Soluble human cytomegalovirus gH/gL/pUL128-131 pentameric complex, but not gH/gL, inhibits viral entry to epithelial cells and presents dominant native neutralizing epitopes

Journal of Biological Chemistry

Volumn 290, Issue 26, 2015, Pages 15985-15995

  Loughney, John W ^a   Rustandi, Richard R ^a   Wang, Dai ^a   Troutman, Matthew C ^a   Dick, Lawrence W ^a   Li, Guanghua ^a   Liu, Zhong ^a   Li, Fengsheng ^a   Freed, Daniel C ^a   Price, Colleen E ^a   Hoang, Van M ^a   Culp, Timothy D ^a   De Phillips, Pete A ^a   Fu, Tong Ming ^a   Ha, Sha ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; CYTOLOGY; ENDOTHELIAL CELLS; EPITOPES; MOLECULAR MASS; STOICHIOMETRY; VACCINES;

BIRTH DEFECTS; CHINESE HAMSTER OVARY CELLS; EPITHELIAL CELLS; HUMAN CYTOMEGALOVIRUS; MANUFACTURING PROCESS; NEUTRALIZING ANTIBODIES; NEUTRALIZING EPITOPE; PENTAMERIC COMPLEX;

CELLS;

GL GH PROTEIN; GL GH PUL128 131 PROTEIN; HYPERIMMUNE GLOBULIN; NEUTRALIZING ANTIBODY; UNCLASSIFIED DRUG; VIRUS VACCINE; EPITOPE; GLYCOPROTEIN H, CYTOMEGALOVIRUS; MEMBRANE PROTEIN; PROTEIN BINDING; UL128 PROTEIN, HUMAN CYTOMEGALOVIRUS; UL130 PROTEIN, HUMAN CYTOMEGALOVIRUS; VIRUS ANTIBODY; VIRUS ENVELOPE PROTEIN;

AMINO TERMINAL SEQUENCE; ANTIBODY RESPONSE; ANTIGEN ANTIBODY REACTION; ANTIGEN PRESENTATION; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DEGLYCOSYLATION; DRUG PROTEIN BINDING; HUMAN CYTOMEGALOVIRUS; IC50; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN SECRETION; PROTEIN SYNTHESIS; VIRUS ENTRY; VIRUS INHIBITION; VIRUS NEUTRALIZATION; ANIMAL; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; EPITHELIUM CELL; GENETICS; HAMSTER; HUMAN; IMMUNOLOGY; PHYSIOLOGY; VIROLOGY;

ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; CRICETINAE; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; EPITHELIAL CELLS; EPITOPES; HUMANS; MEMBRANE GLYCOPROTEINS; PROTEIN BINDING; VIRAL ENVELOPE PROTEINS; VIRUS INTERNALIZATION;

EID: 84941313392     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.652230     Document Type: Article

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