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Volumn 64, Issue 9, 2015, Pages 1454-1465

The mitogen-activated protein kinase ERK5 regulates the development and growth of hepatocellular carcinoma

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE 7; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PROTEIN P15; PROTEIN P27; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR REL; UNCLASSIFIED DRUG; XMD 8 92;

EID: 84941270270     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2014-306761     Document Type: Article
Times cited : (59)

References (50)
  • 1
    • 80053088189 scopus 로고    scopus 로고
    • Hepatocellular carcinoma
    • El-Serag HB. Hepatocellular carcinoma. N Engl J Med 2011;365:1118-27.
    • (2011) N Engl J Med , vol.365 , pp. 1118-1127
    • El-Serag, H.B.1
  • 2
    • 84874084734 scopus 로고    scopus 로고
    • Role of the microenvironment in the pathogenesis and treatment of hepatocellular carcinoma
    • Hernandez-Gea V, Toffanin S, Friedman SL, et al. Role of the microenvironment in the pathogenesis and treatment of hepatocellular carcinoma. Gastroenterology 2013;144:512-27.
    • (2013) Gastroenterology , vol.144 , pp. 512-527
    • Hernandez-Gea, V.1    Toffanin, S.2    Friedman, S.L.3
  • 3
    • 47949116252 scopus 로고    scopus 로고
    • Sorafenib in advanced hepatocellular carcinoma
    • Llovet JM, Ricci S, Mazzaferro V, et al. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 2008;359:378-90.
    • (2008) N Engl J Med , vol.359 , pp. 378-390
    • Llovet, J.M.1    Ricci, S.2    Mazzaferro, V.3
  • 5
    • 0029055761 scopus 로고
    • Components of a new human protein kinase signal transduction pathway
    • Zhou G, Bao ZQ, Dixon JE. Components of a new human protein kinase signal transduction pathway. J Biol Chem 1995;270:12665-9.
    • (1995) J Biol Chem , vol.270 , pp. 12665-12669
    • Zhou, G.1    Bao, Z.Q.2    Dixon, J.E.3
  • 9
    • 59949097637 scopus 로고    scopus 로고
    • ERK5 is a target for gene amplification at 17p11 and promotes cell growth in hepatocellular carcinoma by regulating mitotic entry
    • Zen K, Yasui K, Nakajima T, et al. ERK5 is a target for gene amplification at 17p11 and promotes cell growth in hepatocellular carcinoma by regulating mitotic entry. Genes Chromosomes Cancer 2009;48:109-20.
    • (2009) Genes Chromosomes Cancer , vol.48 , pp. 109-120
    • Zen, K.1    Yasui, K.2    Nakajima, T.3
  • 10
    • 0038639160 scopus 로고    scopus 로고
    • Gene expression profiles of hepatoma cell line HLE
    • Liu LX, Liu ZH, Jiang HC, et al. Gene expression profiles of hepatoma cell line HLE. World J Gastroenterol 2003;9:683-7.
    • (2003) World J Gastroenterol , vol.9 , pp. 683-687
    • Liu, L.X.1    Liu, Z.H.2    Jiang, H.C.3
  • 11
    • 84856751507 scopus 로고    scopus 로고
    • The biphasic nature of hypoxia-induced directional migration of activated human hepatic stellate cells
    • Novo E, Povero D, Busletta C, et al. The biphasic nature of hypoxia-induced directional migration of activated human hepatic stellate cells. J Pathol 2012;226:588-97.
    • (2012) J Pathol , vol.226 , pp. 588-597
    • Novo, E.1    Povero, D.2    Busletta, C.3
  • 12
    • 0019332750 scopus 로고
    • Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen
    • Knowles BB, Howe CC, Aden DP. Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen. Science 1980;209:497-9.
    • (1980) Science , vol.209 , pp. 497-499
    • Knowles, B.B.1    Howe, C.C.2    Aden, D.P.3
  • 13
    • 0019966544 scopus 로고
    • Growth of human hepatoma cells lines with differentiated functions in chemically defined medium
    • Nakabayashi H, Taketa K, Miyano K, et al. Growth of human hepatoma cells lines with differentiated functions in chemically defined medium. Cancer Res 1982;42:3858-63.
    • (1982) Cancer Res , vol.42 , pp. 3858-3863
    • Nakabayashi, H.1    Taketa, K.2    Miyano, K.3
  • 14
    • 35349015771 scopus 로고    scopus 로고
    • Pharmacological inhibition of protein kinase CK2 reverts the multidrug resistance phenotype of a CEM cell line characterized by high CK2 level
    • Di Maira G, Brustolon F, Bertacchini J, et al. Pharmacological inhibition of protein kinase CK2 reverts the multidrug resistance phenotype of a CEM cell line characterized by high CK2 level. Oncogene 2007;26:6915-26.
    • (2007) Oncogene , vol.26 , pp. 6915-6926
    • Di Maira, G.1    Brustolon, F.2    Bertacchini, J.3
  • 15
    • 36549082913 scopus 로고    scopus 로고
    • ERK5 differentially regulates PDGF-induced proliferation and migration of hepatic stellate cells
    • Rovida E, Navari N, Caligiuri A, et al. ERK5 differentially regulates PDGF-induced proliferation and migration of hepatic stellate cells. J Hepatol 2008;48:107-15.
    • (2008) J Hepatol , vol.48 , pp. 107-115
    • Rovida, E.1    Navari, N.2    Caligiuri, A.3
  • 16
    • 84906934973 scopus 로고    scopus 로고
    • Chromatin-associated CSF-1R binds to the promoter of proliferation-related genes in breast cancer cells
    • Barbetti V, Morandi A, Tusa I, et al. Chromatin-associated CSF-1R binds to the promoter of proliferation-related genes in breast cancer cells. Oncogene 2014;33:4359-64.
    • (2014) Oncogene , vol.33 , pp. 4359-4364
    • Barbetti, V.1    Morandi, A.2    Tusa, I.3
  • 17
    • 0035971215 scopus 로고    scopus 로고
    • Signal transduction by the chemokine receptor CXCR3: Activation of Ras/ERK, Src, and phosphatidylinositol 3-kinase/Akt controls cell migration and proliferation in human vascular pericytes
    • Bonacchi A, Romagnani P, Romanelli RG, et al. Signal transduction by the chemokine receptor CXCR3: activation of Ras/ERK, Src, and phosphatidylinositol 3-kinase/Akt controls cell migration and proliferation in human vascular pericytes. J Biol Chem 2001;276:9945-54.
    • (2001) J Biol Chem , vol.276 , pp. 9945-9954
    • Bonacchi, A.1    Romagnani, P.2    Romanelli, R.G.3
  • 18
    • 84874349392 scopus 로고    scopus 로고
    • Time- and residue-specific differences in histone acetylation induced by VPA and SAHA in AML1/ETO-positive leukemia cells
    • Barbetti V, Gozzini A, Cheloni G, et al. Time- and residue-specific differences in histone acetylation induced by VPA and SAHA in AML1/ETO-positive leukemia cells. Epigenetics 2013;8:210-19.
    • (2013) Epigenetics , vol.8 , pp. 210-219
    • Barbetti, V.1    Gozzini, A.2    Cheloni, G.3
  • 19
    • 77957969444 scopus 로고    scopus 로고
    • Pharmacological inhibition of BMK1 suppresses tumor growth through promyelocytic leukemia protein
    • Yang Q, Deng X, Lu B, et al. Pharmacological inhibition of BMK1 suppresses tumor growth through promyelocytic leukemia protein. Cancer Cell 2010;18:258-67.
    • (2010) Cancer Cell , vol.18 , pp. 258-267
    • Yang, Q.1    Deng, X.2    Lu, B.3
  • 21
    • 27844497945 scopus 로고    scopus 로고
    • FOXO transcription factors at the interface between longevity and tumor suppression
    • Greer EL, Brunet A. FOXO transcription factors at the interface between longevity and tumor suppression. Oncogene 2005;24:7410-25.
    • (2005) Oncogene , vol.24 , pp. 7410-7425
    • Greer, E.L.1    Brunet, A.2
  • 22
    • 84856390541 scopus 로고    scopus 로고
    • Hypoxia and hypoxia inducible factors: Diverse roles in liver diseases
    • Nath B, Szabo G. Hypoxia and hypoxia inducible factors: diverse roles in liver diseases. Hepatology 2012;55:622-33.
    • (2012) Hepatology , vol.55 , pp. 622-633
    • Nath, B.1    Szabo, G.2
  • 23
    • 57349164238 scopus 로고    scopus 로고
    • Redox mechanisms switch on hypoxia-dependent epithelial-mesenchymal transition in cancer cells
    • Cannito S, Novo E, Compagnone A, et al. Redox mechanisms switch on hypoxia-dependent epithelial-mesenchymal transition in cancer cells. Carcinogenesis 2008;29:2267-78.
    • (2008) Carcinogenesis , vol.29 , pp. 2267-2278
    • Cannito, S.1    Novo, E.2    Compagnone, A.3
  • 24
    • 0037007208 scopus 로고    scopus 로고
    • Impaired postnatal hepatocyte proliferation and liver regeneration in mice lacking c-jun in the liver
    • Behrens A, Sibilia M, David JP, et al. Impaired postnatal hepatocyte proliferation and liver regeneration in mice lacking c-jun in the liver. EMBO J 2002;21:1782-90.
    • (2002) EMBO J , vol.21 , pp. 1782-1790
    • Behrens, A.1    Sibilia, M.2    David, J.P.3
  • 25
    • 0030694387 scopus 로고    scopus 로고
    • BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C.
    • Kato Y, Kravchenko VV, Tapping RI, et al. BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C. EMBO J 1997;16:7054-66.
    • (1997) EMBO J , vol.16 , pp. 7054-7066
    • Kato, Y.1    Kravchenko, V.V.2    Tapping, R.I.3
  • 26
    • 0034674622 scopus 로고    scopus 로고
    • Big mitogen-activated kinase regulates multiple members of the MEF2 protein family
    • Kato Y, Zhao M, Morikawa A, et al. Big mitogen-activated kinase regulates multiple members of the MEF2 protein family. J Biol Chem 2000;275:18534-40.
    • (2000) J Biol Chem , vol.275 , pp. 18534-18540
    • Kato, Y.1    Zhao, M.2    Morikawa, A.3
  • 27
    • 0033596124 scopus 로고    scopus 로고
    • Aberrant rel/nfkb genes and activity in human cancer
    • Rayet B, Gelinas C. Aberrant rel/nfkb genes and activity in human cancer. Oncogene 1999;18:6938-47.
    • (1999) Oncogene , vol.18 , pp. 6938-6947
    • Rayet, B.1    Gelinas, C.2
  • 28
    • 3342896372 scopus 로고    scopus 로고
    • Roles played by a subset of integrin signaling molecules in cadherin-based cell-cell adhesion
    • Yano H, Mazaki Y, Kurokawa K, et al. Roles played by a subset of integrin signaling molecules in cadherin-based cell-cell adhesion. J Cell Biol 2004;166:283-95.
    • (2004) J Cell Biol , vol.166 , pp. 283-295
    • Yano, H.1    Mazaki, Y.2    Kurokawa, K.3
  • 29
  • 30
    • 77951184829 scopus 로고    scopus 로고
    • Cellular functions of FAK kinases: Insight into molecular mechanisms and novel functions
    • Schaller MD. Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions. J Cell Sci 2010;123:1007-13.
    • (2010) J Cell Sci , vol.123 , pp. 1007-1013
    • Schaller, M.D.1
  • 31
    • 79960833408 scopus 로고    scopus 로고
    • Tyrosine phosphatases in the HER2-directed motility of ovarian cancer cells: Involvement of PTPN12 ERK5 and FAK
    • Villa-Moruzzi E. Tyrosine phosphatases in the HER2-directed motility of ovarian cancer cells: Involvement of PTPN12, ERK5 and FAK. Anal Cell Pathol (Amst) 2011;34:101-12.
    • (2011) Anal Cell Pathol (Amst) , vol.34 , pp. 101-112
    • Villa-Moruzzi, E.1
  • 32
    • 36349020785 scopus 로고    scopus 로고
    • Targeting of FAK Ser910 by ERK5 and PP1delta in non-stimulated and phorbol ester-stimulated cells
    • Villa-Moruzzi E. Targeting of FAK Ser910 by ERK5 and PP1delta in non-stimulated and phorbol ester-stimulated cells. Biochem J 2007;408:7-18.
    • (2007) Biochem J , vol.408 , pp. 7-18
    • Villa-Moruzzi, E.1
  • 33
    • 60849093481 scopus 로고    scopus 로고
    • A novel role of ERK5 in integrin-mediated cell adhesion and motility in cancer cells via Fak signaling
    • Sawhney RS, Liu W, Brattain MG. A novel role of ERK5 in integrin-mediated cell adhesion and motility in cancer cells via Fak signaling. J Cell Physiol 2009;219:152-61.
    • (2009) J Cell Physiol , vol.219 , pp. 152-161
    • Sawhney, R.S.1    Liu, W.2    Brattain, M.G.3
  • 34
    • 0042411985 scopus 로고    scopus 로고
    • Tumour hypoxia, chemotherapeutic resistance and hypoxia-related therapies
    • Shannon AM, Bouchier-Hayes DJ, Condron CM, et al. Tumour hypoxia, chemotherapeutic resistance and hypoxia-related therapies. Cancer Treat Rev 2003;29:297-307.
    • (2003) Cancer Treat Rev , vol.29 , pp. 297-307
    • Shannon, A.M.1    Bouchier-Hayes, D.J.2    Condron, C.M.3
  • 35
    • 0037044718 scopus 로고    scopus 로고
    • ERK5 MAPK regulates embryonic angiogenesis and acts as a hypoxia-sensitive repressor of vascular endothelial growth factor expression
    • Sohn SJ, Sarvis BK, Cado D, et al. ERK5 MAPK regulates embryonic angiogenesis and acts as a hypoxia-sensitive repressor of vascular endothelial growth factor expression. J Biol Chem 2002;277:43344-51.
    • (2002) J Biol Chem , vol.277 , pp. 43344-43351
    • Sohn, S.J.1    Sarvis, B.K.2    Cado, D.3
  • 36
    • 20444489156 scopus 로고    scopus 로고
    • BMK1/ERK5 is a novel regulator of angiogenesis by destabilizing hypoxia inducible factor 1alpha
    • Pi X, Garin G, Xie L, et al. BMK1/ERK5 is a novel regulator of angiogenesis by destabilizing hypoxia inducible factor 1alpha. Circ Res 2005;96:1145-51.
    • (2005) Circ Res , vol.96 , pp. 1145-1151
    • Pi, X.1    Garin, G.2    Xie, L.3
  • 37
    • 52149114431 scopus 로고    scopus 로고
    • ERK5/MAPK is activated by TGFbeta in hepatocytes and required for the GSK-3beta-mediated Snail protein stabilization
    • Marchetti A, Colletti M, Cozzolino AM, et al. ERK5/MAPK is activated by TGFbeta in hepatocytes and required for the GSK-3beta-mediated Snail protein stabilization. Cell Signal 2008;20:2113-18.
    • (2008) Cell Signal , vol.20 , pp. 2113-2118
    • Marchetti, A.1    Colletti, M.2    Cozzolino, A.M.3
  • 38
    • 0041834594 scopus 로고    scopus 로고
    • Activation of cyclin D1 expression by the ERK5 cascade
    • Mulloy R, Salinas S, Philips A, et al. Activation of cyclin D1 expression by the ERK5 cascade. Oncogene 2003;22:5387-98.
    • (2003) Oncogene , vol.22 , pp. 5387-5398
    • Mulloy, R.1    Salinas, S.2    Philips, A.3
  • 39
    • 44849114794 scopus 로고    scopus 로고
    • ERK5/BMK1 is indispensable for optimal colony-stimulating factor 1 (CSF-1)-induced proliferation in macrophages in a Src-dependent fashion
    • Rovida E, Spinelli E, Sdelci S, et al. ERK5/BMK1 is indispensable for optimal colony-stimulating factor 1 (CSF-1)-induced proliferation in macrophages in a Src-dependent fashion. J Immunol 2008;180:4166-72.
    • (2008) J Immunol , vol.180 , pp. 4166-4172
    • Rovida, E.1    Spinelli, E.2    Sdelci, S.3
  • 40
    • 84865975615 scopus 로고    scopus 로고
    • The extracellular-regulated protein kinase 5 (ERK5) promotes cell proliferation through the down-regulation of inhibitors of cyclin dependent protein kinases (CDKs)
    • Perez-Madrigal D, Finegan KG, Paramo B, et al. The extracellular-regulated protein kinase 5 (ERK5) promotes cell proliferation through the down-regulation of inhibitors of cyclin dependent protein kinases (CDKs). Cell Signal 2012;24:2360-8.
    • (2012) Cell Signal , vol.24 , pp. 2360-2368
    • Perez-Madrigal, D.1    Finegan, K.G.2    Paramo, B.3
  • 41
    • 0033564697 scopus 로고    scopus 로고
    • CDK inhibitors: Positive and negative regulators of G1-phase progression
    • Sherr CJ, Roberts JM. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev 1999;13:1501-12.
    • (1999) Genes Dev , vol.13 , pp. 1501-1512
    • Sherr, C.J.1    Roberts, J.M.2
  • 42
    • 33750997878 scopus 로고    scopus 로고
    • Activation of extracellular signal-regulated protein kinase 5 downregulates FasL upon osmotic stress
    • Wang X, Finegan KG, Robinson AC, et al. Activation of extracellular signal-regulated protein kinase 5 downregulates FasL upon osmotic stress. Cell Death Differ 2006;13:2099-108.
    • (2006) Cell Death Differ , vol.13 , pp. 2099-2108
    • Wang, X.1    Finegan, K.G.2    Robinson, A.C.3
  • 43
    • 34247540411 scopus 로고    scopus 로고
    • Regulation of the G2-M cell cycle progression by the ERK5-NFkappaB signaling pathway
    • Cude K, Wang Y, Choi HJ, et al. Regulation of the G2-M cell cycle progression by the ERK5-NFkappaB signaling pathway. J Cell Biol 2007;177:253-64.
    • (2007) J Cell Biol , vol.177 , pp. 253-264
    • Cude, K.1    Wang, Y.2    Choi, H.J.3
  • 44
    • 0035896513 scopus 로고    scopus 로고
    • ERK5 and ERK2 cooperate to regulate NF-kappaB and cell transformation
    • Pearson G, English JM, White MA, et al. ERK5 and ERK2 cooperate to regulate NF-kappaB and cell transformation. J Biol Chem 2001;276:7927-31.
    • (2001) J Biol Chem , vol.276 , pp. 7927-7931
    • Pearson, G.1    English, J.M.2    White, M.A.3
  • 45
    • 77950616462 scopus 로고    scopus 로고
    • The c-Rel subunit of nuclear factor-kappaB regulates murine liver inflammation, wound-healing, and hepatocyte proliferation
    • Gieling RG, Elsharkawy AM, Caamano JH, et al. The c-Rel subunit of nuclear factor-kappaB regulates murine liver inflammation, wound-healing, and hepatocyte proliferation. Hepatology 2010;51:922-31.
    • (2010) Hepatology , vol.51 , pp. 922-931
    • Gieling, R.G.1    Elsharkawy, A.M.2    Caamano, J.H.3
  • 46
    • 33748976352 scopus 로고    scopus 로고
    • Hepatitis C virus core protein induces expression of genes regulating immune evasion and anti-apoptosis in hepatocytes
    • Nguyen H, Sankaran S, Dandekar S. Hepatitis C virus core protein induces expression of genes regulating immune evasion and anti-apoptosis in hepatocytes. Virology 2006;354:58-68.
    • (2006) Virology , vol.354 , pp. 58-68
    • Nguyen, H.1    Sankaran, S.2    Dandekar, S.3
  • 47
    • 43449115379 scopus 로고    scopus 로고
    • Aberrant expression of extracellular signal-regulated kinase 5 in human prostate cancer
    • McCracken SR, Ramsay A, Heer R, et al. Aberrant expression of extracellular signal-regulated kinase 5 in human prostate cancer. Oncogene 2008;27:2978-88.
    • (2008) Oncogene , vol.27 , pp. 2978-2988
    • McCracken, S.R.1    Ramsay, A.2    Heer, R.3
  • 48
    • 84876318758 scopus 로고    scopus 로고
    • Canonical and kinase activity-independent mechanisms for extracellular signal-regulated kinase 5 (ERK5) nuclear translocation require dissociation of Hsp90 from the ERK5-Cdc37 complex
    • Erazo T, Moreno A, Ruiz-Babot G, et al. Canonical and kinase activity-independent mechanisms for extracellular signal-regulated kinase 5 (ERK5) nuclear translocation require dissociation of Hsp90 from the ERK5-Cdc37 complex. Mol Cell Biol 2013;33:1671-86.
    • (2013) Mol Cell Biol , vol.33 , pp. 1671-1686
    • Erazo, T.1    Moreno, A.2    Ruiz-Babot, G.3
  • 49
    • 77956910145 scopus 로고    scopus 로고
    • Multisite phosphorylation of Erk5 in mitosis
    • Diaz-Rodriguez E, Pandiella A. Multisite phosphorylation of Erk5 in mitosis. J Cell Sci 2010;123:3146-56.
    • (2010) J Cell Sci , vol.123 , pp. 3146-3156
    • Diaz-Rodriguez, E.1    Pandiella, A.2
  • 50
    • 57349090407 scopus 로고    scopus 로고
    • Gene expression in fixed tissues and outcome in hepatocellular carcinoma
    • Hoshida Y, Villanueva A, Kobayashi M, et al. Gene expression in fixed tissues and outcome in hepatocellular carcinoma. N Engl J Med 2008;359:1995-2004.
    • (2008) N Engl J Med , vol.359 , pp. 1995-2004
    • Hoshida, Y.1    Villanueva, A.2    Kobayashi, M.3


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