Higher platelet cytochrome oxidase specific activity in surviving than in non-surviving septic patients

Critical Care

Volumn 18, Issue 3, 2014, Pages

  Lorente, Leonardo ^a   Martín, María M ^b   López Gallardo, Esther ^c   Iceta, Ruth ^c   Blanquer, José ^d   Solé Violán, Jordi ^e   Labarta, Lorenzo ^f   Díaz, César ^g   Jiménez, Alejandro ^a   Montoya, Julio ^c   Ruiz Pesini, Eduardo ^c,h  

^a HOSPITAL UNIVERSITARIO DE CANARIAS   (Spain)

^b HOSPITAL UNIVERSITARIO NUESTRA SEÑORA DE CANDELARIA   (Spain)

^c UNIVERSITY OF ZARAGOZA   (Spain)

^d HOSPITAL CLÍNICO UNIVERSITARIO   (Spain)

^e HOSPITAL UNIVERSITARIO DE GRAN CANARIA DR NEGRÍN   (Spain)

^f HOSPITAL SAN JORGE   (Spain)

^g HOSPITAL UNIVERSITARIO INSULAR DE GRAN CANARIA   (Spain)

^h FUNDACIÓN ARAID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME C OXIDASE; LACTIC ACID; BIOLOGICAL MARKER;

ADULT; APACHE; ARTICLE; COMPARATIVE STUDY; CORRELATION ANALYSIS; DISEASE COURSE; DISEASE SEVERITY; ENZYME ACTIVITY; FEMALE; FOLLOW UP; HUMAN; INTERNATIONAL NORMALIZED RATIO; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MORTALITY; MULTICENTER STUDY; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; PARTIAL THROMBOPLASTIN TIME; PROSPECTIVE STUDY; SEPSIS; SEQUENTIAL ORGAN FAILURE ASSESSMENT SCORE; SURVIVAL; SURVIVAL RATE; THROMBOCYTE; THROMBOCYTE COUNT; BLOOD; CLINICAL TRIAL; ENZYMOLOGY; INTENSIVE CARE UNIT; MITOCHONDRION; OXIDATIVE PHOSPHORYLATION; PROGNOSIS; SURVIVOR;

BIOLOGICAL MARKERS; BLOOD PLATELETS; ELECTRON TRANSPORT COMPLEX IV; HUMANS; INTENSIVE CARE UNITS; MITOCHONDRIA; OXIDATIVE PHOSPHORYLATION; PROGNOSIS; PROSPECTIVE STUDIES; SEPSIS; SURVIVORS;

EID: 84903336737     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc13956     Document Type: Article

References (20)

1. Vincent JL, Sakr Y, Sprung CL, Ranieri VM, Reinhart K, Gerlach H, Moreno R, Carlet J, Le Gall JR, Payen D, . Sepsis Occurrence in Acutely Ill Patients Investigators Sepsis in European intensive care units: results of the SOAP study. Crit Care Med 2006, 34:344-353. 10.1097/01.CCM.0000194725.48928.3A, 16424713, Sepsis Occurrence in Acutely Ill Patients Investigators.
2. Fink M. Cytopathic hypoxia in sepsis. Acta Anaesthesiol Scand Suppl 1997, 110:87-95.
3. Lorente L, Marti´n MM, Lo´pez-Gallardo E, Iceta R, Sole´-Viola´n J, Blanquer J, Labarta L, Di´az C, Jime´nez A, Lafuente N, Herna´ndez M, Me´ndez F, Medina N, Ferrer-Agu¨ero JM, Ferreres J, LLimiñana MC, Mora ML, Lubillo S, Sa´nchez-Palacios M, Montoya J, Ruiz-Pesini E. Platelet cytochrome c oxidase activity and quantity in septic patients. Crit Care Med 2011, 39:1289-1294. 10.1097/CCM.0b013e31820ee20c, 21297457.
4. Winters BD, Eberlein M, Leung J, Needham DM, Pronovost PJ, Sevransky JE. Long-term mortality and quality of life in sepsis: a systematic review. Crit Care Med 2010, 38:1276-1283.
5. Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, Cohen J, Opal SM, Vincent JL, Ramsay G, Conference ISD. SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Intensive Care Med 2003, 29:530-538. 10.1007/s00134-003-1662-x, 12664219.
6. Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: a severity of disease classification system. Crit Care Med 1985, 13:818-829. 10.1097/00003246-198510000-00009, 3928249.
7. Vincent JL, Moreno R, Takala J, Willatts S, De Mendonc¸a A, Bruining H, Reinhart CK, Suter PM, Thijs LG, . for the Working Group on Sepsis-related Problems of the European Society of Intensive Care Medicine The Sepsis-related Organ Failure Assessment (SOFA) score to describe organ dysfunction/failure. Intensive Care Med 1996, 22:707-710. 10.1007/BF01709751, 8844239, for the Working Group on Sepsis-related Problems of the European Society of Intensive Care Medicine.
8. Chomyn A. Platelet-mediated transformation of human mitochondrial DNA-less cells. Methods Enzymol 1996, 264:334-339.
9. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976, 72:248-254. 10.1016/0003-2697(76)90527-3, 942051.
10. Zharikov S, Shiva S. Platelet mitochondrial function: from regulation of thrombosis to biomarker of disease. Biochem Soc Trans 2013, 41:118-123. 10.1042/BST20120327, 23356269.
11. Kramer PA, Ravi S, Chacko B, Johnson MS, Darley-Usmar VM. A review of the mitochondrial and glycolytic metabolism in human platelets and leukocytes: Implications for their use as bioenergetic biomarkers. Redox Biol 2014, 2:206-210. 3909784, 24494194.
12. Go´mez-Dura´n A, Pacheu-Grau D, Lo´pez-Gallardo E, Di´ez-Sa´nchez C, Montoya J, Lo´pez-Pe´rez MJ, Ruiz-Pesini E. Unmasking the causes of multifactorial disorders: OXPHOS differences between mitochondrial haplogroups. Hum Mol Genet 2010, 19:3343-3353. 10.1093/hmg/ddq246, 20566709.
13. Lorente L, Iceta R, Marti´n MM, Lo´pez-Gallardo E, Sole´-Viola´n J, Blanquer J, Labarta L, Di´az C, Jime´nez A, Montoya J, Ruiz-Pesini E. Survival and mitochondrial function in septic patients according to mitochondrial DNA haplogroup. Crit Care 2012, 16:R10. 10.1186/cc11150, 3396241, 22251664.
14. Lorente L, Iceta R, Marti´n MM, Lo´pez-Gallardo E, Sole´-Viola´n J, Blanquer J, Labarta L, Di´az C, Borreguero-Leo´n JM, Jime´nez A, Montoya J, Ruiz-Pesini E. Severe septic patients with mitochondrial DNA haplogroup JT show higher survival rates: a prospective, multicenter, observational study. PLoS One 2013, 8:e73320. 10.1371/journal.pone.0073320, 3772099, 24069186.
15. Tomasiak M, Stelmach H, Rusak T, Wysocka J. Nitric oxide and platelet energy metabolism. Acta Biochim Pol 2004, 51:789-803.
16. Barile CJ, Herrmann PC, Tyvoll DA, Collman JP, Decreau RA, Bull BS. Inhibiting platelet-stimulated blood coagulation by inhibition of mitochondrial respiration. Proc Natl Acad Sci USA 2012, 109:2539-2543. 10.1073/pnas.1120645109, 3289322, 22308457.
17. Levi M, Schultz M, van der Poll T. Sepsis and thrombosis. Semin Thromb Hemost 2013, 39:559-566. 10.1055/s-0033-1343894, 23625756.
18. Piel DA, Gruber PJ, Weinheimer CJ, Courtois MR, Robertson CM, Coopersmith CM, Deutschman CS, Levy RJ. Mitochondrial resuscitation with exogenous cytochrome c in the septic heart. Crit Care Med 2007, 35:2120-2127. 10.1097/01.CCM.0000278914.85340.FE, 17855825.
19. Verma R, Huang Z, Deutschman CS, Levy RJ. Caffeine restores myocardial cytochrome oxidase activity and improves cardiac function during sepsis. Crit Care Med 2009, 37:1397-1402. 10.1097/CCM.0b013e31819cecd6, 3970220, 19242342.
20. Groening P, Huang Z, La Gamma EF, Levy RJ. Glutamine restores myocardial cytochrome C oxidase activity and improves cardiac function during experimental sepsis. JPEN J Parenter Enteral Nutr 2011, 35:249-254. 10.1177/0148607110383040, 21378254.