Polymorphisms in the LPL and CETP genes and haplotype in the ESR1 gene are associated with metabolic syndrome in women from Southwestern Mexico

International Journal of Molecular Sciences

Volumn 16, Issue 9, 2015, Pages 21539-21554

  Cahua Pablo, José Ángel ^a   Cruz, Miguel ^b   Méndez Palacios, Abigail ^a   Antúnez Ortiz, Diana Lizzete ^a   Vences Velázquez, Amalia ^a   Alarcón Romero, Luz Del Carmen ^a   Parra, Esteban Juan ^c   Tello Flores, Vianet Argelia ^a   Leyva Vázquez, Marco Antonio ^a   Valladares Salgado, Adán ^b   Pérez Macedonio, Claudia Paola ^a   Flores Alfaro, Eugenia ^a  

^a UNIVERSIDAD AUTÓNOMA DE GUERRERO   (Mexico)

^b INSTITUTO MEXICANO DEL SEGURO SOCIAL   (Mexico)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

ESR1 haplotype; LPL and CETP polymorphisms; Metabolic syndrome

Indexed keywords

GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; CHOLESTEROL ESTER TRANSFER PROTEIN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR ALPHA, HUMAN; LIPOPROTEIN LIPASE;

ADULT; ALLELE; ARTICLE; COLORIMETRY; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DNA ISOLATION; FEMALE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; METABOLIC SYNDROME X; MEXICO; MULTIPLEX POLYMERASE CHAIN REACTION; REAL TIME POLYMERASE CHAIN REACTION; SINGLE NUCLEOTIDE POLYMORPHISM; CASE CONTROL STUDY; GENETIC ASSOCIATION STUDY; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; MIDDLE AGED;

ADULT; ALLELES; CASE-CONTROL STUDIES; CHOLESTEROL ESTER TRANSFER PROTEINS; CROSS-SECTIONAL STUDIES; ESTROGEN RECEPTOR ALPHA; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HAPLOTYPES; HUMANS; LINKAGE DISEQUILIBRIUM; LIPOPROTEIN LIPASE; METABOLIC SYNDROME X; MEXICO; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84941242653     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms160921539     Document Type: Article

References (31)

1. Wilson, P.W.F.; D’Agostino, R.B.; Parise H.; Sullivan, L.; Meigs, J.B. Metabolic syndrome as a precursor of cardiovascular disease and type 2 diabetes mellitus. Circulation 2005, 112, 3066–3072.
2. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of the Third Report of The National Cholesterol Education Program (NCEP). Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001, 285, 2486–2497.
3. Grundy, S.M.; Brewer, H.B., Jr.; Cleeman, J.I.; Smith, S.C., Jr.; Lenfant, C. Definition of metabolic syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Arterioscler. Thromb. Vasc. Biol. 2004, 109, 433–438.
4. Kubrusly, M.; Costa-De Oliveira, C.M.; Freire-Simões, P.S.; de Oliveira-Lima, R.; Rabelo-Galdino, P.N.; Fortaleza-Sousa, P.A.; Carneiro-Jerônimo, A.L. Prevalence of Metabolic Syndrome according to NCEP-ATP III and IDF criteria in Patients on Hemodialysis. J. Bras. Nefrol. 2015, 37, 72–78.
5. Miller, V.M.; Duckles, S.P. Vascular actions of estrogens: Functional implications. Pharmacol. Rev. 2008, 60, 210–241.
6. Gallagher, C.J.; Langefeld, C.D.; Gordon, C.J.; Campbell, J.K.; Mychaleckyj, J.C.; Bryer-Ash, M.; Rich, S.S.; Bowden, D.W.; Sale, M.M. Association of the estrogen receptor-alpha gene with the metabolic syndrome and its component traits in African-American families: The Insulin Resistance Atherosclerosis Family Study. Diabetes 2007, 56, 2135–2141.
7. Ghattas, M.H.; Mehanna, E.T.; Mesbah, N.M.; Abo-Elmatty, D.M. Association of estrogen receptor alpha gene polymorphisms with metabolic syndrome in Egyptian women. Metabolism 2013, 62, 1437–1442.
8. Deroo, B.J.; Korach, K.S. Estrogen receptors and human disease. J. Clin. Investig. 2006, 116, 561–570.
9. Yasuda, T.; Ishida, T.; Rader, D.J. Update on the role of endothelial lipase in high-density lipoprotein metabolism, reverse cholesterol transport, and atherosclerosis. Circ. J. 2010, 74, 2263–2270.
10. Nagano, M.; Yamashita, S.; Hirano, K.; Takano, M.; Maruyama, T.; Ishihara, M.; Sagehashi, Y.; Kujiraoka, T.; Tanaka, K.; Hattori, H. et al. Molecular mechanisms of cholesteryl ester transfer protein deficiency in Japanese. J. Atheroscler. Thromb. 2004, 11, 110–121.
11. Kaur, J. A comprehensive review on metabolic syndrome. Cardiol. Res. Pract. 2014, doi:10.1155/2014/943162.
12. Grundy, S.M. Metabolic syndrome pandemic. Arterioscler. Thromb. Vasc. Biol. 2008, 28, 629–636.
13. Heiss, G.; Snyder, M.L.; Teng, Y.; Schneiderman, N.; Llabre, M.M.; Cowie, C.; Carnethon, M.; Kaplan, R.; Giachello, A.; Gallo, L. et al. Prevalence of metabolic syndrome among Hispanics/Latinos of diverse background: The Hispanic Community Health Study/Study of Latinos. Diabetes Care 2014, 37, 2391–2399.
14. Rojas, R.; Aguilar-Salinas, C.A.; Jiménez-Corona, A.; Shamah-Levy, T.; Rauda, J.; Avila-Burgos, L.; Villalpando, S.; Ponce, E.L. Metabolic syndrome in Mexican adults: Results from the National Health and Nutrition Survey 2006. Salud Publica Mex. 2010, 52, S11–S18.
15. Faulds, M.H.; Zhao, C.; Dahlman-Wright, K.; Gustafsson, J.A. The diversity of sex steroid action: Regulation of metabolism by estrogen signaling. J. Endocrinol. 2012, 212, 3–12.
16. Alonso-Magdalena, P.; Ropero, A.B.; Carrera, M.P.; Cederroth, C.R.; Baquié, M.; Gauthier, B.R.; Nef, S.; Stefani, E.; Nadal, A. Pancreatic insulin content regulation by the estrogen receptor ER alpha. PLoS ONE 2008, 3, E2039.
17. Hopp, T.A.; Fuqua, S.A. Estrogen Receptor Variants. J. Mammary Gland Biol. Neoplasia 1998, 3, 73–83.
18. Anghel, A.; Narita, D.; Seclaman, E.; Popovici, E.; Anghel, M.; Tamas, L. Estrogen receptor alpha polymorphisms and the risk of malignancies. Pathol. Oncol. Res. 2010, 16, 485–496.
19. Klos, K.L.; Boerwinkle, E.; Ferrell, R.E.; Turner, S.T.; Morrison, A.C. ESR1 polymorphism is associated with plasma lipid and apolipoprotein levels in Caucasians of the Rochester Family Heart Study. J. Lipid Res. 2008, 49, 1701–1706.
20. Sowers, M.R.; Wilson, A.L.; Karvonen-Gutierrez, C.A.; Kardia, S.R. Sex steroid hormone pathway genes and health-related measures in women of 4 races/ethnicities: The Study of Women’s Health Across the Nation (SWAN). Am. J. Med. 2006, 119, S103–S110.
21. Goulart, A.C.; Zee, R.Y.; Pradhan, A.; Rexrode, K.M. Associations of the estrogen receptors 1 and 2 gene polymorphisms with the metabolic syndrome in women. Metab. Syndr. Relat. Disord. 2009, 7, 111–117.
22. Rebelo, A.C.; Verlengia, R.; Kunz, V.; Tamburus, N.; Cerda, A.; Hirata, R.; Hirata, M.; Silva, E. Lack of association of estrogen receptor alpha gene polymorphisms with cardiorespiratory and metabolic variables in young women. Int. J. Mol. Sci. 2012, 13, 13691–13703.
23. Dallinga-Thie, G.M.; Franssen, R.; Mooij, H.L.; Visser, M.E.; Hassing, H.C.; Peelman, F.; Kastelein, J.J.; Péterfy, M.; Nieuwdorp, M. The metabolism of triglyceride-rich lipoproteins revisited: New players, new insight. Atherosclerosis 2010, 211, 1–8.
24. Ariza, M.J.; Sánchez-Chaparro, M.A.; Barón, F.J.; Hornos, A.M.; Calvo-Bonacho, E.; Rioja, J.; Valdivielso, P.; Gelpi, J.A.; González-Santos, P. Additive effects of LPL, APOA5 and APOE variant combinations on triglyceride levels and hypertriglyceridemia: Results of the ICARIA genetic sub-study. BMC Med. Genet. 2010, 29, 1–10.
25. Webster, R.J.; Warrington, N.M.; Weedon, M.N.; Hattersley, A.T.; McCaskie, P.A.; Beilby, J.P.; Palmer, L.J.; Frayling, T.M. The association of common genetic variants in the APOA5, LPL and GCK genes with longitudinal changes in metabolic and cardiovascular traits. Diabetologia 2009, 52, 106–114.
26. Emamian, M.; Avan, A.; Pasdar, A.; Mirhafez, S.R.; Sadeghzadeh, M.; Moghadam, M.; Parizadeh, S.M.; Ferns, G.A.; Ghayour-Mobarhan, M. The lipoprotein lipase S447X and cholesteryl ester transfer protein rs5882 polymorphisms and their relationship with lipid profile in human serum of obese individuals. Gene 2015, 558, 195–199.
27. Sandhofer, A.; Tatarczyk, T.; Laimer, M.; Ritsch, A.; Kaser, S.; Paulweber, B.; Ebenbichler, C.F.; Patsch, J.R. The Taq1B-variant in the cholesteryl ester-transfer protein gene and the risk of metabolic syndrome. Obesity 2008, 16, 919–922.
28. López-Ríos, L.; Nóvoa, F.J.; Chirino, R.; Varillas, F.; Boronat-Cortés, M.; Wagner, A.M. Interaction between cholesteryl ester transfer protein and hepatic lipase encoding genes and the risk of type 2 diabetes: Results from the Telde study. PLoS ONE 2011, 6, e27208.
29. Elsammak, M.Y.; Al-Sharkaweey, R.M.; Fahmy, M.; Reda, A.A.; Farid, W.; Emara, A.; Hassan, H.; Kandil, M.H. Taq1B polymorphism of cholesteryl ester transfer protein (CETP) in Egyptian patients with metabolic syndrome. Diabetes Metab. Syndr. 2011, 5, 61–65.
30. Lahiri, D.K.; Nurnberger, J.I., Jr. A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies. Nucleic Acids Res. 1991, 19, doi:10.1093/nar/19.19.5444.
31. Cheverud, J.M. A simple correction for multiple comparisons in interval mapping genome scans. Heredity 2001, 87, 52–58.