Progesterone attenuates Aβ25-35-induced neuronal toxicity via JNK inactivation and progesterone receptor membrane component 1-dependent inhibition of mitochondrial apoptotic pathway

Journal of Steroid Biochemistry and Molecular Biology

Volumn 154, Issue , 2015, Pages 302-311

  Qin, Yabin ^a   Chen, Zesha ^a   Han, Xiaolei ^b   Wu, Honghai ^b   Yu, Yang ^b   Wu, Jie ^a   Liu, Sha ^a   Hou, Yanning ^a,b  

^a HEBEI MEDICAL UNIVERSITY   (China)

^b BETHUNE INTERNATIONAL PEACE HOSPITAL   (China)

Author keywords

Amyloid progesterone apoptosis PGRMC1JNK

Indexed keywords

AMYLOID BETA PROTEIN[25-35]; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CASPASE 3; JANUS KINASE; MIFEPRISTONE; NEUROPROTECTIVE AGENT; PROGESTERONE; PROGESTERONE RECEPTOR; PROGESTERONE RECEPTOR MEMBRANE COMPONENT 1; PROTEIN BAX; PROTEIN BCL 2; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (25-35); MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; PEPTIDE FRAGMENT; PGRMC1 PROTEIN, RAT;

ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN CELL CULTURE; BRAIN CORTEX; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME INACTIVATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; NEUROPROTECTION; NEUROTOXICITY; NEWBORN; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; ENZYMOLOGY; NERVE CELL; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

AMYLOID BETA-PEPTIDES; ANIMALS; APOPTOSIS; CELLS, CULTURED; CEREBRAL CORTEX; MAP KINASE KINASE 4; MEMBRANE PROTEINS; MITOCHONDRIA; NEURONS; PEPTIDE FRAGMENTS; PROGESTERONE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PROGESTERONE;

EID: 84941259193     PISSN: 09600760     EISSN: 18791220     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2015.01.002     Document Type: Article

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