Development and optimisation of mucoadhesive nanoparticles of acyclovir using design of experiments approach

Journal of Microencapsulation

Volumn 32, Issue 6, 2015, Pages 521-532

  Kharia, Ankit Anand ^a,b   Singhai, Akhlesh Kumar ^b,c  

^a ORIENTAL COLLEGE OF PHARMACY   (India)

^b UTTARAKHAND TECHNICAL UNIVERSITY   (India)

^c Lakshmi Narain College of Pharmacy   (India)

Author keywords

Acyclovir; Central composite design; Gastoretention; Gelatin; Mucoadhesion; Pharmacokinetics

Indexed keywords

ACICLOVIR; NANOPARTICLE; ANTIVIRUS AGENT; DELAYED RELEASE FORMULATION; DRUG CARRIER; GELATIN; POLOXAMER; TABLET;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DELIVERY SYSTEM; DRUG HALF LIFE; DRUG RELEASE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; MALE; MEAN RESIDENCE TIME; MUCOADHESION; NONHUMAN; PARTICLE SIZE; PLASMA CONCENTRATION-TIME CURVE; RAT; RESPONSE SURFACE METHOD; TABLET FORMULATION; TIME TO MAXIMUM PLASMA CONCENTRATION; VOLUME OF DISTRIBUTION; ANIMAL; BIOAVAILABILITY; CHEMISTRY; DELAYED RELEASE FORMULATION; NANOMEDICINE; ORAL DRUG ADMINISTRATION; PRECLINICAL STUDY; PROCEDURES; TABLET; WISTAR RAT;

ACYCLOVIR; ADMINISTRATION, ORAL; ANIMALS; ANTIVIRAL AGENTS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; DRUG EVALUATION, PRECLINICAL; GELATIN; MALE; NANOMEDICINE; NANOPARTICLES; PARTICLE SIZE; POLOXAMER; RATS; RATS, WISTAR; TABLETS;

EID: 84940960688     PISSN: 02652048     EISSN: 14645246     Source Type: Journal    
DOI: 10.3109/02652048.2015.1010457     Document Type: Article

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