Decrease of oxidative phosphorylation system function in severe septic patients

Journal of Critical Care

Volumn 30, Issue 5, 2015, Pages 935-939

  Lorente, Leonardo ^a   Martín, María M ^b   López Gallardo, Ester ^c   Blanquer, José ^d   Solé Violán, Jordi ^e   Labarta, Lorenzo ^f   Díaz, César ^g   Jiménez, Alejandro ^a   Montoya, Julio ^c   Ruiz Pesini, Eduardo ^c  

^a HOSPITAL UNIVERSITARIO DE CANARIAS   (Spain)

^b HOSPITAL UNIVERSITARIO NUESTRA SEÑORA DE CANDELARIA   (Spain)

^c UNIVERSITY OF ZARAGOZA   (Spain)

^d HOSPITAL CLÍNICO UNIVERSITARIO   (Spain)

^e HOSPITAL UNIVERSITARIO DE GRAN CANARIA DR NEGRÍN   (Spain)

^f HOSPITAL SAN JORGE   (Spain)

^g HOSPITAL UNIVERSITARIO INSULAR DE GRAN CANARIA   (Spain)

Author keywords

Cytochrome c oxidase; Mitochondria; Mortality; OXPHOS; Sepsis

Indexed keywords

CYTOCHROME C OXIDASE; BIOLOGICAL MARKER;

ADULT; AGED; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; HUMAN; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MOLECULAR DYNAMICS; MORTALITY; OBSERVATIONAL STUDY; OXIDATIVE PHOSPHORYLATION; PATIENT ASSESSMENT; PROSPECTIVE STUDY; PROTEIN DETERMINATION; PROTEIN FUNCTION; SEPSIS; THROMBOCYTE ACTIVATION; CLINICAL TRIAL; DISORDERS OF MITOCHONDRIAL FUNCTIONS; METABOLISM; MITOCHONDRION; MULTICENTER STUDY; THROMBOCYTE;

ADULT; AGED; BIOMARKERS; BLOOD PLATELETS; FEMALE; HUMANS; INTENSIVE CARE UNITS; MALE; MIDDLE AGED; MITOCHONDRIA; MITOCHONDRIAL DISEASES; OXIDATIVE PHOSPHORYLATION; PROSPECTIVE STUDIES; SEPSIS;

EID: 84941316857     PISSN: 08839441     EISSN: 15578615     Source Type: Journal    
DOI: 10.1016/j.jcrc.2015.05.031     Document Type: Article

References (32)

1. Fink M. Cytopathic hypoxia in sepsis. Acta Anaesthesiol Scand Suppl 1997, 110:87-95.
2. Lorente L., Martín M.M., López-Gallardo E., Iceta R., Solé-Violán J., Blanquer J., et al. Platelet cytochrome c oxidase activity and quantity in septic patients. Crit Care Med 2011, 39:1289-1294.
3. Lorente L., Martín M.M., López-Gallardo E., Iceta R., Solé-Violán J., Blanquer J., et al. Higher platelet cytochrome oxidase specific activity in surviving than in non-surviving septic patients. Crit Care 2014, 18:R136.
4. Sjövall F., Morota S., Asander Frostner E., Hansson M.J., Elmér E. Cytokine and nitric oxide levels in patients with sepsis--temporal evolvement and relation to platelet mitochondrial respiratory function. PLoS One 2014, 9:e97673.
5. Protti A., Fortunato F., Caspani M.L., Pluderi M., Lucchini V., Grimoldi N., et al. Mitochondrial changes in platelets are not related to those in skeletal muscle during human septic shock. PLoS One 2014, 9:e96205.
6. Gründler K., Angstwurm M., Hilge R., Baumann P., Annecke T., Crispin A., et al. Platelet mitochondrial membrane depolarization reflects disease severity in patients with sepsis and correlates with clinical outcome. Crit Care 2014, 18:R31.
7. Yamakawa K., Ogura H., Koh T., Ogawa Y., Matsumoto N., Kuwagata Y., et al. Platelet mitochondrial membrane potential correlates with severity in patients with systemic inflammatory response syndrome. J Trauma Acute Care Surg 2013, 74:411-417.
8. Sjövall F., Morota S., Hansson M.J., Friberg H., Gnaiger E., Elmér E. Temporal increase of platelet mitochondrial respiration is negatively associated with clinical outcome in patients with sepsis. Crit Care 2010, 14:R214.
9. Protti A., Fortunato F., Artoni A., Lecchi A., Motta G., Mistraletti G., et al. Platelet mitochondrial dysfunction in critically ill patients: comparison between sepsis and cardiogenic shock. Crit Care 2015, 19:39.
10. Weiss S.L., Selak M.A., Tuluc F., Perales Villarroel J., Nadkarni V.M., et al. Mitochondrial dysfunction in peripheral blood mononuclear cells in pediatric septic shock. Pediatr Crit Care Med 2015, 16:e4-e12.
11. Sjövall F., Morota S., Persson J., Hansson M.J., Elmér E. Patients with sepsis exhibit increased mitochondrial respiratory capacity in peripheral blood immune cells. Crit Care 2013, 17:R152.
12. Japiassú A.M., Santiago A.P., d'Avila J.C., Garcia-Souza L.F., Galina A., Castro Faria-Neto H.C., et al. Bioenergetic failure of human peripheral blood monocytes in patients with septic shock is mediated by reduced F1Fo adenosine-5'-triphosphate synthase activity. Crit Care Med 2011, 39:1056-1063.
13. Garrabou G., Morén C., López S., Tobías E., Cardellach F., Miró O., et al. The effects of sepsis on mitochondria. J Infect Dis 2012, 205:392-400.
14. Belikova I., Lukaszewicz A.C., Faivre V., Damoisel C., Singer M., Payen D. Oxygen consumption of human peripheral blood mononuclear cells in severe human sepsis. Crit Care Med 2007, 35:2702-2708.
15. Adrie C., Bachelet M., Vayssier-Taussat M., Russo-Marie F., Bouchaert I., Adib-Conquy M., et al. Mitochondrial membrane potential and apoptosis peripheral blood monocytes in severe human sepsis. Am J Respir Crit Care Med 2001, 164:389-395.
16. Carré J.E., Orban J.C., Re L., Felsmann K., Felsmann K., Iffert W., et al. Survival in critical illness is associated with early activation of mitochondrial biogenesis. Am J Respir Crit Care Med 2010, 182:745-751.
17. Fredriksson K., Tjäder I., Keller P., Petrovic N., Ahlman B., Schéele C., et al. Dysregulation of mitochondrial dynamics and the muscle transcriptome in ICU patients suffering from sepsis induced multiple organ failure. PLoS One 2008, 3:e3686.
18. Fredriksson K., Hammarqvist F., Strigård K., Hultenby K., Ljungqvist O., Wernerman J., et al. Derangements in mitochondrial metabolism in intercostal and leg muscle of critically ill patients with sepsis-induced multiple organ failure. Am J Physiol Endocrinol Metab 2006, 291:E1044-E1050.
19. Brealey D., Brand M., Hargreaves I., Heales S., Land J., Smolenski R., et al. Association between mitochondrial dysfunction and severity and outcome of septic shock. Lancet 2002, 360:219-223.
20. Gasparetto A., Corbucci G.G., Candiani A., Gohil K., Edwards R.H. Effect of tissue hypoxia and septic shock on human skeletal muscle mitochondria. Lancet 1983, 2:1486.
21. Poderoso J.J., Boveris A., Jorge M.A., Gherardi C.R., Caprile A.W., Turrens J., et al. Mitochondrial function in septic shock. Medicina (B Aires) 1978, 38:371-377.
22. Levy M.M., Fink M.P., Marshall J.C., Abraham E., Angus D., Cook D., et al. International Sepsis Definitions Conference. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Intensive Care Med 2003, 29:530-538.
23. Knaus W.A., Draper E.A., Wagner D.P., Zimmerman J.E. APACHE II: a severity of disease classification system. Crit Care Med 1985, 13:818-829.
24. Vincent J.L., Moreno R., Takala J., Willatts S., De Mendonça A., Bruining H., et al. The Sepsis-related Organ Failure Assessment (SOFA) score to describe organ dysfunction/failure. Intensive Care Med 1996, 22:707-710.
25. Chomyn A. Platelet-mediated transformation of human mitochondrial DNA-less cells. Methods Enzymol 1996, 264:334-339.
26. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976, 72:248-254.
27. Levi M., Schultz M., van der Poll T. Sepsis and thrombosis. Semin Thromb Hemost 2013, 39:559-566.
28. Hoffmann J.J. Reticulated platelets: analytical aspects and clinical utility. Clin Chem Lab Med 2014, 52:1107-1117.
29. De Blasi R.A., Cardelli P., Costante A., Sandri M., Mercieri M., Arcioni R. Immature platelet fraction in predicting sepsis in critically ill patients. Intensive Care Med 2013, 39:636-643.
30. Simonson S.G., Welty-Wolf K., Huang Y.T., Griebel J.A., Caplan M.S., Fracica P.J., et al. Altered mitochondrial redox responses in gram negative septic shock in primates. Circ Shock 1994, 43:34-43.
31. d'Avila J.C., Santiago A.P., Amâncio R.T., Galina A., Oliveira M.F., Bozza F.A. Sepsis induces brain mitochondrial dysfunction. Crit Care Med 2008, 36:1925-1932.
32. Eyenga P., Roussel D., Morel J., Rey B., Romestaing C., Teulier L., et al. Early septic shock induces loss of oxidative phosphorylation yield plasticity in liver mitochondria. J Physiol Biochem 2014, 70:285-296.