Development and application of a reversed-phase high-performance liquid chromatographic method for quantitation and characterization of a Chikungunya virus-like particle vaccine

Journal of Chromatography A

Volumn 1364, Issue , 2014, Pages 192-197

  Shytuhina, Anastasija ^a   Pristatsky, Pavlo ^a   He, Jian ^a   Casimiro, Danilo R ^a   Schwartz, Richard M ^b   Hoang, Van M ^a   Ha, Sha ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Analytical characterization; Chikungunya; CHIKV; RP HPLC; Vaccine; VLP

Indexed keywords

CHROMATOGRAPHIC ANALYSIS; DESORPTION; ELECTROPHORESIS; GLYCOPROTEINS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETRY; PROTEINS; SULFUR COMPOUNDS; VACCINES; VIRUSES;

ANALYTICAL CHARACTERIZATION; CHIKUNGUNYA; CHIKV; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; MATRIX-ASSISTED LASER DESORPTION/IONIZATION TIME OF FLIGHTS; POST-TRANSLATIONAL MODIFICATIONS; RP-HPLC; SODIUM DODECYL SULFATE-POLYACRYLAMIDE GEL ELECTROPHORESIS;

SODIUM DODECYL SULFATE;

CAPSID PROTEIN; CHIKUNGUNYA VIRUS LIKE PARTICLE VACCINE; GLYCOPROTEIN E1; GLYCOPROTEIN E2; TRIFLUOROACETIC ACID; UNCLASSIFIED DRUG; VIRUS LIKE PARTICLE VACCINE; GLYCOPROTEIN; VIRUS PROTEIN; VIRUS VACCINE;

ARTICLE; CONTROLLED STUDY; DEAMINATION; DRUG ANTIGENICITY; DRUG PURITY; DRUG STABILITY; ELUTION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MEASUREMENT ACCURACY; MEASUREMENT PRECISION; NONHUMAN; PH; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN PROCESSING; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; CHIKUNGUNYA VIRUS; HEK293 CELL LINE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IMMUNOLOGY; MOLECULAR WEIGHT; REVERSED PHASE LIQUID CHROMATOGRAPHY; VALIDATION STUDY;

CHIKUNGUNYA VIRUS; MIRIDAE;

CHIKUNGUNYA VIRUS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, REVERSE-PHASE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GLYCOPROTEINS; HEK293 CELLS; HUMANS; MOLECULAR WEIGHT; PROTEIN PROCESSING, POST-TRANSLATIONAL; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; VACCINES, VIRUS-LIKE PARTICLE; VIRAL PROTEINS; VIRAL VACCINES;

EID: 84922058980     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2014.05.087     Document Type: Article

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