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Volumn 73, Issue 6, 2013, Pages 575-593

Insulin degludec and insulin degludec/insulin aspart: A review of their use in the management of diabetes mellitus

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN ASPART PLUS INSULIN DEGLUDEC; INSULIN DEGLUDEC; INSULIN GLARGINE; METFORMIN; PIOGLITAZONE; SITAGLIPTIN; SULFONYLUREA DERIVATIVE;

EID: 84878297344     PISSN: 00126667     EISSN: 11791950     Source Type: Journal    
DOI: 10.1007/s40265-013-0051-1     Document Type: Review
Times cited : (35)

References (69)
  • 1
    • 63149103614 scopus 로고    scopus 로고
    • Intensive glycemic control and the prevention of cardiovascular events: Implications of the ACCORD, ADVANCE, and VA Diabetes trials: A position statement of the American Diabetes Association and a scientific statement of the American College of Cardiology Foundation and the American Heart Association
    • 19092168 10.2337/dc08-9026
    • JS Skyler R Bergenstal RO Bonow, et al. 2009 Intensive glycemic control and the prevention of cardiovascular events: implications of the ACCORD, ADVANCE, and VA Diabetes trials: a position statement of the American Diabetes Association and a scientific statement of the American College of Cardiology Foundation and the American Heart Association Diabetes Care 32 1 187 192 19092168 10.2337/dc08-9026
    • (2009) Diabetes Care , vol.32 , Issue.1 , pp. 187-192
    • Skyler, J.S.1    Bergenstal, R.2    Bonow, R.O.3
  • 2
    • 84871995815 scopus 로고    scopus 로고
    • Standard of medical care in diabetes: 2013
    • American Diabetes Association 10.2337/dc13-S011
    • American Diabetes Association 2013 Standard of medical care in diabetes: 2013 Diabetes Care 36 Suppl 1 S11 S66 10.2337/dc13-S011
    • (2013) Diabetes Care , vol.36 , Issue.SUPPL. 1
  • 3
    • 34547908855 scopus 로고    scopus 로고
    • Towards peakless, reproducible and long-acting insulins. An assessment of the basal analogues based on isoglycaemic clamp studies
    • 17645556 10.1111/j.1463-1326.2007.00756.x 1:CAS:528:DC%2BD2sXhtFGgt7rP
    • T Heise TR Pieber 2007 Towards peakless, reproducible and long-acting insulins. An assessment of the basal analogues based on isoglycaemic clamp studies Diabetes Obes Metab 9 5 648 659 17645556 10.1111/j.1463-1326.2007.00756. x 1:CAS:528:DC%2BD2sXhtFGgt7rP
    • (2007) Diabetes Obes Metab , vol.9 , Issue.5 , pp. 648-659
    • Heise, T.1    Pieber, T.R.2
  • 4
    • 77955824820 scopus 로고    scopus 로고
    • How pharmacokinetic and pharmacodynamic principles pave the way for optimal basal insulin therapy in type 2 diabetes
    • 20618882 10.1111/j.1742-1241.2010.02470.x 1:CAS:528:DC%2BC3cXhtFKrtbjE
    • S Arnolds B Kuglin C Kapitza, et al. 2010 How pharmacokinetic and pharmacodynamic principles pave the way for optimal basal insulin therapy in type 2 diabetes Int J Clin Pract 64 10 1415 1424 20618882 10.1111/j.1742-1241. 2010.02470.x 1:CAS:528:DC%2BC3cXhtFKrtbjE
    • (2010) Int J Clin Pract , vol.64 , Issue.10 , pp. 1415-1424
    • Arnolds, S.1    Kuglin, B.2    Kapitza, C.3
  • 5
    • 33845965337 scopus 로고    scopus 로고
    • Intermediate and long-acting insulins: A review of NPH insulin, insulin glargine and insulin detemir
    • 17166343 10.1185/030079906X154178 1:CAS:528:DC%2BD2sXhsVOltLc%3D
    • GE Peterson 2006 Intermediate and long-acting insulins: a review of NPH insulin, insulin glargine and insulin detemir Curr Med Res Opin 22 12 2613 2619 17166343 10.1185/030079906X154178 1:CAS:528:DC%2BD2sXhsVOltLc%3D
    • (2006) Curr Med Res Opin , vol.22 , Issue.12 , pp. 2613-2619
    • Peterson, G.E.1
  • 6
    • 33746538357 scopus 로고    scopus 로고
    • Twice-daily compared with once-daily insulin glargine in people with type 1 diabetes using meal-time insulin aspart
    • 16911626 10.1111/j.1464-5491.2006.01913.x 1:CAS:528:DC%2BD28XpvFOjs7Y%3D
    • SG Ashwell J Gebbie PD Home 2006 Twice-daily compared with once-daily insulin glargine in people with type 1 diabetes using meal-time insulin aspart Diabet Med 23 8 879 886 16911626 10.1111/j.1464-5491.2006.01913.x 1:CAS:528:DC%2BD28XpvFOjs7Y%3D
    • (2006) Diabet Med , vol.23 , Issue.8 , pp. 879-886
    • Ashwell, S.G.1    Gebbie, J.2    Home, P.D.3
  • 9
    • 84878334056 scopus 로고    scopus 로고
    • Insulin degludec is a new-generation ultra-long acting basal insulin with a unique mechanism of protraction based on multi-hexamer formation [abstract no. 39-OR]
    • Orlando, FL; 25-29 June 2010
    • Jonassen IB, Havelund S, Ribel U, et al. Insulin degludec is a new-generation ultra-long acting basal insulin with a unique mechanism of protraction based on multi-hexamer formation [abstract no. 39-OR]. 70th Annual Scientific Sessions of the American Diabetes Association; Orlando, FL; 25-29 June 2010.
    • 70th Annual Scientific Sessions of the American Diabetes Association
    • Jonassen, I.B.1    Havelund, S.2    Ribel, U.3
  • 10
    • 84864349168 scopus 로고    scopus 로고
    • Multi-hexamer formation is the underlying basis for the ultra-long glucose-lowering effect of insulin degludec [abstract no. 1049]
    • P Kurtzhals T Heise HM Strauss, et al. 2011 Multi-hexamer formation is the underlying basis for the ultra-long glucose-lowering effect of insulin degludec [abstract no. 1049] Diabetologia 54 Suppl 1 S426
    • (2011) Diabetologia , vol.54 , Issue.SUPPL. 1 , pp. 426
    • Kurtzhals, P.1    Heise, T.2    Strauss, H.M.3
  • 11
    • 84891557522 scopus 로고    scopus 로고
    • Ultrastructural visualisation of insulin degludec multi-hexamers in the subcutaneous depot in vivo supports a unique mechanism of protraction [abstract no. 980-P]
    • T Seested S Havelund IB Jonassen, et al. 2012 Ultrastructural visualisation of insulin degludec multi-hexamers in the subcutaneous depot in vivo supports a unique mechanism of protraction [abstract no. 980-P] Diabetes 61 Suppl 1 A250
    • (2012) Diabetes , vol.61 , Issue.SUPPL. 1 , pp. 250
    • Seested, T.1    Havelund, S.2    Jonassen, I.B.3
  • 12
    • 79956152438 scopus 로고    scopus 로고
    • Ultra-long acting insulin degludec can be combined with rapid-acting insulin aspart in a soluble co-formulation [abstract no 380]
    • I Jonassen T Hoeg-Jensen S Havelund, et al. 2010 Ultra-long acting insulin degludec can be combined with rapid-acting insulin aspart in a soluble co-formulation [abstract no 380] J Pept Sci 16 Suppl 1 32
    • (2010) J Pept Sci , vol.16 , Issue.SUPPL. 1 , pp. 32
    • Jonassen, I.1    Hoeg-Jensen, T.2    Havelund, S.3
  • 13
    • 82955198015 scopus 로고    scopus 로고
    • Insulin degludec: A new ultra-long, basal insulin designed to maintain full metabolic effect while minimizing mitogenic potential [abstract no. 974]
    • E Nishimura AR Sørensen BF Hansen, et al. 2010 Insulin degludec: a new ultra-long, basal insulin designed to maintain full metabolic effect while minimizing mitogenic potential [abstract no. 974] Diabetologia 53 Suppl 1 S388 S389
    • (2010) Diabetologia , vol.53 , Issue.SUPPL. 1
    • Nishimura, E.1    Sørensen, A.R.2    Hansen, B.F.3
  • 14
    • 84874287345 scopus 로고    scopus 로고
    • Glucose-lowering effect of insulin degludec is independent of subcutaneous injection region [abstract no. 899-P]
    • L Nosek H-V Coester HF Thomsen, et al. 2012 Glucose-lowering effect of insulin degludec is independent of subcutaneous injection region [abstract no. 899-P] Diabetes 61 Suppl 1 A228
    • (2012) Diabetes , vol.61 , Issue.SUPPL. 1 , pp. 228
    • Nosek, L.1    Coester, H.-V.2    Thomsen, H.F.3
  • 15
    • 84874334144 scopus 로고    scopus 로고
    • Ultra-long-acting insulin degludec: Two different formulations (U100 and U200) are bioequivalent and show similar pharmacodynamics [abstract no. 2349-PO]
    • Korsatko S, Deller S, Zahiragic S, et al. Ultra-long-acting insulin degludec: two different formulations (U100 and U200) are bioequivalent and show similar pharmacodynamics [abstract no. 2349-PO]. Diabetes. 2011;60 Suppl:A624.
    • (2011) Diabetes , vol.60 , Issue.SUPPL.
    • Korsatko, S.1    Deller, S.2    Zahiragic, S.3
  • 16
    • 84891555275 scopus 로고    scopus 로고
    • Insulin degludec 200 U/ml is ultra-long-acting and has a flat and stable glucose-lowering effect [abstract no. 912]
    • U Hövelmann T Heise L Nosek, et al. 2012 Insulin degludec 200 U/ml is ultra-long-acting and has a flat and stable glucose-lowering effect [abstract no. 912] Diabetologia 55 Suppl 1 S374 S375
    • (2012) Diabetologia , vol.55 , Issue.SUPPL. 1
    • Hövelmann, U.1    Heise, T.2    Nosek, L.3
  • 17
    • 84865972844 scopus 로고    scopus 로고
    • Ultra-long-acting insulin degludec has a flat and stable glucose-lowering effect in type 2 diabetes
    • 22726241 10.1111/j.1463-1326.2012.01638.x 1:CAS:528:DC%2BC38XhtlSmtL3M
    • T Heise L Nosek SG Bøttcher, et al. 2012 Ultra-long-acting insulin degludec has a flat and stable glucose-lowering effect in type 2 diabetes Diabetes Obes Metab 14 10 944 950 22726241 10.1111/j.1463-1326.2012.01638.x 1:CAS:528:DC%2BC38XhtlSmtL3M
    • (2012) Diabetes Obes Metab , vol.14 , Issue.10 , pp. 944-950
    • Heise, T.1    Nosek, L.2    Bøttcher, S.G.3
  • 18
    • 84863956945 scopus 로고    scopus 로고
    • Insulin degludec, the new generation basal insulin or just another basal insulin?
    • 22879797 10.4137/CMED.S9494 1:CAS:528:DC%2BC38Xmtlyrt7g%3D
    • SN Nasrallah LR Reynolds 2012 Insulin degludec, the new generation basal insulin or just another basal insulin? Clin Med Insights Endocrinol Diabetes 5 31 37 22879797 10.4137/CMED.S9494 1:CAS:528:DC%2BC38Xmtlyrt7g%3D
    • (2012) Clin Med Insights Endocrinol Diabetes , vol.5 , pp. 31-37
    • Nasrallah, S.N.1    Reynolds, L.R.2
  • 19
    • 84872522953 scopus 로고    scopus 로고
    • Ligand-controlled assembly of hexamers, dihexamers, and linear multihexamer structures by the engineered acylated insulin degludec
    • 10.1021/bi3008609 1:CAS:528:DC%2BC38XhvVKmsbrP
    • DB Steensgaard G Schluckebier HM Strauss, et al. 2013 Ligand-controlled assembly of hexamers, dihexamers, and linear multihexamer structures by the engineered acylated insulin degludec Biochemistry (Moscow) 52 2 295 309 10.1021/bi3008609 1:CAS:528:DC%2BC38XhvVKmsbrP
    • (2013) Biochemistry (Moscow) , vol.52 , Issue.2 , pp. 295-309
    • Steensgaard, D.B.1    Schluckebier, G.2    Strauss, H.M.3
  • 20
    • 84864460325 scopus 로고    scopus 로고
    • Design of the novel protraction mechanism of insulin degludec, an ultra-long-acting basal insulin
    • 22485010 10.1007/s11095-012-0739-z 1:CAS:528:DC%2BC38XltF2jsrc%3D
    • I Jonassen S Havelund T Hoeg-Jensen, et al. 2012 Design of the novel protraction mechanism of insulin degludec, an ultra-long-acting basal insulin Pharm Res 29 8 2104 2114 22485010 10.1007/s11095-012-0739-z 1:CAS:528: DC%2BC38XltF2jsrc%3D
    • (2012) Pharm Res , vol.29 , Issue.8 , pp. 2104-2114
    • Jonassen, I.1    Havelund, S.2    Hoeg-Jensen, T.3
  • 21
    • 84871242664 scopus 로고    scopus 로고
    • Can a new ultra-long acting insulin analog improve patient care? Investigating the potential role of insulin degludec
    • 23145524 10.2165/11642240-000000000-00000 1:CAS:528:DC%2BC3sXit1Wru7o%3D
    • JD Robinson JJ Neumiller RK Campbell 2012 Can a new ultra-long acting insulin analog improve patient care? Investigating the potential role of insulin degludec Drugs 72 18 2319 2325 23145524 10.2165/11642240-000000000-00000 1:CAS:528:DC%2BC3sXit1Wru7o%3D
    • (2012) Drugs , vol.72 , Issue.18 , pp. 2319-2325
    • Robinson, J.D.1    Neumiller, J.J.2    Campbell, R.K.3
  • 22
    • 84868133240 scopus 로고    scopus 로고
    • Insulin degludec/insulin aspart administered once daily at any meal, with insulin aspart at other meals versus a standard basal-bolus regimen in patients with type 1 diabetes: A 26-week, phase 3, randomized, open-label, treat-to-target trial
    • 22933438 10.2337/dc11-2503 1:CAS:528:DC%2BC38XhvFShs7nP
    • IB Hirsch B Bode J-P Courreges, et al. 2012 Insulin degludec/insulin aspart administered once daily at any meal, with insulin aspart at other meals versus a standard basal-bolus regimen in patients with type 1 diabetes: a 26-week, phase 3, randomized, open-label, treat-to-target trial Diabetes Care 35 11 2174 2181 22933438 10.2337/dc11-2503 1:CAS:528:DC%2BC38XhvFShs7nP
    • (2012) Diabetes Care , vol.35 , Issue.11 , pp. 2174-2181
    • Hirsch, I.B.1    Bode, B.2    Courreges, J.-P.3
  • 23
    • 84878301508 scopus 로고    scopus 로고
    • European Medicines Agency Accessed 28 Feb 2013
    • European Medicines Agency. Insulin degludec/insulin aspart: CHMP assessment report. 2013. http://www.emea.europa.eu/docs/en-GB/document-library/ EPAR-Public-assessment-report/human/002499/WC500139013.pdf. Accessed 28 Feb 2013.
    • (2013) Insulin Degludec/insulin Aspart: CHMP Assessment Report
  • 24
    • 84864375931 scopus 로고    scopus 로고
    • Insulin degludec: Four times lower pharmacodynamic variability than insulin glargine under steady-state conditions in type 1 diabetes
    • 22594461 10.1111/j.1463-1326.2012.01627.x 1:CAS:528:DC%2BC38XhtFOmsLbL
    • T Heise L Hermanski L Nosek, et al. 2012 Insulin degludec: four times lower pharmacodynamic variability than insulin glargine under steady-state conditions in type 1 diabetes Diabetes Obes Metab 14 9 859 864 22594461 10.1111/j.1463-1326.2012.01627.x 1:CAS:528:DC%2BC38XhtFOmsLbL
    • (2012) Diabetes Obes Metab , vol.14 , Issue.9 , pp. 859-864
    • Heise, T.1    Hermanski, L.2    Nosek, L.3
  • 25
    • 4644360094 scopus 로고    scopus 로고
    • Insulin aspart: A review of its use in the management of type 1 or 2 diabetes mellitus
    • 15329046 10.2165/00003495-200464170-00013 1:CAS:528:DC%2BD2cXoslGltbo%3D
    • NA Reynolds AJ Wagstaff 2004 Insulin aspart: a review of its use in the management of type 1 or 2 diabetes mellitus Drugs 64 17 1957 1974 15329046 10.2165/00003495-200464170-00013 1:CAS:528:DC%2BD2cXoslGltbo%3D
    • (2004) Drugs , vol.64 , Issue.17 , pp. 1957-1974
    • Reynolds, N.A.1    Wagstaff, A.J.2
  • 26
    • 84859883969 scopus 로고    scopus 로고
    • Insulin degludec: Two-fold longer half-life and a more consistent pharmacokinetic profile than insulin glargine [abstract no. 1046]
    • T Heise U Hövelmann L Nosek, et al. 2011 Insulin degludec: two-fold longer half-life and a more consistent pharmacokinetic profile than insulin glargine [abstract no. 1046] Diabetologia 54 Suppl 1 S425
    • (2011) Diabetologia , vol.54 , Issue.SUPPL. 1 , pp. 425
    • Heise, T.1    Hövelmann, U.2    Nosek, L.3
  • 27
    • 84891561384 scopus 로고    scopus 로고
    • Insulin degludec has similar pharmacokinetic properties in subjects with renal impairment and subjects with normal renal function [abstract no. 923]
    • HL Haahr G Arold SG Bottcher, et al. 2012 Insulin degludec has similar pharmacokinetic properties in subjects with renal impairment and subjects with normal renal function [abstract no. 923] Diabetologia 55 Suppl 1 S379
    • (2012) Diabetologia , vol.55 , Issue.SUPPL. 1 , pp. 379
    • Haahr, H.L.1    Arold, G.2    Bottcher, S.G.3
  • 28
    • 84874333145 scopus 로고    scopus 로고
    • Insulin degludec has similar pharmacokinetic properties in subjects with hepatic impairment when compared to subjects with normal hepatic function [abstract no. 1119-P]
    • Arold G, Kupčová V, Thrane M, et al. Insulin degludec has similar pharmacokinetic properties in subjects with hepatic impairment when compared to subjects with normal hepatic function [abstract no. 1119-P]. Diabetes. 2012;61 Suppl:A289.
    • (2012) Diabetes. , vol.61 , Issue.SUPPL.
    • Arold, G.K.1
  • 29
    • 84865855360 scopus 로고    scopus 로고
    • Ultra-long pharmacokinetic properties of insulin degludec in adults with type 1 diabetes is preserved in children and adolescents after single-dose administration [abstract no. 1047]
    • T Danne T Biester S Blaesig, et al. 2011 Ultra-long pharmacokinetic properties of insulin degludec in adults with type 1 diabetes is preserved in children and adolescents after single-dose administration [abstract no. 1047] Diabetologia 54 Suppl 1 S425 S426
    • (2011) Diabetologia , vol.54 , Issue.SUPPL. 1
    • Danne, T.1    Biester, T.2    Blaesig, S.3
  • 30
    • 84891555181 scopus 로고    scopus 로고
    • Ultra-long pharmacokinetic properties of insulin degludec in younger adults are preserved in geriatric subjects with type 1 diabetes [abstract no. 924]
    • S Korsatko S Deller J Mader, et al. 2012 Ultra-long pharmacokinetic properties of insulin degludec in younger adults are preserved in geriatric subjects with type 1 diabetes [abstract no. 924] Diabetologia 55 Suppl 1 S379 S380
    • (2012) Diabetologia , vol.55 , Issue.SUPPL. 1
    • Korsatko, S.1    Deller, S.2    Mader, J.3
  • 31
    • 84891561469 scopus 로고    scopus 로고
    • Insulin degludec provides similar pharmacokinetic and pharmacodynamic responses in Black, White and Hispanic/Latino patients with type 2 diabetes [abstract no. 925]
    • M Hompesch L Morrow E Watkins, et al. 2012 Insulin degludec provides similar pharmacokinetic and pharmacodynamic responses in Black, White and Hispanic/Latino patients with type 2 diabetes [abstract no. 925] Diabetologia 55 Suppl 1 S380
    • (2012) Diabetologia , vol.55 , Issue.SUPPL. 1 , pp. 380
    • Hompesch, M.1    Morrow, L.2    Watkins, E.3
  • 32
    • 84878317215 scopus 로고    scopus 로고
    • European Medicines Agency Accessed 28 Feb 2013
    • European Medicines Agency. Insulin degludec: CHMP assessment report. 2013. http://www.emea.europa.eu/docs/en-GB/document-library/EPAR-Public- assessment-report/human/002498/WC500139010.pdf. Accessed 28 Feb 2013.
    • (2013) Insulin Degludec: CHMP Assessment Report
  • 33
    • 84875410508 scopus 로고    scopus 로고
    • 200 U/mL Insulin Degludec Improves Glycemic Control Similar to Insulin Glargine with A Low Risk of Hypoglycemia in Insulin-naïve People with Type 2 Diabetes [Abstract No. 207]
    • Philadelphia, PA; 23-27 May 2012 Bergenstal R, Bhargava A, Jain R, et al. 200 U/mL insulin degludec improves glycemic control similar to insulin glargine with a low risk of hypoglycemia in insulin-naïve people with type 2 diabetes [abstract no. 207]. American Association of Clinical Endocrinologists 21st Annual Scientific and Clinical Congress; Philadelphia, PA; 23-27 May 2012
    • Bergenstal R, Bhargava A, Jain R, et al. 200 U/mL insulin degludec improves glycemic control similar to insulin glargine with a low risk of hypoglycemia in insulin-naïve people with type 2 diabetes [abstract no. 207]. American Association of Clinical Endocrinologists 21st Annual Scientific and Clinical Congress; Philadelphia, PA; 23-27 May 2012.
    • American Association of Clinical Endocrinologists 21st Annual Scientific and Clinical Congress
    • Bergenstal, R.1    Bhargava, A.2    Jain, R.3
  • 34
    • 79956110739 scopus 로고    scopus 로고
    • Insulin degludec in type 1 diabetes: A randomized controlled trial of a new-generation ultra-long-acting insulin compared with insulin glargine
    • 21270174 10.2337/dc10-1925
    • KI Birkeland PD Home U Wendisch, et al. 2011 Insulin degludec in type 1 diabetes: a randomized controlled trial of a new-generation ultra-long-acting insulin compared with insulin glargine Diabetes Care 34 3 661 665 21270174 10.2337/dc10-1925
    • (2011) Diabetes Care , vol.34 , Issue.3 , pp. 661-665
    • Birkeland, K.I.1    Home, P.D.2    Wendisch, U.3
  • 35
    • 79952488537 scopus 로고    scopus 로고
    • Insulin degludec, an ultra-long-acting basal insulin, once a day or three times a week versus insulin glargine once a day in patients with type 2 diabetes: A 16-week, randomised, open-label, phase 2 trial
    • 21396703 10.1016/S0140-6736(10)62305-7 1:CAS:528:DC%2BC3MXjtFWgsL4%3D
    • B Zinman G Fulcher PV Rao, et al. 2011 Insulin degludec, an ultra-long-acting basal insulin, once a day or three times a week versus insulin glargine once a day in patients with type 2 diabetes: a 16-week, randomised, open-label, phase 2 trial Lancet 377 9769 924 931 21396703 10.1016/S0140- 6736(10)62305-7 1:CAS:528:DC%2BC3MXjtFWgsL4%3D
    • (2011) Lancet , vol.377 , Issue.9769 , pp. 924-931
    • Zinman, B.1    Fulcher, G.2    Rao, P.V.3
  • 36
    • 84859896417 scopus 로고    scopus 로고
    • Insulin degludec, an ultra-longacting basal insulin, versus insulin glargine in basal-bolus treatment with mealtime insulin aspart in type 1 diabetes (BEGIN Basal-Bolus Type 1): A phase 3, randomised, open-label, treat-to-target non-inferiority trial
    • 22521071 10.1016/S0140-6736(12)60204-9 1:CAS:528:DC%2BC38XlvFKlsbY%3D
    • S Heller J Buse M Fisher, et al. 2012 Insulin degludec, an ultra-longacting basal insulin, versus insulin glargine in basal-bolus treatment with mealtime insulin aspart in type 1 diabetes (BEGIN Basal-Bolus Type 1): a phase 3, randomised, open-label, treat-to-target non-inferiority trial Lancet 379 9825 1489 1497 22521071 10.1016/S0140-6736(12)60204-9 1:CAS:528: DC%2BC38XlvFKlsbY%3D
    • (2012) Lancet , vol.379 , Issue.9825 , pp. 1489-1497
    • Heller, S.1    Buse, J.2    Fisher, M.3
  • 37
    • 84874858316 scopus 로고    scopus 로고
    • Efficacy and safety of insulin degludec in a flexible dosing regimen vs insulin glargine in patients with type 1 diabetes (BEGIN: Flex T1): A 26-week randomized, treat-to-target trial with a 26-week extension
    • 23393185 10.1210/jc.2012-3249 1:CAS:528:DC%2BC3sXksFymu7o%3D
    • C Mathieu P Hollander B Miranda-Palma, et al. 2013 Efficacy and safety of insulin degludec in a flexible dosing regimen vs insulin glargine in patients with type 1 diabetes (BEGIN: Flex T1): a 26-week randomized, treat-to-target trial with a 26-week extension J Clin Endocrinol Metab 98 3 1154 1162 23393185 10.1210/jc.2012-3249 1:CAS:528:DC%2BC3sXksFymu7o%3D
    • (2013) J Clin Endocrinol Metab , vol.98 , Issue.3 , pp. 1154-1162
    • Mathieu, C.1    Hollander, P.2    Miranda-Palma, B.3
  • 38
    • 84871938129 scopus 로고    scopus 로고
    • Insulin degludec improves glycemic control in insulin-naïve patients with type 2 diabetes: Results of a randomized pan-Asian trial [abstract no. 1059-P]
    • Y Onishi SW Park SJ Yoo, et al. 2012 Insulin degludec improves glycemic control in insulin-naïve patients with type 2 diabetes: results of a randomized pan-Asian trial [abstract no. 1059-P] Diabetes 61 Suppl 1 A272
    • (2012) Diabetes , vol.61 , Issue.SUPPL. 1 , pp. 272
    • Onishi, Y.1    Park, S.W.2    Yoo, S.J.3
  • 39
    • 84869842163 scopus 로고    scopus 로고
    • Insulin degludec versus insulin glargine in insulin-naive patients with type 2 diabetes: A 1-year, randomized, treat-to-target trial (BEGIN Once Long)
    • 23043166 10.2337/dc12-1205 1:CAS:528:DC%2BC38XhvFShsrvL
    • B Zinman A Philis-Tsimikas B Cariou, et al. 2012 Insulin degludec versus insulin glargine in insulin-naive patients with type 2 diabetes: a 1-year, randomized, treat-to-target trial (BEGIN Once Long) Diabetes Care 35 12 2464 2471 23043166 10.2337/dc12-1205 1:CAS:528:DC%2BC38XhvFShsrvL
    • (2012) Diabetes Care , vol.35 , Issue.12 , pp. 2464-2471
    • Zinman, B.1    Philis-Tsimikas, A.2    Cariou, B.3
  • 40
    • 84859921058 scopus 로고    scopus 로고
    • Insulin degludec, an ultra-longacting basal insulin, versus insulin glargine in basal-bolus treatment with mealtime insulin aspart in type 2 diabetes (BEGIN Basal-Bolus Type 2): A phase 3, randomised, open-label, treat-to-target non-inferiority trial
    • 22521072 10.1016/S0140-6736(12)60205-0 1:CAS:528:DC%2BC38XlvFKhsrc%3D
    • AJ Garber AB King S Del Prato, et al. 2012 Insulin degludec, an ultra-longacting basal insulin, versus insulin glargine in basal-bolus treatment with mealtime insulin aspart in type 2 diabetes (BEGIN Basal-Bolus Type 2): a phase 3, randomised, open-label, treat-to-target non-inferiority trial Lancet 379 9825 1498 1507 22521072 10.1016/S0140-6736(12)60205-0 1:CAS:528: DC%2BC38XlvFKhsrc%3D
    • (2012) Lancet , vol.379 , Issue.9825 , pp. 1498-1507
    • Garber, A.J.1    King, A.B.2    Del Prato, S.3
  • 41
    • 84891557587 scopus 로고    scopus 로고
    • Insulin degludec is superior to sitagliptin in improving glycaemic control in uncontrolled patients with type 2 diabetes on oral agents [abstract no. 40]
    • A Philis-Tsimikas S Del Prato I Satman, et al. 2012 Insulin degludec is superior to sitagliptin in improving glycaemic control in uncontrolled patients with type 2 diabetes on oral agents [abstract no. 40] Diabetologia 55 Suppl 1 S22
    • (2012) Diabetologia , vol.55 , Issue.SUPPL. 1 , pp. 22
    • Philis-Tsimikas, A.1    Del Prato, S.2    Satman, I.3
  • 42
    • 84875444482 scopus 로고    scopus 로고
    • The efficacy and safety of insulin degludec given in variable once-daily dosing intervals compared with insulin glargine and insulin degludec dosed at the same time daily: A 26-week, randomized, open-label, parallel-group, treat-to-target trial in people with type 2 diabetes
    • 23340894 10.2337/dc12-1668
    • L Meneghini SL Atkin SC Gough, et al. 2013 The efficacy and safety of insulin degludec given in variable once-daily dosing intervals compared with insulin glargine and insulin degludec dosed at the same time daily: a 26-week, randomized, open-label, parallel-group, treat-to-target trial in people with type 2 diabetes Diabetes Care 36 4 858 864 23340894 10.2337/dc12-1668
    • (2013) Diabetes Care , vol.36 , Issue.4 , pp. 858-864
    • Meneghini, L.1    Atkin, S.L.2    Gough, S.C.3
  • 43
    • 84891556457 scopus 로고    scopus 로고
    • Insulin degludec reduces hypoglycemia and improves health status vs. insulin glargine in insulin-naïve type 2 diabetes [abstract no. 1192-P]
    • HW Rodbard Y Handelsman B Cariou, et al. 2012 Insulin degludec reduces hypoglycemia and improves health status vs. insulin glargine in insulin-naïve type 2 diabetes [abstract no. 1192-P] Diabetes 61 Suppl 1 A307 A308
    • (2012) Diabetes , vol.61 , Issue.SUPPL. 1
    • Rodbard, H.W.1    Handelsman, Y.2    Cariou, B.3
  • 44
    • 84878309306 scopus 로고    scopus 로고
    • Reduced nocturnal hypoglycaemia with insulin degludec as compared to insulin glargine: Results of a 2-year randomised trial in type 2 diabetes [abstract no. 920]
    • HW Rodbard B Zinman B Cariou, et al. 2012 Reduced nocturnal hypoglycaemia with insulin degludec as compared to insulin glargine: results of a 2-year randomised trial in type 2 diabetes [abstract no. 920] Diabetologia 55 Suppl 1 S378
    • (2012) Diabetologia , vol.55 , Issue.SUPPL. 1 , pp. 378
    • Rodbard, H.W.1    Zinman, B.2    Cariou, B.3
  • 46
    • 84878285542 scopus 로고    scopus 로고
    • [ClinicalTrials.gov identifier NCT01059799]. US National Institutes of Health, ClinicalTrials.gov (online) Accessed 13 Nov 2012
    • Novo Nordisk. Comparison of NN1250 versus insulin glargine in subjects with type 2 diabetes (BEGIN™) [ClinicalTrials.gov identifier NCT01059799]. US National Institutes of Health, ClinicalTrials.gov (online). 2011. http://www.clinicaltrials.gov. Accessed 13 Nov 2012.
    • (2011) Novo Nordisk. Comparison of NN1250 Versus Insulin Glargine in Subjects with Type 2 Diabetes (BEGIN™)
  • 47
    • 84878285542 scopus 로고    scopus 로고
    • [ClinicalTrials.gov identifier NCT01068665]. US National Institutes of Health, ClinicalTrials.gov (online) Accessed 15 Nov 2012
    • Novo Nordisk. Comparison of NN1250 with insulin glargine in subjects with type 2 diabetes (BEGIN™) [ClinicalTrials.gov identifier NCT01068665]. US National Institutes of Health, ClinicalTrials.gov (online). 2011. http://www.clinicaltrials.gov. Accessed 15 Nov 2012.
    • (2011) Novo Nordisk. Comparison of NN1250 with Insulin Glargine in Subjects with Type 2 Diabetes (BEGIN™)
  • 48
    • 84872699790 scopus 로고    scopus 로고
    • ®) compared with insulin glargine in people with type 2 diabetes starting on basal insulin: A meta-analysis of phase 3a trials
    • 23199058 10.1111/dme.12086 1:CAS:528:DC%2BC3sXjt1elurY%3D
    • ®) compared with insulin glargine in people with type 2 diabetes starting on basal insulin: a meta-analysis of phase 3a trials Diabet Med 30 2 226 232 23199058 10.1111/dme.12086 1:CAS:528:DC%2BC3sXjt1elurY%3D
    • (2013) Diabet Med , vol.30 , Issue.2 , pp. 226-232
    • Freemantle, N.1    Meneghini, L.2    Christensen, T.3
  • 49
    • 79956136690 scopus 로고    scopus 로고
    • A new-generation ultra-long-acting basal insulin with a bolus boost compared with insulin glargine in insulin-naïve people with type 2 diabetes: A randomized, controlled trial
    • 21285389 10.2337/dc10-1905 1:CAS:528:DC%2BC3MXjvFOgs70%3D
    • T Heise CJ Tack R Cuddihy, et al. 2011 A new-generation ultra-long-acting basal insulin with a bolus boost compared with insulin glargine in insulin-naïve people with type 2 diabetes: a randomized, controlled trial Diabetes Care 34 3 669 674 21285389 10.2337/dc10-1905 1:CAS:528: DC%2BC3MXjvFOgs70%3D
    • (2011) Diabetes Care , vol.34 , Issue.3 , pp. 669-674
    • Heise, T.1    Tack, C.J.2    Cuddihy, R.3
  • 50
    • 84891556675 scopus 로고    scopus 로고
    • Superior glycaemic control with once-daily IDegAsp vs insulin glargine in Japanese adults with type 2 diabetes mellitus inadequately controlled with OADs: A randomised controlled, phase 3 trial [abstract no. 949]
    • S Nakamura Y Ono R Rabøl, et al. 2012 Superior glycaemic control with once-daily IDegAsp vs insulin glargine in Japanese adults with type 2 diabetes mellitus inadequately controlled with OADs: a randomised controlled, phase 3 trial [abstract no. 949] Diabetologia 55 Suppl 1 S390
    • (2012) Diabetologia , vol.55 , Issue.SUPPL. 1 , pp. 390
    • Nakamura, S.1    Ono, Y.2    Rabøl, R.3
  • 51
    • 84864331693 scopus 로고    scopus 로고
    • Comparison of a soluble co-formulation of insulin degludec/insulin aspart vs biphasic insulin aspart 30 in type 2 diabetes: A randomised trial
    • 22660026 1:CAS:528:DC%2BC38Xht1Cgsb3F
    • L Niskanen LA Leiter E Franek, et al. 2012 Comparison of a soluble co-formulation of insulin degludec/insulin aspart vs biphasic insulin aspart 30 in type 2 diabetes: a randomised trial Eur J Endocrinol 167 2 287 294 22660026 1:CAS:528:DC%2BC38Xht1Cgsb3F
    • (2012) Eur J Endocrinol , vol.167 , Issue.2 , pp. 287-294
    • Niskanen, L.1    Leiter, L.A.2    Franek, E.3
  • 54
    • 84871937855 scopus 로고    scopus 로고
    • Hypoglycaemia risk with insulin degludec compared with insulin glargine in type 2 and type 1 diabetes: Pre-planned meta-analysis of phase 3 trials
    • 23130654 10.1111/dom.12032 1:CAS:528:DC%2BC3sXjs1SqsQ%3D%3D
    • R Ratner SCL Gough C Mathieu, et al. 2013 Hypoglycaemia risk with insulin degludec compared with insulin glargine in type 2 and type 1 diabetes: pre-planned meta-analysis of phase 3 trials Diabetes Obes Metab 15 2 175 184 23130654 10.1111/dom.12032 1:CAS:528:DC%2BC3sXjs1SqsQ%3D%3D
    • (2013) Diabetes Obes Metab , vol.15 , Issue.2 , pp. 175-184
    • Ratner, R.1    Gough, S.C.L.2    Mathieu, C.3
  • 55
    • 0030866140 scopus 로고    scopus 로고
    • Long-term instability of fasting plasma glucose, a novel predictor of cardiovascular mortality in elderly patients with non-insulin-dependent diabetes mellitus: The Verona Diabetes Study
    • 9323057 10.1161/01.CIR.96.6.1750 1:STN:280:DyaK2svmt1ygsg%3D%3D
    • M Muggeo G Verlato E Bonora, et al. 1997 Long-term instability of fasting plasma glucose, a novel predictor of cardiovascular mortality in elderly patients with non-insulin-dependent diabetes mellitus: the Verona Diabetes Study Circulation 96 6 1750 1754 9323057 10.1161/01.CIR.96.6.1750 1:STN:280:DyaK2svmt1ygsg%3D%3D
    • (1997) Circulation , vol.96 , Issue.6 , pp. 1750-1754
    • Muggeo, M.1    Verlato, G.2    Bonora, E.3
  • 56
    • 84878338696 scopus 로고    scopus 로고
    • European Medicine Agency Accessed 15 Mar 2013
    • European Medicine Agency. Lantus (insulin glargine): EU summary of product characteristics. 2012. http://www.emea.europa.eu/docs/en-GB/document- library/EPAR-Product-Information/human/000284/WC500036082.pdf. Accessed 15 Mar 2013.
    • (2012) Lantus (Insulin Glargine): EU Summary of Product Characteristics
  • 57
    • 84859336766 scopus 로고    scopus 로고
    • Efficacy and safety of ultra-long-acting insulin degludec
    • 23148194 10.1177/2042018812437181 1:CAS:528:DC%2BC38XovVymt74%3D
    • A Wakil SL Atkin 2012 Efficacy and safety of ultra-long-acting insulin degludec Ther Adv Endocrinol Metab 3 2 55 59 23148194 10.1177/2042018812437181 1:CAS:528:DC%2BC38XovVymt74%3D
    • (2012) Ther Adv Endocrinol Metab , vol.3 , Issue.2 , pp. 55-59
    • Wakil, A.1    Atkin, S.L.2
  • 58
    • 18144388647 scopus 로고    scopus 로고
    • Defining and reporting hypoglycaemia in diabetes: A report from the American Diabetes Association Workgroup on Hypoglycemia
    • American Diabetes Association Workgroup on Hypoglycemia 10.2337/diacare.28.5.1245
    • American Diabetes Association Workgroup on Hypoglycemia 2005 Defining and reporting hypoglycaemia in diabetes: a report from the American Diabetes Association Workgroup on Hypoglycemia Diabetes Care 28 5 1245 1249 10.2337/diacare.28.5.1245
    • (2005) Diabetes Care , vol.28 , Issue.5 , pp. 1245-1249
  • 59
    • 84877600800 scopus 로고    scopus 로고
    • European Medicine Agency Accessed 4 Apr 2013 European Medicine Agency. Guideline on clinical investigation of medicinal products in the treatment or prevention of diabetes mellitus. 2012. http://www.ema.europa.eu/docs/en-GB/ document-library/Scientific-guideline/2012/06/WC500129256.pdf. Accessed 4 Apr 2013
    • European Medicine Agency. Guideline on clinical investigation of medicinal products in the treatment or prevention of diabetes mellitus. 2012. http://www.ema.europa.eu/docs/en-GB/document-library/Scientific-guideline/2012/ 06/WC500129256.pdf. Accessed 4 Apr 2013.
    • (2012) Guideline on Clinical Investigation of Medicinal Products in the Treatment or Prevention of Diabetes Mellitus
  • 60
    • 84859899450 scopus 로고    scopus 로고
    • Insulin degludec: A new ultra-longacting insulin
    • 22521058 10.1016/S0140-6736(12)60527-3
    • AA Tahrani CJ Bailey AH Barnett 2012 Insulin degludec: a new ultra-longacting insulin Lancet 379 9825 1465 1467 22521058 10.1016/S0140- 6736(12)60527-3
    • (2012) Lancet , vol.379 , Issue.9825 , pp. 1465-1467
    • Tahrani, A.A.1    Bailey, C.J.2    Barnett, A.H.3
  • 61
    • 84869987007 scopus 로고    scopus 로고
    • Insulin detemir: A review of its use in the management of diabetes mellitus
    • 23110609 10.2165/11470200-000000000-00000 1:CAS:528: DC%2BC3sXovVCiuw%3D%3D
    • GM Keating 2012 Insulin detemir: a review of its use in the management of diabetes mellitus Drugs 72 17 2255 2287 23110609 10.2165/11470200-000000000- 00000 1:CAS:528:DC%2BC3sXovVCiuw%3D%3D
    • (2012) Drugs , vol.72 , Issue.17 , pp. 2255-2287
    • Keating, G.M.1
  • 62
    • 84878272027 scopus 로고    scopus 로고
    • ® (media release). 2013. http://www.novonordisk.com/include/asp/exe-news-attachment.asp? sAttachmentGUID=83700060-0ce3-4577-a35a-f3e57801637d. Accessed 7 Mar 2013
    • ® (media release). 2013. http://www.novonordisk.com/include/asp/exe-news-attachment.asp?sAttachmentGUID= 83700060-0ce3-4577-a35a-f3e57801637d. Accessed 7 Mar 2013.
    • (2013) ® (Media Release)
  • 63
    • 84878283622 scopus 로고    scopus 로고
    • Pharmaceuticals and Medical Devices Agency Accessed 5 Apr 2013
    • Pharmaceuticals and Medical Devices Agency. Insulin degludec submission file. 2013. http://www.pmda.go.jp/index.html. Accessed 5 Apr 2013.
    • (2013) Insulin Degludec Submission File
  • 64
    • 84878311921 scopus 로고    scopus 로고
    • ® now ready to be launched in Japan (media release). 2013. http://novonordisk.com/investors/sea/ sea.asp?sNewsTypeGUID=&lMonth=&lYear=&sLanguageCode= &sSearchText=&fb=4350&cat=pr&sShowNewsItemGUID= 33a77fce-8192-47d1-a360-68275268a048&sShowLanguageCode=en-GB. Accessed 4 Apr 2013
    • ® now ready to be launched in Japan (media release). 2013. http://novonordisk.com/investors/sea/sea.asp? sNewsTypeGUID=&lMonth=&lYear=&sLanguageCode=&sSearchText= &fb=4350&cat=pr&sShowNewsItemGUID=33a77fce-8192-47d1-a360- 68275268a048&sShowLanguageCode=en-GB. Accessed 4 Apr 2013.
    • (2013) ® Now Ready to Be Launched in Japan (Media Release)
  • 65
    • 77955517441 scopus 로고    scopus 로고
    • Diabetes and cancer: A consensus report
    • 20587728 10.2337/dc10-0666
    • E Giovannucci DM Harlan MC Archer, et al. 2010 Diabetes and cancer: a consensus report Diabetes Care 33 7 1674 1685 20587728 10.2337/dc10-0666
    • (2010) Diabetes Care , vol.33 , Issue.7 , pp. 1674-1685
    • Giovannucci, E.1    Harlan, D.M.2    Archer, M.C.3
  • 66
    • 70949084349 scopus 로고    scopus 로고
    • No evidence of increased risk of malignancies in patients with diabetes treated with insulin detemir: A meta-analysis
    • 19838665 10.1007/s00125-009-1568-4 1:STN:280:DC%2BC3c%2Fjslemtw%3D%3D
    • A Dejgaard H Lynggaard J Råstam, et al. 2009 No evidence of increased risk of malignancies in patients with diabetes treated with insulin detemir: a meta-analysis Diabetologia 52 12 2507 2512 19838665 10.1007/s00125-009-1568-4 1:STN:280:DC%2BC3c%2Fjslemtw%3D%3D
    • (2009) Diabetologia , vol.52 , Issue.12 , pp. 2507-2512
    • Dejgaard, A.1    Lynggaard, H.2    Råstam, J.3
  • 67
    • 79959405553 scopus 로고    scopus 로고
    • A review of modern insulin analogue pharmacokinetic and pharmacodynamic profiles in type 2 diabetes: Improvements and limitations
    • 21410860 10.1111/j.1463-1326.2011.01395.x 1:CAS:528:DC%2BC3MXhtVWqu7bP
    • M Evans PM Schumm-Draeger J Vora, et al. 2011 A review of modern insulin analogue pharmacokinetic and pharmacodynamic profiles in type 2 diabetes: improvements and limitations Diabetes Obes Metab 13 8 677 684 21410860 10.1111/j.1463-1326.2011.01395.x 1:CAS:528:DC%2BC3MXhtVWqu7bP
    • (2011) Diabetes Obes Metab , vol.13 , Issue.8 , pp. 677-684
    • Evans, M.1    Schumm-Draeger, P.M.2    Vora, J.3
  • 68
    • 84864270406 scopus 로고    scopus 로고
    • Basal insulin and cardiovascular and other outcomes in dysglycemia
    • 22686416 10.1056/NEJMoa1203858 1:CAS:528:DC%2BC38XhtFegsrvN
    • HC Gerstein J Bosch GR Dagenais, et al. 2012 Basal insulin and cardiovascular and other outcomes in dysglycemia N Engl J Med 367 4 319 328 22686416 10.1056/NEJMoa1203858 1:CAS:528:DC%2BC38XhtFegsrvN
    • (2012) N Engl J Med , vol.367 , Issue.4 , pp. 319-328
    • Gerstein, H.C.1    Bosch, J.2    Dagenais, G.R.3
  • 69
    • 84868523718 scopus 로고    scopus 로고
    • Insulin degludec as an ultralong-acting basal insulin once a day: A systematic review
    • 22826637 10.2147/DMSO.S21979 1:CAS:528:DC%2BC38XhtVChsr%2FE
    • F Wang J Surh M Kaur 2012 Insulin degludec as an ultralong-acting basal insulin once a day: a systematic review Diabetes Metab Syndr Obes 5 191 204 22826637 10.2147/DMSO.S21979 1:CAS:528:DC%2BC38XhtVChsr%2FE
    • (2012) Diabetes Metab Syndr Obes , vol.5 , pp. 191-204
    • Wang, F.1    Surh, J.2    Kaur, M.3


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