Ca2+ entry via Trpm2 is essential for cardiac myocyte bioenergetics maintenance

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 308, Issue 6, 2015, Pages H637-H650

  Hoffman, Nicholas E ^a   Miller, Barbara A ^b   Wang, Ju Fang ^a   Elrod, John W ^a   Rajan, Sudasan ^a   Gao, Erhe ^a   Song, Jianliang ^a   Zhang, Xue Qian ^a   Hirschler Laszkiewicz, Iwona ^b   Shanmughapriya, Santhanam ^a   Koch, Walter J ^a   Feldman, Arthur M ^a   Madesh, Muniswamy ^a   Cheung, Joseph Y ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

Cardiac Trpm2 currents; Doxorubicin cardiomyopathy; Hypoxia reoxygenation; Ischemic cardiomyopathy; Mitochondrial superoxide; Voltage independent Ca2+ channels

Indexed keywords

DOXORUBICIN; GREEN FLUORESCENT PROTEIN; REACTIVE OXYGEN METABOLITE; TRANSIENT RECEPTOR POTENTIAL CHANNEL M2; CALCIUM; TRANSIENT RECEPTOR POTENTIAL CHANNEL M; TRPM2 PROTEIN, MOUSE;

ADENOVIRIDAE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOENERGY; CALCIUM TRANSPORT; CONTROLLED STUDY; HEART FUNCTION; HEART LEFT VENTRICLE; HEART MITOCHONDRION; HEART MUSCLE CELL; HUMAN; HUMAN CELL; HYPOXIA; MOUSE; NONHUMAN; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PRIORITY JOURNAL; REOXYGENATION; SODIUM CALCIUM EXCHANGE; ACTION POTENTIAL; ANIMAL; C57BL MOUSE; CALCIUM SIGNALING; CARDIOMYOPATHIES; CHEMICALLY INDUCED; DEFICIENCY; DISEASE MODEL; ENERGY METABOLISM; GENETIC TRANSFECTION; GENETICS; HEART CONTRACTION; HEART LEFT VENTRICLE FUNCTION; HEART VENTRICLE PRESSURE; HEK293 CELL LINE; KNOCKOUT MOUSE; METABOLISM; MUTATION; MYOCARDIAL REPERFUSION INJURY; PATHOPHYSIOLOGY; TIME;

ACTION POTENTIALS; ANIMALS; CALCIUM; CALCIUM SIGNALING; CARDIOMYOPATHIES; DISEASE MODELS, ANIMAL; DOXORUBICIN; ENERGY METABOLISM; HEK293 CELLS; HUMANS; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOCHONDRIA, HEART; MUTATION; MYOCARDIAL CONTRACTION; MYOCARDIAL REPERFUSION INJURY; MYOCYTES, CARDIAC; OXIDATIVE STRESS; OXYGEN CONSUMPTION; REACTIVE OXYGEN SPECIES; TIME FACTORS; TRANSFECTION; TRPM CATION CHANNELS; VENTRICULAR FUNCTION, LEFT; VENTRICULAR PRESSURE;

EID: 84937510947     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00720.2014     Document Type: Article

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