Expression of Trop2 cell surface glycoprotein in normal and tumor tissues: Potential implications as a cancer therapeutic target

Journal of Histochemistry and Cytochemistry

Volumn 59, Issue 7, 2011, Pages 701-710

  Stepan, Lara P ^a   Trueblood, Esther S ^a   Hale, Kari ^a   Babcook, John ^a   Borges, Luis ^a   Sutherland, Claire L ^a  

^a AMGEN INC   (United States)

Author keywords

Cancer; Human; Murine; Tissue distribution; Trop2

Indexed keywords

CELL SURFACE PROTEIN; PROTEIN TROP2; UNCLASSIFIED DRUG; CELL ADHESION MOLECULE; GLYCOPROTEIN; PROTEIN; TACSTD2 PROTEIN, HUMAN; TROP2 PROTEIN, MOUSE; TUMOR ANTIGEN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CANCER INVASION; CANCER THERAPY; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; ANIMAL; ANTIBODY SPECIFICITY; CELL LINE; METABOLISM; NEOPLASM;

MURINAE;

ANIMALS; ANTIGENS, NEOPLASM; CELL ADHESION MOLECULES; CELL LINE; GLYCOPROTEINS; HUMANS; MICE; NEOPLASMS; ORGAN SPECIFICITY; PROTEINS;

EID: 80051733033     PISSN: 00221554     EISSN: None     Source Type: Journal    
DOI: 10.1369/0022155411410430     Document Type: Article

References (32)

1. Alberti S, Miotti S, Stella M, Klein CE, Fornaro M, Menard S, Colnaghi M. 1992. Biochemical characterization of Trop-2, a cell surface molecule expressed by human carcinomas: formal proof that the monoclonal antibodies T16 and MOv-16 recognize Trop-2. Hybridoma. 11:539-545.
2. Balzar M, Briaire-De Bruijn IH, Rees-Bakker HAM, Prins FA, Helfrich W, De Leij L, Riethmuller G, Alberti S, Warnaar SO, Fleuren GJ, et al. 2001. Epidermal growth factor-like repeats mediate lateral and reciprocal interactions of Ep- CAM molecules in homophilic adhesions. Mol Cell Biol. 21:2570-2580.
3. Bignotti E, Todeschini P, Calza S, Falchetti M, Ravanini M, Tassi RA, Ravaggi A, Bandiera E, Romani C, Zanotti L, et al. 2010. Trop-2 overexpression as an independent marker for poor overall survival in ovarian carcinoma patients. Eur J Cancer. 46:944-953.
4. Cordon-Cardo C, Bander NH, Fradet Y, Finstad CL, Whitmore WF, Lloyd KO, Oettgen HF, Melamed MR, Old LJ. 1984. Immunoanatomic dissection of human urinary tract monoclonal antibodies. J Histochem Cytochem. 32:1035-1040.
5. Cubas R, Zhang S, Li M, Chen C, Yao Q. 2010. Trop2 expression contributes to tumor pathogenesis by activating the ERK MAPK pathway. Mol Cancer. 9:253-265.
6. De Bono JS, Tolcher AW, Forero A, Vanhove GFA, Takimoto C, Bauer RJ, Hammond LA, Patnaik A, White ML, Shen S, et al. 2004. ING-1, a monoclonal antibody targeting Ep-CAM in patients with advanced adenocarcinomas. Clin Cancer Res. 10:7555-7565.
7. El Sewedy T, Fornaro M, Alberti S. 1998. Cloning of the murine Trop2 gene-conservation of a Pip2-binding sequence in the cytoplasmic domain of Trop-2. Intl J Cancer. 75:324-330.
8. Fong D, Moser P, Krammel C, Gostner JM, Margreiter R, Mitterer M, Gastl G, Spizzo G. 2008. High expression of TROP2 correlates with poor prognosis in pancreatic cancer. Br J Cancer. 99:1290-1295.
9. Fong D, Spizzo G, Gostner JM, Gastl G, Moser P, Krammel C, Gerhard S, Rasse M, Laimer K. 2008. TROP2: a novel prognostic marker in squamous cell carcinoma of the oral cavity. Mod Pathol. 21:186-191.
10. Fornaro M, Dell'Arciprete R, Stella M, Bucci C, Nutini M, Capri MG, Alberti S. 1995. Cloning of the gene encoding Trop-2, a cell-surface glycoprotein expressed by human carcinomas. Intl J Cancer. 62:610-618.
11. Fradet Y, Cordon-Cardo C, Thomson T, Daly ME, Whitmore WFJ, Lloyd KO, Melamed MR, Old LJ. 1984. Cell surface antigens of human bladder cancer defined by mouse monoclonal antibodies. Proc Natl Acad Sci U S A. 81:224-228.
12. Goldstein AS, Lawson DA, Cheng D, Sun W, Garraway IP, Witte ON. 2008. Trop2 identifies a subpopulation of murine and human prostate basal cells with stem cell characteristics. Proc Natl Acad Sci U S A. 105:20882-20887.
13. Guerra E, Trerotola M, Dell'Arciprete R, Bonasera V, Palombo B, El-Sewedy T, Ciccimarra T, Crescenzi C, Lorenzini F, Rossi C, et al. 2008. A bicistronic CYCLIN D1-TROP2 mRNA chimera demonstrates a novel oncogenic mechanism in human cancer. Cancer Res. 68:8113-8121.
14. Kinoshita S, Nishida K, Dota A, Inatomi T, Koizumi N, Elliot A, Lewis D, Quantock A, Fullwood N. 2000. Epithelial barrier function and ultrastructure of gelatinous drop-like corneal dystrophy. Cornea. 19:551-555.
15. Klein CEK, Cordon-Cardo C, Soehnchen R, Cote RJ, Oettgen HF, Eisinger M, Old LJ. 1987. Changes in cell surface glycoprotein expression during differentiation of human keratinocytes. J Invest Dermatol. 89:500-506.
16. Lipinski M, Parks DR, Rouse RV, Herzenberg LA. 1981. Human trophoblast cell-surface antigens defined by monoclonal antibodies. Proc Natl Acad Sci U S A. 78:5147-5150.
17. Litvinov SV, Balzar M, Winter MJ, Bakker HAM, Briaire-De Bruijn IH, Prins F, Fleuren GJ, Warnaar SO. 1997. Epithelial cell adhesion molecule (Ep-CAM) modulates cell-cell interactions mediated by classic cadherins. J Cell Biol. 139:1337-1348.
18. Miotti S, Canevari S, Menard S, Mezzanzanica D, Porro G, Pupa SM, Regazzoni M, Tagliabue E, Colnaghi MI. 1987. Characterization of human ovarian carcinoma-associated antigens defined by novel monoclonal antibodies with tumor-restricted specificity. Intl J Cancer. 39:297-303.
19. Muhlmann G, Spizzo G, Gostner J, Maier H, Moser P, Gastl G, Zitt M, Muller HM, Margreiter R, Ofner D, et al. 2009. TROP2 expression as prognostic marker for gastric carcinoma. J Clin Pathol. 62:152-158.
20. Munz M, Baeuerle PA, Gires O. 2009. The emerging role of EpCAM in cancer and stem cell signaling. Cancer Res. 69:5627-5629.
21. Nakatsukasa M, Kawasaki S, Yamasaki K, Fukuoka H, Matsuda A, Tsujikawa M, Tanioka H, Nagata-Takaoka M, Hamuro J, Kinoshita S. 2010. Tumor-associated calcium signal transducer 2 is required for the proper subcellular localization of claudin 1 and 7. Am J Pathol. 177:1344-1355.
22. Ohmachi T, Tanaka F, Mimori K, Inoue H, Yanaga K, Mori M. 2006. Clinical significance of TROP2 expression in colorectal cancer. Clin Cancer Res. 12:3057-3063.
23. Ripani E, Sacchetti A, Corda D, Alberti S. 1998. Human TROP-2 is a tumor-associated calcium signal transducer. Intl J Cancer. 76:671-676.
24. Saleh M, Posey J, Khazaeli Mea. 1998. Phase I trial testing multiple doses of humanized monoclonal antibody (MAb) 3622W94 [abstract]. Proc Am Soc Clin Oncol. 17:436.
25. Saleh MN, LoBuglio AF, Posey JA, Ostroff JB, Khor SP, Thurmond LM, Bigley JW. 1998. Phase I study of different schedules of the humanized anti-EGP40 mAb 3622W94 in patients with antigen-expressing epithelial tumors [abstract]. Cancer Biother Radiopharm. 13:54.
26. Sebastian M, Kiewe P, Schuette W, Brust D, Peschel C, Schneller F, Ruehle KH, Nilius G, Ewert R, Lodziewski S, et al. 2009. Treatment of malignant pleural effusion with the trifunctional antibody catumaxomab (Removab) (Anti-EpCAM x Anti-CD3): results of a phase 1/2 study. J Immunother. 32:195-202.
27. Takiyama Y, Tempero MA, Takasaki H, Onda M, Tsuchiya R, Buchler M, Ness M, Colcher D, Schlom J, Pour PM. 1989. Reactivity of CO17-1A and B72.3 in benign and malignant pancreatic diseases. Hum Pathol. 20:832-838.
28. Trerotola M, Rathore S, Goel HL, Li J, Alberti S, Piantelli M, Adams D, Ziang Z, Languino LR. 2010. Trop-2 and alpha-2beta1 integrin surface receptors as markers of putative human prostate cancer stem cells. Am J Transl Res. 2:135-144.
29. Tsujikawa M, Kurahashi H, Tanaka T, Nishida K, Shimomura Y, Tano Y, Nakamura Y. 1999. Identification of the gene responsible for gelatinous drop-like corneal dystrophy. Nat Genet. 21:420-423.
30. Wang J, Day R, Dong Y, Weintraub SJ, Michel L. 2008. Identification of Trop-2 as an oncogene and an attractive therapeutic target in colon cancers. Mol Cancer Ther. 7:280-285.
31. Weber FL, Bable J. 1980. Gelatinous drop-like dystrophy; a form of primary corneal amyloidosis. Arch Opthamol. 98:144-148.
32. Zanna P, Trerotola M, Vacca G, Bonasera V, Palombo B, Guerra E, Rossi C, Lattanzio R, Piantelli M, Alberti S. 2007. Trop-1 are conserved growth stimulatory molecules that mark early stages of tumor progression. Cancer. 110:452-464.