Neurosteroid allopregnanolone attenuates high glucose-induced apoptosis and prevents experimental diabetic neuropathic pain: In vitro and in vivo studies

Journal of Steroid Biochemistry and Molecular Biology

Volumn 139, Issue , 2014, Pages 98-103

  Afrazi, Samira ^a,b   Esmaeili Mahani, Saeed ^b   Sheibani, Vahid ^a   Abbasnejad, Mehdi ^b  

^a KERMAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b SHAHID BAHONAR UNIVERSITY OF KERMAN   (Iran)

Author keywords

Allopregnanolone; Apoptosis; Diabetic neuropathy; Hyperalgesia; PC12 cells; Rats

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; CASPASE 3; GLUCOSE; PROTEIN BAX; PROTEIN BCL 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DIABETIC NEUROPATHY; ENZYME INHIBITION; HYPERALGESIA; HYPERGLYCEMIA; IMMUNOBLOTTING; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; RAT;

3-[4,5-DIMETHYL-2-THIAZOLYL]-2,5-DIPHENYL-2-TETRAZOLIUM BROMIDE; ADVANCED GLYCATION END PRODUCTS; AGE; ALLO; ALLOPREGNANOLONE; APOPTOSIS; CENTRAL NERVOUS SYSTEM; CNS; DIABETIC NEUROPATHY; DIMETHYL SULFOXIDE; DMSO; ERK-MAPK; EXTRACELLULAR SIGNAL-REGULATED KINASE/MITOGEN-ACTIVATED PROTEIN KINASE; HYPERALGESIA; MTT; N-METHYL-D-ASPARTATE; NMDA; OD; OPTICAL DENSITY; PC12 CELLS; RATS; STREPTOZOTOCIN; STZ;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CELL SURVIVAL; CYTOPROTECTION; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEUROPATHIES; GLUCOSE; MALE; NOCICEPTION; PC12 CELLS; PREGNANOLONE; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, WISTAR; SPINAL CORD;

RATTUS;

EID: 84887278864     PISSN: 09600760     EISSN: 18791220     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2013.10.010     Document Type: Article

References (39)

1. S. Wild, G. Roglic, A. Green, R. Sicree, and H. King Global prevalence of diabetes: estimates for the year 2000 and projections for 2030 Diabetes Care 27 2004 1047 1053 (Pubitemid 38579764)
2. S. Melmed, K.S. Polonsky, P. Reed, L. Kronenberg, and H. Kronenberg Williams Textbook of Endocrinology 12th ed. 2012 Elsevier Mosby/Saunders New York
3. K.M. Ramos, Y. Jiang, C.I. Svensson, and N.A. Calcutt Pathogenesis of spinally mediated hyperalgesia in diabetes Diabetes 56 2007 1569 1576 (Pubitemid 46842613)
4. P. Pacher, and C. Szabo Role of poly (ADP-ribose) polymerase-1 activation in the pathogenesis of diabetic complications: endothelial dysfunction, as a common underlying theme Antioxidants and Redox Signaling 7 2005 1568 1580 (Pubitemid 41767992)
5. J.L. Edwards, A.M. Vincent, H.T. Cheng, and E.L. Feldman Diabetic neuropathy: mechanisms to management Pharmacology and Therapeutics 120 2008 1 34
6. E. Lelkes, B.R. Unsworth, and P.I. Lelkes Reactive oxygen species, apoptosis and altered NGF-induced signaling in PC12 pheochromocytoma cells cultured in elevated glucose: an in vitro cellular model for diabetic neuropathy Neurotoxicity Research 3 2001 189 203 (Pubitemid 32936866)
7. J.W. Russell, D. Golovoy, A.M. Vincent, P. Mahendru, J.A. Olzmann, A. Mentzer, and E.L. Feldman High glucose-induced oxidative stress and mitochondrial dysfunction in neurons FASEB Journal 16 2002 1738 1748 (Pubitemid 35340354)
8. A.M. Vincent, L.L. Mclean, C. Backus, and L.L. Feldman Short-term hyperglycemia produces oxidative damage and apoptosis in neurons FASEB Journal 19 2005 638 640 (Pubitemid 40471270)
9. A. Kaeidi, S. Esmaeili-Mahani, V. Sheibani, M. Abbasnejad, B. Rasoulian, Z. Hajializadeh, and S. Afrazi Olive (Olea europaea L.) leaf extract attenuates early diabetic neuropathic pain through prevention of high glucose-induced apoptosis: In vitro and in vivo studies Journal of Ethnopharmacology 136 2011 188 196
10. M. Sekiguchi, Y. Sekiguchi, S. Konno, H. Kobayashi, Y. Homma, and S. Kikuchi Comparison of neuropathic pain and neuronal apoptosis following nerve root or spinal nerve compression European Spine Journal 18 2009 1978 1985
11. E.E. Benarroch Neurosteroids: endogenous modulators of neuronal excitability and plasticity Neurology 68 2007 945 947 (Pubitemid 46568508)
12. I. Azcoitia, A. Sierra, S. Veiga, and L.M. Garcia-Segura Brain steroidogenesis: emerging therapeutic strategies to prevent neurodegeneration Journal of Neural Transmission 112 2005 171 176 (Pubitemid 40104727)
13. M. Leskiewicz, D. Jantas, B. Budziszewska, and W. Lason Excitatory neurosteroids attenuate apoptotic and excitotoxic cell death in primary cortical neurons Journal of Physiology and Pharmacolgy 59 2008 457 475
14. E.M. Lockhart, D.S. Warner, R.D. Pearlstein, D.H. Penning, S. Mehrabani, and R.M. Boustany Allopregnanolone attenuates N-methyl-d-aspartate-induced excitotoxicity and apoptosis in the human NT2 cell line in culture Neuroscience Letter 328 2002 33 36 (Pubitemid 34786037)
15. S. Zampieri, S.H. Mellon, T.D. Butters, M. Nevyjel, D.F. Covey, B. Bembi, and A. Dardis Oxidative stress in NPC1 deficient cells: protective effect of allopregnanolone Journal of Cellular and Molecular Medicine 13 2009 3786 3796
16. M. Djebaili, Q. Guo, E.H. Pettus, S.W. Hoffman, and D.G. Stein The neurosteroids progesterone and allopregnanolone reduce cell death, gliosis, and functional deficits after traumatic brain injury in rats Journal of Neurotrauma 22 2005 106 118
17. I. Charalampopoulos, E. Remboutsika, A.N. Margioris, and A. Gravanis Neurosteroids as modulators of neurogenesis and neuronal survival Trends in Endocrinology and Metabolism 19 2008 300 307
18. E. Leonelli, R. Bianchi, G. Cavaletti, D. Caruso, D. Crippa, L.M. Garcia-Segura, G. Lauria, V. Magnaghi, I. Roglio, and R.C. Melcangi Progesterone and its derivatives are neuroprotective agents in experimental diabetic neuropathy: a multimodal analysis Neuroscience 144 2007 1293 1304 (Pubitemid 46123820)
19. F. Denizot, and R. Lang Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability Journal of Immunological Methods 89 1986 271 277 (Pubitemid 16080782)
20. M. Zimmermann Ethical guidelines for investigations of experimental pain in conscious animals Pain 16 1983 109 110 (Pubitemid 13058546)
21. Z. Hajializadeh, S. Esmaeili-Mahani, V. Sheibani, A. Kaeidi, M. Atapour, and M. Abbasnejad Changes in the gene expression of specific G-protein subunits correlate with morphine insensitivity in streptozotocin-induced diabetic rats Neuropeptides 44 2010 299 304
22. F.E.D. Amour, and D.L. Smith A method of determining loss of pain sensation Journal of Pharmacology and Experimental Therapeutics 27 1941 74 79
23. 2+ channels in rats Journal of Neuroscience Research 86 2008 471 479 (Pubitemid 351196753)
24. S. Esmaeili-Mahani, M. Javan, F. Motamedi, and A. Ahmadiani Post-adrenalectomy changes in the gene expression of specific G-protein subunits involved in morphine sensitization Neuropeptides 42 2008 169 175
25. I.G. Obrosova, V.R. Drel, P. Pacher, O. Ilnytska, Z.Q. Wang, M.J. Stevens, and M.A. Yorek Oxidative-nitrosative stress and poly (ADP-ribose) polymerase (PARP) activation in experimental diabetic neuropathy: the relation is revisited Diabetes 54 2005 3435 3441 (Pubitemid 43334333)
26. M. Aragno, S. Parola, E. Brignardello, A. Mauro, E. Tamagno, R. Manti, O. Danni, and G. Boccuzzi Dehydroepiandrosterone prevents oxidative injury induced by transient ischemia/reperfusion in the brain of diabetic rats Diabetes 49 2000 1924 1931
27. C. Jia, X. Chen, X. Li, M. Li, C. Miao, B. Sun, Z. Fan, and L. Ren The effect of DHEA treatment on the oxidative stress and myocardial fibrosis induced by Keshan disease pathogenic factors Journal of Trace Elements in Medicine and Biology 25 2011 154 159
28. A. Singh, and A. Kumar Possible GABAergic modulation in the protective effect of allopregnanolone on sleep deprivation-induced anxiety-like behavior and oxidative damage in mice Methods and Findings in Experimental and Clinical Pharmacology 30 2008 681 689
29. T. Simoncini, and A.T. Genazzani Non-genomic action of sex steroids hormons European Journal of Endocrinology 148 2003 281 292 (Pubitemid 36410713)
30. A.M. Sharifi, H. Eslami, B. Larijani, and J. Davoodi Involvement of caspase 8, 9, and 3 in high glucose-induced apoptosis in PC12 cells Neuroscience Letters 459 2009 47 51
31. I. Charalampopoulos, V.I. Alexaki, I. Lazaridis, E. Dermitzaki, N. Avlonitis, C. Tsatsanis, T. Calogeropoulou, A.N. Margioris, E. Castanas, and A. Gravanis G protein-associated, specific membrane binding sites mediate the neuroprotective effect of dehydroepiandrosterone FASEB Journal 20 2006 577 579 (Pubitemid 46671255)
32. K. Chopra, V. Tiwari, V. Arora, and A. Kuhad Sesamol suppresses neuro-inflammatory cascade in experimental model of diabetic neuropathy Journal of Pain 11 2010 950 957
33. K. Pabreja, K. Dua, S. Sharma, S.S. Padi, and S.K. Kulkarni Minocycline attenuates the development of diabetic neuropathic pain: possible anti-inflammatory and anti-oxidant mechanisms European Journal of Pharmacology 661 2011 15 21
34. J. He, C.O. Evans, S.W. Hoffman, N.M. Oyesiku, and D.G. Stein Progesterone and allopregnanolone reduce inflammatory cytokines after traumatic brain injury Experimental Neurology 189 2004 404 412 (Pubitemid 39221832)
35. S.P. Janssen, M. Truin, M. Van Kleef, and E.A. Joosten Differential GABAergic disinhibition during the development of painful peripheral neuropathy Neuroscience 184 2011 183 194
36. C.G. Jolivalt, C.A. Lee, K.M. Ramos, and N.A. Calcutt Allodynia and hyperalgesia in diabetic rats are mediated by GABA and depletion of spinal potassium-chloride co-transporters Pain 140 2008 48 57
37. S. Jergova, I.D. Hentall, S. Gajavelli, M.S. Varghese, and J. Sagen Intraspinal transplantation of GABAergic neural progenitors attenuates neuropathic pain in rats: a pharmacologic and neurophysiological evaluation Experimental Neurology 234 2012 39 49
38. A. Di Lio, D. Benke, M. Besson, J. Desmeules, Y. Daali, Z.J. Wang, Z.J.R. Edwankar, J.M. Cook, and H.U. Zeilhofer HZ166 a novel GABAA receptor subtype-selective benzodiazepine site ligand, is antihyperalgesic in mouse models of inflammatory and neuropathic pain Neuropharmacology 60 2011 626 632
39. M. Wang Neurosteroids and GABA-A Receptor Function Frontiers in Endocrinology (Lausanne) 2 2011 44