The IL-33/ST2 axis is specifically required for development of adipose tissue-resident regulatory T cells

Cellular and Molecular Immunology

Volumn 12, Issue 5, 2015, Pages 521-524

  Hu, Zhi Qing ^a   Zhao, Wei Hua ^a  

^a SHOWA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; INTERLEUKIN 33; INTERLEUKIN 33 RECEPTOR ALPHA; INTERLEUKIN RECEPTOR; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG; INTERLEUKIN-33 RECEPTOR, MOUSE;

ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CENTRAL REGULATORY T LYMPHOCYTE; EFFECTOR CELL; FOLLICULAR REGULATORY T LYMPHOCYTE; INDUCED REGULATORY T LYMPHOCYTE; INTRAABDOMINAL FAT; NATURAL KILLER T CELL; NATURAL REGULATORY T LYMPHOCYTE; NONHUMAN; PERIPHERALLY DERIVED REGULATORY T LYMPHOCYTE; REGULATORY T LYMPHOCYTE; T CELL CULTURE; THYMUS DERIVED REGULATORY T LYMPHOCYTE; ANIMAL; BIOLOGICAL MODEL; C57BL MOUSE; CYTOLOGY; HUMAN; IMMUNOLOGY; LYMPHOCYTE SUBPOPULATION; METABOLISM; PHENOTYPE; SIGNAL TRANSDUCTION;

ANIMALS; HUMANS; INTERLEUKIN-33; INTRA-ABDOMINAL FAT; LYMPHOCYTE SUBSETS; MICE, INBRED C57BL; MODELS, BIOLOGICAL; PHENOTYPE; RECEPTORS, INTERLEUKIN; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, REGULATORY;

EID: 84941129585     PISSN: 16727681     EISSN: None     Source Type: Journal    
DOI: 10.1038/cmi.2015.49     Document Type: Article

References (15)

1. Burzyn D, Benoist C, Mathis D. Regulatory T cells in nonlymphoid tissues. Nat Immunol 2013; 14: 1007-1013.
2. Zhou X, Tang J, Cao H, Fan H, Li B. Tissue resident regulatory T cells: novel therapeutic targets for human disease. Cell Mol Immunol 2015; 12: 543-552.
3. Ryba-Stanislawowska M, Stanislawowski M, Mysliwska J. Effector and regulatory T cell subsets in diabetes-associated inflammation. Is there a connection with ST2/IL-33 axis? Perspective. Autoimmunity 2014; 47: 361-371.
4. Cipolletta D, Kolodin D, Benoist C, Mathis D. Tissular Tregs: a unique population of adipose-tissue-resident Foxp31CD41 T cells that impacts organismal metabolism. Semin Immunol 2011; 23: 431-437.
5. Vasanthakumar A, Moro K, Xin A, Liao Y, Gloury R, Kawamoto S et a l . The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells. Nat Immunol 2015; 16: 276-285.
6. Zeng H, Zhang R, Jin B, Chen L. Type 1 regulatory T cells: a new mechanism for the peripheral immune tolerance. Cell Mol Immunol 2015; 12: 566-571.
7. KimHJ, Verbinnen B, Tang X, Lu L, Cantor H. Inhibition of follicular T-helper cells by CD81 regulatory T cells is essential for self tolerance. Nature 2010; 467: 328-332.
8. Peterson RA. Regulatory T-cells: diverse phenotypes integral to immune homeostasis and suppression. Toxicol Pathol 2012; 40: 186-204.
9. Jonuleit H, Schmitt E. The regulatory T cell family: distinct subsets and their interrelations. J Immunol 2003; 171: 6323-6327.
10. Shevach EM, Thornton AM. tTregs, pTregs, and iTregs: similarities and differences. Immunol Rev 2014; 259: 88-102.
11. Sage PT, Francisco LM, Carman CV, Sharpe AH. The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood. Nat Immunol 2013; 14: 152-161.
12. Liston A, Gray DH. Homeostatic control of regulatory T cell diversity. Nat Rev Immunol 2014; 14: 154-165.
13. Cretney E, Xin A, Shi W, Minnich M, Masson F, Miasari M et al. The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells. Nat Immunol 2011; 12: 304-311.
14. Cipolletta D, Feuerer M, Li A, Kamei N, Lee J, Shoelson SE et al. PPAR-c is a major driver of the accumulation and phenotype of adipose tissue Treg cells. Nature 2012; 486: 549-553.
15. Feuerer M, Herrero L, Cipolletta D, Naaz A, Wong J, Nayer A et al. Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med 2009; 15: 930-939.