Iodine supplementation decreases hypercholesterolemia in iodine-deficient, overweight women: A randomized controlled trial

Journal of Nutrition

Volumn 145, Issue 9, 2015, Pages 2067-2075

  Herter Aeberli, Isabelle ^a   Cherkaoui, Mohamed ^b   El Ansari, Nawal ^c,d   Rohner, Riccarda ^a   Stinca, Sara ^a   Chabaa, Laila ^d   von Eckardstein, Arnold ^e   Aboussad, Abdelmounaim ^c,d   Zimmermann, Michael B ^a,f  

^a ETH ZURICH   (Switzerland)

^b FACULTÉ DES SCIENCES SEMLALIA   (Morocco)

^c CADI AYYAD UNIVERSITY   (Morocco)

^d CHU Mohammed VI   (Morocco)

^e UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^f Iodine Global Network   (Switzerland)

Author keywords

Cardiovascular disease; Cholesterol; Double burden; Iodine deficiency; Lipid profile; Morocco; Obesity; Subclinical hypothyroidism

Indexed keywords

IODINE; LIOTHYRONINE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLACEBO; THYROGLOBULIN; THYROTROPIN; THYROXINE; GLUCOSE BLOOD LEVEL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN;

ADULT; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; FEMALE; GLUCOSE METABOLISM; HUMAN; HYPERCHOLESTEROLEMIA; INTERVENTION STUDY; IODINE DEFICIENCY; LIOTHYRONINE BLOOD LEVEL; LIPID METABOLISM; MAJOR CLINICAL STUDY; OBESITY; OUTCOME ASSESSMENT; RANDOMIZED CONTROLLED TRIAL; SUPPLEMENTATION; THYROGLOBULIN BLOOD LEVEL; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL; BLOOD; BODY MASS; COMPLICATION; DEFICIENCY; DIET SUPPLEMENTATION; GLUCOSE BLOOD LEVEL; HYPOTHYROIDISM; METABOLISM; MIDDLE AGED; MOROCCO; ORAL DRUG ADMINISTRATION; STATISTICAL MODEL; TREATMENT OUTCOME; YOUNG ADULT;

ADMINISTRATION, ORAL; ADULT; BLOOD GLUCOSE; BODY MASS INDEX; CHOLESTEROL, HDL; CHOLESTEROL, LDL; DIETARY SUPPLEMENTS; FEMALE; HUMANS; HYPERCHOLESTEROLEMIA; HYPOTHYROIDISM; INSULIN; IODINE; LOGISTIC MODELS; MIDDLE AGED; MOROCCO; OBESITY; OVERWEIGHT; THYROGLOBULIN; THYROXINE; TREATMENT OUTCOME; TRIIODOTHYRONINE; YOUNG ADULT;

EID: 84941099050     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.115.213439     Document Type: Article

References (39)

1. Zimmermann MB. Iodine deficiency and endemic cretinism. In: Braverman L, Cooper SC, editors. The thyroid. Philadelphia: Lippincott, Williams & Wilkins; 2013.
2. Chopra IJ, Hershman JM, Hornabrook RW. Serum thyroid hormone and thyrotropin levels in subjects from endemic goiter regions of New Guinea. J Clin Endocrinol Metab 1975;40:326-33.
3. Delange F, Camus M, Ermans AM. Circulating thyroid hormones in endemic goiter. J Clin Endocrinol Metab 1972;34:891-5.
4. Andersson M, Karumbunathan V, Zimmermann MB. Global iodine status in 2011 and trends over the past decade. J Nutr 2012;142:744-50.
5. Papi G, Uberti ED, Betterle C, Carani C, Pearce EN, Braverman LE, Roti E. Subclinical hypothyroidism. Curr Opin Endocrinol Diabetes Obes 2007;14:197-208.
6. Zimmermann MB. Iodine deficiency. Endocr Rev 2009;30:376-408.
7. Pearce EN. Update in lipid alterations in subclinical hypothyroidism. J Clin Endocrinol Metab 2012;97:326-33.
8. Biondi B, Cooper DS. The clinical significance of subclinical thyroid dysfunction. Endocr Rev 2008;29:76-131.
9. Asvold BO, Vatten LJ, Nilsen TIL, Bjoro T. The association between TSH within the reference range and serum lipid concentrations in a populationbased study: the HUNT study. Eur J Endocrinol 2007;156:181-6.
10. Knudsen N, Laurberg P, Rasmussen LB, Bulow I, Perrild H, Ovesen L, Jorgensen T. Small differences in thyroid function may be important for body mass index and the occurrence of obesity in the population. J Clin Endocrinol Metab 2005;90:4019-24.
11. Asvold BO, Bjoro T, Nilsen TIL, Gunnell D, Vatten LJ. Thyrotropin levels and risk of fatal coronary heart disease. Arch Intern Med 2008;168:855-60.
12. Caraccio N, Ferrannini E, Monzani F. Lipoprotein profile in subclinical hypothyroidism: response to levothyroxine replacement, a randomized placebo-controlled study. J Clin Endocrinol Metab 2002;87:1533-8.
13. Monzani F, Caraccio N, Kozakowa M, Dardano A, Vittone F, Virdis A, Taddei S, Palombo C, Ferrannini E. Effect of levothyroxine replacement on lipid profile and intima-media thickness in subclinical hypothyroidism: a double-blind, placebo-controlled study. J Clin Endocrinol Metab 2004;89:2099-106.
14. Razvi S, Ingoe L, Keeka G, Oates C, McMillan C, Weaver JU. The beneficial effect of L-thyroxine on cardiovascular risk factors, endothelial function, and quality of life in subclinical hypothyroidism: randomized, crossover trial. J Clin Endocrinol Metab 2007;92:1715-23.
15. Rönnefarth G, Kauf E, Deschner F, Forberger M. [Therapy of iodine deficiency goiter in adolescents with iodine or a combination of iodine and levothyroxine with special reference to lipid parameters.] Klin Padiatr 1996;208:123-8 (in German).
16. Zimmermann MB, Aeberli I, Melse-Boonstra A, Grimci L, Bridson J, Chaouki N, Mbhenyane X, Jooste PL. Iodine treatment in children with subclinical hypothyroidism due to chronic iodine deficiency decreases thyrotropin and C-peptide concentrations and improves the lipid profile. Thyroid 2009;19:1099-104.
17. Santini F, Marzullo P, Rotondi M, Ceccarini G, Pagano L, Ippolito S, Chiovato L, Biondi B. Mechanisms in endocrinology: the crosstalk between thyroid gland and adipose tissue: signal integration in health and disease. Eur J Endocrinol 2014;171:R137-52.
18. Klop B, Elte JWF, Cabezas MC. Dyslipidemia in obesity: mechanisms and potential targets. Nutrients 2013;5:1218-40.
19. Chaouki N, Ottmani S, Saad A, Hamdaoui ME, Benabdejlil B, Kadiri A. Study on the prevalence of iodine deficiency disorders in children between 6 and 12 years of age in Morocco. Etude de prévalence des troubles dus a la carence iodée chez les enfants agés de 6 a 12 ans au Maroc. Bull Epidemiol 1996;7:2-15 (in French).
20. Benjelloun S. Nutrition transition in Morocco. Public Health Nutr 2002;5: 1A:135-40.
21. Bouhouch RR, Bouhouch S, Cherkaoui M, Aboussad A, Stinca S, Haldimann M, Andersson M, Zimmermann MB. Direct iodine supplementation of infants versus supplementation of their breastfeeding mothers: a double-blind, randomised, placebo-controlled trial. Lancet Diabetes Endocrinol 2014;2:197-209.
22. Pino S, Fang SL, Braverman LE. Ammonium persulfate: a safe alternative oxidizing reagent for measuring urinary iodine. Clin Chem 1996; 42:239-43.
23. Zimmermann MB, Jooste PL, Pandav CS. Iodine-deficiency disorders. Lancet 2008;372:1251-62.
24. Zimmermann MB. Thyroid gland: iodine deficiency and thyroid nodules. Nat Rev Endocrinol 2014;10:707-8.
25. Duntas LH. Environmental factors and thyroid autoimmunity. Ann Endocrinol (Paris) 2011;72:108-13.
26. Garduño-Garcia JJ, Alvirde-Garcia U, Lopez-Carrasco G, Mendoza MEP, Mehta R, Arellano-Campos O, Choza R, Sauque L, Garay-Sevilla ME, Malacara JM, et al. TSH and free thyroxine concentrations are associated with differing metabolic markers in euthyroid subjects. Eur J Endocrinol 2010;163:273-8.
27. Lu L, Wang BB, Shan ZY, Jiang FW, Teng XC, Chen YY, Lai YX, Wang JI, Xue HB, Wang S, et al. The correlation between thyrotropin and dyslipidemia in a population-based study. J Korean Med Sci 2011;26:243-9.
28. Shin DJ, Osborne TF. Thyroid hormone regulation and cholesterol metabolism are connected through sterol regulatory element-binding protein-2 (SREBP-2). J Biol Chem 2003;278:34114-8.
29. Gälman C, Bonde Y, Matasconi M, Angelin B, Rudling M. Dramatically increased intestinal absorption of cholesterol following hypophysectomy is normalized by thyroid hormone. Gastroenterology 2008;134:1127-36.
30. Lam KSL, Chan MK, Yeung RTT. High-density-lipoprotein cholesterol, hepatic lipase and lipoprotein-lipase activities in thyroid-dysfunction-effects of treatment. Q J Med 1986;59:513-21.
31. Danese MD, Ladenson PW, Meinert CL, Powe NR. Effect of thyroxine therapy on serum lipoproteins in patients with mild thyroid failure: a quantitative review of the literature. J Clin Endocrinol Metab 2000; 85:2993-3001.
32. Villar HCCE, Saconato H, Valente O, Atallah AN. Thyroid hormone replacement for subclinical hypothyroidism. Cochrane Database Syst Rev 2007;3:CD003419.
33. Reinehr T, Isa A, de Sousa G, Dieffenbach R, Andler W. Thyroid hormones and their relation to weight status. Horm Res 2008; 70:51-7.
34. Ahima RS, Flier JS. Leptin. Annu Rev Physiol 2000;62:413-37.
35. Ortiga-Carvalho TM, Oliveira KJ, Soares BA, Pazos-Moura CC. The role of leptin in the regulation of TSH secretion in the fed state: in vivo and in vitro studies. J Endocrinol 2002;174:121-5.
36. Menendez C, Baldelli R, Camina JP, Escudero B, Peino R, Dieguez C, Casanueva FF. TSH stimulates leptin secretion by a direct effect on adipocytes. J Endocrinol 2003;176:7-12.
37. Bakker SJL, ter Maaten JC, Popp-Snijders C, Slaets JPJ, Heine RJ, Gans ROB. The relationship between thyrotropin and low density lipoprotein cholesterol is modified by insulin sensitivity in healthy euthyroid subjects. J Clin Endocrinol Metab 2001;86:1206-11.
38. Brenta G, Berg G, Arias P, Zago V, Schnitman M, Muzzio ML, Sinay I, Schreier L. Lipoprotein alterations, hepatic lipase activity, and insulin sensitivity in subclinical hypothyroidism: response to L-T-4 treatment. Thyroid 2007;17:453-60.
39. Pearce EN, Andersson M, Zimmermann MB. Global iodine nutrition: where do we stand in 2013? Thyroid 2013;23:523-8.