Binding interaction of SGLT with sugar and thiosugar by the molecular dynamics simulation

Biochimica et Biophysica Acta - Biomembranes

Volumn 1848, Issue 11, 2015, Pages 2799-2804

  Tamura, Yunoshin ^a   Miyagawa, Hiroh ^a   Yoshida, Tatsusada ^b   Chuman, Hiroshi ^b  

^a TAISHO PHARMACEUTICAL CO LTD   (Japan)

^b UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Bennett's acceptance ratio method; Binding free energy; Co transporter; Luseogliflozin; Molecular dynamics

Indexed keywords

SODIUM GLUCOSE COTRANSPORTER 1; SUGAR; THIOSUGAR; BACTERIAL PROTEIN; GALACTOSE; GLUCOSE; PROTEIN BINDING; SLC5A2 PROTEIN, HUMAN; SODIUM; SODIUM GLUCOSE COTRANSPORTER; SODIUM GLUCOSE COTRANSPORTER 2;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; BINDING SITE; HYDROGEN BOND; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN CARBOHYDRATE INTERACTION; PROTEIN TERTIARY STRUCTURE; SODIUM EXCRETION; STATIC ELECTRICITY; VAN DER WAALS INTERACTION; VIBRIO PARAHAEMOLYTICUS; BINDING COMPETITION; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; KINETICS; METABOLISM; PRINCIPAL COMPONENT ANALYSIS; PROTEIN SECONDARY STRUCTURE; THERMODYNAMICS;

BACTERIAL PROTEINS; BINDING SITES; BINDING, COMPETITIVE; GALACTOSE; GLUCOSE; HUMANS; KINETICS; MOLECULAR DYNAMICS SIMULATION; MOLECULAR STRUCTURE; PRINCIPAL COMPONENT ANALYSIS; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SODIUM; SODIUM-GLUCOSE TRANSPORT PROTEINS; SODIUM-GLUCOSE TRANSPORTER 2; THERMODYNAMICS; THIOSUGARS; VIBRIO PARAHAEMOLYTICUS;

EID: 84941332884     PISSN: 00052736     EISSN: 18792642     Source Type: Journal    
DOI: 10.1016/j.bbamem.2015.08.001     Document Type: Article

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