Anti-inflammatory activity of ginsenosides in LPS-stimulated RAW 264.7 cells

Science Bulletin

Volumn 60, Issue 8, 2015, Pages 773-784

  Ahn, Sungeun ^a   Siddiqi, Muhammad Hanif ^a   Noh, Hae Yong ^a   Kim, Yu Jin ^a   Kim, Yeon Ju ^a   Jin, Chi Gyu ^a   Yang, Deok Chun ^a  

^a Kyung Hee University   (South Korea)

Author keywords

Ginsenosides; Inflammation; NF B IKK; Protopanaxadiol; Protopanaxatriol; RAW 264.7

Indexed keywords

EID: 84941118690     PISSN: 20959273     EISSN: 20959281     Source Type: Journal    
DOI: 10.1007/s11434-015-0773-4     Document Type: Article

References (38)

1. Baldwin AS Jr (1996) The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol 14:649–683
2. Chen YQ, Ghosh S, Ghosh G (1998) A novel DNA recognition mode by the NF-kappa B p65 homodimer. Nat Struct Biol 5:67–73
3. Yamamoto Y, Gaynor RB (2004) I kappa B kinases: key regulators of the NF-kappa B pathway. Trends Biochem Sci 29:72–79
4. Laskin DL, Pendino KJ (1995) Macrophages and inflammatory mediators in tissue injury. Annu Rev Pharmacol Toxicol 35:655–677
5. Guzik TJ, Korbut R, Adamek-Guzik T (2003) Nitric oxide and superoxide in inflammation and immune regulation. J Physiol Pharmacol 54:469–487
6. Guha M, Mackman N (2001) LPS induction of gene expression in human monocytes. Cell Signal 13:85–94
7. Zhang G, Ghosh S (2001) Toll-like receptor-mediated NF-kappa B activation: a phylogenetically conserved paradigm in innate immunity. J Clin Investig 107:13–19
8. Xie QW, Kashiwabara Y, Nathan C (1994) Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase. J Biol Chem 269:4705–4708
9. Barnes PJ, Karin M (1997) Nuclear factor-kappa B: a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 336:1066–1071
10. Karin M, Ben-Neriah Y (2000) Phosphorylation meets ubiquitination: the control of NF-[kappa] B activity. Annu Rev Immunol 18:621–663
11. De Bosscher K, Vanden Berghe W, Vermeulen L et al (2000) Glucocorticoids repress NF-kappa B-driven genes by disturbing the interaction of p65 with the basal transcription machinery, irrespective of coactivator levels in the cell. Proc Natl Acad Sci USA 97:3919–3924
12. Yamamoto Y, Gaynor RB (2001) Therapeutic potential of inhibition of the NF-kappa B pathway in the treatment of inflammation and cancer. J Clin Investig 107:135–142
13. Pan MH, Lai CS, Dushenkov S et al (2009) Modulation of inflammatory genes by natural dietary bioactive compounds. J Agric Food Chem 57:4467–4477
14. Bosscher KD, Berghe WV, Haegeman G (2003) The interplay between the glucocorticoid receptor and nuclear factor-κB or activator protein-1: molecular mechanisms for gene repression. Endocr Rev 24:488–522
15. Digital Briefs (2009) New software and websites for the chemical enterprise. Chem Eng News 87:48
16. Muller CW, Rey FA, Sodeoka M et al (1995) Structure of the NF-kappa B p50 homodimer bound to DNA. Nature 373:311–317
17. Maestro. 7.0 (2004) Schrodinger, LLC, Portland
18. Sterck HD (2013) Steepest descent preconditioning for nonlinear GMRES optimization. Numer Linear Algebra Appl 20:453–471
19. Barzilai JJ, Borwein M (1988) Two-point step size gradient methods. IMA J Numer Anal 8:141–148
20. Lautraite S, Bigot-Lasserre D, Bars R et al (2003) Optimization of cell based assays for medium through screening of oxidative stress. Toxicol Vitro 17:207–220
21. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta CT) method. Methods 25:402–408
22. Mohan CG, Gandhi T, Garg D et al (2007) Computer-assisted methods in chemical toxicity prediction. Mini-Rev Med Chem 7:499–507
23. Poroikov VV, Filimonov DA, Ihlenfeldt WD et al (2003) PASS biological activity spectrum predictions in the enhanced open NCI database browser. J Chem Inf Comput Sci 43:228–236
24. Bonizzi G, Karin M (2004) The two NF-kappa B activation pathways and their role in innate and adaptive immunity. Trends Immunol 25:280–288
25. Karin M, Cao Y, Greten FR et al (2002) NF-kappa B in cancer: from innocent bystander to major culprit. Nat Rev Cancer 2:301–310
26. Jun CD, Choi BM, Kim HM et al (1995) Involvement of protein kinase C during taxol-induced activation of murine peritoneal macrophages. J Immunol 154:6541–6547
27. Corriveau CC, Danner RL (1993) Antiendotoxin therapies for septic shock. Infect Agents Dis 1:44–52
28. Shapira L, Soskolne WA, Houri Y et al (1996) Protection against endotoxic shock and lipopolysaccharide induced local inflammation by tetracycline: correlation with inhibition of cytokine secretion. Infect Immun 64:825–828
29. Janeway CA Jr, Medzhitov R (2002) Innate immune recognition. Annu Rev Immunol 20:197–216
30. Bao HY, Zhang J, Yeo SJ et al (2005) Memory enhancing and neuroprotective effects of selected ginsenosides. Arch Pharm Res 28:335–342
31. Shin YW, Bae EA, Kim DH (2006) Inhibitory effect of ginsenoside Rg5 and its metabolite ginsenoside Rh3 in an oxazolone-induced mouse chronic dermatitis model. Arch Pharm Res 29:685–690
32. Tawab MA, Bahr U, Karas M et al (2003) Degradation of ginsenosides in humans after oral administration. Drug Metab Dispos 31:1065–1107
33. Mukaida N (2000) The roles of cytokine receptors in diseases. Rinsho Byori 48:409–415
34. Song SB, Tung NH, Quang TH et al (2012) Inhibition of TNF-alpha-mediated NF-kappa B transcriptional activity in HepG2 cells by dammarane-type saponins from Panax ginseng leaves. J Ginseng Res 36:146–152
35. Tilg H, Wilmer A, Vogel W et al (1992) Serum levels of cytokines in chronic liver diseases. Gastroenterology 103:264–274
36. Li Q, Verma IM (2002) NF-kappa B regulation in the immune system. Nat Rev Immunol 2:725–734
37. Shibata W, Maeda S, Hikiba Y et al (2007) Cutting edge: the I kappa B kinase (IKK) inhibitor, NEMO-binding domain peptide, blocks inflammatory injury in murine colitis. J Immunol 179:2681–2685
38. Surh YJ, Chun KS, Cha HH et al (2001) Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation. Mutat Res 480–481:243–268