Mitochondrial calcium overload is a key determinant in heart failure

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 36, 2015, Pages 11389-11394

  Santulli, Gaetano ^a   Xie, Wenjun ^a   Reiken, Steven R ^a   Marks, Andrew R ^a  

^a Medical Center ^*  (United States)

Author keywords

Calcium; Heart failure; IP3 receptor; Mitochondria; Ryanodine receptor

Indexed keywords

CALCIUM; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR TYPE 2; NITRATE REDUCTASE [NAD(P)H]; NITRIC OXIDE SYNTHASE; REACTIVE OXYGEN METABOLITE; RYANODINE RECEPTOR 2; UNCLASSIFIED DRUG; XANTHINE OXIDASE; IP3R2 PROTEIN, MOUSE; RYANODINE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; AUTOPHAGY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENDOPLASMIC RETICULUM STRESS; HEART FAILURE; HEART FUNCTION; HEART INFARCTION; MITOCHONDRIAL DYSFUNCTION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MOUSE; NITROSYLATION; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; UPREGULATION; ANIMAL; CARDIAC MUSCLE; CARDIAC MUSCLE CELL; CELL CULTURE; DISEASE MODEL; GENETICS; HEART MITOCHONDRION; IMMUNOBLOTTING; METABOLISM; MUTATION; OXIDATIVE STRESS; PATHOLOGY; SARCOPLASMIC RETICULUM; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE;

ANIMALS; CALCIUM; CELLS, CULTURED; DISEASE MODELS, ANIMAL; HEART FAILURE; IMMUNOBLOTTING; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS; MICE; MICROSCOPY, ELECTRON, TRANSMISSION; MITOCHONDRIA, HEART; MUTATION; MYOCARDIAL INFARCTION; MYOCARDIUM; MYOCYTES, CARDIAC; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SARCOPLASMIC RETICULUM;

EID: 84941243899     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1513047112     Document Type: Article

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