The association of common genetic variants in the APOA5, LPL and GCK genes with longitudinal changes in metabolic and cardiovascular traits

Diabetologia

Volumn 52, Issue 1, 2009, Pages 106-114

  Webster, R J ^a   Warrington, N M ^a   Weedon, M N ^b   Hattersley, A T ^b   McCaskie, P A ^a   Beilby, J P ^a,c   Palmer, L J ^a,d   Frayling, T M ^b  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b UNIVERSITY OF EXETER   (United Kingdom)

^c PATHWEST LABORATORY MEDICINE   (Australia)

^d UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

APOA5; Association; GCK; Longitudinal; LPL; SNP; Type 2 diabetes

Indexed keywords

APOLIPOPROTEIN A5; GLUCOKINASE; GLUCOSE; LIPID; LIPOPROTEIN LIPASE; TRIACYLGLYCEROL;

ADULT; AGED; ALLELE; ARTICLE; CARDIOVASCULAR FUNCTION; CROSS-SECTIONAL STUDY; FEMALE; FOLLOW UP; GENE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GLUCOSE BLOOD LEVEL; HUMAN; LIPID BLOOD LEVEL; MALE; METABOLISM; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; TRIACYLGLYCEROL BLOOD LEVEL;

ADOLESCENT; ADULT; APOLIPOPROTEINS A; AUSTRALIA; BLOOD GLUCOSE; DNA; GENETIC VARIATION; GLUCOKINASE; HEALTH SURVEYS; HUMANS; LIPIDS; LIPOPROTEIN LIPASE; LONGITUDINAL STUDIES; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; TRIGLYCERIDES; YOUNG ADULT;

EID: 57249113728     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-008-1175-9     Document Type: Article

References (34)

1. MN Weedon G Lettre RM Freathy 2007 A common variant of HMGA2 is associated with adult and childhood height in the general population Nat Genet 39 1245 1250
2. TM Frayling NJ Timpson MN Weedon 2007 A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity Science 316 889 894
3. E Zeggini MN Weedon CM Lindgren 2007 Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes Science 316 1336 1341
4. Wellcome Trust Case Control Consortium 2007 Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls Nature 447 661 678
5. CJ Willer S Sanna AU Jackson 2008 Newly identified loci that influence lipid concentrations and risk of coronary artery disease Nat Genet 40 161 169
6. K Endo H Yanagi J Araki C Hirano K Yamakawa-Kobayashi S Tomura 2002 Association found between the promoter region polymorphism in the apolipoprotein A-V gene and the serum triglyceride level in Japanese schoolchildren Hum Genet 111 570 572
7. S Martin V Nicaud SE Humphries PJ Talmud 2003 Contribution of APOA5 gene variants to plasma triglyceride determination and to the response to both fat and glucose tolerance challenges Biochim Biophys Acta 1637 217 225
8. L Dongxia H Qi L Lisong G Jincheng 2008 Association of peroxisome proliferator-activated receptorgamma gene Pro12Ala and C161T polymorphisms with metabolic syndrome Circ J 72 551 557
9. MN Weedon VJ Clark Y Qian 2006 A common haplotype of the glucokinase gene alters fasting glucose and birth weight: association in six studies and population-genetics analyses Am J Hum Genet 79 991 1001
10. D Melzer A Murray AJ Hurst 2006 Effects of the diabetes linked TCF7L2 polymorphism in a representative older population BMC Med 4 34
11. AR Folsom DR Jacobs Jr LE Wagenknecht 1996 Increase in fasting insulin and glucose over seven years with increasing weight and inactivity of young adults. The CARDIA Study. Coronary Artery Risk Development in Young Adults Am J Epidemiol 144 235 246
12. T Wilsgaard E Arnesen 2004 Change in serum lipids and body mass index by age, sex, and smoking status: the Tromso study 1986-1995 Ann Epidemiol 14 265 273
13. K Auro K Kristiansson B Zethelius 2008 USF1 gene variants contribute to metabolic traits in men in a longitudinal 32-year follow-up study Diabetologia 51 464 472
14. CA Derby HA Feldman LL Bausserman DR Parker KM Gans RA Carleton 1998 HDL cholesterol: trends in two southeastern New England communities, 1981-1993 Ann Epidemiol 8 84 91
15. M Vaxillaire J Veslot C Dina 2008 Impact of common type 2 diabetes risk polymorphisms in the DESIR prospective study Diabetes 57 244 254
16. GM Dallinga-Thie A van Tol H Hattori LC van Vark-van der Zee H Jansen EJ Sijbrands 2006 Plasma apolipoprotein A5 and triglycerides in type 2 diabetes Diabetologia 49 1505 1511
17. CQ Lai S Demissie LA Cupples 2004 Influence of the APOA5 locus on plasma triglyceride, lipoprotein subclasses, and CVD risk in the Framingham Heart Study J Lipid Res 45 2096 2105
18. LA Pennacchio M Olivier JA Hubacek 2001 An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing Science 294 169 173
19. PJ Talmud E Hawe S Martin 2002 Relative contribution of variation within the APOC3/A4/A5 gene cluster in determining plasma triglycerides Hum Mol Genet 11 3039 3046
20. SE Gagne MG Larson SN Pimstone 1999 A common truncation variant of lipoprotein lipase (Ser447X) confers protection against coronary heart disease: the Framingham Offspring Study Clin Genet 55 450 454
21. SF Wung MV Kulkarni CR Pullinger MJ Malloy JP Kane BE Aouizerat 2006 The lipoprotein lipase gene in combined hyperlipidemia: evidence of a protective allele depletion Lipids Health Dis 5 19
22. MN Weedon TM Frayling B Shields 2005 Genetic regulation of birth weight and fasting glucose by a common polymorphism in the islet cell promoter of the glucokinase gene Diabetes 54 576 581
23. MW Knuiman KJ Cullen MK Bulsara TA Welborn MS Hobbs 1994 Mortality trends, 1965 to 1989, in Busselton, the site of repeated health surveys and interventions Aust J Public Health 18 129 135
24. MW Knuiman K Jamrozik TA Welborn MK Bulsara ML Divitini DE Whittall 1995 Age and secular trends in risk factors for cardiovascular disease in Busselton Aust J Public Health 19 375 382
25. AL James LJ Palmer E Kicic 2005 Decline in lung function in the Busselton Health Study: the effects of asthma and cigarette smoking Am J Respir Crit Care Med 171 109 114
26. CM Chapman LJ Palmer BM McQuillan 2001 Polymorphisms in the angiotensinogen gene are associated with carotid intimal-medial thickening in females from a community-based population Atherosclerosis 159 209 217
27. JC Levy DR Matthews MP Hermans 1998 Correct homeostasis model assessment (HOMA) evaluation uses the computer program Diabetes Care 21 2191 2192
28. DR Matthews JP Hosker AS Rudenski BA Naylor DF Treacher RC Turner 1985 Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man Diabetologia 28 412 419
29. Diabetes Trials Unit, University of Oxford (2004) HOMA Calculator, Version 2.2.2. Available from http://www.dtu.ox.ac.uk/homa, accessed February 2008
30. R Ihaka R Gentleman 1996 R: A language for data analysis and graphics J Comput Graph Stat 5 299 314
31. GR Abecasis LR Cardon WO Cookson 2000 A general test of association for quantitative traits in nuclear families Am J Hum Genet 66 279 292
32. NM Laird JH Ware 1982 Random-effects models for longitudinal data Biometrics 38 963 974
33. WJ Gauderman 2002 Sample size requirements for association studies of gene-gene interaction Am J Epidemiol 155 478 484
34. LA Pennacchio M Olivier JA Hubacek RM Krauss EM Rubin JC Cohen 2002 Two independent apolipoprotein A5 haplotypes influence human plasma triglyceride levels Hum Mol Genet 11 3031 3038