The critical role of proteolytic relay through cathepsins B and E in the phenotypic change of microglia/macrophage

Journal of Neuroscience

Volumn 35, Issue 36, 2015, Pages 12488-12501

  Ni, Junjun ^a   Wu, Zhou ^a   Peterts, Christoph ^b   Yamamoto, Kenji ^a   Qing, Hong ^c   Nakanishi, Hiroshi ^a,d  

^a KYUSHU UNIVERSITY   (Japan)

^b UNIVERSITY OF FREIBURG   (Germany)

^c BEIJING INSTITUTE OF TECHNOLOGY   (China)

^d JAPAN AGENCY FOR MEDICAL RESEARCH AND DEVELOPMENT   (Japan)

Author keywords

Autophagy; Cathepsin B; Cathepsin E; Hypoxic ischemia; Microglia; Phenotypic change

Indexed keywords

CATHEPSIN B; CATHEPSIN E; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEASOME; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; CA 074 METHYL ESTER; DIPEPTIDE; NEUROPROTECTIVE AGENT; PROTEINASE INHIBITOR; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; CELL VIABILITY; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE MICROSCOPY; HIPPOCAMPUS; HISTOLOGY; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE; MACROPHAGE; MICROGLIA; MOUSE; NONHUMAN; PHENOTYPIC VARIATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL CULTURE; DRUG EFFECTS; GENETICS; HYPOXIC ISCHEMIC ENCEPHALOPATHY; METABOLISM; NERVE CELL; PHENOTYPE;

ANIMALS; CATHEPSIN B; CATHEPSIN E; CELLS, CULTURED; DIPEPTIDES; HIPPOCAMPUS; HYPOXIA-ISCHEMIA, BRAIN; MACROPHAGES; MICE; MICE, INBRED C57BL; MICROGLIA; NEURONS; NEUROPROTECTIVE AGENTS; NF-KAPPA B; PHENOTYPE; PROTEASE INHIBITORS; PROTEOLYSIS; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND;

EID: 84941241689     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1599-15.2015     Document Type: Article

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