메뉴 건너뛰기




Volumn 75, Issue 13, 2015, Pages 1523-1534

Insulin Degludec/Liraglutide: A Review in Type 2 Diabetes

Author keywords

[No Author keywords available]

Indexed keywords

EXENDIN 4; GLUCAGON LIKE PEPTIDE 1 RECEPTOR AGONIST; HEMOGLOBIN A1C; INSULIN DEGLUDEC; INSULIN DEGLUDEC PLUS LIRAGLUTIDE; INSULIN GLARGINE; LIRAGLUTIDE; ORAL ANTIDIABETIC AGENT; PLACEBO; ANTIDIABETIC AGENT; DRUG COMBINATION; GLYCOSYLATED HEMOGLOBIN; LONG ACTING INSULIN;

EID: 84941180379     PISSN: 00126667     EISSN: 11791950     Source Type: Journal    
DOI: 10.1007/s40265-015-0448-0     Document Type: Review
Times cited : (16)

References (31)
  • 1
    • 84882282813 scopus 로고    scopus 로고
    • Breaking down patient and physician barriers to optimize glycemic control in type 2 diabetes
    • 23953078
    • Ross SA. Breaking down patient and physician barriers to optimize glycemic control in type 2 diabetes. Am J Med. 2013;126(9 Suppl 1):S38-48.
    • (2013) Am J Med , vol.126 , Issue.9 , pp. S38-S48
    • Ross, S.A.1
  • 2
    • 84919344081 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor agonist and basal insulin combination treatment for the management of type 2 diabetes: A systematic review and meta-analysis
    • 1:CAS:528:DC%2BC2MXmtVSrug%3D%3D 25220191
    • Eng C, Kramer CK, Zinman B, et al. Glucagon-like peptide-1 receptor agonist and basal insulin combination treatment for the management of type 2 diabetes: a systematic review and meta-analysis. Lancet. 2014;384(9961):2228-34.
    • (2014) Lancet , vol.384 , Issue.9961 , pp. 2228-2234
    • Eng, C.1    Kramer, C.K.2    Zinman, B.3
  • 3
    • 84921770360 scopus 로고    scopus 로고
    • New developments in insulin therapy for type 2 diabetes
    • 1:CAS:528:DC%2BC2cXhslCisb3L 25282012
    • Sorli C. New developments in insulin therapy for type 2 diabetes. Am J Med. 2014;127(10 Suppl):S39-48.
    • (2014) Am J Med , vol.127 , Issue.10 , pp. S39-S48
    • Sorli, C.1
  • 4
    • 84866268783 scopus 로고    scopus 로고
    • Management of hyperglycemia in type 2 diabetes: A patient-centered approach: Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
    • 3357214 1:CAS:528:DC%2BC38Xps1Kitb4%3D 22517736
    • Inzucchi SE, Bergenstal RM, Buse JB, et al. Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care. 2012;35(6):1364-79.
    • (2012) Diabetes Care , vol.35 , Issue.6 , pp. 1364-1379
    • Inzucchi, S.E.1    Bergenstal, R.M.2    Buse, J.B.3
  • 5
    • 84922102164 scopus 로고    scopus 로고
    • Combining a GLP-1 receptor agonist and basal insulin: Study evidence and practical considerations
    • 1:CAS:528:DC%2BC2cXhvF2htrzJ 25414121
    • Carris NW, Taylor JR, Gums JG. Combining a GLP-1 receptor agonist and basal insulin: study evidence and practical considerations. Drugs. 2014;74(18):2141-52.
    • (2014) Drugs , vol.74 , Issue.18 , pp. 2141-2152
    • Carris, N.W.1    Taylor, J.R.2    Gums, J.G.3
  • 6
    • 84907351456 scopus 로고    scopus 로고
    • Insulin plus incretin: A glucose-lowering strategy for type 2-diabetes
    • 3932426 24567800
    • Ahrén B. Insulin plus incretin: a glucose-lowering strategy for type 2-diabetes. World J Diabetes. 2014;5(1):40-51.
    • (2014) World J Diabetes , vol.5 , Issue.1 , pp. 40-51
    • Ahrén, B.1
  • 7
    • 84896739603 scopus 로고    scopus 로고
    • Insulin plus incretin agent combination therapy in type 2 diabetes: A systematic review
    • 24106875
    • Goldenberg R. Insulin plus incretin agent combination therapy in type 2 diabetes: a systematic review. Curr Med Res Opin. 2013;30(3):431-45.
    • (2013) Curr Med Res Opin , vol.30 , Issue.3 , pp. 431-445
    • Goldenberg, R.1
  • 8
    • 84900821247 scopus 로고    scopus 로고
    • Insulin degludec/liraglutide: Innovation-driven combination for advancement in diabetes therapy
    • 1:CAS:528:DC%2BC2cXot1ynt70%3D 24702171
    • Kumar A. Insulin degludec/liraglutide: innovation-driven combination for advancement in diabetes therapy. Expert Opin Biol Ther. 2014;14(6):869-78.
    • (2014) Expert Opin Biol Ther , vol.14 , Issue.6 , pp. 869-878
    • Kumar, A.1
  • 10
    • 84878297344 scopus 로고    scopus 로고
    • Insulin degludec and insulin degludec/insulin aspart: A review of their use in the management of diabetes mellitus
    • 1:CAS:528:DC%2BC3sXhvVWmurzI 23620200
    • Keating GM. Insulin degludec and insulin degludec/insulin aspart: a review of their use in the management of diabetes mellitus. Drugs. 2013;73(6):575-93.
    • (2013) Drugs , vol.73 , Issue.6 , pp. 575-593
    • Keating, G.M.1
  • 11
    • 84922005009 scopus 로고    scopus 로고
    • Liraglutide: A review of its use in adult patients with type 2 diabetes mellitus
    • 1:CAS:528:DC%2BC2cXhvFSnurrL 25367717
    • Scott LJ. Liraglutide: a review of its use in adult patients with type 2 diabetes mellitus. Drugs. 2014;74(18):2161-74.
    • (2014) Drugs , vol.74 , Issue.18 , pp. 2161-2174
    • Scott, L.J.1
  • 12
    • 84973888343 scopus 로고    scopus 로고
    • Improved postprandial glycaemic control in Type 2 diabetes with a combination of insulin degludec and liraglutide: Results from a meal test [abstract no. P113]
    • Vora J, Linjawi S, Gough SC, et al. Improved postprandial glycaemic control in Type 2 diabetes with a combination of insulin degludec and liraglutide: results from a meal test [abstract no. P113]. Diabet Med. 2014;31(Suppl 1):61.
    • (2014) Diabet Med , vol.31 , pp. 61
    • Vora, J.1    Linjawi, S.2    Gough, S.C.3
  • 13
    • 84922519772 scopus 로고    scopus 로고
    • Efficacy and safety of a fixed-ratio combination of insulin degludec and liraglutide (IDegLira) compared with its components given alone: Results of a phase 3, open-label, randomised, 26-week, treat-to-target trial in insulin-naive patients with type 2 diabetes
    • 1:CAS:528:DC%2BC2MXhtlWhsrk%3D 25190523
    • Gough SC, Bode B, Woo V, et al. Efficacy and safety of a fixed-ratio combination of insulin degludec and liraglutide (IDegLira) compared with its components given alone: results of a phase 3, open-label, randomised, 26-week, treat-to-target trial in insulin-naive patients with type 2 diabetes. Lancet Diabetes Endocrinol. 2014;2(11):885-93.
    • (2014) Lancet Diabetes Endocrinol , vol.2 , Issue.11 , pp. 885-893
    • Gough, S.C.1    Bode, B.2    Woo, V.3
  • 14
    • 84941184397 scopus 로고    scopus 로고
    • Preserved pharmacokinetic exposure and distinct glycemic effects of insulin degludec and liraglutide in IDegLira, a fixed-ratio combination therapy
    • Kapitza C, Bode B, Ingwersen SH, et al. Preserved pharmacokinetic exposure and distinct glycemic effects of insulin degludec and liraglutide in IDegLira, a fixed-ratio combination therapy. J Clin Pharmacol. 2015. doi: 10.1002/jcph.549.
    • (2015) J Clin Pharmacol
    • Kapitza, C.1    Bode, B.2    Ingwersen, S.H.3
  • 17
    • 84910049684 scopus 로고    scopus 로고
    • Contribution of liraglutide in the fixed-ratio combination of insulin degludec and liraglutide (IDegLira)
    • 1:CAS:528:DC%2BC2cXitVWltbfM 25114296
    • Buse JB, Vilsboll T, Thurman J, et al. Contribution of liraglutide in the fixed-ratio combination of insulin degludec and liraglutide (IDegLira). Diabetes Care. 2014;37(11):2926-33.
    • (2014) Diabetes Care , vol.37 , Issue.11 , pp. 2926-2933
    • Buse, J.B.1    Vilsboll, T.2    Thurman, J.3
  • 18
    • 84973893528 scopus 로고    scopus 로고
    • Efficacy and safety of IDegLira (combination of insulin degludec + liraglutide), in insulin-naive patients with T2D uncontrolled on GLP-1 receptor agonist (GLP-1RA) therapy [abstract no. 1002-P plus poster]
    • Linjawi S, Bode B, Chaykin LB, et al. Efficacy and safety of IDegLira (combination of insulin degludec + liraglutide), in insulin-naive patients with T2D uncontrolled on GLP-1 receptor agonist (GLP-1RA) therapy [abstract no. 1002-P plus poster]. In: American Diabetes Association 75th Scientific Sessions. 2015.
    • (2015) American Diabetes Association 75th Scientific Sessions
    • Linjawi, S.1    Bode, B.2    Chaykin, L.B.3
  • 19
    • 84973910414 scopus 로고    scopus 로고
    • IDegLira in insulin-naive patients with type 2 diabetes (T2D) inadequately controlled on sulfonylureas (SU) alone or in combination with metformin: The DUAL IV study [abstract no. 1003-P plus poster]
    • Rodbard HW, Bode B, Harris SB, et al. IDegLira in insulin-naive patients with type 2 diabetes (T2D) inadequately controlled on sulfonylureas (SU) alone or in combination with metformin: the DUAL IV study [abstract no. 1003-P plus poster]. In: American Diabetes Association 75th Scientific Sessions. 2015.
    • (2015) American Diabetes Association 75th Scientific Sessions
    • Rodbard, H.W.1    Bode, B.2    Harris, S.B.3
  • 20
    • 84973889622 scopus 로고    scopus 로고
    • Insulin degludec/liraglutide (IDegLira) is superior to insulin glargine (IG) in A1c reduction, risk of hypoglycemia, and weight change: DUAL v study [abstract no. 166-OR]
    • Buse J, Pérez Manghi FC, García-Hernández PA, et al. Insulin degludec/liraglutide (IDegLira) is superior to insulin glargine (IG) in A1c reduction, risk of hypoglycemia, and weight change: DUAL V study [abstract no. 166-OR]. In: American Diabetes Association 75th Scientific Sessions. 2015.
    • (2015) American Diabetes Association 75th Scientific Sessions
    • Buse J, P.1
  • 21
    • 84942296569 scopus 로고    scopus 로고
    • One-year efficacy and safety of a fixed combination of insulin degludec and liraglutide in patients with type 2 diabetes: Results of a 26-week extension to a 26-week main trial
    • Gough SC, Bode B, Woo VC, et al. One-year efficacy and safety of a fixed combination of insulin degludec and liraglutide in patients with type 2 diabetes: results of a 26-week extension to a 26-week main trial. Diabetes Obes Metab. 2015. doi: 10.1111/dom.12498.
    • (2015) Diabetes Obes Metab
    • Gough, S.C.1    Bode, B.2    Woo, V.C.3
  • 22
    • 84864568658 scopus 로고    scopus 로고
    • US National Institutes of Health Accessed 21 Jul 2015
    • US National Institutes of Health. ClinicalTrials.gov identifier NCT01676116. 2012. http://www.clinicaltrials.gov. Accessed 21 Jul 2015.
    • (2012) ClinicalTrials.gov Identifier NCT01676116
  • 23
    • 84878227722 scopus 로고    scopus 로고
    • US National Institutes of Health Accessed 21 Jul 2015
    • US National Institutes of Health. ClinicalTrials.gov identifier NCT01952145. 2013. http://www.clinicaltrials.gov. Accessed 21 Jul 2015.
    • (2013) ClinicalTrials.gov Identifier NCT01952145
  • 24
    • 84864568658 scopus 로고    scopus 로고
    • US National Institutes of Health Accessed 21 Jul 2015
    • US National Institutes of Health. ClinicalTrials.gov identifier NCT01618162. 2012. http://www.clinicaltrials.gov. Accessed 21 Jul 2015.
    • (2012) ClinicalTrials.gov Identifier NCT01618162
  • 25
    • 84973910341 scopus 로고    scopus 로고
    • Novel combination of insulin degludec and liraglutide (IDegLira) is efficacious across the range of disease progression in type 2 diabetes [abstract no. 835]
    • Rodbard HW, Buse JB, Woo VC, et al. Novel combination of insulin degludec and liraglutide (IDegLira) is efficacious across the range of disease progression in type 2 diabetes [abstract no. 835]. Diabetologia. 2014;57(Suppl 1):S338-9.
    • (2014) Diabetologia , vol.57 , pp. S338-S339
    • Rodbard, H.W.1    Buse, J.B.2    Woo, V.C.3
  • 26
    • 84941192965 scopus 로고    scopus 로고
    • Impact of BMI on HbA1c reduction, hypoglycemia rates, and insulin requirements in response to IDegLira in patients with type 2 diabetes (T2D) [abstract no. 66-OR]
    • Buse JB, Rodbard HW, Woo VC, et al. Impact of BMI on HbA1c reduction, hypoglycemia rates, and insulin requirements in response to IDegLira in patients with type 2 diabetes (T2D) [abstract no. 66-OR]. Diabetes. 2014;63(Suppl 1):A18.
    • (2014) Diabetes , vol.63 , pp. A18
    • Buse, J.B.1    Rodbard, H.W.2    Woo, V.C.3
  • 27
    • 84973889706 scopus 로고    scopus 로고
    • IDegLira, a combination of insulin degludec and liraglutide, enables patients with type 2 diabetes to reach target glycaemic control faster than its individual components alone [abstract no. 836 plus poster]
    • Vilsboll T, Vora J, Jarlov H, et al. IDegLira, a combination of insulin degludec and liraglutide, enables patients with type 2 diabetes to reach target glycaemic control faster than its individual components alone [abstract no. 836 plus poster]. Diabetologia. 2014;57(Suppl 1):S339.
    • (2014) Diabetologia , vol.57 , pp. S339
    • Vilsboll, T.1    Vora, J.2    Jarlov, H.3
  • 28
    • 84966304238 scopus 로고    scopus 로고
    • IDegLira, a combination of insulin degludec and liraglutide, improves both pre- and postprandial plasma glucose in patients with type 2 diabetes [abstract no. 243]
    • King A, Philis-Tsimikas A, Langbakke IH, et al. IDegLira, a combination of insulin degludec and liraglutide, improves both pre- and postprandial plasma glucose in patients with type 2 diabetes [abstract no. 243]. Diabetologia. 2014;57(Suppl 1):S108-9.
    • (2014) Diabetologia , vol.57 , pp. S108-S109
    • King, A.1    Philis-Tsimikas, A.2    Langbakke, I.H.3
  • 30
    • 84973925796 scopus 로고    scopus 로고
    • In insulin-naive patient with T2DM uncontrolled on GLP-1 receptor agonists (GLP-1RA), IDegLira (novel combination of insulin degludec + liraglutide) resulted in improved patient-reported outcomes vs. Unchanged GLP-1RA [abstract no. 1150-P plus poster]
    • Linjawi S, Brod M, Bode B, et al. In insulin-naive patient with T2DM uncontrolled on GLP-1 receptor agonists (GLP-1RA), IDegLira (novel combination of insulin degludec + liraglutide) resulted in improved patient-reported outcomes vs. unchanged GLP-1RA [abstract no. 1150-P plus poster]. In: American Diabetes Association 75th Scientific Sessions. 2015.
    • (2015) American Diabetes Association 75th Scientific Sessions
    • Linjawi, S.1    Brod, M.2    Bode, B.3
  • 31
    • 84973889139 scopus 로고    scopus 로고
    • Incidence of gastrointestinal side effects similar between IDegLira and non-GLP-1RA comparators [abstract no. 1009-P plus poster]
    • Aroda VR, Jaeckel E, Jarlov H, et al. Incidence of gastrointestinal side effects similar between IDegLira and non-GLP-1RA comparators [abstract no. 1009-P plus poster]. In: American Diabetes Association 75th Scientific Sessions. 2015.
    • (2015) American Diabetes Association 75th Scientific Sessions
    • Aroda, V.R.1    Jaeckel, E.2    Jarlov, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.