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Volumn 16, Issue 17, 2015, Pages 2041-2044
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Bottom-up design of small molecules that stimulate exon 10 skipping in mutant MAPT pre-mRNA
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Author keywords
chemical biology; drug design; mRNA; nucleic acids; small molecules
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Indexed keywords
FIREFLY LUCIFERASE;
LIGAND;
MESSENGER RNA;
MESSENGER RNA PRECURSOR;
MUTANT PROTEIN;
SMALL MOLECULE;
SMALL NUCLEAR RIBONUCLEOPROTEIN;
TAU PROTEIN;
UNCLASSIFIED DRUG;
MAPT PROTEIN, HUMAN;
MOLECULAR LIBRARY;
RNA PRECURSOR;
ARTICLE;
BINDING AFFINITY;
CALCULATION;
CHROMOSOME 17;
CONTROLLED STUDY;
DRUG DESIGN;
DRUG IDENTIFICATION;
DRUG PROTEIN BINDING;
DRUG SELECTIVITY;
DRUG TARGETING;
ENZYME ACTIVITY;
EXON SKIPPING;
FRONTOTEMPORAL DEMENTIA;
GENE MUTATION;
HUMAN;
HUMAN CELL;
INTRON;
MOLECULAR INTERACTION;
NONHUMAN;
PARKINSONISM;
PRIORITY JOURNAL;
PROTEIN EXPRESSION;
PROTEIN FOLDING;
PROTEIN STABILITY;
PROTEIN SYNTHESIS;
RNA HAIRPIN;
RNA SPLICING;
RNA STABILITY;
RNA STRUCTURE;
SINGLE NUCLEOTIDE POLYMORPHISM;
THERMOSTABILITY;
CHEMISTRY;
DRUG EFFECTS;
EXON;
GENETICS;
MOLECULAR LIBRARY;
MUTATION;
PARKINSONIAN DISORDERS;
PHARMACOLOGY;
DRUG DESIGN;
EXONS;
HUMANS;
MUTATION;
PARKINSONIAN DISORDERS;
RNA PRECURSORS;
RNA, MESSENGER;
SMALL MOLECULE LIBRARIES;
TAU PROTEINS;
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EID: 84941027886
PISSN: 14394227
EISSN: 14397633
Source Type: Journal
DOI: 10.1002/cbic.201402069 Document Type: Article |
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Times cited : (34)
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References (20)
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