Crystal Structures of Human HMG-CoA Synthase Isoforms Provide Insights into Inherited Ketogenesis Disorders and Inhibitor Design

Journal of Molecular Biology

Volumn 398, Issue 4, 2010, Pages 497-506

  Shafqat, Naeem ^a   Turnbull, Andrew ^a   Zschocke, Johannes ^b   Oppermann, Udo ^a,c   Yue, Wyatt W ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^c NIHR OXFORD BIOMEDICAL RESEARCH CENTRE   (United Kingdom)

Author keywords

Condensation; HMG CoA; Ketone bodies; Mevalonate; Mitochondrial HMGCS deficiency

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A SYNTHASE; ISOPROTEIN; KETONE;

ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; CYTOSOL; ENZYME DEFICIENCY; GENE MAPPING; HYDROXYMETHYLGLUTARYL COENZYME A SYNTHASE DEFICIENCY; KETOGENESIS; MISSENSE MUTATION; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; STRUCTURAL HOMOLOGY; STRUCTURE ANALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; DIMERIZATION; DRUG ANTAGONISM; GENETICS; HUMAN; METABOLISM; PROTEIN QUATERNARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

EUKARYOTA; MAMMALIA; POSIBACTERIA; PROKARYOTA;

CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; HUMANS; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; KETONES; MODELS, MOLECULAR; MUTATION, MISSENSE; PROTEIN ISOFORMS; PROTEIN STRUCTURE, QUATERNARY;

EID: 77951923438     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2010.03.034     Document Type: Article

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