Green tea extract activates AMPK and ameliorates white adipose tissue metabolic dysfunction induced by obesity

European Journal of Nutrition

Volumn 55, Issue 7, 2016, Pages 2231-2244

  Rocha, Andréa ^a   Bolin, Anaysa Paola ^a,b   Cardoso, Claudia Andrea Lima ^c   Otton, Rosemari ^a,b  

^a UNIVERSIDADE CRUZEIRO DO SUL   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c Mato Grosso do Sul University   (Brazil)

Author keywords

Flavonoids; Gene expression; Metabolism; Obesity; Polyphenols

Indexed keywords

CAFFEINE; CHOLESTEROL; FAT DROPLET; FLAVONOID; GLUCOSE; GLUCOSE TRANSPORTER 4; GREEN TEA EXTRACT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; MESSENGER RNA; POLYPHENOL; TRIACYLGLYCEROL; ALANINE AMINOTRANSFERASE; ANTIOXIDANT; ASPARTATE AMINOTRANSFERASE; CYTOKINE; GLUCOSE BLOOD LEVEL; LIPID; PLANT EXTRACT; TEA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIET INDUCED OBESITY; FATTY ACID OXIDATION; FEEDING; GENE EXPRESSION; GLUCOSE TOLERANCE TEST; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOLOGY; HYPERLIPIDEMIA; INSULIN RESISTANCE; INSULIN SENSITIVITY; INSULIN TOLERANCE TEST; LIPID LIVER LEVEL; LIPID STORAGE; LIPOGENESIS; LIPOLYSIS; MALE; NONHUMAN; OBESITY; RAT; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT GAIN; WHITE ADIPOSE TISSUE; WISTAR RAT; ANIMAL; BLOOD; CHEMISTRY; DRUG EFFECTS; GLUCOSE BLOOD LEVEL; LIVER; METABOLISM; TEA;

ADIPOSE TISSUE, WHITE; ALANINE TRANSAMINASE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ANTIOXIDANTS; ASPARTATE AMINOTRANSFERASES; BLOOD GLUCOSE; CAFFEINE; CYTOKINES; FLAVONOIDS; GLUCOSE TOLERANCE TEST; INSULIN RESISTANCE; LIPIDS; LIPOGENESIS; LIPOLYSIS; LIVER; MALE; OBESITY; PLANT EXTRACTS; POLYPHENOLS; RATS; RATS, WISTAR; TEA; WEIGHT GAIN;

EID: 84941350650     PISSN: 14366207     EISSN: 14366215     Source Type: Journal    
DOI: 10.1007/s00394-015-1033-8     Document Type: Article

References (27)

1. Ahmadian M, Duncan RE, Sul HS (2009) The skinny on fat: lipolysis and fatty acid utilization in adipocytes. Trends Endocrinol Metab: TEM 20(9):424–428. doi:10.1016/j.tem.2009.06.002
2. Postic C, Girard J (2008) Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice. J Clin Investig 118(3):829–838. doi:10.1172/JCI34275
3. Zhang BB, Zhou G, Li C (2009) AMPK: an emerging drug target for diabetes and the metabolic syndrome. Cell Metab 9(5):407–416. doi:10.1016/j.cmet.2009.03.012
4. Lage R, Dieguez C, Vidal-Puig A, Lopez M (2008) AMPK: a metabolic gauge regulating whole-body energy homeostasis. Trends Mol Med 14(12):539–549. doi:10.1016/j.molmed.2008.09.007
5. Basu A, Betts NM, Mulugeta A, Tong C, Newman E, Lyons TJ (2013) Green tea supplementation increases glutathione and plasma antioxidant capacity in adults with the metabolic syndrome. Nutr Res 33(3):180–187. doi:10.1016/j.nutres.2012.12.010
6. Sae-tan S, Grove KA, Lambert JD (2011) Weight control and prevention of metabolic syndrome by green tea. Pharmacol Res 64(2):146–154. doi:10.1016/j.phrs.2010.12.013
7. Park HJ, DiNatale DA, Chung MY, Park YK, Lee JY, Koo SI, O’Connor M, Manautou JE, Bruno RS (2011) Green tea extract attenuates hepatic steatosis by decreasing adipose lipogenesis and enhancing hepatic antioxidant defenses in ob/ob mice. J Nutr Biochem 22(4):393–400. doi:10.1016/j.jnutbio.2010.03.009
8. Singh BN, Shankar S, Srivastava RK (2011) Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications. Biochem Pharmacol 82(12):1807–1821. doi:10.1016/j.bcp.2011.07.093
9. Hong MH, Kim MH, Chang HJ, Kim NH, Shin BA, Ahn BW, Jung YD (2007) (-)-Epigallocatechin-3-gallate inhibits monocyte chemotactic protein-1 expression in endothelial cells via blocking NF-kappaB signaling. Life Sci 80(21):1957–1965. doi:10.1016/j.lfs.2007.02.024
10. Lin YL, Lin JK (1997) (-)-Epigallocatechin-3-gallate blocks the induction of nitric oxide synthase by down-regulating lipopolysaccharide-induced activity of transcription factor nuclear factor-kappaB. Mol Pharmacol 52(3):465–472
11. Zang M, Xu S, Maitland-Toolan KA, Zuccollo A, Hou X, Jiang B, Wierzbicki M, Verbeuren TJ, Cohen RA (2006) Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-deficient mice. Diabetes 55(8):2180–2191. doi:10.2337/db05-1188
12. Huang HC, Lin JK (2012) Pu-erh tea, green tea, and black tea suppresses hyperlipidemia, hyperleptinemia and fatty acid synthase through activating AMPK in rats fed a high-fructose diet. Food Funct 3(2):170–177. doi:10.1039/c1fo10157a
13. Hansen MJ, Jovanovska V, Morris MJ (2004) Adaptive responses in hypothalamic neuropeptide Y in the face of prolonged high-fat feeding in the rat. J Neurochem 88(4):909–916
14. Anesini C, Ferraro GE, Filip R (2008) Total polyphenol content and antioxidant capacity of commercially available tea (Camellia sinensis) in Argentina. J Agric Food Chem 56(19):9225–9229. doi:10.1021/jf8022782
15. Kersten S (2001) Mechanisms of nutritional and hormonal regulation of lipogenesis. EMBO Rep 2(4):282–286. doi:10.1093/embo-reports/kve071
16. Raederstorff DG, Schlachter MF, Elste V, Weber P (2003) Effect of EGCG on lipid absorption and plasma lipid levels in rats. J Nutr Biochem 14(6):326–332
17. Whitehead JP, Richards AA, Hickman IJ, Macdonald GA, Prins JB (2006) Adiponectin—a key adipokine in the metabolic syndrome. Diabetes Obes Metab 8(3):264–280. doi:10.1111/j.1463-1326.2005.00510.x
18. Berg AH, Combs TP, Du X, Brownlee M, Scherer PE (2001) The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med 7(8):947–953. doi:10.1038/90992
19. 2+/calmodulin-dependent protein kinase kinase-dependent pathways. J Biol Chem 284(33):22426–22435. doi:10.1074/jbc.M109.028357
20. Kadowaki T, Yamauchi T (2011) Adiponectin receptor signaling: a new layer to the current model. Cell Metab 13(2):123–124. doi:10.1016/j.cmet.2011.01.012
21. Tomas E, Tsao TS, Saha AK, Murrey HE, Zhang Cc C, Itani SI, Lodish HF, Ruderman NB (2002) Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation. Proc Natl Acad Sci USA 99(25):16309–16313. doi:10.1073/pnas.222657499
22. Rg IJ, Stehouwer CD, de Geus EJ, van Weissenbruch MM, Delemarre-van de Waal HA, Boomsma DI (2003) Low birth weight is associated with increased sympathetic activity: dependence on genetic factors. Circulation 108(5):566–571. doi:10.1161/01.CIR.0000081778.35370.1B
23. Dulloo AG, Seydoux J, Girardier L, Chantre P, Vandermander J (2000) Green tea and thermogenesis: interactions between catechin-polyphenols, caffeine and sympathetic activity. Int J Obes Relat Metab Disorders 24(2):252–258
24. Shixian Q, VanCrey B, Shi J, Kakuda Y, Jiang Y (2006) Green tea extract thermogenesis-induced weight loss by epigallocatechin gallate inhibition of catechol-O-methyltransferase. J Med Food 9(4):451–458. doi:10.1089/jmf.2006.9.451
25. Westerterp-Plantenga MS (2010) Green tea catechins, caffeine and body-weight regulation. Physiol Behav 100(1):42–46. doi:10.1016/j.physbeh.2010.02.005
26. Lee H, Bae S, Yoon Y (2013) The anti-adipogenic effects of (-)epigallocatechin gallate are dependent on the WNT/beta-catenin pathway. J Nutr Biochem 24(7):1232–1240. doi:10.1016/j.jnutbio.2012.09.007
27. Tsuchida A, Yamauchi T, Takekawa S, Hada Y, Ito Y, Maki T, Kadowaki T (2005) Peroxisome proliferator-activated receptor (PPAR)alpha activation increases adiponectin receptors and reduces obesity-related inflammation in adipose tissue: comparison of activation of PPARalpha, PPARgamma, and their combination. Diabetes 54(12):3358–3370