메뉴 건너뛰기




Volumn 30, Issue 3, 2014, Pages 431-445

Insulin plus incretin agent combination therapy in type 2 diabetes: A systematic review

Author keywords

Dipeptidylpeptidase 4 inhibitor; Glucagon like peptide 1 receptor agonist; Incretin; Insulin; Type 2 diabetes

Indexed keywords

DIPEPTIDYL PEPTIDASE IV INHIBITOR; EXENDIN 4; GLUCAGON LIKE PEPTIDE 1 RECEPTOR AGONIST; INCRETIN; INSULIN; INSULIN DEGLUDEC; INSULIN GLARGINE; LINAGLIPTIN; LIRAGLUTIDE; METFORMIN; PIOGLITAZONE; PLACEBO; SAXAGLIPTIN; SITAGLIPTIN; SULFONYLUREA;

EID: 84896739603     PISSN: 03007995     EISSN: 14734877     Source Type: Journal    
DOI: 10.1185/03007995.2013.852078     Document Type: Review
Times cited : (16)

References (92)
  • 1
    • 0028817815 scopus 로고
    • U.K. prospective diabetes study 16. Overview of 6 years' therapy of type II diabetes: a progressive disease. U.K. Prospective Diabetes Study Group
    • U.K. prospective diabetes study 16. Overview of 6 years' therapy of type II diabetes: a progressive disease. U.K. Prospective Diabetes Study Group. Diabetes 1995;44:1249-58
    • (1995) Diabetes , vol.44 , pp. 1249-1258
  • 2
    • 84881227906 scopus 로고    scopus 로고
    • Clinical practice guidelines
    • Canadian Diabetes Association
    • Canadian Diabetes Association. Clinical Practice Guidelines. Can J Diabetes 2013;37(Suppl 1):S1-212
    • (2013) Can J Diabetes , vol.37 , Issue.SUPPL. 1
  • 3
    • 84855539606 scopus 로고    scopus 로고
    • American association of clinical endocrinologists medical guidelines for clinical practice for developing a diabetes mellitus comprehensive care plan
    • Handelsman Y, Mechanick JI, Blonde L, et al. American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for developing a diabetes mellitus comprehensive care plan. Endocr Pract 2011; 17(Suppl 2):1-53
    • (2011) Endocr Pract , vol.17 , Issue.SUPPL. 2 , pp. 1-53
    • Handelsman, Y.1    Mechanick, J.I.2    Blonde, L.3
  • 4
    • 84866268783 scopus 로고    scopus 로고
    • Management of hyperglycemia in type 2 diabetes: A patient-centered approach: Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
    • Inzucchi SE, Bergenstal RM, Buse JB, et al. Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care 2012;35:1364-79
    • (2012) Diabetes Care , vol.35 , pp. 1364-1379
    • Inzucchi, S.E.1    Bergenstal, R.M.2    Buse, J.B.3
  • 5
    • 77956581914 scopus 로고    scopus 로고
    • Incretin agents in type 2 diabetes
    • Ross SA, Ekoe JM. Incretin agents in type 2 diabetes. Can Fam Physician 2010;56:639-48
    • (2010) Can Fam Physician , vol.56 , pp. 639-648
    • Ross, S.A.1    Ekoe, J.M.2
  • 6
    • 0034511625 scopus 로고    scopus 로고
    • New developments in the biology of the glucagon-like peptides GLP-1 and GLP-2
    • Drucker DJ, Lovshin J, Baggio L, et al. New developments in the biology of the glucagon-like peptides GLP-1 and GLP-2. Ann N Y Acad Sci 2000;921: 226-32
    • (2000) Ann N y Acad Sci , vol.921 , pp. 226-232
    • Drucker, D.J.1    Lovshin, J.2    Baggio, L.3
  • 7
    • 67651173077 scopus 로고    scopus 로고
    • Incretin-based therapies for type 2 diabetes mellitus
    • Lovshin JA, Drucker DJ. Incretin-based therapies for type 2 diabetes mellitus. Nat Rev Endocrinol 2009;5:262-9
    • (2009) Nat Rev Endocrinol , vol.5 , pp. 262-269
    • Lovshin, J.A.1    Drucker, D.J.2
  • 8
    • 84870215481 scopus 로고    scopus 로고
    • Comparison of efficacy between incretinbased therapies for type 2 diabetes mellitus
    • Nisal K, Kela R, Khunti K, Davies MJ. Comparison of efficacy between incretinbased therapies for type 2 diabetes mellitus. BMC Med 2012;10:152
    • (2012) BMC Med , vol.10 , pp. 152
    • Nisal, K.1    Kela, R.2    Khunti, K.3    Davies, M.J.4
  • 9
    • 48949098988 scopus 로고    scopus 로고
    • Safety and efficacy of exenatide in combination with insulin in patients with type 2 diabetes mellitus
    • Sheffield CA, Kane MP, Busch RS, et al. Safety and efficacy of exenatide in combination with insulin in patients with type 2 diabetes mellitus. Endocr Pract 2008;14:285-92
    • (2008) Endocr Pract , vol.14 , pp. 285-292
    • Sheffield, C.A.1    Kane, M.P.2    Busch, R.S.3
  • 10
    • 79959428521 scopus 로고    scopus 로고
    • Safety, efficacy and tolerability of exenatide in combination with insulin in the association of british clinical diabetologists nationwide exenatide audit
    • Thong KY, Jose B, Sukumar N, et al. Safety, efficacy and tolerability of exenatide in combination with insulin in the Association of British Clinical Diabetologists nationwide exenatide audit. Diabetes Obes Metab 2011;13:703-10
    • (2011) Diabetes Obes Metab , vol.13 , pp. 703-710
    • Thong, K.Y.1    Jose, B.2    Sukumar, N.3
  • 11
    • 84888587857 scopus 로고    scopus 로고
    • A retrospective audit of type 2 diabetes patients prescribed liraglutide in real-life clinical practice
    • Mulligan CM, Harper R, Harding J, et al. A retrospective audit of type 2 diabetes patients prescribed liraglutide in real-life clinical practice. Diabetes Ther 2013;4:147-51
    • (2013) Diabetes Ther , vol.4 , pp. 147-151
    • Mulligan, C.M.1    Harper, R.2    Harding, J.3
  • 12
    • 84874288415 scopus 로고    scopus 로고
    • Incretin-based therapy in combination with basal insulin: A promising tactic for the treatment of type 2 diabetes
    • Vora J, Bain SC, Damci T, et al. Incretin-based therapy in combination with basal insulin: a promising tactic for the treatment of type 2 diabetes. Diabetes Metab 2013;39:6-15
    • (2013) Diabetes Metab , vol.39 , pp. 6-15
    • Vora, J.1    Bain, S.C.2    Damci, T.3
  • 13
    • 84871125993 scopus 로고    scopus 로고
    • Combining GLP-1 receptor agonists with insulin: Therapeutic rationales and clinical findings
    • Holst JJ, Vilsboll T. Combining GLP-1 receptor agonists with insulin: therapeutic rationales and clinical findings. Diabetes Obes Metab 2013;15:3-14
    • (2013) Diabetes Obes Metab , vol.15 , pp. 3-14
    • Holst, J.J.1    Vilsboll, T.2
  • 14
    • 67649666737 scopus 로고    scopus 로고
    • Liraglutide once a day versus exenatide twice a day for type 2 diabetes: A 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)
    • Buse JB, Rosenstock J, Sesti G, et al. Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6). Lancet 2009;374:39-47
    • (2009) Lancet , vol.374 , pp. 39-47
    • Buse, J.B.1    Rosenstock, J.2    Sesti, G.3
  • 15
    • 79952755181 scopus 로고    scopus 로고
    • One year of liraglutide treatment offers sustained and more effective glycaemic control and weight reduction compared with sitagliptin, both in combination with metformin, in patients with type 2 diabetes: A randomised, parallel-group, open-label trial
    • Pratley R, Nauck M, Bailey T, et al. One year of liraglutide treatment offers sustained and more effective glycaemic control and weight reduction compared with sitagliptin, both in combination with metformin, in patients with type 2 diabetes: a randomised, parallel-group, open-label trial. Int J Clin Pract 2011;65:397-407
    • (2011) Int J Clin Pract , vol.65 , pp. 397-407
    • Pratley, R.1    Nauck, M.2    Bailey, T.3
  • 16
    • 79952694840 scopus 로고    scopus 로고
    • Cardiovascular safety of exenatide BID: An integrated analysis from controlled clinical trials in participants with type 2 diabetes
    • Ratner R, Han J, Nicewarner D, et al. Cardiovascular safety of exenatide BID: an integrated analysis from controlled clinical trials in participants with type 2 diabetes. Cardiovasc Diabetol 2011;10:22
    • (2011) Cardiovasc Diabetol , vol.10 , pp. 22
    • Ratner, R.1    Han, J.2    Nicewarner, D.3
  • 17
    • 84926261253 scopus 로고    scopus 로고
    • Options for prandial glucose management in type 2 diabetes patients using basal insulin: Addition of a short-acting GLP-1 analogue versus progression to basal-bolus therapy
    • [Epub ahead of print May 27]
    • Hirsch IB, Buse JB, Leahy J, et al. Options for prandial glucose management in type 2 diabetes patients using basal insulin: addition of a short-acting GLP-1 analogue versus progression to basal-bolus therapy. Diabetes Obes Metab. [Epub ahead of print 2013 May 27]
    • (2013) Diabetes Obes Metab.
    • Hirsch, I.B.1    Buse, J.B.2    Leahy, J.3
  • 18
    • 84857531976 scopus 로고    scopus 로고
    • Clinical outcomes using longterm combination therapy with insulin glargine and exenatide in patients with type 2 diabetes mellitus
    • Levin PA, Mersey JH, Zhou S, Bromberger LA. Clinical outcomes using longterm combination therapy with insulin glargine and exenatide in patients with type 2 diabetes mellitus. Endocr Pract 2012;18:17-25
    • (2012) Endocr Pract , vol.18 , pp. 17-25
    • Levin, P.A.1    Mersey, J.H.2    Zhou, S.3    Bromberger, L.A.4
  • 19
    • 84877633796 scopus 로고    scopus 로고
    • Combination therapy with GLP-1 receptor agonists and basal insulin: A systematic review of the literature
    • Balena R, Hensley IE, Miller S, Barnett AH. Combination therapy with GLP-1 receptor agonists and basal insulin: a systematic review of the literature. Diabetes Obes Metab 2013;15:485-502
    • (2013) Diabetes Obes Metab , vol.15 , pp. 485-502
    • Balena, R.1    Hensley, I.E.2    Miller, S.3    Barnett, A.H.4
  • 20
    • 79955556781 scopus 로고    scopus 로고
    • The effect of liraglutide added to U-500 insulin in patients with type 2 diabetes and high insulin requirements
    • Lane W, Weinrib S, Rappaport J. The effect of liraglutide added to U-500 insulin in patients with type 2 diabetes and high insulin requirements. Diabetes Technol Ther 2011;13:592-5
    • (2011) Diabetes Technol Ther , vol.13 , pp. 592-595
    • Lane, W.1    Weinrib, S.2    Rappaport, J.3
  • 21
    • 77955915187 scopus 로고    scopus 로고
    • Exenatide therapy in insulin-treated type 2 diabetes and obesity
    • Nayak UA, Govindan J, Baskar V, et al. Exenatide therapy in insulin-treated type 2 diabetes and obesity. QJM 2010;103:687-94
    • (2010) QJM , vol.103 , pp. 687-694
    • Nayak, U.A.1    Govindan, J.2    Baskar, V.3
  • 22
    • 35148814453 scopus 로고    scopus 로고
    • Exenatide therapy in obese patients with type 2 diabetes mellitus treated with insulin
    • Viswanathan P, Chaudhuri A, Bhatia R, et al. Exenatide therapy in obese patients with type 2 diabetes mellitus treated with insulin. Endocr Pract 2007;13:444-50
    • (2007) Endocr Pract , vol.13 , pp. 444-450
    • Viswanathan, P.1    Chaudhuri, A.2    Bhatia, R.3
  • 23
    • 4344713643 scopus 로고    scopus 로고
    • Effect of intravenous infusion of exenatide (synthetic exendin-4) on glucose-dependent insulin secretion and counterregulation during hypoglycemia
    • Degn KB, Brock B, Juhl CB, et al. Effect of intravenous infusion of exenatide (synthetic exendin-4) on glucose-dependent insulin secretion and counterregulation during hypoglycemia. Diabetes 2004;53:2397-403
    • (2004) Diabetes , vol.53 , pp. 2397-2403
    • Degn, K.B.1    Brock, B.2    Juhl, C.B.3
  • 24
    • 80053390364 scopus 로고    scopus 로고
    • Effects of exenatide twice daily versus sitagliptin on 24-h glucose, glucoregulatory and hormonal measures: A randomized, double-blind, crossover study
    • Berg JK, Shenouda SK, Heilmann CR, et al. Effects of exenatide twice daily versus sitagliptin on 24-h glucose, glucoregulatory and hormonal measures: a randomized, double-blind, crossover study. Diabetes Obes Metab 2011;13:982-9
    • (2011) Diabetes Obes Metab , vol.13 , pp. 982-989
    • Berg, J.K.1    Shenouda, S.K.2    Heilmann, C.R.3
  • 25
    • 83455230039 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibitors and preservation of pancreatic islet-cell function: A critical appraisal of the evidence
    • van Genugten RE, van Raalte DH, Diamant M. Dipeptidyl peptidase-4 inhibitors and preservation of pancreatic islet-cell function: a critical appraisal of the evidence. Diabetes Obes Metab 2012;14:101-11
    • (2012) Diabetes Obes Metab , vol.14 , pp. 101-111
    • Van Genugten, R.E.1    Van Raalte, D.H.2    Diamant, M.3
  • 26
    • 78650430047 scopus 로고    scopus 로고
    • Clinical inertia in patients with T2DM requiring insulin in family practice
    • Harris SB, Kapor J, Lank CN, et al. Clinical inertia in patients with T2DM requiring insulin in family practice. Can Fam Physician 2010;56:e418-24
    • (2010) Can Fam Physician , vol.56
    • Harris, S.B.1    Kapor, J.2    Lank, C.N.3
  • 27
    • 81855194753 scopus 로고    scopus 로고
    • Barriers to effective insulin treatment: The persistence of poor glycemic control in type 2 diabetes
    • Ross SA, Tildesley HD, Ashkenas J. Barriers to effective insulin treatment: the persistence of poor glycemic control in type 2 diabetes. Curr Med Res Opin 2011;27(Suppl 3):13-20
    • (2011) Curr Med Res Opin , vol.27 , Issue.SUPPL. 3 , pp. 13-20
    • Ross, S.A.1    Tildesley, H.D.2    Ashkenas, J.3
  • 28
    • 84876014866 scopus 로고    scopus 로고
    • Type 2 diabetes mellitus management in canada: Is it improving?
    • Leiter LA, Berard L, Bowering CK, et al. Type 2 diabetes mellitus management in Canada: is it improving? Can J Diabetes 2013;37:82-9
    • (2013) Can J Diabetes , vol.37 , pp. 82-89
    • Leiter, L.A.1    Berard, L.2    Bowering, C.K.3
  • 29
    • 84867867691 scopus 로고    scopus 로고
    • Assessing achievement and maintenance of glycemic control by patients initiating basal insulin
    • Wu N, Aagren M, Boulanger L, et al. Assessing achievement and maintenance of glycemic control by patients initiating basal insulin. Curr Med Res Opin 2012;28:1647-56
    • (2012) Curr Med Res Opin , vol.28 , pp. 1647-1656
    • Wu, N.1    Aagren, M.2    Boulanger, L.3
  • 30
    • 84896737874 scopus 로고    scopus 로고
    • Boehringer Ingelheim (Canada) Ltd. August 29
    • Boehringer Ingelheim (Canada) Ltd. Trajenta Product Monograph. August 29, 2013
    • (2013) Trajenta Product Monograph
  • 31
    • 84896716999 scopus 로고    scopus 로고
    • Bristol-Myers Squibb Canada. April 30
    • Bristol-Myers Squibb Canada. Onglyza Product Monograph. April 30, 2013
    • (2013) Onglyza Product Monograph
  • 32
    • 84896711464 scopus 로고    scopus 로고
    • Merck Canada Inc. February 18
    • Merck Canada Inc. Januvia Product Monograph. February 18, 2013
    • (2013) Januvia Product Monograph
  • 33
    • 84896723108 scopus 로고    scopus 로고
    • Boehringer Ingelheim (Canada) Ltd. March 6
    • Boehringer Ingelheim (Canada) Ltd. Jentadueto Product Monograph. March 6, 2013
    • (2013) Jentadueto Product Monograph
  • 34
    • 84896732318 scopus 로고    scopus 로고
    • Merck Canada Inc. February 18
    • Merck Canada Inc. Janumet Product Monograph. February 18, 2013
    • (2013) Janumet Product Monograph
  • 35
    • 84896711566 scopus 로고    scopus 로고
    • Bristol-Myers Squibb Canada. September 20
    • Bristol-Myers Squibb Canada. Komboglyze Product Monograph. September 20, 2012
    • (2012) Komboglyze Product Monograph
  • 36
    • 80051569955 scopus 로고    scopus 로고
    • Response at 3 months to insulin dose decisions made at exenatide initiation in the Association of British Clinical Diabetologists (ABCD) nationwide exenatide audit
    • Thong KY, Jose B, Blann AD, et al. Response at 3 months to insulin dose decisions made at exenatide initiation in the Association of British Clinical Diabetologists (ABCD) nationwide exenatide audit. Diabetes Res Clin Pract 2011;93:e87-91
    • (2011) Diabetes Res Clin Pract , vol.93
    • Thong, K.Y.1    Jose, B.2    Blann, A.D.3
  • 37
    • 78751706714 scopus 로고    scopus 로고
    • Efficacy and safety of insulin detemir once daily in combination with sitagliptin and metformin: The TRANSITION randomized controlled trial
    • Hollander P, Raslova K, Skjoth TV, et al. Efficacy and safety of insulin detemir once daily in combination with sitagliptin and metformin: the TRANSITION randomized controlled trial. Diabetes Obes Metab 2011;13:268-75
    • (2011) Diabetes Obes Metab , vol.13 , pp. 268-275
    • Hollander, P.1    Raslova, K.2    Skjoth, T.V.3
  • 38
    • 84865861808 scopus 로고    scopus 로고
    • Differentiating among incretin therapies: A multiple-target approach to type 2 diabetes
    • Cornell S. Differentiating among incretin therapies: a multiple-target approach to type 2 diabetes. J Clin Pharm Ther 2012;37:510-24
    • (2012) J Clin Pharm Ther , vol.37 , pp. 510-524
    • Cornell, S.1
  • 39
    • 55249092256 scopus 로고    scopus 로고
    • Therapeutic potential of dipeptidyl peptidase-IV inhibitors in patients with diabetes mellitus
    • Moore KB, Saudek CD. Therapeutic potential of dipeptidyl peptidase-IV inhibitors in patients with diabetes mellitus. Am J Ther 2008;15:484-91
    • (2008) Am J Ther , vol.15 , pp. 484-491
    • Moore, K.B.1    Saudek, C.D.2
  • 40
    • 84871158996 scopus 로고    scopus 로고
    • Longer term safety of dipeptidyl peptidase-4 inhibitors in patients with type 2 diabetes mellitus: Systematic review and meta-analysis
    • Epub ahead of print Apr 20
    • Goossen K, Graber S. Longer term safety of dipeptidyl peptidase-4 inhibitors in patients with type 2 diabetes mellitus: systematic review and meta-analysis. Diabetes Obes Metab. [Epub ahead of print 2012 Apr 20]
    • (2012) Diabetes Obes Metab
    • Goossen, K.1    Graber, S.2
  • 41
    • 84859731126 scopus 로고    scopus 로고
    • Effect of saxagliptin as add-on therapy in patients with poorly controlled type 2 diabetes on insulin alone or insulin combined with metformin
    • Barnett AH, Charbonnel B, Donovan M, et al. Effect of saxagliptin as add-on therapy in patients with poorly controlled type 2 diabetes on insulin alone or insulin combined with metformin. Curr Med Res Opin 2012;28:513-23
    • (2012) Curr Med Res Opin , vol.28 , pp. 513-523
    • Barnett, A.H.1    Charbonnel, B.2    Donovan, M.3
  • 42
    • 84864373418 scopus 로고    scopus 로고
    • Comparison between sitagliptin as addon therapy to insulin and insulin dose-increase therapy in uncontrolled Korean type 2 diabetes: CSI study
    • Hong ES, Khang AR, Yoon JW, et al. Comparison between sitagliptin as addon therapy to insulin and insulin dose-increase therapy in uncontrolled Korean type 2 diabetes: CSI study. Diabetes Obes Metab 2012;14:795-802
    • (2012) Diabetes Obes Metab , vol.14 , pp. 795-802
    • Hong, E.S.1    Khang, A.R.2    Yoon, J.W.3
  • 43
    • 73349119110 scopus 로고    scopus 로고
    • Efficacy and safety of sitagliptin when added to insulin therapy in patients with type 2 diabetes
    • Vilsboll T, Rosenstock J, Yki-Jarvinen H, et al. Efficacy and safety of sitagliptin when added to insulin therapy in patients with type 2 diabetes. Diabetes Obes Metab 2010;12:167-77
    • (2010) Diabetes Obes Metab , vol.12 , pp. 167-177
    • Vilsboll, T.1    Rosenstock, J.2    Yki-Jarvinen, H.3
  • 44
    • 84889857731 scopus 로고    scopus 로고
    • Effects of adding linagliptin to basal insulin regimen for inadequately controlled type 2 diabetes
    • Epub ahead of print September 23
    • Yki-Järvinen H, Rosenstock J, Durán-Garcia S, et al. Effects of adding linagliptin to basal insulin regimen for inadequately controlled Type 2 diabetes. Diabetes Care. [Epub ahead of print 2013 September 23]
    • (2013) Diabetes Care
    • Yki-Järvinen, H.1    Rosenstock, J.2    Durán-Garcia, S.3
  • 46
    • 84885130771 scopus 로고    scopus 로고
    • Saxagliptin add-on therapy to insulin with or without metformin for type 2 diabetes mellitus: 52-week safety and efficacy
    • Barnett AH, Charbonnel B, Li J, et al. Saxagliptin add-on therapy to insulin with or without metformin for type 2 diabetes mellitus: 52-week safety and efficacy. Clin Drug Investig 2013;33:707-17
    • (2013) Clin Drug Investig , vol.33 , pp. 707-717
    • Barnett, A.H.1    Charbonnel, B.2    Li, J.3
  • 48
    • 84859443837 scopus 로고    scopus 로고
    • The effects of exenatide bid on metabolic control, medication use and hospitalization in patients with type 2 diabetes mellitus in clinical practice: A systematic review
    • Best JH, Lavillotti K, DeYoung MB, Garrison LP. The effects of exenatide bid on metabolic control, medication use and hospitalization in patients with type 2 diabetes mellitus in clinical practice: a systematic review. Diabetes Obes Metab 2012;14:387-98
    • (2012) Diabetes Obes Metab , vol.14 , pp. 387-398
    • Best, J.H.1    Lavillotti, K.2    Deyoung, M.B.3    Garrison, L.P.4
  • 49
    • 68649099986 scopus 로고    scopus 로고
    • Exenatide added to insulin therapy: A retrospective review of clinical practice over two years in an academic endocrinology outpatient setting
    • Yoon NM, Cavaghan MK, Brunelle RL, Roach P. Exenatide added to insulin therapy: a retrospective review of clinical practice over two years in an academic endocrinology outpatient setting. Clin Ther 2009;31:1511-23
    • (2009) Clin Ther , vol.31 , pp. 1511-1523
    • Yoon, N.M.1    Cavaghan, M.K.2    Brunelle, R.L.3    Roach, P.4
  • 51
    • 79551615182 scopus 로고    scopus 로고
    • Use of twice-daily exenatide in basal insulin-treated patients with type 2 diabetes: A randomized, controlled trial
    • Buse JB, Bergenstal RM, Glass LC, et al. Use of twice-daily exenatide in basal insulin-treated patients with type 2 diabetes: a randomized, controlled trial. Ann Intern Med 2011;154:103-12
    • (2011) Ann Intern Med , vol.154 , pp. 103-112
    • Buse, J.B.1    Bergenstal, R.M.2    Glass, L.C.3
  • 52
    • 37349008890 scopus 로고    scopus 로고
    • Tolerability and efficacy of exenatide and titrated insulin glargine in adult patients with type 2 diabetes previously uncontrolled with metformin or a sulfonylurea: A multinational, randomized, openlabel, two-period, crossover noninferiority trial
    • Barnett AH, Burger J, Johns D, et al. Tolerability and efficacy of exenatide and titrated insulin glargine in adult patients with type 2 diabetes previously uncontrolled with metformin or a sulfonylurea: a multinational, randomized, openlabel, two-period, crossover noninferiority trial. Clin Ther 2007;29:2333-48
    • (2007) Clin Ther , vol.29 , pp. 2333-2348
    • Barnett, A.H.1    Burger, J.2    Johns, D.3
  • 53
    • 84896723420 scopus 로고    scopus 로고
    • Eli Lilly Canada. July 27
    • Eli Lilly Canada. Byetta Product Monograph. July 27, 2012
    • (2012) Byetta Product Monograph
  • 55
    • 84862109466 scopus 로고    scopus 로고
    • Baseline factors associated with glycemic control and weight loss when exenatide twice daily is added to optimized insulin glargine in patients with type 2 diabetes
    • Rosenstock J, Shenouda SK, Bergenstal RM, et al. Baseline factors associated with glycemic control and weight loss when exenatide twice daily is added to optimized insulin glargine in patients with type 2 diabetes. Diabetes Care 2012;35:955-8
    • (2012) Diabetes Care , vol.35 , pp. 955-958
    • Rosenstock, J.1    Shenouda, S.K.2    Bergenstal, R.M.3
  • 56
    • 84868700326 scopus 로고    scopus 로고
    • Efficacy and safety comparison between liraglutide as add-on therapy to insulin and insulin dose-increase in chinese subjects with poorly controlled type 2 diabetes and abdominal obesity
    • Li CJ, Li J, Zhang QM, et al. Efficacy and safety comparison between liraglutide as add-on therapy to insulin and insulin dose-increase in Chinese subjects with poorly controlled type 2 diabetes and abdominal obesity. Cardiovasc Diabetol 2012;11:142
    • (2012) Cardiovasc Diabetol , vol.11 , pp. 142
    • Li, C.J.1    Li, J.2    Zhang, Q.M.3
  • 58
    • 84874160370 scopus 로고    scopus 로고
    • Stepwise intensification of insulin therapy in type 2 diabetes management - exploring the concept of the basal-plus approach in clinical practice
    • Owens DR. Stepwise intensification of insulin therapy in type 2 diabetes management - exploring the concept of the basal-plus approach in clinical practice. Diabet Med 2013;30:276-88
    • (2013) Diabet Med , vol.30 , pp. 276-288
    • Owens, D.R.1
  • 60
    • 77952309372 scopus 로고    scopus 로고
    • Liraglutide versus sitagliptin for patients with type 2 diabetes who did not have adequate glycaemic control with metformin: A 26-week, randomised, parallel-group, open-label trial
    • Pratley RE, Nauck M, Bailey T, et al. Liraglutide versus sitagliptin for patients with type 2 diabetes who did not have adequate glycaemic control with metformin: a 26-week, randomised, parallel-group, open-label trial. Lancet 2010;375:1447-56
    • (2010) Lancet , vol.375 , pp. 1447-1456
    • Pratley, R.E.1    Nauck, M.2    Bailey, T.3
  • 61
    • 77952315531 scopus 로고    scopus 로고
    • Addition of incretin therapy to metformin in type 2 diabetes
    • Scheen AJ, Radermecker RP. Addition of incretin therapy to metformin in type 2 diabetes. Lancet 2010;375:1410-12
    • (2010) Lancet , vol.375 , pp. 1410-1412
    • Scheen, A.J.1    Radermecker, R.P.2
  • 62
    • 77955262909 scopus 로고    scopus 로고
    • Further improvement in postprandial glucose control with addition of exenatide or sitagliptin to combination therapy with insulin glargine and metformin: A proof-of-concept study
    • Arnolds S, Dellweg S, Clair J, et al. Further improvement in postprandial glucose control with addition of exenatide or sitagliptin to combination therapy with insulin glargine and metformin: a proof-of-concept study. Diabetes Care 2010;33:1509-15
    • (2010) Diabetes Care , vol.33 , pp. 1509-1515
    • Arnolds, S.1    Dellweg, S.2    Clair, J.3
  • 64
    • 84862903186 scopus 로고    scopus 로고
    • Sequential intensification of metformin treatment in type 2 diabetes with liraglutide followed by randomized addition of basal insulin prompted by a1c targets
    • DeVries JH, Bain SC, Rodbard HW, et al. Sequential intensification of metformin treatment in type 2 diabetes with liraglutide followed by randomized addition of basal insulin prompted by A1C targets. Diabetes Care 2012;35:1446-54
    • (2012) Diabetes Care , vol.35 , pp. 1446-1454
    • Devries, J.H.1    Bain, S.C.2    Rodbard, H.W.3
  • 65
    • 84883778164 scopus 로고    scopus 로고
    • One-year sustained glycemic control and weight reduction in type 2 diabetes after addition of liraglutide to metformin followed by insulin detemir according to hba target
    • Rosenstock J, Rodbard HW, Bain SC, et al. One-year sustained glycemic control and weight reduction in type 2 diabetes after addition of liraglutide to metformin followed by insulin detemir according to HbA target. J Diabetes Complications 2013;27:492-500
    • (2013) J Diabetes Complications , vol.27 , pp. 492-500
    • Rosenstock, J.1    Rodbard, H.W.2    Bain, S.C.3
  • 66
    • 77953103244 scopus 로고    scopus 로고
    • Exenatide is non-inferior to insulin in reducing hba1c: An integrated analysis of 1423 patients with type 2 diabetes
    • Blevins T, Han J, Nicewarner D, et al. Exenatide is non-inferior to insulin in reducing HbA1c: an integrated analysis of 1423 patients with type 2 diabetes. Postgrad Med 2010;122:118-28
    • (2010) Postgrad Med , vol.122 , pp. 118-128
    • Blevins, T.1    Han, J.2    Nicewarner, D.3
  • 67
    • 69949117621 scopus 로고    scopus 로고
    • Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met+SU): A randomised controlled trial
    • Russell-Jones D, Vaag A, Schmitz O, et al. Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met+SU): a randomised controlled trial. Diabetologia 2009;52:2046-55
    • (2009) Diabetologia , vol.52 , pp. 2046-2055
    • Russell-Jones, D.1    Vaag, A.2    Schmitz, O.3
  • 68
    • 70350534273 scopus 로고    scopus 로고
    • Three-year efficacy of complex insulin regimens in type 2 diabetes
    • Holman RR, Farmer AJ, Davies MJ, et al. Three-year efficacy of complex insulin regimens in type 2 diabetes. N Engl J Med 2009;361:1736-47
    • (2009) N Engl J Med , vol.361 , pp. 1736-1747
    • Holman, R.R.1    Farmer, A.J.2    Davies, M.J.3
  • 69
    • 73349087520 scopus 로고    scopus 로고
    • Barriers to insulin initiation and intensification and how to overcome them
    • Kunt T, Snoek FJ. Barriers to insulin initiation and intensification and how to overcome them. Int J Clin Pract Suppl 2009;164:6-10
    • (2009) Int J Clin Pract Suppl , vol.164 , pp. 6-10
    • Kunt, T.1    Snoek, F.J.2
  • 70
    • 78649694786 scopus 로고    scopus 로고
    • Co-administration of liraglutide with insulin detemir demonstrates additive pharmacodynamic effects with no pharmacokinetic interaction
    • Morrow L, Hompesch M, Guthrie H, et al. Co-administration of liraglutide with insulin detemir demonstrates additive pharmacodynamic effects with no pharmacokinetic interaction. Diabetes Obes Metab 2011;13:75-80
    • (2011) Diabetes Obes Metab , vol.13 , pp. 75-80
    • Morrow, L.1    Hompesch, M.2    Guthrie, H.3
  • 71
    • 79959259385 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor agonists and cardiovascular events: A meta-analysis of randomized clinical trials
    • Monami M, Cremasco F, Lamanna C, et al. Glucagon-like peptide-1 receptor agonists and cardiovascular events: a meta-analysis of randomized clinical trials. Exp Diabetes Res 2011;2011:215764
    • (2011) Exp Diabetes Res , vol.2011 , pp. 215764
    • Monami, M.1    Cremasco, F.2    Lamanna, C.3
  • 72
    • 84891895360 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide-1 receptor agonists on cardiovascular risk: A metanalysis of randomised clinical trials
    • Epub ahead of print Jul 6
    • Monami M, Dicembrini I, Nardini C, et al. Effects of glucagon-like peptide-1 receptor agonists on cardiovascular risk: a metanalysis of randomised clinical trials. Diabetes Obes Metab. [Epub ahead of print 2013 Jul 6]
    • (2013) Diabetes Obes Metab
    • Monami, M.1    Dicembrini, I.2    Nardini, C.3
  • 73
    • 84883765959 scopus 로고    scopus 로고
    • Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus
    • Scirica BM, Bhatt DL, Braunwald E, et al. Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus. N Engl J Med 2013;369:1317-26
    • (2013) N Engl J Med , vol.369 , pp. 1317-1326
    • Scirica, B.M.1    Bhatt, D.L.2    Braunwald, E.3
  • 74
    • 84876063836 scopus 로고    scopus 로고
    • Glucagonlike peptide 1-based therapies and risk of hospitalization for acute pancreatitis in type 2 diabetes mellitus: A population-based matched case-control study
    • Singh S, Chang HY, Richards TM, et al. Glucagonlike peptide 1-based therapies and risk of hospitalization for acute pancreatitis in type 2 diabetes mellitus: a population-based matched case-control study. JAMA Intern Med 2013;173:534-9
    • (2013) JAMA Intern Med , vol.173 , pp. 534-539
    • Singh, S.1    Chang, H.Y.2    Richards, T.M.3
  • 75
    • 84878352363 scopus 로고    scopus 로고
    • Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors
    • Butler AE, Campbell-Thompson M, Gurlo T, et al. Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors. Diabetes 2013;62:2595-604
    • (2013) Diabetes , vol.62 , pp. 2595-2604
    • Butler, A.E.1    Campbell-Thompson, M.2    Gurlo, T.3
  • 76
    • 79959559653 scopus 로고    scopus 로고
    • Pancreatitis, pancreatic, and thyroid cancer with glucagon-like peptide-1-based therapies
    • Elashoff M, Matveyenko AV, Gier B, et al. Pancreatitis, pancreatic, and thyroid cancer with glucagon-like peptide-1-based therapies. Gastroenterology 2011;141:150-6
    • (2011) Gastroenterology , vol.141 , pp. 150-156
    • Elashoff, M.1    Matveyenko, A.V.2    Gier, B.3
  • 77
    • 84880091008 scopus 로고    scopus 로고
    • Incretin therapy and islet pathology - A time for caution
    • Kahn SE. Incretin therapy and islet pathology - a time for caution. Diabetes 2013;62:2178-80
    • (2013) Diabetes , vol.62 , pp. 2178-2180
    • Kahn, S.E.1
  • 78
    • 84867053241 scopus 로고    scopus 로고
    • Exenatide therapy and the risk of pancreatitis and pancreatic cancer in a privately insured population
    • Romley JA, Goldman DP, Solomon M, et al. Exenatide therapy and the risk of pancreatitis and pancreatic cancer in a privately insured population. Diabetes Technol Ther 2012;14:904-11
    • (2012) Diabetes Technol Ther , vol.14 , pp. 904-911
    • Romley, J.A.1    Goldman, D.P.2    Solomon, M.3
  • 79
    • 47049084841 scopus 로고    scopus 로고
    • Sustained efficacy and reduced hypoglycemia during one year of treatment with vildagliptin added to insulin in patients with type 2 diabetes mellitus
    • Fonseca V, Baron M, Shao Q, Dejager S. Sustained efficacy and reduced hypoglycemia during one year of treatment with vildagliptin added to insulin in patients with type 2 diabetes mellitus. Horm Metab Res 2008;40:427-30
    • (2008) Horm Metab Res , vol.40 , pp. 427-430
    • Fonseca, V.1    Baron, M.2    Shao, Q.3    Dejager, S.4
  • 80
    • 34247874561 scopus 로고    scopus 로고
    • Addition of vildagliptin to insulin improves glycaemic control in type 2 diabetes
    • Fonseca V, Schweizer A, Albrecht D, et al. Addition of vildagliptin to insulin improves glycaemic control in type 2 diabetes. Diabetologia 2007;50:1148-55
    • (2007) Diabetologia , vol.50 , pp. 1148-1155
    • Fonseca, V.1    Schweizer, A.2    Albrecht, D.3
  • 81
    • 84873873967 scopus 로고    scopus 로고
    • Improved glycaemic control with vildagliptin added to insulin, with or without metformin, in patients with type 2 diabetes mellitus
    • Kothny W, Foley J, Kozlovski P, et al. Improved glycaemic control with vildagliptin added to insulin, with or without metformin, in patients with type 2 diabetes mellitus. Diabetes Obes Metab 2013;15:252-7
    • (2013) Diabetes Obes Metab , vol.15 , pp. 252-257
    • Kothny, W.1    Foley, J.2    Kozlovski, P.3
  • 82
    • 84873848407 scopus 로고    scopus 로고
    • Efficacy of vildagliptin in combination with insulin in patients with type 2 diabetes and severe renal impairment
    • Lukashevich V, Schweizer A, Foley JE, et al. Efficacy of vildagliptin in combination with insulin in patients with type 2 diabetes and severe renal impairment. Vasc Health Risk Manag 2013;9:21-8
    • (2013) Vasc Health Risk Manag , vol.9 , pp. 21-28
    • Lukashevich, V.1    Schweizer, A.2    Foley, J.E.3
  • 83
    • 70450173642 scopus 로고    scopus 로고
    • Alogliptin added to insulin therapy in patients with type 2 diabetes reduces hba(1c) without causing weight gain or increased hypoglycaemia
    • Rosenstock J, Rendell MS, Gross JL, et al. Alogliptin added to insulin therapy in patients with type 2 diabetes reduces HbA(1C) without causing weight gain or increased hypoglycaemia. Diabetes Obes Metab 2009;11:1145-52
    • (2009) Diabetes Obes Metab , vol.11 , pp. 1145-1152
    • Rosenstock, J.1    Rendell, M.S.2    Gross, J.L.3
  • 84
    • 84878592117 scopus 로고    scopus 로고
    • Adding once-daily lixisenatide for type 2 diabetes inadequately controlled by established basal insulin: A 24-week, randomized, placebo-controlled comparison (GetGoal-L)
    • Riddle MC, Aronson R, Home P, et al. Adding once-daily lixisenatide for type 2 diabetes inadequately controlled by established basal insulin: a 24-week, randomized, placebo-controlled comparison (GetGoal-L). Diabetes Care 2013;36:2489-96
    • (2013) Diabetes Care , vol.36 , pp. 2489-2496
    • Riddle, M.C.1    Aronson, R.2    Home, P.3
  • 85
    • 84878603672 scopus 로고    scopus 로고
    • Adding once-daily lixisenatide for type 2 diabetes inadequately controlled with newly initiated and continuously titrated basal insulin glargine: A 24-week, randomized, placebo-controlled study (GetGoal-duo 1)
    • Riddle MC, Forst T, Aronson R, et al. Adding once-daily lixisenatide for type 2 diabetes inadequately controlled with newly initiated and continuously titrated basal insulin glargine: a 24-week, randomized, placebo-controlled study (GetGoal-Duo 1). Diabetes Care 2013;36:2497-503
    • (2013) Diabetes Care , vol.36 , pp. 2497-2503
    • Riddle, M.C.1    Forst, T.2    Aronson, R.3
  • 86
    • 84865979163 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled trial of the once-daily GLP-1 receptor agonist lixisenatide in Asian patients with type 2 diabetes insufficiently controlled on basal insulin with or without a sulfonylurea (GetGoal-L-Asia)
    • Seino Y, Min KW, Niemoeller E, Takami A. Randomized, double-blind, placebo-controlled trial of the once-daily GLP-1 receptor agonist lixisenatide in Asian patients with type 2 diabetes insufficiently controlled on basal insulin with or without a sulfonylurea (GetGoal-L-Asia). Diabetes Obes Metab 2012;14:910-17
    • (2012) Diabetes Obes Metab , vol.14 , pp. 910-917
    • Seino, Y.1    Min, K.W.2    Niemoeller, E.3    Takami, A.4
  • 90
    • 84896698675 scopus 로고    scopus 로고
    • Novo Nordisk Canada Inc. August 23
    • Novo Nordisk Canada Inc. Victoza Product Monograph. August 23, 2013
    • (2013) Victoza Product Monograph
  • 91
    • 84896718543 scopus 로고    scopus 로고
    • Novo Nordisk Canada Inc. August 23
    • Novo Nordisk Canada Inc. Levemir Product Monograph. August 23, 2013
    • (2013) Levemir Product Monograph
  • 92
    • 84896733451 scopus 로고    scopus 로고
    • Safety and efficacy of linagliptin and basal insulin combination therapy in elderly patients (age >= 70 years) with type 2 diabetes (T2D)
    • Woerle HJ, Neubacher D, Patel S, Von Eynatten M. Safety and efficacy of linagliptin and basal insulin combination therapy in elderly patients (age >= 70 years) with type 2 diabetes (T2D). J Amer Soc Geriatrics 2013;61(Suppl 1):S31-2
    • (2013) J Amer Soc Geriatrics , vol.61 , Issue.SUPPL. 1
    • Woerle, H.J.1    Neubacher, D.2    Patel, S.3    Von Eynatten, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.