Design and optimization of floating drug delivery system of acyclovir

Indian Journal of Pharmaceutical Sciences

Volumn 72, Issue 5, 2010, Pages 599-606

  Kharia, A A ^a   Hiremath, S N ^b   Singhai, A K ^c   Omray, L K ^d   Jain, S K ^e  

^a ORIENTAL COLLEGE OF PHARMACY   (India)

^b PRES'S College of Pharmacy   (India)

^c Lakshmi Narain College of Pharmacy   (India)

^d Sagar Institute of Pharmaceutical Sciences   (India)

^e GURU GHASIDAS UNIVERSITY   (India)

Author keywords

Acyclovir; factorial design; gastro retentive drug delivery; hydroxypropylmethylcellulose; psyllium husk

Indexed keywords

ACICLOVIR; BICARBONATE; HYDROXYPROPYLMETHYLCELLULOSE; POLYMER; PSYLLIUM HUSK; UNCLASSIFIED DRUG;

ARTICLE; DEPENDENT VARIABLE; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG FORMULATION; DRUG GRANULATION; DRUG RELEASE; DRUG SOLUBILITY; FACTORIAL DESIGN; HIGUCHI KINETICS; INDEPENDENT VARIABLE; KINETICS; TABLET FRIABILITY; TABLET HARDNESS; VALIDITY; WEIGHT;

EID: 79955115764     PISSN: 0250474X     EISSN: 19983743     Source Type: Journal    
DOI: 10.4103/0250-474X.78527     Document Type: Article

References (24)

1. Patil JM, Hirlekar RS, Gide PS, Kadam VJ. Trends in fl oating drug delivery systems. J Sci Ind Res 2006;65:11-21. (Pubitemid 43085756)
2. Kumar R, Philip A. Gastroretentive dosage forms for prolonging gastric residence time. Int J Pharm Med 2007;21:157-71. (Pubitemid 46715476)
3. Arora S, Ali J, Ahuja A, Khar RK, Baboota S. Floating drug delivery systems: A Review. AAPS PharmSciTech 2005;06:E372-90.
4. Jain SK, Awasthi AM, Jain NK, Agrawal GP. Calcium Silicate Based Microspheres of Repaglinide for Gastroretentive Floating Drug Delivery: Preparation and In vitro Characterization. J Control Release 2005;107:300-9. (Pubitemid 41316292)
5. Jain SK, Agrawal GP, Jain NK. Evaluation of porous carrier-based floating microspheres for gastric delivery. AAPS PharmSciTech 2006;7:E1-7.
6. Sweetman SC editor. Martindale: The Complete Drug Reference. 33rd ed. London: Pharmaceutical Press; 2002. p. 612.
7. Groning R, Berntgen M, Geogarakis M. Acyclovir serum concentrations following peroral administration of magnetic depot tablets and the infl uence of extra corporal magnet to control gastrointestinal transit. Eur J Pharm Biopharm 1996;46:285-91. (Pubitemid 29057675)
8. Lewis L, Fowle A, Bittiner S, Bye A, Isaacs P. Human gastrointestinal absorption of acyclovir from tablet, duodenal infusion and sipped solution. Br J Clin Pharmacol 1986;21:459-62. (Pubitemid 17173267)
9. Vergin H, Kikuta C, Mascher H, Metz R. Pharmacokinetics and bioavailability of different formulations of acyclovir. Arzneim Forsch 1995;45:508-15.
10. Belgamwar VS, Surana SJ. Floating bioadhesive drug delivery system using novel effervescent agents. Asian J Pharm 2009;2:156-60.
11. Rao BP, Kottan NA, Snehith VS, Ramesh C. Development of gastroretentive drug delivery system of cephalexin by using factorial design. Ars Pharma 2009;50:8-23.
12. Prajapati ST, Patel LD, Patel DM. Studies on formulation and in vitro evaluation of fl oating matrix tablet of domperidone. Indian J Pharm Sci 2009;71:19-23.
13. Shoufeng L, Senshang L, Chein YW, Daggy BP, Mirchandani HL. Statistical optimization of gastric fl oating system for oral controlled delivery of calcium. AAPS PharmSciTech 2001;2:1-12.
14. Gohel MC, Parikh RK, Amin AF, Surati AK. Preparation and formulation optimization of sugar crosslinked gelatin microspheres of diclofenac sodium. Indian J Pharm Sci 2005;67:575-81.
15. Chavanpatil MD, Jain P, Chaudhari S, Shear R, Vavia PR. Development of sustained release gastrorentantive drug delivery system for ofl oxacin: in vitro and in vivo evaluation. Int J Pharm 2005;304:178-84. (Pubitemid 41427660)
16. Siber BM, Bialer M, Yacobi A. Pharmacokinetic/phamacodynamic basis of controlled drug delivery. In: Robinson JR, Lee VHL, editors. Controlled drug delivery fundamentals and applications. 2nd ed. New York: Marcel Dekker Inc; 2005. p. 213-51.
17. Notari RE. Biopharmaceutics and clinical pharmacokinetics. 4th ed. New York: Marcel Dekker Inc; 1987. p. 6-21.
18. Higuchi T. Mechanism of sustained-action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices. J Pharm Sci 1963;51:1145-9.
19. Peppas NA. Analysis of Fickian and non-Fickian drug release from polymers. Pharm Acta Helv 1985;60:110-1.
20. Dave BS, Amin AE, Patel MM. Gastroretentive drug delivery system of ranitidine HCl: Formulation and in vitro evaluation. AAPS PharmSciTech 2004;5:E34.
21. Patel VF, Patel NM. Intragastric floating drug delivery system of cefuroxime axetil: in vitro evaluation. AAPS PharmSciTech 2006;7:E17.
22. Dortunc B, Gunal N. Release of acetazolamide from swellable Hydroxypropylmethylcellulose matrix tablets. Drug Dev Ind Pharm 1997;23:1245-9. (Pubitemid 28030028)
23. Bolton S, Bon C. Pharmaceutical statistics: Practical and clinical applications. 4th ed. New York: Marcel Dekker Inc; 2004. p. 506-39.
24. Schwartz JB, Connor RE, Schnaare RL. Optimization techniques in pharmaceutical formulation and processing. In: Banker GS, Rhodes CT, editors. Modern pharmaceutics. 4th ed. New York: Marcel Dekker Inc; 2002. p. 607-26.