5,7,3′-trihydroxy-3,4′-dimethoxyflavone-induced cell death in human leukemia cells is dependent on caspases and activates the MAPK pathway

Molecular Carcinogenesis

Volumn 49, Issue 5, 2010, Pages 464-475

  Torres, Fernando ^a,b   Quintana, José ^a,b   Estévez, Francisco ^a,b  

^a UNIVERSITY OF LAS PALMAS DE GRAN CANARIA   (Spain)

^b Madrid Spain   (Spain)

Author keywords

Apoptosis; c jun N terminal kinases; Cell cycle arrest; Extracellular signal regulated kinases; Flavonoids; Mitogen activated protein kinases

Indexed keywords

5,7,3' TRIHYDROXY 3,4 DIMETHOXYFLAVONE; CASPASE; CASPASE 3; CASPASE 6; CASPASE 7; CASPASE 9; CYTOCHROME C; FLAVONOID; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BCL 2; PROTEIN BCL XL; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; 5,7,3' TRIHYDROXY 3,4' DIMETHOXYFLAVONE; 5,7,3'-TRIHYDROXY-3,4'-DIMETHOXYFLAVONE; ANTINEOPLASTIC AGENT; FLAVONE DERIVATIVE;

APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL DEATH; CELL VIABILITY; CYTOTOXICITY; DRUG EFFECT; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LEUKEMIA; LEUKEMIA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TUMOR CELL LINE; CELL DIVISION; ENZYME ACTIVATION; ENZYMOLOGY; FLOW CYTOMETRY; LYMPHOCYTE; METABOLISM; MYELOID LEUKEMIA; PATHOLOGY; SIGNAL TRANSDUCTION;

ANTICARCINOGENIC AGENTS; APOPTOSIS; CASPASES; CELL DIVISION; CELL LINE, TUMOR; ENZYME ACTIVATION; FLAVONES; FLOW CYTOMETRY; G2 PHASE; HUMANS; LEUKEMIA, MYELOID; LYMPHOCYTES; MAP KINASE SIGNALING SYSTEM;

EID: 77953033838     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.20619     Document Type: Article

References (38)

1. Middleton E, Kandaswami C, Theoharides TC. The effects of plant flavonoids on mammalian cells: Implications for inflammation, heart disease, and cancer. Pharmacol Rev 2000;52:673-751.
2. Teofili L, Pierelli L, Iovino MS, et al. The combination of quercetin and cytosine arabinoside synergistically inhibits leukemic cell growth. Leuk Res 1992;16:497-503.
3. Wei YQ, Zhao X, Kariya Y, Fukata H, Teshigawara K, Uchida A. Induction of apoptosis by quercetin: Involvement of heat shock protein. Cancer Res 1994;54:4952-4957. (Pubitemid 24289427)
4. Thornberry NA, Lazebnik Y. Caspases: Enemies within. Science 1998;281:1312-1316.
5. Boatright KM, Salvesen GS. Mechanisms of caspase activation. Curr Opin Cell Biol 2003;15:725-731.
6. Nagata S. Apoptosis by death factor. Cell 1997;88:355-365.
7. Cohen GM. Caspases: The executioners of apoptosis. Biochem J 1997;326:1-16.
8. Breckenridge DG, Germain M, Mathai JP, Nguyen M, Shore GC. Regulation of apoptosis by endoplasmic reticulum pathways. Oncogene 2003;22:8608-8618.
9. Chipuk JE, Green DR. Do inducers of apoptosis trigger caspase-independent cell death? Nat Rev Mol Cell Biol 2005;6:268-275.
10. Raman M, Chen W, Cobb MH. Differential regulation and properties of MAPKs. Oncogene 2007;26:3100-3112.
11. Verheij M, Bose R, Lin XH, et al. Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature 1996;380:75-79.
12. Davis RJ. Signal transduction by the JNK group of MAP kinases. Cell 2000;103:239-252.
13. Rubio S, Quintana J, López M, Eiroa JL, Triana J, Estévez F. Phenylbenzopyrones structure-activity studies identify betuletol derivatives as potential antitumoral agents. Eur J Pharmacol 2006;548:9-20.
14. 2-M phase arrest and apoptosis by α-methylene-γ-butyrolactones in human leukaemia cells. Cancer Lett 2008;269:139-147.
15. Rubio S, Quintana J, Eiroa JL, Triana J, Estévez F. Acetyl derivative of quercetin 3-methyl ether-induced cell death in human leukemia cells is amplified by the inhibition of ERK. Carcinogenesis 2007;28:2105-2113.
16. Kaczmarek L, Calabretta B, Baserga R. Expression of cell-cycle-dependent genes in phytohemagglutinin-stimulated humanlymphocytes. Proc Natl Acad Sci USA 1985;82:5375-5379.
17. Torres F, Quintana J, Díaz JG, Carmona AJ, Estévez F. Trifolin acetate-induced cell death in human leukaemia cells is dependent on caspase-6 and activates the MAPK pathway. Apoptosis 2008;13:716-728.
18. De Lean A, Munson PJ, Rodbard D. Simultaneous analysis of families of sigmoidal curves: Application to bioassay, radio-ligand assay, and physiological dose-response curves. Am J Physiol 1978;235:E97-E102.
19. Zhang L, Yu J, Park BH, Kinzler KW, Vogelstein B. Role of BAX in the apoptotic response to anticancer agents. Science 2000;290:989-992.
20. Perlman H, Zhang X, Chen MW, Walsh K, Buttyan R. An elevated bax/bcl-2 ratio corresponds with the onset of prostate epithelial cell apoptosis. Cell Death Differ 1999;6:48-54. (Pubitemid 29051854)
21. Soldani C, Scovassi AI. Poly(ADP-ribose) polymerase-1 cleavage during apoptosis: An update. Apoptosis 2002;7:321-328.
22. Amundson SA, Myers TG, Scudiero D, Kitada S, Reed JC, Fornace AJ, Jr. An informatics approach identifying markers of chemosensitivity in human cancer cell lines. Cancer Res 2000;60:6101-6110.
23. Addeo R, Caraglia M, Baldi A, et al. Prognostic role of bcl-xL and p53 in childhood acute lymphoblastic leukemia (ALL). Cancer Biol Ther 2005;4:32-38.
24. Tobiume K, Matsuzawa A, Takahashi T, et al. ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis. EMBO Rep 2001;2:222-228.
25. Ghatan S, Larner S, Kinoshita Y, et al. p38 MAP kinase mediates bax translocation in nitric oxide-induced apoptosis in neurons. J Cell Biol 2000;150:335-347.
26. Bulavin DV, Higashimoto Y, Popoff IJ, et al. Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase. Nature 2001;411:102-107.
27. Matsusaka T, Pines J. Chfr acts with the p38 stress kinases to block entry to mitosis in mammalian cells. J Cell Biol 2004;166:507-516.
28. Beutler JA, Hamel E, Vlietinck AJ, et al. Structure-activity requirements for flavone cytotoxicity and binding to tubulin. J Med Chem 1998;41:2333-2338.
29. Brantley-Finley C, Lyle CS, Du L, et al. The JNK, ERK and p53 pathways play distinct roles in apoptosis mediated by the antitumor agents vinblastine, doxorubicin, and etoposide. Biochem Pharmacol 2003;66:459-469.
30. Mingo-Sion AM, Marietta PM, Koller E, Wolf DM, Van Den Berg CL. Inhibition of JNK reduces G2/M transit independent of p53, leading to endoreduplication, decreased proliferation, and apoptosis in breast cancer cells. Oncogene 2004;23:596-604.
31. Chauhan D, Li G. JNK-dependent release of mitochondrial protein, Smac, during apoptosis in multiple myeloma (MM) cells. J Biol Chem 2003;278:17593-17596. (Pubitemid 36799359)
32. Owens DM, Keyse SM. Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases. Oncogene 2007;26:3203-3213.
33. Kamata H, Honda S, Maeda S, Chang L, Hirata H, Karin M. Reactive oxygen species promote TNFa-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell 2005;120:649-661.
34. Tonks NK. Redox redux: Revisiting PTPs and the control of cell signaling. Cell 2005;121:667-670.
35. Lien S-C, Usami S, Chien S, Chiu J-J. Phosphatidylinositol 3-kinase/Akt pathway is involved in transforming growth factor-β1-induced phenotypic modulation of 10T1/2 cells to smooth muscle cells. Cell Signal 2006;18:1270-1278.
36. Nguyen TTT, Tran E, Nguyen TH, Do PT, Huynh TH, Huynh H. The role of activated MEK-ERK pathway in quercetin-induced growth inhibition and apoptosis in A549 lung cancer cells. Carcinogenesis 2004;25:647-659.
37. Rubio S, Quintana J, Eiroa JL, Triana J, Estévez F. Betuletol 3-methyl ether induces G2-M phase arrest and activates the sphingomyelin and MAPK pathways in human leukemia cells. Mol Carcinog 2010;49:32-43.
38. Apel K, Hirt H. Reactive oxygen species: Metabolism, oxidative stress, and signal transduction. Annu Rev Plant Biol 2004;55:373-399.