메뉴 건너뛰기




Volumn 43, Issue 2, 2015, Pages 1056-1068

Human PrimPol is a highly error-prone polymerase regulated by single-stranded DNA binding proteins

Author keywords

[No Author keywords available]

Indexed keywords

CYCLINE; DNA BINDING PROTEIN; DNA DIRECTED DNA POLYMERASE; DNA PRIMASE; MITOCHONDRIAL PROTEIN; MULTIFUNCTIONAL ENZYME; PRIMER DNA; PRIMPOL PROTEIN, HUMAN; REPLICATION FACTOR A; SSBP1 PROTEIN, HUMAN;

EID: 84941038735     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gku1321     Document Type: Article
Times cited : (89)

References (46)
  • 1
    • 39449096135 scopus 로고    scopus 로고
    • Genome instability: A mechanistic view of its causes and consequences
    • Aguilera, A., Gómez-González, B. (2008) Genome instability: a mechanistic view of its causes and consequences. Nat. Rev. Genet., 9, 204-217.
    • (2008) Nat. Rev. Genet , vol.9 , pp. 204-217
    • Aguilera, A.1    Gómez-González, B.2
  • 2
    • 84857411787 scopus 로고    scopus 로고
    • Y-family DNA polymerases and their role in tolerance of cellular DNA damage
    • Sale, J.E., Lehmann, A.R., Woodgate, R. (2012) Y-family DNA polymerases and their role in tolerance of cellular DNA damage. Nat. Rev. Mol. Cell Biol., 13, 141-152.
    • (2012) Nat. Rev. Mol. Cell Biol , vol.13 , pp. 141-152
    • Sale, J.E.1    Lehmann, A.R.2    Woodgate, R.3
  • 3
    • 38049173021 scopus 로고    scopus 로고
    • Homologous recombination in DNA repair and DNA damage tolerance
    • Li, X., Heyer, W.-D. (2008) Homologous recombination in DNA repair and DNA damage tolerance. Cell Res., 18, 99-113.
    • (2008) Cell Res , vol.18 , pp. 99-113
    • Li, X.1    Heyer, W.-D.2
  • 4
    • 31844456472 scopus 로고    scopus 로고
    • Replication fork reactivation downstream of a blocked nascent leading strand
    • Heller, R.C., Marians, K.J. (2006) Replication fork reactivation downstream of a blocked nascent leading strand. Nature, 439, 557-562.
    • (2006) Nature , vol.439 , pp. 557-562
    • Heller, R.C.1    Marians, K.J.2
  • 5
    • 19444383801 scopus 로고    scopus 로고
    • Trading places: How do DNA polymerases switch during translesion DNA synthesis
    • Friedberg, E.C., Lehmann, A.R., Fuchs, R.P. (2005) Trading places: how do DNA polymerases switch during translesion DNA synthesis Mol. Cell, 18, 499-505.
    • (2005) Mol Cell , vol.18 , pp. 499-505
    • Friedberg, E.C.1    Lehmann, A.R.2    Fuchs, R.P.3
  • 6
    • 84945221802 scopus 로고    scopus 로고
    • PrimPol-a new polymerase on the block
    • Rudd, S.G., Bianchi, J., Doherty, A.J. (2014) PrimPol-a new polymerase on the block. Mol. Cell. Oncol., E960754. doi:10.4161/23723548.2014.960754.
    • (2014) Mol. Cell. Oncol. , pp. E960754
    • Rudd, S.G.1    Bianchi, J.2    Doherty, A.J.3
  • 8
    • 84888156088 scopus 로고    scopus 로고
    • PPL2 translesion polymerase is essential for the completion of chromosomal DNA replication in the African Trypanosome
    • Rudd, S.G., Glover, L., Jozwiakowski, S.K., Horn, D., Doherty, A.J. (2013) PPL2 translesion polymerase is essential for the completion of chromosomal DNA replication in the African Trypanosome. Mol. Cell, 52, 554-565.
    • (2013) Mol. Cell , vol.52 , pp. 554-565
    • Rudd, S.G.1    Glover, L.2    Jozwiakowski, S.K.3    Horn, D.4    Doherty, A.J.5
  • 9
    • 84889093850 scopus 로고    scopus 로고
    • HPrimpol1/CCDC111 is a human DNA primase-polymerase required for the maintenance of genome integrity
    • Wan, L., Lou, J., Xia, Y., Su, B., Liu, T., Cui, J., Sun, Y., Lou, H., Huang, J. (2013) hPrimpol1/CCDC111 is a human DNA primase-polymerase required for the maintenance of genome integrity. EMBO Rep., 14, 1104-1112.
    • (2013) EMBO Rep , vol.14 , pp. 1104-1112
    • Wan, L.1    Lou, J.2    Xia, Y.3    Su, B.4    Liu, T.5    Cui, J.6    Sun, Y.7    Lou, H.8    Huang, J.9
  • 10
    • 84888205939 scopus 로고    scopus 로고
    • PrimPol, an archaic primase/polymerase operating in human cells
    • Garcia-Gomez, S., Reyes, A., Martńez-Jiménez, M.I., Chocrón, E.S., Mourón, S., Terrados, G., Powell, C., Salido, E., Mendez, J., Holt, I.J. et al. (2013) PrimPol, an archaic primase/polymerase operating in human cells. Mol. Cell, 52, 541-553.
    • (2013) Mol. Cell , vol.52 , pp. 541-553
    • Garcia-Gomez, S.1
  • 11
    • 84901325632 scopus 로고    scopus 로고
    • Molecular dissection of the domain architecture and catalytic activities of human PrimPol
    • Keen, B.A., Jozwiakowski, S.K., Bailey, L.J., Bianchi, J., Doherty, A.J. (2014) Molecular dissection of the domain architecture and catalytic activities of human PrimPol. Nucleic Acids Res., 42, 5830-5845.
    • (2014) Nucleic Acids Res , vol.42 , pp. 5830-5845
    • Keen, B.A.1    Jozwiakowski, S.K.2    Bailey, L.J.3    Bianchi, J.4    Doherty, A.J.5
  • 12
    • 0030848209 scopus 로고    scopus 로고
    • Role of protein-protein interactions in the function of replication protein A (RPA): RPA modulates the activity of DNA polymerase alpha by multiple mechanisms
    • Braun, K.A., Lao, Y., He, Z., Ingles, C.J., Wold, M.S. (1997) Role of protein-protein interactions in the function of replication protein A (RPA): RPA modulates the activity of DNA polymerase alpha by multiple mechanisms. Biochemistry, 36, 8443-8454.
    • (1997) Biochemistry , vol.36 , pp. 8443-8454
    • Braun, K.A.1    Lao, Y.2    He, Z.3    Ingles, C.J.4    Wold, M.S.5
  • 13
    • 0024851541 scopus 로고
    • Multiple replication factors augment DNA synthesis by the two eukaryotic DNA polymerases,and
    • Toshiki, T., Stillman, B. (1989) Multiple replication factors augment DNA synthesis by the two eukaryotic DNA polymerases,-and-. EMBO J., 8, 3883-3889.
    • (1989) EMBO J , vol.8 , pp. 3883-3889
    • Toshiki, T.1    Stillman, B.2
  • 14
    • 78149459202 scopus 로고    scopus 로고
    • Functional roles of the N-and C-terminal regions of the human mitochondrial single-stranded DNA-binding protein
    • Oliveira, M.T., Kaguni, L.S. (2010) Functional roles of the N-and C-terminal regions of the human mitochondrial single-stranded DNA-binding protein. PLoS ONE, 5, e15379. doi:10.1371/journal.pone.0015379.
    • (2010) PLoS ONE , vol.5 , pp. e15379
    • Oliveira, M.T.1    Kaguni, L.S.2
  • 15
    • 0033434080 scopus 로고    scopus 로고
    • Probability-based protein identification by searching sequence databases using mass spectrometry data
    • Perkins, D.N., Pappin, D.J.C., Creasy, D.M., Cottrell, J.S. (1999) Probability-based protein identification by searching sequence databases using mass spectrometry data. Electrophoresis, 20, 3551-3567.
    • (1999) Electrophoresis , vol.20 , pp. 3551-3567
    • Perkins, D.N.1    Pappin, D.J.C.2    Creasy, D.M.3    Cottrell, J.S.4
  • 16
    • 0037108887 scopus 로고    scopus 로고
    • Empirical statistical model to estimate the accuracy of peptide identifications made by MS/MS and database search
    • Keller, A., Nesvizhskii, A.I., Kolker, E., Aebersold, R. (2002) Empirical statistical model to estimate the accuracy of peptide identifications made by MS/MS and database search. Anal. Chem., 74, 5383-5392.
    • (2002) Anal. Chem , vol.74 , pp. 5383-5392
    • Keller, A.1    Nesvizhskii, A.I.2    Kolker, E.3    Aebersold, R.4
  • 17
    • 36749059976 scopus 로고    scopus 로고
    • Dynamics of human replication factors in the elongation phase of DNA replication
    • Masuda, Y., Suzuki, M., Piao, J., Gu, Y., Tsurimoto, T., Kamiya, K. (2007) Dynamics of human replication factors in the elongation phase of DNA replication. Nucleic Acids Res., 35, 6904-6916.
    • (2007) Nucleic Acids Res , vol.35 , pp. 6904-6916
    • Masuda, Y.1    Suzuki, M.2    Piao, J.3    Gu, Y.4    Tsurimoto, T.5    Kamiya, K.6
  • 18
    • 70349766074 scopus 로고    scopus 로고
    • Preparation of human mitochondrial single-stranded DNA-binding protein
    • Longley, M.J., Smith, L.A., Copeland, W.C. (2009) Preparation of human mitochondrial single-stranded DNA-binding protein. Methods Mol. Biol., 554, 73-85.
    • (2009) Methods Mol. Biol , vol.554 , pp. 73-85
    • Longley, M.J.1    Smith, L.A.2    Copeland, W.C.3
  • 19
    • 0025633829 scopus 로고
    • Purification of Thermus aquaticus DNA polymerase expressed in Escherichia coli
    • Engelke, D.R., Krikos, A., Bruck, M.E., Ginsburg, D. (1990). Purification of Thermus aquaticus DNA polymerase expressed in Escherichia coli. Anal. Biochem., 191, 396-400.
    • (1990) Anal. Biochem , vol.191 , pp. 396-400
    • Engelke, D.R.1    Krikos, A.2    Bruck, M.E.3    Ginsburg, D.4
  • 20
    • 0034160088 scopus 로고    scopus 로고
    • Improving dideoxynucleotidetriphosphate utilisation by the hyper-thermophilic DNA polymerase from Pyrococcus furiosus
    • Evans, S.J., Fogg, M.J., Mamone, A., Davis, M., Pearl, L.H., Connolly, B.A. (2000) Improving dideoxynucleotidetriphosphate utilisation by the hyper-thermophilic DNA polymerase from Pyrococcus furiosus. Nucleic Acids Res., 28, 1059-1066.
    • (2000) Nucleic Acids Res , vol.28 , pp. 1059-1066
    • Evans, S.J.1    Fogg, M.J.2    Mamone, A.3    Davis, M.4    Pearl, L.H.5    Connolly, B.A.6
  • 23
    • 84870717515 scopus 로고    scopus 로고
    • A plasmid-based lacZ gene assay for DNA polymerase fidelity measurement
    • Keith, B.J., Jozwiakowski, S.K., Connolly, B.A. (2012) A plasmid-based lacZ gene assay for DNA polymerase fidelity measurement. Anal. Biochem., 433, 153-161.
    • (2012) Anal. Biochem , vol.433 , pp. 153-161
    • Keith, B.J.1    Jozwiakowski, S.K.2    Connolly, B.A.3
  • 24
    • 39149094942 scopus 로고    scopus 로고
    • DNA polymerase kappa produces interrupted mutations and displays polar pausing within mononucleotide microsatellite sequences
    • Hile, S.E., Eckert, K.A. (2008) DNA polymerase kappa produces interrupted mutations and displays polar pausing within mononucleotide microsatellite sequences. Nucleic Acids Res., 36, 688-696.
    • (2008) Nucleic Acids Res , vol.36 , pp. 688-696
    • Hile, S.E.1    Eckert, K.A.2
  • 25
    • 0037143581 scopus 로고    scopus 로고
    • Misalignment-mediated DNA polymerase beta mutations: Comparison of microsatellite and frame-shift error rates using a forward mutation assay
    • Eckert, K.A., Mowery, A., Hile, S.E. (2002) Misalignment-mediated DNA polymerase beta mutations: comparison of microsatellite and frame-shift error rates using a forward mutation assay. Biochemistry, 41, 10490-10498.
    • (2002) Biochemistry , vol.41 , pp. 10490-10498
    • Eckert, K.A.1    Mowery, A.2    Hile, S.E.3
  • 26
    • 0034687093 scopus 로고    scopus 로고
    • Hydrophobic interactions in the hinge domain of DNA polymerase B are important but not sufficient for maintaining fidelity of DNA synthesis
    • Opresko, P.L., Shiman, R., Eckert, K.A. (2000) Hydrophobic interactions in the hinge domain of DNA polymerase B are important but not sufficient for maintaining fidelity of DNA synthesis. Biochemistry, 39, 11399-11407.
    • (2000) Biochemistry , vol.39 , pp. 11399-11407
    • Opresko, P.L.1    Shiman, R.2    Eckert, K.A.3
  • 28
    • 29444454665 scopus 로고    scopus 로고
    • Ubiquitinated proliferating cell nuclear antigen activates translesion DNA polymerases eta and REV1
    • Garg, P., Burgers, P.M. (2005) Ubiquitinated proliferating cell nuclear antigen activates translesion DNA polymerases eta and REV1. Proc. Natl. Acad. Sci. U.S.A., 102, 18361-18366.
    • (2005) Proc. Natl. Acad. Sci. U.S.A , vol.102 , pp. 18361-18366
    • Garg, P.1    Burgers, P.M.2
  • 29
    • 0029865819 scopus 로고    scopus 로고
    • Interaction between the strep-tag affinity peptide and its cognate target streptavidin
    • Schmidt, T.G., Koepke, J., Frank, R., Skerra, A. (1996) Interaction between the strep-tag affinity peptide and its cognate target, streptavidin. J. Mol. Biol., 255, 753-766.
    • (1996) J. Mol. Biol , vol.255 , pp. 753-766
    • Schmidt, T.G.1    Koepke, J.2    Frank, R.3    Skerra, A.4
  • 30
    • 0030780364 scopus 로고    scopus 로고
    • Mutagenesis of a flexible loop in streptavidin leads to higher affinity for the Strep-tag II peptide and improved performance in recombinant protein purification
    • Voss, S., Skerra, A. (1997) Mutagenesis of a flexible loop in streptavidin leads to higher affinity for the Strep-tag II peptide and improved performance in recombinant protein purification. Protein Eng. Design Selection, 10, 975-982.
    • (1997) Protein Eng. Design Selection , vol.10 , pp. 975-982
    • Voss, S.1    Skerra, A.2
  • 32
    • 61449172037 scopus 로고    scopus 로고
    • Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
    • Huang, D.W., Sherman, B.T., Lempicki, R.A. (2008). Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat. Protoc., 4, 44-57.
    • (2008) Nat. Protoc , vol.4 , pp. 44-57
    • Huang, D.W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 33
    • 0026058311 scopus 로고
    • Effects of T antigen and replication protein A on the initiation of DNA synthesis by DNA polymerase-primase
    • Collins, K.L., Kelly, T.J. (1991) Effects of T antigen and replication protein A on the initiation of DNA synthesis by DNA polymerase-primase. Mol. Cell Biol., 11, 2108-2115.
    • (1991) Mol. Cell Biol , vol.11 , pp. 2108-2115
    • Collins, K.L.1    Kelly, T.J.2
  • 34
    • 18244371925 scopus 로고    scopus 로고
    • Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint
    • Byun, T.S., Pacek, M., Yee, M.C., Walter, J.C., Cimprich, K.A. (2005) Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint. Genes Dev., 19, 1040-1052.
    • (2005) Genes Dev , vol.19 , pp. 1040-1052
    • Byun, T.S.1    Pacek, M.2    Yee, M.C.3    Walter, J.C.4    Cimprich, K.A.5
  • 35
    • 34249870372 scopus 로고    scopus 로고
    • 8-oxo-guanine bypass by human DNA polymerases in the presence of auxiliary proteins
    • Maga, G., Villani, G., Crespan, E., Wimmer, U., Ferrari, E., Bertocci, B., Hübscher, U. (2007) 8-oxo-guanine bypass by human DNA polymerases in the presence of auxiliary proteins. Nat. Lett., 447, 606-608.
    • (2007) Nat. Lett , vol.447 , pp. 606-608
    • Maga, G.1    Villani, G.2    Crespan, E.3    Wimmer, U.4    Ferrari, E.5    Bertocci, B.6    Hübscher, U.7
  • 36
    • 84890105942 scopus 로고    scopus 로고
    • Repriming of DNA synthesis at stalled replication forks by human PrimPol
    • Mourón, S., Rodriguez-Acebes, S., Martńez-Jiménez, M., Garcá-Gómez, S., Chocrón, S., Blanco, L., Méndez, J. (2013) Repriming of DNA synthesis at stalled replication forks by human PrimPol. Nat. Struct. Mol. Biol., 20, 1383-1389.
    • (2013) Nat. Struct. Mol. Biol , vol.20 , pp. 1383-1389
    • Mourón, S.1
  • 37
    • 84922557556 scopus 로고    scopus 로고
    • An archaeal family-B DNA polymerase variant able to replicate past DNA damage: Occurrence of replicative and translesion synthesis polymerases within B family
    • Jozwiakowski, S.K., Keith, B.J., Gilroy, L., Doherty, A.J., Connolly, B.A. (2014) An archaeal family-B DNA polymerase variant able to replicate past DNA damage: occurrence of replicative and translesion synthesis polymerases within B family. Nucleic Acids Res., 42, 9949-9963.
    • (2014) Nucleic Acids Res , vol.42 , pp. 9949-9963
    • Jozwiakowski, S.K.1    Keith, B.J.2    Gilroy, L.3    Doherty, A.J.4    Connolly, B.A.5
  • 38
    • 23844522523 scopus 로고    scopus 로고
    • Saccharomyces cerevisiae DNA polymerase high fidelity for base substitutions but lower fidelity for single-and multi-base deletions
    • Fortune, J.M., Pavlov, Y.I., Welch, C.M., Johansson, E., Burgers, P.M., Kunkel, T.A. (2005) Saccharomyces cerevisiae DNA polymerase-high fidelity for base substitutions but lower fidelity for single-and multi-base deletions. J. Biol. Chem., 280, 29980-29987.
    • (2005) J. Biol. Chem , vol.280 , pp. 29980-29987
    • Fortune, J.M.1    Pavlov, Y.I.2    Welch, C.M.3    Johansson, E.4    Burgers, P.M.5    Kunkel, T.A.6
  • 41
    • 84905457336 scopus 로고    scopus 로고
    • Microsatellite interruptions stabilize primate genomes and exist as population-specific single nucleotide polymorphisms within individual human genomes
    • Ananda, G., Hile, S.E., Breski, A., Wang, Y., Kelkar, Y., Makova, K.D., Eckert, K.A. (2014) Microsatellite interruptions stabilize primate genomes and exist as population-specific single nucleotide polymorphisms within individual human genomes. PLoS Genet., 10, e1004498.
    • (2014) PLoS Genet , vol.10 , pp. e1004498
    • Ananda, G.1    Hile, S.E.2    Breski, A.3    Wang, Y.4    Kelkar, Y.5    Makova, K.D.6    Eckert, K.A.7
  • 42
    • 84868672661 scopus 로고    scopus 로고
    • DNA polymerase kappa microsatellite synthesis: Two distinct mechanisms of slippage-mediated errors
    • Baptiste, B.A., Eckert, K.A. (2012) DNA polymerase kappa microsatellite synthesis: two distinct mechanisms of slippage-mediated errors. Environ. Mol. Mutagen., 53, 787-796.
    • (2012) Environ. Mol. Mutagen , vol.53 , pp. 787-796
    • Baptiste, B.A.1    Eckert, K.A.2
  • 43
    • 0024852589 scopus 로고
    • Multiple functions of human single-stranded DNA binding protein insimian virus 40 DNA replication: Single strand stabilization and stimulation of DNA polymerases alpha and delta
    • Kenny, M.K., Lee, S.-H., Hurwitz, J. (1989) Multiple functions of human single-stranded DNA binding protein insimian virus 40 DNA replication: single strand stabilization and stimulation of DNA polymerases alpha and delta. Proc. Natl. Acad. Sci. U.S.A., 86, 9757-9761.
    • (1989) Proc. Natl. Acad. Sci. U.S.A , vol.86 , pp. 9757-9761
    • Kenny, M.K.1    Lee, S.-H.2    Hurwitz, J.3
  • 44
    • 84875823810 scopus 로고    scopus 로고
    • RecA acts as a switch to regulate polymerase occupancy in a moving replication fork
    • Indiani, C., Patel, M., Goodman, M. F., O'Donnell, M.E. (2013) RecA acts as a switch to regulate polymerase occupancy in a moving replication fork. Proc. Natl. Acad. Sci., 110, 5410-5415.
    • (2013) Proc. Natl. Acad. Sci , vol.110 , pp. 5410-5415
    • Indiani, C.1    Patel, M.2    Goodman, M.F.3    O'Donnell, M.E.4
  • 45
    • 84864034189 scopus 로고    scopus 로고
    • Interaction between Escherichia coli DNA polymerase IV and single-stranded DNA-binding protein is required for DNA synthesis on SSB-coated DNA
    • Furukohri, A., Nishikawa, Y., Akiyama, M.T., Maki, H. (2012) Interaction between Escherichia coli DNA polymerase IV and single-stranded DNA-binding protein is required for DNA synthesis on SSB-coated DNA. Nucleic Acids Res., 40, 6039-6048.
    • (2012) Nucleic Acids Res , vol.40 , pp. 6039-6048
    • Furukohri, A.1    Nishikawa, Y.2    Akiyama, M.T.3    Maki, H.4
  • 46
    • 8644285427 scopus 로고    scopus 로고
    • Idling by DNA polymerasemaintains a ligatable nick during lagging-strand DNA replication
    • Garg, P., Stith, C.M., Sabouri, N., Johansson, E., Burgers, P.M. (2004) Idling by DNA polymerase-maintains a ligatable nick during lagging-strand DNA replication. Genes Dev., 18, 2764-2773.
    • (2004) Genes Dev , vol.18 , pp. 2764-2773
    • Garg, P.1    Stith, C.M.2    Sabouri, N.3    Johansson, E.4    Burgers, P.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.