, 497-506 (2010).
-
(2010)
Journal of Molecular Biology
, vol.398
, pp. 497-506
-
-
Shafqat, N.1
Turnbull, A.2
Zschocke, J.3
Oppermann, U.4
Yue, W.W.5
-
29
-
-
79955500310
-
Dietary Arachidonate Differentially Alters Desaturase-Elongase Pathway Flux and Gene Expression in Liver and Intestine of Suckling Pigs
-
Jacobi, S. K. et al. Dietary Arachidonate Differentially Alters Desaturase-Elongase Pathway Flux and Gene Expression in Liver and Intestine of Suckling Pigs. Journal of Nutrition 141, 548-553 (2011).
-
(2011)
Journal of Nutrition
, vol.141
, pp. 548-553
-
-
Jacobi, S.K.1
-
30
-
-
77449154762
-
Remodeling of Retinal Fatty Acids in an Animal Model of Diabetes A Decrease in Long-Chain Polyunsaturated Fatty Acids Is Associated with a Decrease in Fatty Acid Elongases Elovl2 and Elovl4
-
Tikhonenko, M. et al. Remodeling of Retinal Fatty Acids in an Animal Model of Diabetes A Decrease in Long-Chain Polyunsaturated Fatty Acids Is Associated With a Decrease in Fatty Acid Elongases Elovl2 and Elovl4. Diabetes 59, 219-227 (2010).
-
(2010)
Diabetes
, vol.59
, pp. 219-227
-
-
Tikhonenko, M.1
-
31
-
-
33644878716
-
Coordinated alteration of hepatic gene expression in fatty acid and triglyceride synthesis in LCAT-null mice is associated with altered PUFA metabolism
-
Song, H. et al. Coordinated alteration of hepatic gene expression in fatty acid and triglyceride synthesis in LCAT-null mice is associated with altered PUFA metabolism. Am J Physiol-Endoc M 290, E17-E25 (2006).
-
(2006)
Am J Physiol-Endoc M
, vol.290
, pp. E17-E25
-
-
Song, H.1
-
32
-
-
33746959419
-
Identification and characterization of associated with lipid droplet protein 1: A novel membrane-associated protein that resides on hepatic lipid droplets
-
Turro, S. et al. Identification and characterization of associated with lipid droplet protein 1: A novel membrane-associated protein that resides on hepatic lipid droplets. Traffic 7, 1254-1269 (2006).
-
(2006)
Traffic
, vol.7
, pp. 1254-1269
-
-
Turro, S.1
-
33
-
-
79959193993
-
Changes in carnitine octanoyltransferase activity induce alteration in fatty acid metabolism
-
Le Borgne, F., Ben Mohamed, A., Logerot, M., Garnier, E. & Demarquoy, J. Changes in carnitine octanoyltransferase activity induce alteration in fatty acid metabolism. Biochem Bioph Res Co 409, 699-704 (2011).
-
(2011)
Biochem Bioph Res Co
, vol.409
, pp. 699-704
-
-
Le Borgne, F.1
Ben Mohamed, A.2
Logerot, M.3
Garnier, E.4
Demarquoy, J.5
-
34
-
-
23044475041
-
Creatine synthesis and transport during rat embryogenesis: Spatiotemporal expression of AGAT
-
Braissant, O. et al. Creatine synthesis and transport during rat embryogenesis: Spatiotemporal expression of AGAT, GAMT and CT1. BMC Dev Biol 5, 9 (2005).
-
(2005)
GAMT and CT1. BMC Dev Biol
, vol.5
, pp. 9
-
-
Braissant, O.1
-
35
-
-
42949158785
-
Cardiac manifestations in a child with a novel mutation in creatine transporter gene SLC6A8
-
Anselm, I. A., Coulter, D. L. & Darras, B. T. Cardiac manifestations in a child with a novel mutation in creatine transporter gene SLC6A8. Neurology 70, 1642-1644 (2008).
-
(2008)
Neurology
, vol.70
, pp. 1642-1644
-
-
Anselm, I.A.1
Coulter, D.L.2
Darras, B.T.3
-
36
-
-
0027360398
-
The gene for creatine kinase, mitochondrial 2 (sarcomeric; CKMT2), maps to chromosome 5q13.3
-
Richard I., Devaud C., Cherif D., Cohen D., Beckmann J. S. The gene for creatine kinase, mitochondrial 2 (sarcomeric; CKMT2), maps to chromosome 5q13.3. Genomics 18, 134-136 (1993).
-
(1993)
Genomics
, vol.18
, pp. 134-136
-
-
Richard, I.1
Devaud, C.2
Cherif, D.3
Cohen, D.4
Beckmann, J.S.5
-
37
-
-
2442475483
-
Severely altered guanidino compound levels, disturbed body weight homeostasis and impaired fertility in a mouse model of guanidinoacetate N-methyltransferase (GAMT) deficiency
-
Schmidt, A. et al. Severely altered guanidino compound levels, disturbed body weight homeostasis and impaired fertility in a mouse model of guanidinoacetate N-methyltransferase (GAMT) deficiency. Hum Mol Genet 13, 905-921 (2004).
-
(2004)
Hum Mol Genet
, vol.13
, pp. 905-921
-
-
Schmidt, A.1
-
38
-
-
84872406355
-
And oxidant stress in alcoholic and non-alcoholic fatty liver disease
-
Leung, T. M. & Nieto, N. CYP2E1 and oxidant stress in alcoholic and non-alcoholic fatty liver disease. J Hepatol 58, 395-398 (2013).
-
(2013)
J Hepatol
, vol.58
, pp. 395-398
-
-
Leung, T.M.1
Cype, N.N.2
-
39
-
-
77949677097
-
Role of alcohol metabolism in non-alcoholic steatohepatitis
-
Baker, S. S., Baker, R. D., Liu, W., Nowak, N. J. & Zhu, L. Role of alcohol metabolism in non-alcoholic steatohepatitis. PLoS One 5, e9570 (2010).
-
(2010)
PLoS One
, vol.5
, pp. e9570
-
-
Baker, S.S.1
Baker, R.D.2
Liu, W.3
Nowak, N.J.4
Zhu, L.5
-
40
-
-
14544308375
-
Nonalcoholic fatty liver disease: A clinical review
-
Sass, D. A., Chang, P. & Chopra, K. B. Nonalcoholic fatty liver disease: a clinical review. Dig Dis Sci 50, 171-180 (2005).
-
(2005)
Dig Dis Sci
, vol.50
, pp. 171-180
-
-
Sass, D.A.1
Chang, P.2
Chopra, K.B.3
-
41
-
-
0034529050
-
Cell biology-How cells handle cholesterol
-
Simons, K. & Ikonen, E. Cell biology-How cells handle cholesterol. Science 290, 1721-1726 (2000).
-
(2000)
Science
, vol.290
, pp. 1721-1726
-
-
Simons, K.1
Ikonen, E.2
-
42
-
-
55649103668
-
Insulin resistance, inflammation, and non-alcoholic fatty liver disease
-
Tilg, H. & Moschen, A. R. Insulin resistance, inflammation, and non-alcoholic fatty liver disease. Trends Endocrin Met 19, 371-379 (2008).
-
(2008)
Trends Endocrin Met
, vol.19
, pp. 371-379
-
-
Tilg, H.1
Moschen, A.R.2
-
43
-
-
82355191481
-
Pathology of the liver in obese and diabetic ob/ob and db/db mice fed a standard or high-calorie diet
-
Trak-Smayra, V. et al. Pathology of the liver in obese and diabetic ob/ob and db/db mice fed a standard or high-calorie diet. International Journal of Experimental Pathology 92, 413-421 (2011).
-
(2011)
International Journal of Experimental Pathology
, vol.92
, pp. 413-421
-
-
Trak-Smayra, V.1
-
44
-
-
84875164496
-
Hepatic triacylglycerol synthesis and secretion: DGAT2 as the link between glycaemia and triglyceridaemia
-
Zammit, V. A. Hepatic triacylglycerol synthesis and secretion: DGAT2 as the link between glycaemia and triglyceridaemia. Biochemical Journal 451, 1-12 (2013).
-
(2013)
Biochemical Journal
, vol.451
, pp. 1-12
-
-
Zammit, V.A.1
-
45
-
-
84931571498
-
Ketone body production is differentially altered in steatosis and non-alcoholic steatohepatitis in obese humans
-
Mannisto, V. T. et al. Ketone body production is differentially altered in steatosis and non-alcoholic steatohepatitis in obese humans. Liver International, doi: 10.1111/liv.12769 (2015).
-
(2015)
Liver International
-
-
Mannisto, V.T.1
-
46
-
-
0036080081
-
P-450 metabolites of arachidonic acid in the control of cardiovascular function
-
Roman, R. J. P-450 metabolites of arachidonic acid in the control of cardiovascular function. Physiol Rev 82, 131-185 (2002).
-
(2002)
Physiol Rev
, vol.82
, pp. 131-185
-
-
Roman, R.J.1
-
47
-
-
31344464596
-
Role of cytochrome P450 in phospholipase A2-and arachidonic acid-mediated cytotoxicity
-
Caro, A. A. & Cederbaum, A. I. Role of cytochrome P450 in phospholipase A2-and arachidonic acid-mediated cytotoxicity. Free Radical Bio Med 40, 364-375 (2006).
-
(2006)
Free Radical Bio Med
, vol.40
, pp. 364-375
-
-
Caro, A.A.1
Cederbaum, A.I.2
-
48
-
-
69249233513
-
Role of hepatic iron in non-alcoholic steatohepatitis
-
Sumida, Y., Yoshikawa, T. & Okanoue, T. Role of hepatic iron in non-alcoholic steatohepatitis. Hepatology Research 39, 213-222 (2009).
-
(2009)
Hepatology Research
, vol.39
, pp. 213-222
-
-
Sumida, Y.1
Yoshikawa, T.2
Okanoue, T.3
-
49
-
-
80053083941
-
The mammalian target of rapamycin regulates cholesterol biosynthetic gene expression and exhibits a rapamycin-resistant transcriptional profile
-
Wang, B. T. et al. The mammalian target of rapamycin regulates cholesterol biosynthetic gene expression and exhibits a rapamycin-resistant transcriptional profile. P Natl Acad Sci USA 108, 15201-15206 (2011).
-
(2011)
P Natl Acad Sci USA
, vol.108
, pp. 15201-15206
-
-
Wang, B.T.1
-
50
-
-
84872486137
-
Early growth response protein 1 upregulation and nuclear translocation by 2 -benzoyloxycinnamaldehyde induces prostate cancer cell death
-
Kang, H. S. et al. Early growth response protein 1 upregulation and nuclear translocation by 2 -benzoyloxycinnamaldehyde induces prostate cancer cell death. Cancer Lett 329, 217-227 (2013).
-
(2013)
Cancer Lett
, vol.329
, pp. 217-227
-
-
Kang, H.S.1
-
51
-
-
18644381734
-
ATF3 induction following DNA damage is regulated by distinct signaling pathways and over-expression of ATF3 protein suppresses cells growth
-
Fan, F. Y. et al. ATF3 induction following DNA damage is regulated by distinct signaling pathways and over-expression of ATF3 protein suppresses cells growth. Oncogene 21, 7488-7496 (2002).
-
(2002)
Oncogene
, vol.21
, pp. 7488-7496
-
-
Fan, F.Y.1
-
52
-
-
78650539308
-
From RNA-seq reads to differential expression results
-
Oshlack, A., Robinson, M. D. & Young, M. D. From RNA-seq reads to differential expression results. Genome Biol 11, 220 (2010).
-
(2010)
Genome Biol
, vol.11
, Issue.220
-
-
Oshlack, A.1
Robinson, M.D.2
Young, M.D.3
-
53
-
-
79952709611
-
Improving RNA-Seq expression estimates by correcting for fragment bias
-
Roberts, A., Trapnell, C., Donaghey, J., Rinn, J. L. & Pachter, L. Improving RNA-Seq expression estimates by correcting for fragment bias. Genome Biol 12, R22 (2011).
-
(2011)
Genome Biol
, vol.12
, Issue.R22
-
-
Roberts, A.1
Trapnell, C.2
Donaghey, J.3
Rinn, J.L.4
Pachter, L.5
-
54
-
-
84883644707
-
Comprehensive evaluation of differential gene expression analysis methods for RNA-seq data
-
Rapaport, F. et al. Comprehensive evaluation of differential gene expression analysis methods for RNA-seq data. Genome Biol 14, R95 (2013).
-
(2013)
Genome Biol
, vol.14
, Issue.R95
-
-
Rapaport, F.1
|