Structural and biochemical studies of HCMV gH/gL/gO and pentamer reveal mutually exclusive cell entry complexes

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 6, 2015, Pages 1767-1772

  Ciferri, Claudio ^a,f   Chandramouli, Sumana ^a   Donnarumma, Danilo ^b   Nikitin, Pavel A ^c   Cianfrocco, Michael A ^d,e   Gerrein, Rachel ^a   Feire, Adam L ^c   Barnett, Susan W ^a   Lilja, Anders E ^a,g   Rappuoli, Rino ^b   Norais, Nathalie ^b   Settembre, Ethan C ^a   Carfi, Andrea ^a  

^a Novartis Vaccines Cambridge   (United States)

^b NOVARTIS VACCINES AND DIAGNOSTICS   (Italy)

^c NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^d HARVARD UNIVERSITY   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

^f GENENTECH INC   (United States)

^g HOOKIPA BIOTECH AG   (Austria)

Author keywords

GH gL gO; HCMV; Human cytomegalovirus; Pentamer complex; Virus entry

Indexed keywords

GH GL GO COMPLEX; MULTIPROTEIN COMPLEX; NEUTRALIZING ANTIBODY; PENTAMER; SEVIRUMAB; UNCLASSIFIED DRUG; VIRUS GLYCOPROTEIN; DISULFIDE; GLYCOPROTEIN H, CYTOMEGALOVIRUS; GLYCOPROTEIN O, CYTOMEGALOVIRUS; MEMBRANE PROTEIN; PROTEIN BINDING; UL115 PROTEIN, HUMAN HERPESVIRUS 5; UL128 PROTEIN, HUMAN CYTOMEGALOVIRUS; UL130 PROTEIN, HUMAN CYTOMEGALOVIRUS; VIRUS ENVELOPE PROTEIN;

ANTIBODY COMBINING SITE; ANTIBODY RESPONSE; ANTIGEN BINDING; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; COVALENT BOND; DIMERIZATION; DISULFIDE BOND; ENDOTHELIUM CELL; EPITHELIUM CELL; EPSTEIN BARR VIRUS; FIBROBLAST; HEK293 CELL LINE; HUMAN; HUMAN CELL; HUMAN CYTOMEGALOVIRUS; HUMORAL IMMUNITY; MASS SPECTROMETRY; MUTAGENESIS; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; VIRUS ENTRY; AFFINITY CHROMATOGRAPHY; BINDING SITE; CHEMISTRY; CYTOMEGALOVIRUS; ELECTRON MICROSCOPY; FLOW CYTOMETRY; GENETICS; IMAGE PROCESSING; IMMUNOLOGY; METABOLISM; MUTATION; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; SITE DIRECTED MUTAGENESIS; WESTERN BLOTTING;

HUMAN HERPESVIRUS 5; SIMPLEXVIRUS;

ANTIBODIES, NEUTRALIZING; BINDING SITES; BLOTTING, WESTERN; CHROMATOGRAPHY, AFFINITY; CONSERVED SEQUENCE; CYTOMEGALOVIRUS; DISULFIDES; FLOW CYTOMETRY; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MASS SPECTROMETRY; MEMBRANE GLYCOPROTEINS; MICROSCOPY, ELECTRON; MULTIPROTEIN COMPLEXES; MUTAGENESIS; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEIN BINDING; VIRAL ENVELOPE PROTEINS; VIRUS INTERNALIZATION;

EID: 84922661298     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1424818112     Document Type: Article

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