Interaction between Cholesteryl Ester Transfer Protein and Hepatic Lipase Encoding Genes and the Risk of Type 2 Diabetes: Results from the Telde Study

PLoS ONE

Volumn 6, Issue 11, 2013, Pages

  López Ríos, Laura ^a,b   Nóvoa, Francisco J ^a,b   Chirino, Ricardo ^b   Varillas, Francisco ^c   Boronat Cortés, Mauro ^a,b   Wägner, Ana M ^a,b  

^a HOSPITAL UNIVERSITARIO INSULAR DE GRAN CANARIA   (Spain)

^b UNIVERSITY OF LAS PALMAS DE GRAN CANARIA   (Spain)

^c Hospital General de Fuerteventura   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL ESTER TRANSFER PROTEIN; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIVER TRIACYLGLYCEROL LIPASE; PRIMER DNA; TRIACYLGLYCEROL LIPASE;

ADULT; ARTICLE; CASE CONTROL STUDY; CETP GENE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENE; GENE FREQUENCY; GENE INTERACTION; GENOTYPE; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; HUMAN; INSULIN RESISTANCE; LIPC GENE; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PREVALENCE; RISK ASSESSMENT; RISK FACTOR; AGAR GEL ELECTROPHORESIS; COHORT ANALYSIS; ENZYMOLOGY; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; LIVER; METABOLISM; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION;

BASE SEQUENCE; CASE-CONTROL STUDIES; CHOLESTEROL ESTER TRANSFER PROTEINS; COHORT STUDIES; DIABETES MELLITUS, TYPE 2; DNA PRIMERS; ELECTROPHORESIS, AGAR GEL; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LIPASE; LIVER; MALE; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; PREVALENCE;

EID: 84875407187     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0027208     Document Type: Article

References (35)

1. Wilding JP, (2007) The importance of free fatty acids in the development of Type 2 diabetes. Diabet Med 24: 934-945.
2. Morton RE, (1999) Cholesteryl ester transfer protein and its plasma regulator: lipid transfer inhibitor protein. Curr Opin Lipidol 10: 321-327.
3. Thuren T, (2000) Hepatic lipase and HDL metabolism. Curr Opin Lipidol 11: 277-283.
4. Lagrost L, Gandjini H, Athias A, Guyard-Dangremont V, Lallemant C, et al.(1993) Influence of plasma cholesteryl ester transfer activity on the LDL and HDL distribution profiles in normolipidemic subjects. Arterioscler Thromb 13: 815-825.
5. Zambon A, Deeb SS, Pauletto P, Crepaldi G, Brunzell JD, (2003) Hepatic lipase: a marker for cardiovascular disease risk and response to therapy. Curr Opin Lipidol 14: 179-189.
6. Ikewaki K, Rader DJ, Sakamoto T, Nishiwaki M, Wakimoto N, et al.(1993) Delayed catabolism of high density lipoprotein apolipoproteins A-I and A-II in human cholesteryl ester transfer protein deficiency. J Clin Invest 92: 1650-1658.
7. Kondo I, Berg K, Drayna D, Lawn R, (1989) DNA polymorphism at the locus for human cholesteryl ester transfer protein (CETP) is associated with high density lipoprotein cholesterol and apolipoprotein levels. Clin Genet 35: 49-56.
8. Noone E, Roche HM, Black I, Tully AM, Gibney MJ, (2000) Effect of postprandial lipaemia and Taq 1B polymorphism of the cholesteryl ester transfer protein (CETP) gene on CETP mass, activity, associated lipoproteins and plasma lipids. Br J Nutr 84: 203-209.
9. Boekholdt SM, Kuivenhoven JA, Hovingh GK, Jukema JW, Kastelein JJ, et al.(2004) CETP gene variation: relation to lipid parameters and cardiovascular risk. Curr Opin Lipidol 15: 393-398.
10. Corella D, Saiz C, Guillen M, Portoles O, Mulet F, et al.(2000) Association of TaqIB polymorphism in the cholesteryl ester transfer protein gene with plasma lipid levels in a healthy Spanish population. Atherosclerosis 152: 367-376.
11. Isaacs A, Sayed-Tabatabaei FA, Njajou OT, Witteman JC, van Duijn CM, (2004) The-514 C->T hepatic lipase promoter region polymorphism and plasma lipids: a meta-analysis. J Clin Endocrinol Metab 89: 3858-3863.
12. Blades B, Vega GL, Grundy SM, (1993) Activities of lipoprotein lipase and hepatic triglyceride lipase in postheparin plasma of patients with low concentrations of HDL cholesterol. Arterioscler Thromb 13: 1227-1235.
13. Todorova B, Kubaszek A, Pihlajamaki J, Lindstrom J, Eriksson J, et al.(2004) The G-250A promoter polymorphism of the hepatic lipase gene predicts the conversion from impaired glucose tolerance to type 2 diabetes mellitus: the Finnish Diabetes Prevention Study. J Clin Endocrinol Metab 89: 2019-2023.
14. Deeb SS, Peng R, (2000) The C-514T polymorphism in the human hepatic lipase gene promoter diminishes its activity. J Lipid Res 41: 155-158.
15. Tahvanainen E, Syvanne M, Frick MH, Murtomaki-Repo S, Antikainen M, et al.(1998) Association of variation in hepatic lipase activity with promoter variation in the hepatic lipase gene. The LOCAT Study Invsestigators. J Clin Invest 101: 956-960.
16. Zambon A, Deeb SS, Hokanson JE, Brown BG, Brunzell JD, (1998) Common variants in the promoter of the hepatic lipase gene are associated with lower levels of hepatic lipase activity, buoyant LDL, and higher HDL2 cholesterol. Arterioscler Thromb Vasc Biol 18: 1723-1729.
17. Zacharova J, Todorova BR, Chiasson JL, Laakso M, (2005) The G-250A substitution in the promoter region of the hepatic lipase gene is associated with the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial. J Intern Med 257: 185-193.
18. Boronat M, Varillas VF, Saavedra P, Suarez V, Bosch E, et al.(2006) Diabetes mellitus and impaired glucose regulation in the Canary Islands (Spain): prevalence and associated factors in the adult population of Telde, Gran Canaria. Diabet Med 23: 148-155.
19. Novoa FJ, Boronat M, Saavedra P, Diaz-Cremades JM, Varillas VF, et al.(2005) Differences in cardiovascular risk factors, insulin resistance, and insulin secretion in individuals with normal glucose tolerance and in subjects with impaired glucose regulation: the Telde Study. Diabetes Care 28: 2388-2393.
20. Wu JH, Lee YT, Hsu HC, Hsieh LL, (2001) Influence of CETP gene variation on plasma lipid levels and coronary heart disease: a survey in Taiwan. Atherosclerosis 159: 451-458.
21. Ye S, Dhillon S, Ke X, Collins AR, Day IN, (2001) An efficient procedure for genotyping single nucleotide polymorphisms. Nucleic Acids Res 29: E88-88.
22. Gudnason V, Kakko S, Nicaud V, Savolainen MJ, Kesaniemi YA, et al.(1999) Cholesteryl ester transfer protein gene effect on CETP activity and plasma high-density lipoprotein in European populations. The EARS Group. Eur J Clin Invest 29: 116-128.
23. Dullaart RP, Sluiter WJ, Dikkeschei LD, Hoogenberg K, Van Tol A, (1994) Effect of adiposity on plasma lipid transfer protein activities: a possible link between insulin resistance and high density lipoprotein metabolism. Eur J Clin Invest 24: 188-194.
24. Smaoui M, Hammami S, Attia N, Chaaba R, Abid N, et al.(2006) Modulation of plasma cholesteryl ester transfer protein activity by unsaturated fatty acids in Tunisian type 2 diabetic women. Nutr Metab Cardiovasc Dis 16: 44-53.
25. Sandhofer A, Tatarczyk T, Laimer M, Ritsch A, Kaser S, et al.(2008) The Taq1B-variant in the cholesteryl ester-transfer protein gene and the risk of metabolic syndrome. Obesity (Silver Spring) 16: 919-922.
26. López-Ríos L, Pérez-Jiménez P, Martínez-Quintana E, Rodríguez González G, Díaz-Chico BN, et al.(2009) Association of Taq 1B CETP polymorphism with insulin and HOMA levels in the population of the Canary Islands. Nutrition, Metabolism and Cardiovascular Diseases in press.
27. Lambert G, Chase MB, Dugi K, Bensadoun A, Brewer HB Jr, et al.(1999) Hepatic lipase promotes the selective uptake of high density lipoprotein-cholesteryl esters via the scavenger receptor B1. J Lipid Res 40: 1294-1303.
28. Andersen RV, Wittrup HH, Tybjaerg-Hansen A, Steffensen R, Schnohr P, et al.(2003) Hepatic lipase mutations,elevated high-density lipoprotein cholesterol, and increased risk of ischemic heart disease: the Copenhagen City Heart Study. J Am Coll Cardiol 41: 1972-1982.
29. Lindi V, Schwab U, Louheranta A, Vessby B, Hermansen K, et al.(2008) The G-250A polymorphism in the hepatic lipase gene promoter is associated with changes in hepatic lipase activity and LDL cholesterol: The KANWU Study. Nutr Metab Cardiovasc Dis 18: 88-95.
30. Carr MC, Hokanson JE, Deeb SS, Purnell JQ, Mitchell ES, et al.(1999) A hepatic lipase gene promoter polymorphism attenuates the increase in hepatic lipase activity with increasing intra-abdominal fat in women. Arterioscler Thromb Vasc Biol 19: 2701-2707.
31. Jackson KG, Zampelas A, Knapper JM, Roche HM, Gibney MJ, et al.(2000) Differences in glucose-dependent insulinotrophic polypeptide hormone and hepatic lipase in subjects of southern and northern Europe: implications for postprandial lipemia. Am J Clin Nutr 71: 13-20.
32. Despres JP, Ferland M, Moorjani S, Nadeau A, Tremblay A, et al.(1989) Role of hepatic-triglyceride lipase activity in the association between intra-abdominal fat and plasma HDL cholesterol in obese women. Arteriosclerosis 9: 485-492.
33. Grarup N, Andreasen CH, Andersen MK, Albrechtsen A, Sandbaek A, et al.(2008) The-250G>A promoter variant in hepatic lipase associates with elevated fasting serum high-density lipoprotein cholesterol modulated by interaction with physical activity in a study of 16,156 Danish subjects. J Clin Endocrinol Metab 93: 2294-2299.
34. Isaacs A, Aulchenko YS, Hofman A, Sijbrands EJ, Sayed-Tabatabaei FA, et al.(2007) Epistatic effect of cholesteryl ester transfer protein and hepatic lipase on serum high-density lipoprotein cholesterol levels. J Clin Endocrinol Metab 92: 2680-2687.
35. Soyala AS, Hahnea P, Oberkoflera H, Feldera T, Iglsederc B, et al.(2011) Cholesteryl ester transfer protein and hepatic lipase gene polymorphisms: Effects on hepatic mRNA levels, plasma lipids and carotid atherosclerosis. Atherosclerosis 216: 374-380.