Oncostatin M promotes mucosal epithelial barrier dysfunction, and its expression is increased in patients with eosinophilic mucosal disease

Journal of Allergy and Clinical Immunology

Volumn 136, Issue 3, 2015, Pages 737-746.e4

  Pothoven, Kathryn L ^a   Norton, James E ^a   Hulse, Kathryn E ^a   Suh, Lydia A ^a   Carter, Roderick G ^a   Rocci, Erin ^b   Harris, Kathleen E ^a   Shintani Smith, Stephanie ^a   Conley, David B ^a   Chandra, Rakesh K ^a   Liu, Mark C ^c   Kato, Atsushi ^a   Gonsalves, Nirmala ^a   Grammer, Leslie C ^a   Peters, Anju T ^a   Kern, Robert C ^a   Bryce, Paul J ^a   Tan, Bruce K ^a   Schleimer, Robert P ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b LOYOLA UNIVERSITY CHICAGO   (United States)

^c JOHNS HOPKINS ASTHMA AND ALLERGY CENTER   (United States)

Author keywords

atopic asthma; chronic rhinosinusitis; eosinophilic esophagitis; epithelial barrier; Oncostatin M; tight junctions; transepithelial electrical resistance

Indexed keywords

ALPHA 2 MACROGLOBULIN; FLUORESCEIN ISOTHIOCYANATE DEXTRAN; MESSENGER RNA; ONCOSTATIN M; TISSUE EXTRACT; DEXTRAN; FLUORESCEIN ISOTHIOCYANATE; OSM PROTEIN, HUMAN;

ADULT; AGED; ALLERGIC ASTHMA; ARTICLE; BRONCHUS MUCOSA; CELL CULTURE; CELL LYSATE; CELL PERMEABILIZATION; CELL STRUCTURE; CELL VIABILITY; CHRONIC RHINOSINUSITIS; CLINICAL ARTICLE; CONTROLLED STUDY; ELECTRIC RESISTANCE; EOSINOPHILIA; EOSINOPHILIC ESOPHAGITIS; EPITHELIUM CELL; ESOPHAGUS BIOPSY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; LUNG LAVAGE; MALE; MUCOSAL DISEASE; MUCOSAL EPITHELIAL BARRIER DYSFUNCTION; NOSE POLYP; NOSE SECRETION; PERMEABILITY BARRIER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROVOCATION TEST; TIGHT JUNCTION; ANALOGS AND DERIVATIVES; ASTHMA; BRONCHOALVEOLAR LAVAGE FLUID; CASE CONTROL STUDY; CHEMISTRY; CHRONIC DISEASE; GENETICS; IMMUNOLOGY; METABOLISM; MIDDLE AGED; NOSE MUCOSA; PATHOLOGY; PERMEABILITY; PRIMARY CELL CULTURE; RHINITIS; SINUSITIS;

ADULT; AGED; ASTHMA; BRONCHOALVEOLAR LAVAGE FLUID; CASE-CONTROL STUDIES; CHRONIC DISEASE; DEXTRANS; EOSINOPHILIC ESOPHAGITIS; EPITHELIAL CELLS; FEMALE; FLUORESCEIN-5-ISOTHIOCYANATE; GENE EXPRESSION; HUMANS; MALE; MIDDLE AGED; NASAL MUCOSA; NASAL POLYPS; ONCOSTATIN M; PERMEABILITY; PRIMARY CELL CULTURE; RHINITIS; RNA, MESSENGER; SINUSITIS; TIGHT JUNCTIONS;

EID: 84941186673     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2015.01.043     Document Type: Article

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