-
1
-
-
39849109338
-
Autophagy fights disease through cellular self-digestion
-
Mizushima N, Levine B, Cuervo AM, Klionsky DJ. Autophagy fights disease through cellular self-digestion. Nature 2008; 451: 1069-1075.
-
(2008)
Nature
, vol.451
, pp. 1069-1075
-
-
Mizushima, N.1
Levine, B.2
Cuervo, A.M.3
Klionsky, D.J.4
-
2
-
-
50249084987
-
Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum
-
Axe EL, Walker SA, Manifava M, Chandra P, Roderick HL, Habermann et al. Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum. J Cell Biol 2008; 182: 685-701.
-
(2008)
J Cell Biol
, vol.182
, pp. 685-701
-
-
Axe, E.L.1
Walker, S.A.2
Manifava, M.3
Chandra, P.4
Roderick, H.L.5
Habermann6
-
3
-
-
77952495224
-
Mitochondria supply membranes for autophagosome biogenesis during starvation
-
Hailey DW, Rambold AS, Satpute-Krishnan P, Mitra K, Sougrat R, Kim PK et al. Mitochondria supply membranes for autophagosome biogenesis during starvation. Cell 2010; 141: 656-667.
-
(2010)
Cell
, vol.141
, pp. 656-667
-
-
Hailey, D.W.1
Rambold, A.S.2
Satpute-Krishnan, P.3
Mitra, K.4
Sougrat, R.5
Kim, P.K.6
-
4
-
-
77955131007
-
Plasma membrane contributes to the formation of pre-autophagosomal structures
-
Ravikumar B, Moreau K, Jahreiss L, Puri C, Rubinsztein DC. Plasma membrane contributes to the formation of pre-autophagosomal structures. Nat Cell Biol 2010; 12: 747-757.
-
(2010)
Nat Cell Biol
, vol.12
, pp. 747-757
-
-
Ravikumar, B.1
Moreau, K.2
Jahreiss, L.3
Puri, C.4
Rubinsztein, D.C.5
-
5
-
-
77956414236
-
The origin of the autophagosomal membrane
-
Tooze SA, Yoshimori T. The origin of the autophagosomal membrane. Nat Cell Biol 2010; 12: 831-835.
-
(2010)
Nat Cell Biol
, vol.12
, pp. 831-835
-
-
Tooze, S.A.1
Yoshimori, T.2
-
6
-
-
34848886914
-
Autophagosome formation: Core machinery and adaptations
-
Xie Z, Klionsky DJ. Autophagosome formation: core machinery and adaptations. Nat Cell Biol 2007; 9: 1102-1109.
-
(2007)
Nat Cell Biol
, vol.9
, pp. 1102-1109
-
-
Xie, Z.1
Klionsky, D.J.2
-
7
-
-
1342321743
-
Two ubiquitin-like conjugation systems essential for autophagy
-
Ohsumi Y, Mizushima N. Two ubiquitin-like conjugation systems essential for autophagy. Semin Cell Dev Biol 2004; 15: 231-236.
-
(2004)
Semin Cell Dev Biol
, vol.15
, pp. 231-236
-
-
Ohsumi, Y.1
Mizushima, N.2
-
8
-
-
0034329418
-
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
-
Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 2000; 19: 5720-5728.
-
(2000)
EMBO J
, vol.19
, pp. 5720-5728
-
-
Kabeya, Y.1
Mizushima, N.2
Ueno, T.3
Yamamoto, A.4
Kirisako, T.5
Noda, T.6
-
9
-
-
84901815187
-
Cargo recognition and trafficking in selective autophagy
-
Stolz A, Ernst A, Dikic I. Cargo recognition and trafficking in selective autophagy. Nat Cell Biol 2014; 16: 495-501.
-
(2014)
Nat Cell Biol
, vol.16
, pp. 495-501
-
-
Stolz, A.1
Ernst, A.2
Dikic, I.3
-
10
-
-
62949091373
-
Autophagy: A lysosomal degradation pathway with a central role in health and disease
-
Eskelinen EL, Saftig P. Autophagy: A lysosomal degradation pathway with a central role in health and disease. Biochim Biophys Acta 2009; 1793: 664-673.
-
(2009)
Biochim Biophys Acta
, vol.1793
, pp. 664-673
-
-
Eskelinen, E.L.1
Saftig, P.2
-
11
-
-
36249025723
-
Autophagy: Process and function
-
Mizushima N. Autophagy: process and function. Genes Dev 2007; 21: 2861-2873.
-
(2007)
Genes Dev
, vol.21
, pp. 2861-2873
-
-
Mizushima, N.1
-
12
-
-
37649005234
-
Autophagy in the pathogenesis of disease
-
Levine B, Kroemer G. Autophagy in the pathogenesis of disease. Cell 2008; 132: 27-42.
-
(2008)
Cell
, vol.132
, pp. 27-42
-
-
Levine, B.1
Kroemer, G.2
-
13
-
-
76149096897
-
Autophagy: An adaptable modifier of tumourigenesis
-
Wilkinson S, Ryan KM. Autophagy: an adaptable modifier of tumourigenesis. Curr Opin Genet Dev 2010; 20: 57-64.
-
(2010)
Curr Opin Genet Dev
, vol.20
, pp. 57-64
-
-
Wilkinson, S.1
Ryan, K.M.2
-
14
-
-
4644273585
-
Uth1p is involved in the autophagic degradation of mitochondria
-
Kissova I, Deffieu M, Manon S, Camougrand N. Uth1p is involved in the autophagic degradation of mitochondria. J Biol Chem 2004; 279: 39068-39074.
-
(2004)
J Biol Chem
, vol.279
, pp. 39068-39074
-
-
Kissova, I.1
Deffieu, M.2
Manon, S.3
Camougrand, N.4
-
15
-
-
16844366524
-
Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging
-
Lemasters JJ. Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging. Rejuvenation Res 2005; 8: 3-5.
-
(2005)
Rejuvenation Res
, vol.8
, pp. 3-5
-
-
Lemasters, J.J.1
-
17
-
-
19944434059
-
Inhibition of macroautophagy triggers apoptosis
-
Boya P, Gonzalez-Polo RA, Casares N, Perfettini JL, Dessen P, Larochette N et al. Inhibition of macroautophagy triggers apoptosis. Mol Cell Biol 2005; 25: 1025-1040.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 1025-1040
-
-
Boya, P.1
Gonzalez-Polo, R.A.2
Casares, N.3
Perfettini, J.L.4
Dessen, P.5
Larochette, N.6
-
18
-
-
11144245626
-
The role of autophagy during the early neonatal starvation period
-
Kuma A, Hatano M, Matsui M, Yamamoto A, Nakaya H, Yoshimori T et al. The role of autophagy during the early neonatal starvation period. Nature 2004; 432: 1032-1036.
-
(2004)
Nature
, vol.432
, pp. 1032-1036
-
-
Kuma, A.1
Hatano, M.2
Matsui, M.3
Yamamoto, A.4
Nakaya, H.5
Yoshimori, T.6
-
19
-
-
0042322394
-
Autophagy in yeast: A TOR-mediated response to nutrient starvation
-
Kamada Y, Sekito T, Ohsumi Y. Autophagy in yeast: a TOR-mediated response to nutrient starvation. Curr Top Microbiol Immunol 2004; 279: 73-84.
-
(2004)
Curr Top Microbiol Immunol
, vol.279
, pp. 73-84
-
-
Kamada, Y.1
Sekito, T.2
Ohsumi, Y.3
-
20
-
-
33745885329
-
DRAM, a p53-induced modulator of autophagy, is critical for apoptosis
-
Crighton D, Wilkinson S, O'Prey J, Syed N, Smith P, Harrison PR et al. DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. Cell 2006; 126: 121-134.
-
(2006)
Cell
, vol.126
, pp. 121-134
-
-
Crighton, D.1
Wilkinson, S.2
O'Prey, J.3
Syed, N.4
Smith, P.5
Harrison, P.R.6
-
21
-
-
33846260837
-
DRAM links autophagy to p53 and programmed cell death
-
Crighton D, Wilkinson S, Ryan KM. DRAM links autophagy to p53 and programmed cell death. Autophagy 2007; 3: 72-74.
-
(2007)
Autophagy
, vol.3
, pp. 72-74
-
-
Crighton, D.1
Wilkinson, S.2
Ryan, K.M.3
-
22
-
-
68049108333
-
Analysis of DRAM-related proteins reveals evolutionarily conserved and divergent roles in the control of autophagy
-
O'Prey J, Skommer J, Wilkinson S, Ryan KM. Analysis of DRAM-related proteins reveals evolutionarily conserved and divergent roles in the control of autophagy. Cell Cycle 2009; 8: 2260-2265.
-
(2009)
Cell Cycle
, vol.8
, pp. 2260-2265
-
-
O'Prey, J.1
Skommer, J.2
Wilkinson, S.3
Ryan, K.M.4
-
23
-
-
0024297354
-
Multiple sequence alignment with hierarchical clustering
-
Corpet F. Multiple sequence alignment with hierarchical clustering. Nucleic Acids Res 1988; 16: 10881-10890.
-
(1988)
Nucleic Acids Res
, vol.16
, pp. 10881-10890
-
-
Corpet, F.1
-
24
-
-
0034689773
-
Role of NF-kappaB in p53-mediated programmed cell death
-
Ryan KM, Ernst MK, Rice NR, Vousden KH. Role of NF-kappaB in p53-mediated programmed cell death. Nature 2000; 404: 892-897.
-
(2000)
Nature
, vol.404
, pp. 892-897
-
-
Ryan, K.M.1
Ernst, M.K.2
Rice, N.R.3
Vousden, K.H.4
-
25
-
-
84856446797
-
DRAM-1 encodes multiple isoforms that regulate autophagy
-
Mah LY, O'Prey J, Baudot AD, Hoekstra A, Ryan KM. DRAM-1 encodes multiple isoforms that regulate autophagy. Autophagy 2012; 8: 18-28.
-
(2012)
Autophagy
, vol.8
, pp. 18-28
-
-
Mah, L.Y.1
O'Prey, J.2
Baudot, A.D.3
Hoekstra, A.4
Ryan, K.M.5
-
26
-
-
84862295360
-
Guidelines for the use and interpretation of assays for monitoring autophagy
-
Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 2012; 8: 445-544.
-
(2012)
Autophagy
, vol.8
, pp. 445-544
-
-
Klionsky, D.J.1
Abdalla, F.C.2
Abeliovich, H.3
Abraham, R.T.4
Acevedo-Arozena, A.5
Adeli, K.6
-
27
-
-
84924423404
-
Using enhanced-mitophagy to measure autophagic flux
-
Baudot AD, Haller M, Mrschtik M, Tait SW, Ryan KM. Using enhanced-mitophagy to measure autophagic flux. Methods 2014; 75: 105-111.
-
(2014)
Methods
, vol.75
, pp. 105-111
-
-
Baudot, A.D.1
Haller, M.2
Mrschtik, M.3
Tait, S.W.4
Ryan, K.M.5
-
28
-
-
0035037802
-
Characterization of XIAP-deficient mice
-
Harlin H, Reffey SB, Duckett CS, Lindsten T, Thompson CB. Characterization of XIAP-deficient mice. Mol Cell Biol 2001; 21: 3604-3608.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 3604-3608
-
-
Harlin, H.1
Reffey, S.B.2
Duckett, C.S.3
Lindsten, T.4
Thompson, C.B.5
-
29
-
-
78751672975
-
Autophagy in immunity and inflammation
-
Levine B, Mizushima N, Virgin HW. Autophagy in immunity and inflammation. Nature 2011; 469: 323-335.
-
(2011)
Nature
, vol.469
, pp. 323-335
-
-
Levine, B.1
Mizushima, N.2
Virgin, H.W.3
-
30
-
-
84877628647
-
Autophagy in human health and disease
-
Choi AM, Ryter SW, Levine B. Autophagy in human health and disease. N Engl J Med 2013; 368: 1845-1846.
-
(2013)
N Engl J Med
, vol.368
, pp. 1845-1846
-
-
Choi, A.M.1
Ryter, S.W.2
Levine, B.3
-
31
-
-
34249056243
-
p73 regulates DRAM-independent autophagy that does not contribute to programmed cell death
-
Crighton D, O'Prey J, Bell HS, Ryan KM. p73 regulates DRAM-independent autophagy that does not contribute to programmed cell death. Cell Death Differ 2007; 14: 1071-1079.
-
(2007)
Cell Death Differ
, vol.14
, pp. 1071-1079
-
-
Crighton, D.1
O'Prey, J.2
Bell, H.S.3
Ryan, K.M.4
-
32
-
-
33845329178
-
Signalling via integrins: Implications for cell survival and anticancer strategies
-
Hehlgans S, Haase M, Cordes N. Signalling via integrins: implications for cell survival and anticancer strategies. Biochim Biophys Acta 2007; 1775: 163-180.
-
(2007)
Biochim Biophys Acta
, vol.1775
, pp. 163-180
-
-
Hehlgans, S.1
Haase, M.2
Cordes, N.3
-
33
-
-
33748651894
-
DNA-binding independent cell death from a minimal proapoptotic region of E2F-1
-
Bell LA, O'Prey J, Ryan KM. DNA-binding independent cell death from a minimal proapoptotic region of E2F-1. Oncogene 2006; 25: 5656-5663.
-
(2006)
Oncogene
, vol.25
, pp. 5656-5663
-
-
Bell, L.A.1
O'Prey, J.2
Ryan, K.M.3
-
34
-
-
3042780178
-
Loss of nuclear factor-kappaB is tumor promoting but does not substitute for loss of p53
-
Ryan KM, O'Prey J, Vousden KH. Loss of nuclear factor-kappaB is tumor promoting but does not substitute for loss of p53. Cancer Res 2004; 64: 4415-4418.
-
(2004)
Cancer Res
, vol.64
, pp. 4415-4418
-
-
Ryan, K.M.1
O'Prey, J.2
Vousden, K.H.3
-
35
-
-
84888438277
-
Widespread mitochondrial depletion via mitophagy does not compromise necroptosis
-
Tait SW, Oberst A, Quarato G, Milasta S, Haller M, Wang R et al. Widespread mitochondrial depletion via mitophagy does not compromise necroptosis. Cell Rep 2013; 5: 878-885.
-
(2013)
Cell Rep
, vol.5
, pp. 878-885
-
-
Tait, S.W.1
Oberst, A.2
Quarato, G.3
Milasta, S.4
Haller, M.5
Wang, R.6
-
36
-
-
84873729095
-
Multiplex genome engineering using CRISPR/Cas systems
-
Cong L, Ran FA, Cox D, Lin S, Barretto R, Habib N et al. Multiplex genome engineering using CRISPR/Cas systems. Science 2013; 339: 819-823.
-
(2013)
Science
, vol.339
, pp. 819-823
-
-
Cong, L.1
Ran, F.A.2
Cox, D.3
Lin, S.4
Barretto, R.5
Habib, N.6
-
37
-
-
84905822307
-
E2F1 drives chemotherapeutic drug resistance via ABCG2
-
Rosenfeldt MT, Bell LA, Long JS, O'Prey J, Nixon C, Roberts F et al. E2F1 drives chemotherapeutic drug resistance via ABCG2. Oncogene 2013; 33: 4164-4172.
-
(2013)
Oncogene
, vol.33
, pp. 4164-4172
-
-
Rosenfeldt, M.T.1
Bell, L.A.2
Long, J.S.3
O'Prey, J.4
Nixon, C.5
Roberts, F.6
-
38
-
-
84887193301
-
Extracellular adenosine sensing-a metabolic cell death priming mechanism downstream of p53
-
Long JS, Crighton D, O'Prey J, Mackay G, Zheng L, Palmer TM et al. Extracellular adenosine sensing-a metabolic cell death priming mechanism downstream of p53. Mol Cell 2013; 50: 394-406.
-
(2013)
Mol Cell
, vol.50
, pp. 394-406
-
-
Long, J.S.1
Crighton, D.2
O'Prey, J.3
Mackay, G.4
Zheng, L.5
Palmer, T.M.6
-
39
-
-
84890432985
-
p53 status determines the role of autophagy in pancreatic tumour development
-
Rosenfeldt MT, O'Prey J, Morton JP, Nixon C, MacKay G, Mrowinska et al. p53 status determines the role of autophagy in pancreatic tumour development. Nature 2013; 504: 296-300.
-
(2013)
Nature
, vol.504
, pp. 296-300
-
-
Rosenfeldt, M.T.1
O'Prey, J.2
Morton, J.P.3
Nixon, C.4
MacKay, G.5
Mrowinska6
|