-
2
-
-
84878582896
-
The remarkable con-formational plasticity of alpha-synuclein: Blessing or curse?
-
Deleersnijder A, Gerard M, Debyser Z, Baekelandt V. The remarkable con-formational plasticity of alpha-synuclein: blessing or curse? Trends Mol Med 2013; 19:368-377.
-
(2013)
Trends Mol Med
, vol.19
, pp. 368-377
-
-
Deleersnijder, A.1
Gerard, M.2
Debyser, Z.3
Baekelandt, V.4
-
3
-
-
84896267689
-
Evidence of native a-synuclein conformers in the human brain
-
Gould N, Mor DE, Lightfoot R, et al. Evidence of native a-synuclein conformers in the human brain. J Biol Chem 2014; 289:7929-7934.
-
(2014)
J Biol Chem
, vol.289
, pp. 7929-7934
-
-
Gould, N.1
Mor, D.E.2
Lightfoot, R.3
-
4
-
-
84861563520
-
Direct observation of the interconver-sion of normal and toxic forms of a-synuclein
-
Cremades N, Cohen SIA, Deas E, et al. Direct observation of the interconver-sion of normal and toxic forms of a-synuclein. Cell 2012; 149:1048-1059.
-
(2012)
Cell
, vol.149
, pp. 1048-1059
-
-
Cremades, N.1
Sia, C.2
Deas, E.3
-
5
-
-
84925206268
-
Structure based aggregation studies reveal the presence of helix-rich intermediate during a-synuclein aggregation
-
Ghosh D, Singh PK, Sahay S, et al. Structure based aggregation studies reveal the presence of helix-rich intermediate during a-synuclein aggregation. Sci Rep 2015; 5:9228.
-
(2015)
Sci Rep
, vol.5
, pp. 9228
-
-
Ghosh, D.1
Singh, P.K.2
Sahay, S.3
-
6
-
-
84875415994
-
A-Synuclein oligomers and clinical implications for Parkinson disease
-
Kalia LV, Kalia SK, McLean PJ, et al. a-Synuclein oligomers and clinical implications for Parkinson disease. Ann Neurol 2013; 73:155-169.
-
(2013)
Ann Neurol
, vol.73
, pp. 155-169
-
-
Kalia, L.V.1
Kalia, S.K.2
McLean, P.J.3
-
7
-
-
84924410540
-
Extracellular a-synuclein alters synaptic transmission in brain neurons by perforating the neuronal plasma membrane
-
Pacheco CR, Morales CN, Ramírez AE, et al. Extracellular a-synuclein alters synaptic transmission in brain neurons by perforating the neuronal plasma membrane. J Neurochem 2015; 132:731-741.
-
(2015)
J Neurochem
, vol.132
, pp. 731-741
-
-
Pacheco, C.R.1
Morales, C.N.2
Ramírez, A.E.3
-
8
-
-
84922668668
-
Identification of synaptosomal proteins binding to monomeric and oligomeric a-synuclein
-
Betzer C, Movius AJ, Shi M, et al. Identification of synaptosomal proteins binding to monomeric and oligomeric a-synuclein. PLoS One 2015; 10:e0116473.
-
(2015)
PLoS One
, vol.10
, pp. e0116473
-
-
Betzer, C.1
Movius, A.J.2
Shi, M.3
-
9
-
-
84874611934
-
Large a-synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking
-
Choi B-K, Choi M-G, Kim J-Y, et al. Large a-synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking. Proc Natl Acad Sci 2013; 110:4087-4092.
-
(2013)
Proc Natl Acad Sci
, vol.110
, pp. 4087-4092
-
-
Choi, B.-K.1
Choi, M.-G.2
Kim, J.-Y.3
-
10
-
-
84881259462
-
A-Synuclein oligomers impair neuronal microtubule-kinesin interplay
-
Prots I, Veber V, Brey S, et al. a-Synuclein oligomers impair neuronal microtubule-kinesin interplay. J Biol Chem 2013; 288:21742-21754.
-
(2013)
J Biol Chem
, vol.288
, pp. 21742-21754
-
-
Prots, I.1
Veber, V.2
Brey, S.3
-
11
-
-
84899889312
-
Accumulation of oligomer-prone a-synuclein exacerbates synaptic and neuronal degeneration in vivo
-
Rockenstein E, Nuber S, Overk CR, et al. Accumulation of oligomer-prone a-synuclein exacerbates synaptic and neuronal degeneration in vivo. Brain 2014; 137:1496-1513.
-
(2014)
Brain
, vol.137
, pp. 1496-1513
-
-
Rockenstein, E.1
Nuber, S.2
Overk, C.R.3
-
12
-
-
84919424987
-
Alpha-synuclein spreading in Parkinson's disease
-
Recasens A, Dehay B. Alpha-synuclein spreading in Parkinson's disease. Front Neuroanat 2014; 8:159.
-
(2014)
Front Neuroanat
, vol.8
, pp. 159
-
-
Recasens, A.1
Dehay, B.2
-
13
-
-
84862609075
-
Intracerebral inoculation of pathological alpha-synuclein initiates a rapidly progressive neurodegenerative alpha-synu-cleinopathy in mice
-
Luk KC, Kehm VM, Zhang B, et al. Intracerebral inoculation of pathological alpha-synuclein initiates a rapidly progressive neurodegenerative alpha-synu-cleinopathy in mice. J Exp Med 2012; 209:975-986.
-
(2012)
J Exp Med
, vol.209
, pp. 975-986
-
-
Luk, K.C.1
Kehm, V.M.2
Zhang, B.3
-
14
-
-
84869109864
-
Pathological alpha-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice
-
Luk KC, Kehm V, Carroll J, et al. Pathological alpha-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice. Science 2012; 338:949-953.
-
(2012)
Science
, vol.338
, pp. 949-953
-
-
Luk, K.C.1
Kehm, V.2
Carroll, J.3
-
15
-
-
84897977607
-
Lewy body extracts from Parkinson disease brains trigger a-synuclein pathology and neurodegeneration in mice and monkeys
-
Recasens A, Dehay B, Bové J, et al. Lewy body extracts from Parkinson disease brains trigger a-synuclein pathology and neurodegeneration in mice and monkeys. Ann Neurol 2014; 75:351-362.
-
(2014)
Ann Neurol
, vol.75
, pp. 351-362
-
-
Recasens, A.1
Dehay, B.2
Bové, J.3
-
16
-
-
84904636970
-
Intramuscular injection of a-synuclein induces CNS a-synuclein pathology and a rapid-onset motor phenotype in transgenic mice
-
Sacino AN, Brooks M, Thomas MA, et al. Intramuscular injection of a-synuclein induces CNS a-synuclein pathology and a rapid-onset motor phenotype in transgenic mice. Proc Natl Acad Sci 2014; 111:10732-10737.
-
(2014)
Proc Natl Acad Sci
, vol.111
, pp. 10732-10737
-
-
Sacino, A.N.1
Brooks, M.2
Thomas, M.A.3
-
17
-
-
69149089854
-
Inclusion formation and neuronal cell death through neuron-to-neuron transmission of a-synuclein
-
Desplats P, Lee HJ, Bae EJ, et al. Inclusion formation and neuronal cell death through neuron-to-neuron transmission of a-synuclein. Proc Natl Acad Sci 2009; 106:13010-13015.
-
(2009)
Proc Natl Acad Sci
, vol.106
, pp. 13010-13015
-
-
Desplats, P.1
Lee, H.J.2
Bae, E.J.3
-
18
-
-
79551519276
-
A-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells
-
Hansen C, Angot E, Bergström A-L, et al. a-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells. J Clin Invest 2011; 121:715-725.
-
(2011)
J Clin Invest
, vol.121
, pp. 715-725
-
-
Hansen, C.1
Angot, E.2
Bergström, A.-L.3
-
19
-
-
79960285197
-
Transfer of host-derived alpha synuclein to grafted dopaminergic neurons in rat
-
Kordower JH, Dodiya HB, Kordower AM, et al. Transfer of host-derived alpha synuclein to grafted dopaminergic neurons in rat. Neurobiol Dis 2011; 43:552-557.
-
(2011)
Neurobiol Dis
, vol.43
, pp. 552-557
-
-
Kordower, J.H.1
Dodiya, H.B.2
Kordower, A.M.3
-
20
-
-
84885470591
-
Transfer of human a-synuclein from the olfactory bulb to interconnected brain regions in mice
-
Rey NL, Petit GH, Bousset L, et al. Transfer of human a-synuclein from the olfactory bulb to interconnected brain regions in mice. Acta Neuropathol 2013; 126:555-573.
-
(2013)
Acta Neuropathol
, vol.126
, pp. 555-573
-
-
Rey, N.L.1
Petit, G.H.2
Bousset, L.3
-
21
-
-
84874975430
-
The dynamic structure of a-synuclein multimers
-
Gurry T, Ullman O, Fisher CK, et al. The dynamic structure of a-synuclein multimers. J Am Chem Soc 2013; 135:3865-3872.
-
(2013)
J Am Chem Soc
, vol.135
, pp. 3865-3872
-
-
Gurry, T.1
Ullman, O.2
Fisher, C.K.3
-
22
-
-
84924554924
-
Progressive aggregation of alpha-synuclein and selective degeneration of Lewy inclusion-bearing neurons in a mouse model of parkinsonism
-
Osterberg VR, Spinelli KJ, Weston LJ, et al. Progressive aggregation of alpha-synuclein and selective degeneration of Lewy inclusion-bearing neurons in a mouse model of parkinsonism. Cell Rep 2015; 10:1252-1260.
-
(2015)
Cell Rep
, vol.10
, pp. 1252-1260
-
-
Osterberg, V.R.1
Spinelli, K.J.2
Weston, L.J.3
-
23
-
-
84940956493
-
Parkinson's disease
-
[Epub ahead of print]
-
Kalia LV, Lang AE. Parkinson's disease. Lancet 2015; doi: 10.1016/S0140-6736(14)61393-3 [Epub ahead of print]
-
(2015)
Lancet
-
-
Kalia, L.V.1
Lang, A.E.2
-
24
-
-
84879122389
-
The Lewy body in Parkinson's disease and related neurodegenerative disorders
-
Wakabayashi K, Tanji K, Odagiri S, et al. The Lewy body in Parkinson's disease and related neurodegenerative disorders. Mol Neurobiol 2013; 47:495-508.
-
(2013)
Mol Neurobiol
, vol.47
, pp. 495-508
-
-
Wakabayashi, K.1
Tanji, K.2
Odagiri, S.3
-
25
-
-
84911142289
-
Clinical, positron emission tomography, and pathological studies of DNAJC13 p.N855S Parkinsonism
-
Appel-Cresswell S, Rajput AH, Sossi V, et al. Clinical, positron emission tomography, and pathological studies of DNAJC13 p.N855S Parkinsonism. Mov Disord 2014; 29:1684-1687.
-
(2014)
Mov Disord
, vol.29
, pp. 1684-1687
-
-
Appel-Cresswell, S.1
Rajput, A.H.2
Sossi, V.3
-
26
-
-
84923226964
-
CHCHD2 mutations in autosomal dominant late-onset Parkinson's disease: A genome-wide linkage and sequencing study
-
Funayama M, Ohe K, Amo T, et al. CHCHD2 mutations in autosomal dominant late-onset Parkinson's disease: a genome-wide linkage and sequencing study. Lancet Neurol 2015; 14:274-282.
-
(2015)
Lancet Neurol
, vol.14
, pp. 274-282
-
-
Funayama, M.1
Ohe, K.2
Amo, T.3
-
27
-
-
84881610810
-
The Sac1 domain of SYNJ1 identified mutated in a family with early-onset progressive parkinsonism with generalized seizures
-
Krebs CE, Karkheiran S, Powell JC, et al. The Sac1 domain of SYNJ1 identified mutated in a family with early-onset progressive parkinsonism with generalized seizures. Hum Mutat 2013; 34:1200-1207.
-
(2013)
Hum Mutat
, vol.34
, pp. 1200-1207
-
-
Krebs, C.E.1
Karkheiran, S.2
Powell, J.C.3
-
28
-
-
84881612311
-
Mutation in the SYNJ1 gene associated with autosomal recessive, early-onset parkinsonism
-
Quadri M, Fang M, Picillo M, et al. Mutation in the SYNJ1 gene associated with autosomal recessive, early-onset parkinsonism. Hum Mutat 2013; 34:1208-1215.
-
(2013)
Hum Mutat
, vol.34
, pp. 1208-1215
-
-
Quadri, M.1
Fang, M.2
Picillo, M.3
-
29
-
-
84919650942
-
Mutations in RAB39B cause X-linked intellectual disability and early-onset Parkinson disease with a-synuclein pathology
-
Wilson GR, Sim JCH, McLean C, et al. Mutations in RAB39B cause X-linked intellectual disability and early-onset Parkinson disease with a-synuclein pathology. Am J Hum Genet 2014; 95:729-735.
-
(2014)
Am J Hum Genet
, vol.95
, pp. 729-735
-
-
Wilson, G.R.1
Jch, S.2
McLean, C.3
-
30
-
-
84887258206
-
Association between early-onset Parkinson disease and 22q11.2 deletion syndrome: Identification of a novel genetic form of Parkinson disease and its clinical implications
-
Butcher NJ, Kiehl T-R, Hazrati L-N, et al. Association between early-onset Parkinson disease and 22q11.2 deletion syndrome: identification of a novel genetic form of Parkinson disease and its clinical implications. JAMA Neurol 2013; 70:1359-1366.
-
(2013)
JAMA Neurol
, vol.70
, pp. 1359-1366
-
-
Butcher, N.J.1
Kiehl, T.-R.2
Hazrati, L.-N.3
-
31
-
-
84879602725
-
LRRK2 interactions with a-synuclein in Parkinson's disease brains and in cell models
-
Guerreiro PS, Huang Y, Gysbers A, et al. LRRK2 interactions with a-synuclein in Parkinson's disease brains and in cell models. J Mol Med 2013; 91:513-522.
-
(2013)
J Mol Med
, vol.91
, pp. 513-522
-
-
Guerreiro, P.S.1
Huang, Y.2
Gysbers, A.3
-
32
-
-
84905646690
-
Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration
-
Tsika E, Glauser L, Moser R, et al. Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration. Hum Mol Genet 2014; 23:4621-4638.
-
(2014)
Hum Mol Genet
, vol.23
, pp. 4621-4638
-
-
Tsika, E.1
Glauser, L.2
Moser, R.3
-
34
-
-
84878842493
-
Sequence variants in eukaryotic translation initiation factor 4-g (eIF4G1) are associated with Lewy body dementia
-
Fujioka S, Sundal C, Strongosky AJ, et al. Sequence variants in eukaryotic translation initiation factor 4-g (eIF4G1) are associated with Lewy body dementia. Acta Neuropathol 2013; 125:425-438.
-
(2013)
Acta Neuropathol
, vol.125
, pp. 425-438
-
-
Fujioka, S.1
Sundal, C.2
Strongosky, A.J.3
-
35
-
-
85005847592
-
ATP13A2 (PARK9) protein levels are reduced in brain tissue of cases with Lewy bodies
-
Murphy KE, Cottle L, Gysbers AM, et al. ATP13A2 (PARK9) protein levels are reduced in brain tissue of cases with Lewy bodies. Acta Neuropathol Com-mun 2013; 1:11.
-
(2013)
Acta Neuropathol Com-mun
, vol.1
, pp. 11
-
-
Murphy, K.E.1
Cottle, L.2
Gysbers, A.M.3
-
36
-
-
84878636079
-
FBXO7 immunoreactivity in a-synuclein-containing inclusions in Parkinson disease and multiple system atrophy
-
Zhao T, Severijnen L-A, van der Weiden M, et al. FBXO7 immunoreactivity in a-synuclein-containing inclusions in Parkinson disease and multiple system atrophy. J Neuropathol Exp Neurol 2013; 72:482-488.
-
(2013)
J Neuropathol Exp Neurol
, vol.72
, pp. 482-488
-
-
Zhao, T.1
Severijnen, L.-A.2
Van Der Weiden, M.3
-
38
-
-
84862689309
-
The neuropathology of genetic Parkinson's disease
-
Poulopoulos M, Levy OA, Alcalay RN. The neuropathology of genetic Parkinson's disease. Mov Disord 2012; 27:831-842.
-
(2012)
Mov Disord
, vol.27
, pp. 831-842
-
-
Poulopoulos, M.1
Levy, O.A.2
Alcalay, R.N.3
-
39
-
-
84877727171
-
Parkin disease: A clinicopathologic entity?
-
Doherty KM. Parkin disease: a clinicopathologic entity? JAMA Neurol 2013; 70:571-579.
-
(2013)
JAMA Neurol
, vol.70
, pp. 571-579
-
-
Doherty, K.M.1
-
40
-
-
84921033215
-
Clinical correlations with Lewy body pathology in LRRK2-related Parkinson disease
-
Kalia LV, Lang AE, Hazrati L-N, et al. Clinical correlations with Lewy body pathology in LRRK2-related Parkinson disease. JAMA Neurol 2015; 72:100.
-
(2015)
JAMA Neurol
, vol.72
, pp. 100
-
-
Kalia, L.V.1
Lang, A.E.2
Hazrati, L.-N.3
-
41
-
-
77957276285
-
Involvement of the cerebral cortex in Parkinson disease linked with G2019S LRRK2 mutation without cognitive impairment
-
Gomez A, Ferrer I. Involvement of the cerebral cortex in Parkinson disease linked with G2019S LRRK2 mutation without cognitive impairment. Acta Neuropathol 2010; 120:155-167.
-
(2010)
Acta Neuropathol
, vol.120
, pp. 155-167
-
-
Gomez, A.1
Ferrer, I.2
-
42
-
-
84879573207
-
Divergent a-synuclein solubility and aggregation properties in G2019S LRRK2 Parkinson's disease brains with Lewy body pathology compared to idiopathic cases
-
Mamais A, Raja M, Manzoni C, et al. Divergent a-synuclein solubility and aggregation properties in G2019S LRRK2 Parkinson's disease brains with Lewy body pathology compared to idiopathic cases. Neurobiol Dis 2013; 58:183-190.
-
(2013)
Neurobiol Dis
, vol.58
, pp. 183-190
-
-
Mamais, A.1
Raja, M.2
Manzoni, C.3
|