Trop-2 is a novel target for solid cancer therapy with sacituzumab govitecan (IMMU-132), an antibody-drug conjugate (ADC)

Oncotarget

Volumn 6, Issue 26, 2015, Pages 22496-22512

  Goldenberg, David M ^a   Cardillo, Thomas M ^a   Govindan, Serengulam V ^a   Rossi, Edmund A ^a   Sharkey, Robert M ^a  

^a IMMUNOMEDICS INC   (United States)

Author keywords

Antibody drug conjugate; SN 38; Solid cancers; Triple negative breast cancer; Trop 2

Indexed keywords

FIRTECAN; GLYCOPROTEIN; IRINOTECAN; PROTEIN TROP 2; SACITUZUMAB GOVITECAN; UNCLASSIFIED DRUG; ANTIBODY CONJUGATE; CAMPTOTHECIN; CELL ADHESION MOLECULE; MONOCLONAL ANTIBODY; TACSTD2 PROTEIN, HUMAN; TUMOR ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG EFFICACY; DRUG SPECIFICITY; DRUG STRUCTURE; DRUG TARGETING; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NON SMALL CELL LUNG CANCER; NONHUMAN; PROTEIN EXPRESSION; SINGLE DRUG DOSE; SMALL CELL LUNG CANCER; TRIPLE NEGATIVE BREAST CANCER; TUMOR VOLUME; TUMOR XENOGRAFT; ANALOGS AND DERIVATIVES; ANIMAL; BIOSYNTHESIS; DRUG SCREENING; IMMUNOLOGY; MCF-7 CELL LINE; MOLECULARLY TARGETED THERAPY; NUDE MOUSE; TRIPLE NEGATIVE BREAST NEOPLASMS; TUMOR CELL LINE;

ANIMALS; ANTIBODIES, MONOCLONAL, HUMANIZED; ANTIGENS, NEOPLASM; CAMPTOTHECIN; CELL ADHESION MOLECULES; CELL LINE, TUMOR; FEMALE; HUMANS; IMMUNOCONJUGATES; MCF-7 CELLS; MICE, NUDE; MOLECULAR TARGETED THERAPY; TRIPLE NEGATIVE BREAST NEOPLASMS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84941253818     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.4318     Document Type: Article

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