Lack of association of estrogen receptor alpha gene polymorphisms with cardiorespiratory and metabolic variables in young women

International Journal of Molecular Sciences

Volumn 13, Issue 10, 2012, Pages 13691-13703

  Rebelo, Ana Cristina ^a   Verlengia, Rozangela ^b   Kunz, Vandeni ^c   Tamburus, Nayara ^d   Cerda, Alvaro ^e   Hirata, Rosario ^e   Hirata, Mario ^e   Silva, Ester ^d  

^a FEDERAL UNIVERSITY OF GOIÁS   (Brazil)

^b METHODIST UNIVERSITY OF PIRACICABA   (Brazil)

^c UNASP   (Brazil)

^d FEDERAL UNIVERSITY OF SÃO CARLOS   (Brazil)

^e FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Aerobic capacity; Estrogen receptor alpha; Gene polymorphisms; Heart rate variability; Lipids

Indexed keywords

DNA; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ADULT; AEROBIC CAPACITY; ARTICLE; BLOOD SAMPLING; CARDIOPULMONARY EXERCISE TEST; CARDIOVASCULAR PARAMETERS; CONTROLLED STUDY; ESTROGEN RECEPTOR ALPHA GENE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPING TECHNIQUE; HAPLOTYPE; HEART RATE VARIABILITY; HUMAN; HUMAN EXPERIMENT; LIPID BLOOD LEVEL; MALE; METABOLIC PARAMETERS; OUTCOME ASSESSMENT; OXYGEN CONSUMPTION; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT; URINALYSIS; WOMEN'S HEALTH; ADOLESCENT; BLOOD; CARDIOVASCULAR DISEASES; DEMOGRAPHY; FEMALE; GENETICS; GENOTYPE; HEART RATE; PHYSIOLOGY; RISK FACTOR; STATISTICAL MODEL; YOUNG ADULT;

ADOLESCENT; ADULT; CARDIOVASCULAR DISEASES; DEMOGRAPHY; ESTROGEN RECEPTOR ALPHA; FEMALE; GENE FREQUENCY; GENOTYPE; HAPLOTYPES; HEART RATE; HUMANS; LINEAR MODELS; LIPIDS; OXYGEN CONSUMPTION; POLYMORPHISM, GENETIC; RISK FACTORS; YOUNG ADULT;

EID: 84870675688     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms131013691     Document Type: Article

References (36)

1. Kjaergaard, A.D.; Ellervik, C.; Tybjaerg-Hansen, A.; Axelsson, C.K.; Grønholdt, M.L.; Grande, P.; Jensen, G.B.; Nordestgaard, B.G. Estrogen receptor alpha polymorphism and risk of cardiovascular disease, cancer and hip fracture: Cross sectional, cohort, and case-control studies and a meta-analysis. Circulation 2007, 115, 861-871.
2. Alevizaki, M.; Saltiki, K.; Cimponeriu, A.; Kanakakis, I.; Xita, N.; Alevizaki, C.C.; Georgiou, I.; Sarika, H.L. Severity of cardiovascular disease in postmenopausal women: Associations with common estrogenreceptor alpha polymorphic variants. Eur. J. Endocrinol. 2007, 156, 489-496.
3. McEwen, B.S.; Akama, K.T.; Spencer-Segal, J.L.; Milner, T.A.; Waters, E.M. Estrogen effects on the brain: Actions beyond the hypothalamus via novel mechanisms. Behav. Neurosci. 2012, 126, 4-16.
4. Saleh, T.M.; Connell, B.J. Role of oestrogen in the central regulation of autonomic function. Clin. Exp. Pharmacol. Physiol. 2007, 34, 827-832.
5. Uusitalo, A.L.; Vanninen, E.; Levälahti, E.; Battié, M.C.; Videman, T.; Kaprio, J. Role of genetic and environmental influences on heart rate variability in middle-aged men. Am. J. Physiol. Heart Circ. Physiol. 2007, 293, 1013-1022.
6. Hedelin, R.; Bjerle, P.; Henriksson-Larsén, K. Heart rate variability in athletes: Relationship with central and peripheral performance. Med. Sci. Sports Exerc. 2001, 33, 1394-1398.
7. Hautala, A.J.; Mäkikallio, T.H.; Kiviniemi, A.; Laukkanen, R.T.; Nissilä, S.; Huikuri, H.V.; Tulppo, M.P. Cardiovascular autonomic function correlates with the response to aerobic training in healthy sedentary subjects. Am. J. Physiol. Heart Circ. Physiol. 2003, 285, 1747-1752.
8. Kouidi, E.; Haritonidis, K.; Koutlianos, N.; Deligiannis, A. Effects of athletic training on heart rate variability triangular index. Clin. Physiol. Funct. Imaging 2002, 22, 279-284.
9. Loimaala, A.; Huikuri, H.; Oja, P.; Pasanen, M.; Vuori, I. Controlled 5-mo aerobic training improves heart rate but not heart rate variability or baroreflex sensitivity. J. Appl. Physiol. 2000, 89, 1825-1829.
10. Riahi, S.; Schmidt, E.B.; Amanavicius, N.; Karmisholt, J.; Jensen, H.S.; Christoffersen, R.P.; Niebuhr, U.; Christensen, J.H.; Toft, E. The effect of atorvastatin on heart rate variability and lipoproteins in patients treated with coronary bypass surgery. Int. J. Cardiol. 2006, 111, 436-441.
11. Thayer, J.F.; Yamamoto, S.S.; Brosschot, J.F. The relationship of autonomic imbalance, heart rate variability and cardiovascular disease risk factors. Int. J. Cardiol. 2010, 141, 122-131.
12. Santos, M.C.S.; Rebelo, A.C.S.; Zuttin, R.S.; César, M.C.; Catai, A.M.; Silva, E. Influence of oral contraceptive use on lipid levels and cardiorespiratory responses among healthy sedentary women. Rev. Bras. Fisioter. 2008, 12, 188-194.
13. Winkler, U.H.; Sudik, R. The effects of two monophasic oral contraceptives containing 30 mcg of ethinyl estradiol and either 2 mg of chlormadinone acetate or 0.15 mg of desogestrel on lipid, hormone and metabolic parameters. Contraception 2009, 79, 15-23.
14. Yildizhan, R.; Yildizhan, B.; Adali, E.; Yoruk, P.; Birol, F.; Suer, N. Effects of two combined oral contraceptives containing ethinyl estradiol 30 microg combined with either gestodene or drospirenone on hemostatic parameters, lipid profiles and blood pressure. Arch. Gynecol. Obst. 2009, 280, 255-261.
15. Leitman, D.C.; Paruthiyil, S.; Yuan, C.; Herber, C.B.; Olshansky, M.; Tagliaferri, M.; Cohen, I.; Speed, T.P. Tissue-specific regulation of genes by estrogen receptors. Semin. Reprod. Med. 2012, 684, 119-126.
16. Govind, A.P.; Thampan, R.V. Membrane associated estrogen receptors and related proteins: Localization at the plasma membrane and the endoplasmic reticulum. Mol. Cell. Biochem. 2003, 253, 233-240.
17. Lenfant, F.; Trémollières, F.; Gourdy, P.; Arnal, J.F. Timing of the vascular actions of estrogens in experimental and human studies: Why protective early, and not when delayed? Maturitas 2011, 68, 165-173.
18. Rokach, A.; Pollak, A.; Rosen, L.; Friedlander, Y.; Blumenfeld, A.; Reznik, L.; Dresner-Pollak, R. ESR1 gene polymorphisms are associated with the angiographic extent of coronary artery disease. J. Clin. Endocrinol. Metab. 2005, 90, 6556-6560.
19. Lu, H.; Higashikata, T.; Inazu, A.; Nohara, A.; Yu, W.; Shimizu, M.; Mabuchi, H. Association of estrogen receptor-alpha gene polymorphisms with coronary artery disease in patients with familial hypercholesterolemia. Arterioscler. Thromb. Vasc. Biol. 2002, 1, 817-823.
20. Brautbar, A.; Pompeii, L.A.; Dehghan, A.; Ngwa, J.S.; Nambi, V.; Virani, S.S.; Rivadeneira, F.; Uitterlinden, A.G.; Hofman, A.; Witteman, J.C. et al. A genetic risk score based on direct associations with coronary heart disease improves coronary heart disease risk prediction in the Atherosclerosis Risk in Communities (ARIC), but not in the Rotterdam and Framingham Offspring, Studies. Atherosclerosis 2012, 223, 421-426.
21. Meshkani, R.; Saberi, H.; Mohammad Taghvaei, N.; Tabatabaiefar, M.A. Estrogen receptor alpha gene polymorphisms are associated with type 2 diabetes and fasting glucose in male subjects. Mol. Cell. Biochem. 2012, 359, 225-233.
22. Matsunaga, T.; Gu, N.; Yamazaki, H.; Adachi, T.; Yasuda, K.; Moritani, T.; Tsuda, K.; Nishiyama, T.; Nonaka, M. Association of estrogen receptor-α gene polymorphisms with cardiac autonomic nervous activity in healthy young Japanese males. Clin. Chim. Acta 2010, 411, 505-509.
23. Matsubara, Y.; Murata, M.; Kawano, K.; Zama, T.; Aoki, N.; Yoshino, H.; Watanabe, G.; Ishikawa, K.; Ikeda, Y. Genotype distribution of estrogen receptor polymorphisms in men and postmenopausal women from healthy and coronary populations and its relation to serum lipid levels. Arterioscler. Thromb. Vasc. Biol. 1997, 17, 3006-3012.
24. Molvarec, A.; Nagy, B.; Kovács, M.; Walentin, S.; Imreh, E.; Rigó, J., Jr.; Szalay, J.; Füst, G.; Prohászka, Z.; Karádi, I. Lipid, haemostatic and inflammatory variables in relation to the estrogen receptor alpha (ESR1) PvuII and XbaI gene polymorphisms. Clin. Chim. Acta 2007, 380, 157-164.
25. Klos, K.L.; Boerwinkle, E.; Ferrell, R.E.; Turner, S.T.; Morrison, A.C. ESR1 polymorphism is associated with plasma lipid and apolipoprotein levels in Caucasians of the Rochester Family Heart. J. Lipid Res. 2008, 49, 1701-1706.
26. Herrington, D.M.; Howard, T.D.; Brosnihan, K.B.; McDonnell, D.P.; Li, X.; Hawkins, G.A.; Reboussin, D.M.; Xu, J.; Zheng, S.L.; Meyers, D.A. et al. Common estrogen receptor polymorphism augments effects of hormone replacement therapy on E-selectin but not C-reactive protein. Circulation 2002, 105, 1879-1882.
27. Almeida, S.; Hutz, M.H. Estrogen receptor 1 gene polymorphisms in premenopausal women: Interaction between genotype and smoking on lipid levels. Braz. J. Med. Biol. Res. 2008, 41, 872-876.
28. Gurd, B.J.; Scheid, J.; Paterson, D.H.; Kowalchuk, J.M. O2 uptake and muscle deoxygenation kinetics during the transition to moderate-intensity exercise in different phases of the menstrual cycle in young adult females. Eur. J. Appl. Physiol. 2007, 101, 321-330.
29. Campbell, K.L.; Westerlind, K.C.; Harber, V.J.; Bell, G.J.; Mackey, J.R.; Courneya, K.S. Effects of aerobic exercise training on estrogen metabolism in premenopausal women: A randomized controlled trial. Cancer Epidemiol. Biomarkers Prev. 2007, 16, 731-739.
30. Aubert, A.E.; Beckers, F.; Ramaekers, D. Short-term heart rate variability in young athletes. J. Cardiol. 2001, 37, 85-88.
31. Rebelo, A.C.; Tamburús, N.; Salviati, M.; Celante, V.; Takahashi, A.; de Sá, M.F.; Catai, A.; Silva, E. Influence of third-generation oral contraceptives on the complexity analysis and symbolic dynamics of heart rate variability. Eur. J. Contracept. Reprod. Health Care 2011, 16, 289-297.
32. Wasserman, K.; Hansen, J.E.; Sue, D.Y.; Stringer, W.W.; Whipp, B.J. Measurements during integrative cardiopulmonary exercise testing. In Principles of Exercise Testing and Interpretation; Lippincott Williams & Wilkins: Philadelphia, PA, USA, 2005; pp. 76-110.
33. Silva, E.; Catai, A.M.; Trevelin, L.C.; Guimarães, J.O.; Silva, J.R.; Silva, L.M.P. Design of a computerized system to evaluate the cardiac function during dynamic exercise. Phys. Med. Biol. 1994, 33, P409.
34. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Heart rate variability: standards of measurement, physiological interpretation and clinical use. Circulation 1996, 93, 1043-1065.
35. Salazar, L.A.; Hirata, M.H.; Cavalli, S.A.; Machado, M.O.; Hirata, R.D. Optimized procedure for human blood useful in clinical molecular testing. Clin. Chem. 1998, 44, 1748-1750.
36. Kurt, O.; Yilmaz-Aydogan, H.; Uyar, M.; Isbir, T.; Seyhan, M.F.; Can, A. Evaluation of ERα and VDR gene polymorphisms in relation to bone mineral density in Turkish postmenopausal women. Mol. Biol. Rep. 2012, 39, 6723-6730.