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Volumn 127, Issue 10, 2014, Pages S39-S48

New developments in insulin therapy for type 2 diabetes

Author keywords

Basal insulin; Insulin; Type 2 diabetes

Indexed keywords

BIOD 530; GLUCOSE; HEMOGLOBIN A1C; INCRETIN; INSULIN; INSULIN ASPART; INSULIN ASPART PLUS INSULIN DEGLUDEC; INSULIN DEGLUDEC; INSULIN DEGLUDEC PLUS LIRAGLUTIDE; INSULIN DETEMIR; INSULIN GLARGINE; INSULIN GLULISINE; INSULIN PEGLISPRO; LIXISENATIDE; ORMD 0801; RECOMBINANT HUMAN INSULIN; UNCLASSIFIED DRUG; ANTIDIABETIC AGENT;

EID: 84921770360     PISSN: 00029343     EISSN: 15557162     Source Type: Journal    
DOI: 10.1016/j.amjmed.2014.07.006     Document Type: Article
Times cited : (26)

References (97)
  • 1
    • 3042714557 scopus 로고    scopus 로고
    • The burden of treatment failure in type 2 diabetes
    • Brown JB, Nichols GA, Perry A. The burden of treatment failure in type 2 diabetes. Diabetes Care. 2004;27:1535-1540.
    • (2004) Diabetes Care , vol.27 , pp. 1535-1540
    • Brown, J.B.1    Nichols, G.A.2    Perry, A.3
  • 2
    • 33644798145 scopus 로고    scopus 로고
    • Resistance to insulin therapy among patients and providers: Results of the cross-national Diabetes Attitudes, Wishes, and Needs (DAWN) study
    • Peyrot M, Rubin RR, Lauritzen T, et al. Resistance to insulin therapy among patients and providers: results of the cross-national Diabetes Attitudes, Wishes, and Needs (DAWN) study. Diabetes Care. 2005;28: 2673-2679.
    • (2005) Diabetes Care , vol.28 , pp. 2673-2679
    • Peyrot, M.1    Rubin, R.R.2    Lauritzen, T.3
  • 3
    • 84855544890 scopus 로고    scopus 로고
    • Time to insulin initiation, glucose control and occurrence of diabetes related complications in France, Germany and UK from 2005 to 2010
    • Kostev K, Mergenthaler U. Time to insulin initiation, glucose control and occurrence of diabetes related complications in France, Germany and UK from 2005 to 2010. Diabetologia. 2011;54(Suppl 1):S159.
    • (2011) Diabetologia , vol.54 , pp. S159
    • Kostev, K.1    Mergenthaler, U.2
  • 4
    • 84920943092 scopus 로고    scopus 로고
    • Individualizing insulin therapy in the management of type 2 diabetes
    • Moghissi E, King AB. Individualizing insulin therapy in the management of type 2 diabetes. Am J Med. 2014;127(Suppl 1):S3-S10.
    • (2014) Am J Med. , vol.127 , pp. S3-S10
    • Moghissi, E.1    King, A.B.2
  • 5
    • 77954323314 scopus 로고    scopus 로고
    • The stunned beta cell: A brief history
    • Ferrannini E. The stunned beta cell: a brief history. Cell Metab. 2010;11:349-352.
    • (2010) Cell Metab. , vol.11 , pp. 349-352
    • Ferrannini, E.1
  • 6
    • 0034609223 scopus 로고    scopus 로고
    • Insulin glargine
    • Bolli GB, Owens DR. Insulin glargine. Lancet. 2000;356:443-445.
    • (2000) Lancet , vol.356 , pp. 443-445
    • Bolli, G.B.1    Owens, D.R.2
  • 7
    • 33845965337 scopus 로고    scopus 로고
    • Intermediate and long-acting insulins: A review of NPH insulin, insulin glargine and insulin detemir
    • Peterson GE. Intermediate and long-acting insulins: a review of NPH insulin, insulin glargine and insulin detemir. Curr Med Res Opin. 2006;22:2613-2619.
    • (2006) Curr Med Res Opin. , vol.22 , pp. 2613-2619
    • Peterson, G.E.1
  • 8
    • 0032973103 scopus 로고    scopus 로고
    • Long-acting insulin analogs
    • Rosskamp RH, Park G. Long-acting insulin analogs. Diabetes Care. 1999;22(Suppl 2):B109-B113.
    • (1999) Diabetes Care , vol.22 , pp. B109-B113
    • Rosskamp, R.H.1    Park, G.2
  • 9
    • 34547908855 scopus 로고    scopus 로고
    • Towards peakless, reproducible and long-acting insulins. An assessment of the basal analogues based on isoglycaemic clamp studies
    • Heise T, Pieber TR. Towards peakless, reproducible and long-acting insulins. An assessment of the basal analogues based on isoglycaemic clamp studies. Diabetes Obes Metab. 2007;9:648-659.
    • (2007) Diabetes Obes Metab. , vol.9 , pp. 648-659
    • Heise, T.1    Pieber, T.R.2
  • 10
    • 84921709085 scopus 로고    scopus 로고
    • Evolution of insulin: From human to analog
    • Tibaldi JM. Evolution of insulin: from human to analog. Am J Med. 2014;127(Suppl 1):S25-S38.
    • (2014) Am J Med. , vol.127 , pp. S25-S38
    • Tibaldi, J.M.1
  • 11
    • 84864460325 scopus 로고    scopus 로고
    • Design of the novel protraction mechanism of insulin degludec, an ultra-long-acting basal insulin
    • Jonassen I, Havelund S, Hoeg-Jensen T, et al. Design of the novel protraction mechanism of insulin degludec, an ultra-long-acting basal insulin. Pharm Res. 2012;29:2104-2114.
    • (2012) Pharm Res. , vol.29 , pp. 2104-2114
    • Jonassen, I.1    Havelund, S.2    Hoeg-Jensen, T.3
  • 12
    • 84872522953 scopus 로고    scopus 로고
    • Ligand-controlled assembly of hexamers, dihexamers, and linear multihexamer structures by the engineered acylated insulin degludec
    • Steensgaard DB, Schluckebier G, Strauss HM, et al. Ligand-controlled assembly of hexamers, dihexamers, and linear multihexamer structures by the engineered acylated insulin degludec. Biochemistry. 2013;52: 295-309.
    • (2013) Biochemistry , vol.52 , pp. 295-309
    • Steensgaard, D.B.1    Schluckebier, G.2    Strauss, H.M.3
  • 13
    • 84859921058 scopus 로고    scopus 로고
    • Insulin degludec, an ultra-longacting basal insulin, versus insulin glargine in basal-bolus treatment with mealtime insulin aspart in type 2 diabetes (BEGIN Basal-Bolus Type 2): A phase 3, randomised, open-label, treat-to-target non-inferiority trial
    • Garber AJ, King AB, Del Prato S, et al. Insulin degludec, an ultra-longacting basal insulin, versus insulin glargine in basal-bolus treatment with mealtime insulin aspart in type 2 diabetes (BEGIN Basal-Bolus Type 2): a phase 3, randomised, open-label, treat-to-target non-inferiority trial. Lancet. 2012;379:1498-1507.
    • (2012) Lancet , vol.379 , pp. 1498-1507
    • Garber, A.J.1    King, A.B.2    Del Prato, S.3
  • 14
    • 84859896417 scopus 로고    scopus 로고
    • Insulin degludec, an ultra-longacting basal insulin, versus insulin glargine in basal-bolus treatment with mealtime insulin aspart in type 1 diabetes (BEGIN Basal-Bolus Type 1): A phase 3, randomised, open-label, treat-to-target non-inferiority trial
    • Heller S, Buse J, Fisher M, et al. Insulin degludec, an ultra-longacting basal insulin, versus insulin glargine in basal-bolus treatment with mealtime insulin aspart in type 1 diabetes (BEGIN Basal-Bolus Type 1): a phase 3, randomised, open-label, treat-to-target non-inferiority trial. Lancet. 2012;379:1489-1497.
    • (2012) Lancet , vol.379 , pp. 1489-1497
    • Heller, S.1    Buse, J.2    Fisher, M.3
  • 15
    • 84871937855 scopus 로고    scopus 로고
    • Hypoglycaemia risk with insulin degludec compared with insulin glargine in type 2 and type 1 diabetes: A pre-planned meta-analysis of phase 3 trials
    • Ratner R, Gough SC, Mathieu C, et al. Hypoglycaemia risk with insulin degludec compared with insulin glargine in type 2 and type 1 diabetes: a pre-planned meta-analysis of phase 3 trials. Diabetes Obes Metab. 2013;15:175-184.
    • (2013) Diabetes Obes Metab. , vol.15 , pp. 175-184
    • Ratner, R.1    Gough, S.C.2    Mathieu, C.3
  • 16
    • 84869842163 scopus 로고    scopus 로고
    • Insulin degludec versus insulin glargine in insulin-naive patients with type 2 diabetes: A 1-year, randomized, treat-to-target trial (BEGIN Once Long)
    • Zinman B, Philis-Tsimikas A, Cariou B, et al. Insulin degludec versus insulin glargine in insulin-naive patients with type 2 diabetes: a 1-year, randomized, treat-to-target trial (BEGIN Once Long). Diabetes Care. 2012;35:2464-2471.
    • (2012) Diabetes Care , vol.35 , pp. 2464-2471
    • Zinman, B.1    Philis-Tsimikas, A.2    Cariou, B.3
  • 17
    • 84874858316 scopus 로고    scopus 로고
    • Efficacy and safety of insulin degludec in a flexible dosing regimen vs insulin glargine in patients with type 1 diabetes (BEGIN: Flex T1): A 26-week randomized, treat-to-target trial with a 26-week extension
    • Mathieu C, Hollander P, Miranda-Palma B, et al. Efficacy and safety of insulin degludec in a flexible dosing regimen vs insulin glargine in patients with type 1 diabetes (BEGIN: Flex T1): A 26-week randomized, treat-to-target trial with a 26-week extension. J Clin Endocrinol Metab. 2013;98:1154-1162.
    • (2013) J Clin Endocrinol Metab. , vol.98 , pp. 1154-1162
    • Mathieu, C.1    Hollander, P.2    Miranda-Palma, B.3
  • 18
    • 84875444482 scopus 로고    scopus 로고
    • The efficacy and safety of insulin degludec given in variable once-daily dosing intervals compared with insulin glargine and insulin degludec dosed at the same time daily: A 26-week, randomized, open-label, parallel-group, treat-totarget trial in people with type 2 diabetes
    • Meneghini L, Atkin SL, Gough SCL, et al. The efficacy and safety of insulin degludec given in variable once-daily dosing intervals compared with insulin glargine and insulin degludec dosed at the same time daily: a 26-week, randomized, open-label, parallel-group, treat-totarget trial in people with type 2 diabetes. Diabetes Care. 2013;36: 858-864.
    • (2013) Diabetes Care , vol.36 , pp. 858-864
    • Meneghini, L.1    Atkin, S.L.2    Gough, S.C.L.3
  • 20
    • 84874415108 scopus 로고    scopus 로고
    • LY2605541: Leveraging hydrodynamic size to develop a novel basal insulin
    • Hansen RJ, Cutler GB, Vick A, et al. LY2605541: leveraging hydrodynamic size to develop a novel basal insulin. Diabetes. 2012;61: A228.
    • (2012) Diabetes , vol.61 , pp. A228
    • Hansen, R.J.1    Cutler, G.B.2    Vick, A.3
  • 21
    • 84900825441 scopus 로고    scopus 로고
    • Single-dose pharmacokinetics and glucodynamics of the novel, long-acting basal insulin LY2605541 in healthy subjects
    • Sinha VP, Choi SL, Soon DK, et al. Single-dose pharmacokinetics and glucodynamics of the novel, long-acting basal insulin LY2605541 in healthy subjects. J Clin Pharmacol. 2014;54:792-799.
    • (2014) J Clin Pharmacol. , vol.54 , pp. 792-799
    • Sinha, V.P.1    Choi, S.L.2    Soon, D.K.3
  • 22
    • 20044368667 scopus 로고    scopus 로고
    • Pulsatile insulin secretion dictates systemic insulin delivery by regulating hepatic insulin extraction in humans
    • Meier JJ, Veldhuis JD, Butler PC. Pulsatile insulin secretion dictates systemic insulin delivery by regulating hepatic insulin extraction in humans. Diabetes. 2005;54:1649-1656.
    • (2005) Diabetes , vol.54 , pp. 1649-1656
    • Meier, J.J.1    Veldhuis, J.D.2    Butler, P.C.3
  • 23
    • 35048841093 scopus 로고    scopus 로고
    • Insulin-associated weight gain in diabetesecauses, effects and coping strategies
    • Russell-Jones D, Khan R. Insulin-associated weight gain in diabetesecauses, effects and coping strategies. Diabetes Obes Metab. 2007;9:799-812.
    • (2007) Diabetes Obes Metab. , vol.9 , pp. 799-812
    • Russell-Jones, D.1    Khan, R.2
  • 24
    • 84868131614 scopus 로고    scopus 로고
    • A randomized, controlled study of once-daily LY2605541, a novel long-acting basal insulin, versus insulin glargine in basal insulin-treated patients with type 2 diabetes
    • Bergenstal RM, Rosenstock J, Arakaki RF, et al. A randomized, controlled study of once-daily LY2605541, a novel long-acting basal insulin, versus insulin glargine in basal insulin-treated patients with type 2 diabetes. Diabetes Care. 2012;35:2140-2147.
    • (2012) Diabetes Care , vol.35 , pp. 2140-2147
    • Bergenstal, R.M.1    Rosenstock, J.2    Arakaki, R.F.3
  • 25
    • 84893090167 scopus 로고    scopus 로고
    • Novel pegylated basal insulin LY2605541 has a preferential hepatic effect on glucose metabolism
    • Moore M, Smith MS, Sinha VP, et al. Novel pegylated basal insulin LY2605541 has a preferential hepatic effect on glucose metabolism. Diabetes. 2014;63:494-504.
    • (2014) Diabetes , vol.63 , pp. 494-504
    • Moore, M.1    Smith, M.S.2    Sinha, V.P.3
  • 26
    • 84895133323 scopus 로고    scopus 로고
    • Steady-state pharmacokinetics and glucodynamics of the novel, long-acting basal insulin LY2605541 dosed once-daily in patients with type 2 diabetes mellitus
    • Sinha VP, Howey DC, Choi SL, Mace KF, Heise T. Steady-state pharmacokinetics and glucodynamics of the novel, long-acting basal insulin LY2605541 dosed once-daily in patients with type 2 diabetes mellitus. Diabetes Obes Metab. 2014;16:344-350.
    • (2014) Diabetes Obes Metab. , vol.16 , pp. 344-350
    • Sinha, V.P.1    Howey, D.C.2    Choi, S.L.3    Mace, K.F.4    Heise, T.5
  • 27
    • 84874413470 scopus 로고    scopus 로고
    • Better glycemic control and weight loss with the novel long-acting basal insulin LY2605541 compared with insulin glargine in type 1 diabetes: A randomized, crossover study
    • Rosenstock J, Bergenstal RM, Blevins TC, et al. Better glycemic control and weight loss with the novel long-acting basal insulin LY2605541 compared with insulin glargine in type 1 diabetes: a randomized, crossover study. Diabetes Care. 2013;36:522-528.
    • (2013) Diabetes Care , vol.36 , pp. 522-528
    • Rosenstock, J.1    Bergenstal, R.M.2    Blevins, T.C.3
  • 29
    • 0033661903 scopus 로고    scopus 로고
    • Five fold increase of insulin concentration delays the absorption of subcutaneously injected human insulin suspensions in pigs
    • Jorgensen KH, Hansen AK, Buschard K. Five fold increase of insulin concentration delays the absorption of subcutaneously injected human insulin suspensions in pigs. Diabetes Res Clin Pract. 2000;50:161-167.
    • (2000) Diabetes Res Clin Pract. , vol.50 , pp. 161-167
    • Jorgensen, K.H.1    Hansen, A.K.2    Buschard, K.3
  • 30
    • 84890882556 scopus 로고    scopus 로고
    • Euglycemic clamp profile of new insulin glargine U300 formulation in patients with type 1 diabetes (T1DM) is different from glargine U100
    • Tillner J, Bergmann K, Tiechert L, et al. Euglycemic clamp profile of new insulin glargine U300 formulation in patients with type 1 diabetes (T1DM) is different from glargine U100. Diabetes. 2013;62(Suppl 1): A234.
    • (2013) Diabetes , vol.62 , pp. A234
    • Tillner, J.1    Bergmann, K.2    Tiechert, L.3
  • 32
    • 84905721701 scopus 로고    scopus 로고
    • Investigational new insulin glargine 300 U/ml has the same metabolism as insulin glargine 100 U/ml
    • Epub ahead of print
    • Steinstraesser A, Schmidt R, Bergmann K, Dahmen R, Becker RH. Investigational new insulin glargine 300 U/ml has the same metabolism as insulin glargine 100 U/ml. Diabetes Obes Metab. 2014. http://dx. doi.org/10.1111/dom.12283. [Epub ahead of print].
    • (2014) Diabetes Obes Metab.
    • Steinstraesser, A.1    Schmidt, R.2    Bergmann, K.3    Dahmen, R.4    Becker, R.H.5
  • 35
    • 84908179629 scopus 로고    scopus 로고
    • On behalf of the EDITION 1 Study Investigators. New insulin glargine 300 Units/mL versus glargine 100 Units/mL in people with type 2 diabetes using basal and mealtime insulin: Glucose control and hypoglycemia in a 6-month randomized controlled trial (EDITION 1)
    • Jul 30. pii: DC-140991. [Epub ahead of print]
    • Riddle MC, Bolli GB, Ziemen M, Muehlen-Bartmer I, Bizet F, Home PD; on behalf of the EDITION 1 Study Investigators. New insulin glargine 300 Units/mL versus glargine 100 Units/mL in people with type 2 diabetes using basal and mealtime insulin: glucose control and hypoglycemia in a 6-month randomized controlled trial (EDITION 1). Diabetes Care . 2014 Jul 30. pii: DC-140991. [Epub ahead of print].
    • (2014) Diabetes Care
    • Riddle, M.C.1    Bolli, G.B.2    Ziemen, M.3    Muehlen-Bartmer, I.4    Bizet, F.5    Home, P.D.6
  • 36
    • 85030397468 scopus 로고    scopus 로고
    • An investigational new insulin U300: Glucose control and hypoglycemia in people with type 2 diabetes on basal insulin and OADs (EDITION II) (Abstract O-0075)
    • Abstract accepted for presentation at the December 2-6
    • Yki-Jarvinen H. An investigational new insulin U300: glucose control and hypoglycemia in people with type 2 diabetes on basal insulin and OADs (EDITION II) (Abstract O-0075). Abstract accepted for presentation at the IDF 2013 World Diabetes Congress, Melbourne, Australia, December 2-6, 2013.
    • (2013) IDF 2013 World Diabetes Congress, Melbourne, Australia
    • Yki-Jarvinen, H.1
  • 40
    • 85030402881 scopus 로고    scopus 로고
    • BIOD-530 U-400 concentrated recombinant human insulin:Pharmacokinetic (PK) and pharmacodynamic (PD) profiles in diabetic swine compared to U-500 regular human insulin (U-500R) and insulin lispro U-100 (IL)
    • Pohl R, Hauser R, Li M, et al. BIOD-530 U-400 concentrated recombinant human insulin: pharmacokinetic (PK) and pharmacodynamic (PD) profiles in diabetic swine compared to U-500 regular human insulin (U-500R) and insulin lispro U-100 (IL). Diabetes. 2013;62(Suppl 1):A233.
    • (2013) Diabetes , vol.62 , pp. A233
    • Pohl, R.1    Hauser, R.2    Li, M.3
  • 41
    • 84879814052 scopus 로고    scopus 로고
    • A comparison of the steadystate pharmacokinetic and pharmacodynamic profi les of 100 and 200 U/mL formulations of ultra-long-acting insulin degludec
    • Korsatko S, Deller S, Koehler G, et al. A comparison of the steadystate pharmacokinetic and pharmacodynamic profi les of 100 and 200 U/mL formulations of ultra-long-acting insulin degludec. Clin Drug Investig. 2013;33:515-521.
    • (2013) Clin Drug Investig. , vol.33 , pp. 515-521
    • Korsatko, S.1    Deller, S.2    Koehler, G.3
  • 42
    • 84864375931 scopus 로고    scopus 로고
    • Insulin degludec: Four times lower pharmacodynamic variability than insulin glargine under steadystate conditions in type 1 diabetes
    • Heise T, Hermanski L, Nosek L, et al. Insulin degludec: four times lower pharmacodynamic variability than insulin glargine under steadystate conditions in type 1 diabetes. Diabetes Obes Metab. 2012;14: 859-864.
    • (2012) Diabetes Obes Metab. , vol.14 , pp. 859-864
    • Heise, T.1    Hermanski, L.2    Nosek, L.3
  • 43
    • 84865972844 scopus 로고    scopus 로고
    • Ultra-long-acting insulin degludec has a flat and stable glucose-lowering effect in type 2 diabetes
    • Heise T, Nosek L, Bottcher SG, Hastrup H, Haahr H. Ultra-long-acting insulin degludec has a flat and stable glucose-lowering effect in type 2 diabetes. Diabetes Obes Metab. 2012;14:944-950.
    • (2012) Diabetes Obes Metab. , vol.14 , pp. 944-950
    • Heise, T.1    Nosek, L.2    Bottcher, S.G.3    Hastrup, H.4    Haahr, H.5
  • 44
    • 84889648892 scopus 로고    scopus 로고
    • Low volume insulin degludec 200 units/mL once daily improves glycemic control similar to insulin glargine with a low risk of hypoglycemia in insulin-naïve patients with type 2 diabetes: A 26-week, randomized, controlled, multinational, treat-to-target trial: The BEGIN- LOW VOLUME trial
    • Gough SCL, Bhargava A, Jain R, et al. Low volume insulin degludec 200 units/mL once daily improves glycemic control similar to insulin glargine with a low risk of hypoglycemia in insulin-naïve patients with type 2 diabetes: a 26-week, randomized, controlled, multinational, treat-to-target trial: the BEGIN- LOW VOLUME trial. Diabetes Care. 2013;36:2536-2542.
    • (2013) Diabetes Care , vol.36 , pp. 2536-2542
    • Gough, S.C.L.1    Bhargava, A.2    Jain, R.3
  • 50
    • 84873191592 scopus 로고    scopus 로고
    • A review of a family of ultra-rapidacting insulins: Formulation development
    • Krasner A, Pohl R, Simms P, et al. A review of a family of ultra-rapidacting insulins: formulation development. J Diabetes Sci Technol. 2012;6:786-796.
    • (2012) J Diabetes Sci Technol. , vol.6 , pp. 786-796
    • Krasner, A.1    Pohl, R.2    Simms, P.3
  • 51
    • 67649849974 scopus 로고    scopus 로고
    • Accelerated pharmacokinetics and glucodynamics of prandial insulins injected with recombinant human hyaluronidase
    • Vaughn DE, Yocum RC, Muchmore DB, et al. Accelerated pharmacokinetics and glucodynamics of prandial insulins injected with recombinant human hyaluronidase. Diabetes Technol Ther. 2009;11: 345-352.
    • (2009) Diabetes Technol Ther. , vol.11 , pp. 345-352
    • Vaughn, D.E.1    Yocum, R.C.2    Muchmore, D.B.3
  • 52
    • 84873878280 scopus 로고    scopus 로고
    • Comparative pharmacokinetics and insulin action for three rapid-acting insulin analogs injected subcutaneously with and without hyaluronidase
    • Morrow l, Muchmore DB, Hompesch M, Ludington EA, Vaughn DE. Comparative pharmacokinetics and insulin action for three rapid-acting insulin analogs injected subcutaneously with and without hyaluronidase. Diabetes Care. 2013;36:273-275.
    • (2013) Diabetes Care , vol.36 , pp. 273-275
    • Morrow, L.1    Muchmore, D.B.2    Hompesch, M.3    Ludington, E.A.4    Vaughn, D.E.5
  • 53
    • 79956073035 scopus 로고    scopus 로고
    • Accelerated insulin pharmacokinetics and improved postprandial glycemic control in patients with type 1 diabetes after coadministration of prandial insulins with hyaluronidase
    • Hompesch M, Muchmore DB, Morrow l, Vaughn DE. Accelerated insulin pharmacokinetics and improved postprandial glycemic control in patients with type 1 diabetes after coadministration of prandial insulins with hyaluronidase. Diabetes Care. 2011;34:666-668.
    • (2011) Diabetes Care , vol.34 , pp. 666-668
    • Hompesch, M.1    Muchmore, D.B.2    Morrow, L.3    Vaughn, D.E.4
  • 54
    • 80053426508 scopus 로고    scopus 로고
    • Reduction in intrasubject variability in the pharmacokinetic response to insulin after subcutaneous co-administration with recombinant human hyaluronidase in healthy volunteers
    • Morrow l, Muchmore DB, Ludington EA, Vaughn DE, Hompesch M. Reduction in intrasubject variability in the pharmacokinetic response to insulin after subcutaneous co-administration with recombinant human hyaluronidase in healthy volunteers. Diabetes Technol Ther. 2011;13: 1039-1045.
    • (2011) Diabetes Technol Ther. , vol.13 , pp. 1039-1045
    • Morrow, L.1    Muchmore, D.B.2    Ludington, E.A.3    Vaughn, D.E.4    Hompesch, M.5
  • 55
    • 0028817815 scopus 로고
    • Overview of 6 years' therapy of type II diabetes: A progressive disease (UKPDS 16)
    • Erratum in Diabetes. 1996;45:1655
    • United Kingdom Prospective Diabetes Study (UKPDS). Overview of 6 years' therapy of type II diabetes: a progressive disease (UKPDS 16). Diabetes. 1995;44:1249-1258, Erratum in Diabetes. 1996;45:1655.
    • (1995) Diabetes , vol.44 , pp. 1249-1258
  • 56
    • 0242269000 scopus 로고    scopus 로고
    • The treat-to-target trial: Randomized addition of glargine or human NPH insulin to oral therapy of type 2 diabetic patients
    • Riddle MC, Rosenstock J, Gerich J. The treat-to-target trial: randomized addition of glargine or human NPH insulin to oral therapy of type 2 diabetic patients. Diabetes Care. 2003;26:3080-3086.
    • (2003) Diabetes Care , vol.26 , pp. 3080-3086
    • Riddle, M.C.1    Rosenstock, J.2    Gerich, J.3
  • 57
    • 0142090756 scopus 로고    scopus 로고
    • Clinical significance of targeting postprandial and fasting hyperglycemia in managing type 2 diabetes mellitus
    • Fonseca V. Clinical significance of targeting postprandial and fasting hyperglycemia in managing type 2 diabetes mellitus. Curr Med Res Opin. 2003;19:635-641.
    • (2003) Curr Med Res Opin. , vol.19 , pp. 635-641
    • Fonseca, V.1
  • 58
    • 34247636085 scopus 로고    scopus 로고
    • Impact of fasting and postprandial glycemia on overall glycemic control in type 2 diabetes importance of postprandial glycemia to achieve target HbA1c levels
    • Woerle HJ, Neumann C, Zschau S, et al. Impact of fasting and postprandial glycemia on overall glycemic control in type 2 diabetes Importance of postprandial glycemia to achieve target HbA1c levels. Diabetes Res Clin Pract. 2007;77:280-285.
    • (2007) Diabetes Res Clin Pract. , vol.77 , pp. 280-285
    • Woerle, H.J.1    Neumann, C.2    Zschau, S.3
  • 59
    • 84862275919 scopus 로고    scopus 로고
    • Hypoglycaemia: A therapeutic concern in type 2 diabetes
    • Garber AJ. Hypoglycaemia: a therapeutic concern in type 2 diabetes. Lancet. 2012;379:2215-2216.
    • (2012) Lancet , vol.379 , pp. 2215-2216
    • Garber, A.J.1
  • 60
    • 84866268783 scopus 로고    scopus 로고
    • Management of hyperglycemia in type 2 diabetes: A patient-centered approach: Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
    • Erratum in Diabetes Care. 2013;36:490
    • Inzucchi SE, Bergenstal RM, Buse JB, et al. Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care. 2012;35:1364-1379, Erratum in Diabetes Care. 2013;36:490.
    • (2012) Diabetes Care , vol.35 , pp. 1364-1379
    • Inzucchi, S.E.1    Bergenstal, R.M.2    Buse, J.B.3
  • 61
    • 84882276623 scopus 로고    scopus 로고
    • AACE comprehensive diabetes management algorithm 2013
    • Garber AJ, Abrahamson MJ, Barzilay JI, et al. AACE comprehensive diabetes management algorithm 2013. Endocr Pract. 2013;19: 327-336.
    • (2013) Endocr Pract. , vol.19 , pp. 327-336
    • Garber, A.J.1    Abrahamson, M.J.2    Barzilay, J.I.3
  • 63
    • 84871125993 scopus 로고    scopus 로고
    • Combining GLP-1 receptor agonists with insulin: Therapeutic rationales and clinical findings
    • Holst JJ, Vilsboll T. Combining GLP-1 receptor agonists with insulin: therapeutic rationales and clinical findings. Diabetes Obes Metab. 2013;15:3-14.
    • (2013) Diabetes Obes Metab. , vol.15 , pp. 3-14
    • Holst, J.J.1    Vilsboll, T.2
  • 64
    • 84874288415 scopus 로고    scopus 로고
    • Incretin-based therapy in combination with basal insulin: A promising tactic for the treatment of type 2 diabetes
    • Vora J, Bain SC, Damci T, et al. Incretin-based therapy in combination with basal insulin: a promising tactic for the treatment of type 2 diabetes. Diabetes Metab. 2013;39:6-15.
    • (2013) Diabetes Metab. , vol.39 , pp. 6-15
    • Vora, J.1    Bain, S.C.2    Damci, T.3
  • 65
    • 84888607940 scopus 로고    scopus 로고
    • Combining incretin-based therapies with insulin: Realizing the potential in type 2 diabetes
    • Erratum in Diabetes Care. 2013;36:4172
    • Vora J. Combining incretin-based therapies with insulin: realizing the potential in type 2 diabetes. Diabetes Care. 2013;36(Suppl 2): S226-S232, Erratum in Diabetes Care. 2013;36:4172.
    • (2013) Diabetes Care. , vol.36 , pp. S226-S232
    • Vora, J.1
  • 66
    • 84863230184 scopus 로고    scopus 로고
    • Combination therapy with insulin glargine and exenatide: Real-world outcomes in patients with type 2 diabetes
    • Levin P, Wei W, Wang L, et al. Combination therapy with insulin glargine and exenatide: real-world outcomes in patients with type 2 diabetes. Curr Med Res Opin. 2012;28:439-446.
    • (2012) Curr Med Res Opin. , vol.28 , pp. 439-446
    • Levin, P.1    Wei, W.2    Wang, L.3
  • 67
    • 84857531976 scopus 로고    scopus 로고
    • Clinical outcomes using long-term combination therapy with insulin glargine and exenatide in patients with type 2 diabetes mellitus
    • Levin PA, Mersey JH, Zhou S, Bromberger LA. Clinical outcomes using long-term combination therapy with insulin glargine and exenatide in patients with type 2 diabetes mellitus. Endocr Pract. 2012;18: 17-25.
    • (2012) Endocr Pract. , vol.18 , pp. 17-25
    • Levin, P.A.1    Mersey, J.H.2    Zhou, S.3    Bromberger, L.A.4
  • 68
    • 84878592117 scopus 로고    scopus 로고
    • Adding once-daily lixisenatide for type 2 diabetes inadequately controlled by established basal insulin: A 24-week, randomized, placebo-controlled comparison (GetGoal-L)
    • Riddle MC, Aronson R, Home P, et al. Adding once-daily lixisenatide for type 2 diabetes inadequately controlled by established basal insulin: a 24-week, randomized, placebo-controlled comparison (GetGoal-L). Diabetes Care. 2013;36:2489-2496.
    • (2013) Diabetes Care , vol.36 , pp. 2489-2496
    • Riddle, M.C.1    Aronson, R.2    Home, P.3
  • 69
    • 84878603672 scopus 로고    scopus 로고
    • Adding once-daily lixisenatide for type 2 diabetes inadequately controlled with newly initiated and continuously titrated basal insulin glargine: A 24-week, randomized, placebo-controlled study (GetGoal-Duo 1)
    • Riddle MC, Forst T, Aronson R, et al. Adding once-daily lixisenatide for type 2 diabetes inadequately controlled with newly initiated and continuously titrated basal insulin glargine: a 24-week, randomized, placebo-controlled study (GetGoal-Duo 1). Diabetes Care. 2013;36: 2497-2503.
    • (2013) Diabetes Care , vol.36 , pp. 2497-2503
    • Riddle, M.C.1    Forst, T.2    Aronson, R.3
  • 70
    • 84859731126 scopus 로고    scopus 로고
    • Effect of saxagliptin as add-on therapy in patients with poorly controlled type 2 diabetes on insulin alone or insulin combined with metformin
    • Barnett AH, Charbonnel B, Donovan M, Fleming D, Chen R. Effect of saxagliptin as add-on therapy in patients with poorly controlled type 2 diabetes on insulin alone or insulin combined with metformin. Curr Med Res Opin. 2012;28:513-523.
    • (2012) Curr Med Res Opin. , vol.28 , pp. 513-523
    • Barnett, A.H.1    Charbonnel, B.2    Donovan, M.3    Fleming, D.4    Chen, R.5
  • 71
    • 84883778164 scopus 로고    scopus 로고
    • One-year sustained glycemic control and weight reduction in type 2 diabetes after addition of liraglutide to metformin followed by insulin detemir according to HbA target
    • Rosenstock J, Rodbard HW, Bain SC, et al. One-year sustained glycemic control and weight reduction in type 2 diabetes after addition of liraglutide to metformin followed by insulin detemir according to HbA target. J Diabetes Complications. 2013;27:492-500.
    • (2013) J Diabetes Complications , vol.27 , pp. 492-500
    • Rosenstock, J.1    Rodbard, H.W.2    Bain, S.C.3
  • 72
    • 84903121563 scopus 로고    scopus 로고
    • A comparison of adding liraglutide versus a single daily dose of insulin aspart to insulin degludec in subjects with type 2 diabetes (BEGIN: VICTOZA ADDON)
    • Mathieu C, Rodbard HW, Cariou B, et al. A comparison of adding liraglutide versus a single daily dose of insulin aspart to insulin degludec in subjects with type 2 diabetes (BEGIN: VICTOZA ADDON). Diabetes Obes Metab. 2014;16:636-644.
    • (2014) Diabetes Obes Metab. , vol.16 , pp. 636-644
    • Mathieu, C.1    Rodbard, H.W.2    Cariou, B.3
  • 73
    • 84922519772 scopus 로고    scopus 로고
    • Efficacy and safety of a fixed-ratio combination of insulin degludec and liraglutide compared to each of its components given alone: Results of a phase 3, randomised, 26-week, treat-to-target trial in insulin-naïve patients with type 2 diabetes
    • Gough SCL, Bode B, Woo V, et al. Efficacy and safety of a fixed-ratio combination of insulin degludec and liraglutide compared to each of its components given alone: results of a phase 3, randomised, 26-week, treat-to-target trial in insulin-naïve patients with type 2 diabetes. LancetDiabetes Endocrinol. 2014. http://dx.doi.org/10.1016/S2213-8587(14)70174-3.
    • (2014) Lancet Diabetes Endocrinol
    • Gough, S.C.L.1    Bode, B.2    Woo, V.3
  • 74
    • 84922587490 scopus 로고    scopus 로고
    • The fixed ratio combination of insulin degludec and liraglutide in a randomized clinical trial: A novel alternative to basal insulin in the management of type 2 diabetes
    • in press
    • Buse JB, Vilsbøll T, Thurman J, et al. The fixed ratio combination of insulin degludec and liraglutide in a randomized clinical trial: a novel alternative to basal insulin in the management of type 2 diabetes. Diabetes Care. 2014: in press.
    • (2014) Diabetes Care
    • Buse, J.B.1    Vilsbøll, T.2    Thurman, J.3
  • 78
    • 72749107757 scopus 로고    scopus 로고
    • Oral insulin: The rationale for this approach and current developments
    • Arbit E, Kidron M. Oral insulin: the rationale for this approach and current developments. J Diabetes Sci Technol. 2009;3:562-567.
    • (2009) J Diabetes Sci Technol. , vol.3 , pp. 562-567
    • Arbit, E.1    Kidron, M.2
  • 83
    • 84876059641 scopus 로고    scopus 로고
    • Glucose-reducing effect of the ORMD-0801 oral insulin preparation in patients with uncontrolled type 1 diabetes: A pilot study
    • Eldor R, Arbit E, Corcos A, Kidron M. Glucose-reducing effect of the ORMD-0801 oral insulin preparation in patients with uncontrolled type 1 diabetes: a pilot study. PLoS One. 2013;8:e59524.
    • (2013) PLoS One , vol.8 , pp. e59524
    • Eldor, R.1    Arbit, E.2    Corcos, A.3    Kidron, M.4
  • 84
    • 84900834720 scopus 로고    scopus 로고
    • Dose response to oral insulin capsules in fasting, healthy subjects
    • Eldor R, Arbit E, Schurr D, Kidron M, Hersko A. Dose response to oral insulin capsules in fasting, healthy subjects. Diabetes. 2013;62(Suppl 1):A272.
    • (2013) Diabetes , vol.62 , pp. A272
    • Eldor, R.1    Arbit, E.2    Schurr, D.3    Kidron, M.4    Hersko, A.5
  • 85
    • 34548412091 scopus 로고    scopus 로고
    • Coverage of postprandial blood glucose excursions with inhaled technosphere insulin in comparison to subcutaneously injected regular human insulin in subjects with type 2 diabetes
    • Rave K, Heise T, Pfutzner A, Boss AH. Coverage of postprandial blood glucose excursions with inhaled technosphere insulin in comparison to subcutaneously injected regular human insulin in subjects with type 2 diabetes. Diabetes Care. 2007;30:2307-2308.
    • (2007) Diabetes Care , vol.30 , pp. 2307-2308
    • Rave, K.1    Heise, T.2    Pfutzner, A.3    Boss, A.H.4
  • 86
    • 70449469675 scopus 로고    scopus 로고
    • Pharmacokinetics and linear exposure of AFRESA compared with the subcutaneous injection of regular human insulin
    • Rave K, Potocka E, Heinemann L, et al. Pharmacokinetics and linear exposure of AFRESA compared with the subcutaneous injection of regular human insulin. Diabetes Obes Metab. 2009;11:715-720.
    • (2009) Diabetes Obes Metab. , vol.11 , pp. 715-720
    • Rave, K.1    Potocka, E.2    Heinemann, L.3
  • 87
    • 77953839066 scopus 로고    scopus 로고
    • Prandial inhaled insulin plus basal insulin glargine versus twice daily biaspart insulin for type 2 diabetes: A multicentre randomised trial
    • Rosenstock J, Lorber DL, Gnudi L, et al. Prandial inhaled insulin plus basal insulin glargine versus twice daily biaspart insulin for type 2 diabetes: a multicentre randomised trial. Lancet. 2010;375:2244-2253.
    • (2010) Lancet , vol.375 , pp. 2244-2253
    • Rosenstock, J.1    Lorber, D.L.2    Gnudi, L.3
  • 88
    • 84855359884 scopus 로고    scopus 로고
    • Pulmonary function over 2 years in diabetic patients treated with prandial inhaled Technosphere Insulin or usual antidiabetes treatment: A randomized trial
    • Raskin P, Heller S, Honka M, et al. Pulmonary function over 2 years in diabetic patients treated with prandial inhaled Technosphere Insulin or usual antidiabetes treatment: a randomized trial. Diabetes Obes Metab. 2012;14:163-173.
    • (2012) Diabetes Obes Metab. , vol.14 , pp. 163-173
    • Raskin, P.1    Heller, S.2    Honka, M.3
  • 89
    • 79959616082 scopus 로고    scopus 로고
    • Closed-loop insulin delivery: From bench to clinical practice
    • Hovorka R. Closed-loop insulin delivery: from bench to clinical practice. Nat Rev Endocrinol. 2011;7:385-395.
    • (2011) Nat Rev Endocrinol. , vol.7 , pp. 385-395
    • Hovorka, R.1
  • 90
    • 84862501914 scopus 로고    scopus 로고
    • Management of diabetes mellitus: Is the pump mightier than the pen?
    • Pickup JC. Management of diabetes mellitus: is the pump mightier than the pen? Nat Rev Endocrinol. 2012;8:425-433.
    • (2012) Nat Rev Endocrinol. , vol.8 , pp. 425-433
    • Pickup, J.C.1
  • 91
    • 85030388477 scopus 로고    scopus 로고
    • New technologies for diabetes: A review of the present and the future
    • Ramchandani N, Heptulla RA. New technologies for diabetes: a review of the present and the future. Int J Pediatr Endocrinol. 2012; 2012:28.
    • (2012) Int J Pediatr Endocrinol.
    • Ci, N.1    Heptulla, R.A.2
  • 92
    • 33845340831 scopus 로고    scopus 로고
    • OmniPod Insulin Management System: Patient perceptions, preference, and glycemic control
    • Zisser H, Jovanovic L. OmniPod Insulin Management System: patient perceptions, preference, and glycemic control. Diabetes Care. 2006;29: 2175.
    • (2006) Diabetes Care , vol.29 , pp. 2175
    • Zisser, H.1    Jovanovic, L.2
  • 93
    • 78149329097 scopus 로고    scopus 로고
    • A prospective trial of U500 insulin delivered by Omnipod in patients with type 2 diabetes mellitus and severe insulin resistance
    • Lane WS, Weinrib SL, Rappaport JM, Przestrzelski T. A prospective trial of U500 insulin delivered by Omnipod in patients with type 2 diabetes mellitus and severe insulin resistance. Endocr Pract. 2010;16: 778-784.
    • (2010) Endocr Pract. , vol.16 , pp. 778-784
    • Lane, W.S.1    Weinrib, S.L.2    Rappaport, J.M.3    Przestrzelski, T.4
  • 94
    • 84867367735 scopus 로고    scopus 로고
    • TheV-Go insulin delivery device used in clinical practice: Patient perception and retrospective analysis of glycemic control
    • Rosenfeld CR, Bohannon NJ, Bode B, et al. TheV-Go insulin delivery device used in clinical practice: patient perception and retrospective analysis of glycemic control. Endocr Pract . 2012;18: 660-667.
    • (2012) Endocr Pract , vol.18 , pp. 660-667
    • Rosenfeld, C.R.1    Bohannon, N.J.2    Bode, B.3
  • 96
    • 0034117192 scopus 로고    scopus 로고
    • Characterization of glucose-sensitive insulin release systems in simulated in vivo conditions
    • Traitel T, Cohen Y, Kost J. Characterization of glucose-sensitive insulin release systems in simulated in vivo conditions. Biomaterials. 2000;21:1679-1687.
    • (2000) Biomaterials , vol.21 , pp. 1679-1687
    • Traitel, T.1    Cohen, Y.2    Kost, J.3
  • 97
    • 77957354612 scopus 로고    scopus 로고
    • In vivo study of a polymeric glucosesensitive insulin delivery system using a rat model
    • Taylor MJ, Tanna S, Sahota T. In vivo study of a polymeric glucosesensitive insulin delivery system using a rat model. J Pharm Sci. 2010;99:4215-4227.
    • (2010) J Pharm Sci. , vol.99 , pp. 4215-4227
    • Taylor, M.J.1    Tanna, S.2    Sahota, T.3


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