Indomethacin-loaded microspheres: Preparation, characterization and in-vitro evaluation regarding ethylcellulose matrix material

Turkish Journal of Pharmaceutical Sciences

Volumn 5, Issue 3, 2008, Pages 129-141

  Yüce, Meral ^a   Canefe, Kandemir ^b  

^a Eczaciba i Zentiva Health Products Co   (Turkey)

^b ANKARA UNIVERSITY   (Turkey)

Author keywords

Emulsion solvent evaporation technique; Ethylcellulose; Indomethacin; Microspheres; Modified release

Indexed keywords

ETHYL CELLULOSE; INDOMETACIN; MICROSPHERE; POLYMER; SURFACTANT;

ARTICLE; DRUG RELEASE; EXTRACELLULAR MATRIX; FLOW RATE; IN VITRO STUDY; PARTICLE SIZE; TOPOGRAPHY; VISCOSITY;

EID: 68149091882     PISSN: 1304530X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. AHFS Drug Information, pp. 1991-2001, 2005.
2. Nokhodchi, A., Javadzadeh, Y., Siahi-Shadbad, M.R., Barzegar-Jalali, M., "The effect of type and concentration of vehicles on the dissolution rate of a poorly soluble drug (indomethacin) from liquisolid compacts" J. Pharm. Sci., 8(1), 18-25, 2005. (Pubitemid 41528866)
3. Bakan, J.A., Powell, T.C., Szotak, P.S., Recent advances in microencapsulation of drugs to obtain reduced gastric irritation. in: Microcapsules and Nanoparticles in Medicine and Pharmacy, Ed: M. Donbrow, Chapter 10, CRC Press, 1992.
4. Uzunkaya, G., Bergisadi, N., "In vitro drug liberation and kinetics of sustained release indomethacin suppository" Il. Farmaco., 58, 509-512, 2003. (Pubitemid 36765351)
5. Amperiadou, A., Georgarakis, M., "Controlled release salbutamol sulphate microcapsules prepared by emulsion solvent-evaporation technique and study on the release affected parameters" Int. J. Pharm., 115, 1-8, 1995.
6. Wu, P-C., Huang, Y-B., Chang, J-S., Tsai, M-I., Tsai, Y-H., "Design and evaluation of sustained release microspheres of potassium chloride prepared by Eudragit® " Eur. J. Pharm. Sci., 19(2-3), 115-122, 2003. (Pubitemid 36668037)
7. The United States Pharmacopoeia 28-The National Pharmacopoeia 23, The United States Pharmacopoeial Convention, Inc., 2005.
8. Torrado-Duran, J.J., Torrado-Valeiras, J.J., Cadorniga, R., "Microaggregated egg albumin particles containing paracetamol for tableting processes" Drug Dev. Ind. Pharm., 17(10), 1305-1323, 1991.
9. The Merck Index, 13th Edition, Merck&Co., Inc., 2001.
10. Streubel, A., Siepmann, J., Bodmeier, R., "Floating microparticles based on low density foam powder" Int. J. Pharm., 241(2), 279-292, 2002. (Pubitemid 34718029)
11. Malamataris, S., Avgerinos, A., "Controlled release indomethacin microspheres prepared by using an emulsion solvent-diffusion technique" Int. J. Pharm., 62, 105-111, 1990. (Pubitemid 20261779)
12. Haznedar, S., Dortunç, B., "Preparation and in vitro evaluation of Eudragit microspheres containing acetazolamide" Int. J. Pharm., 269(1), 131-140, 2004. (Pubitemid 38032830)
13. Hanna, S. A., Stability- Kinetics. in: Pharmaceutical Dosage Forms: Tablets, Eds: H. A. Lieberman, L. Lachman, Vol.3, pp. 339-366, Marcel Dekker, Inc., New York, 1982.
14. Stavchansky, S. A., McGinity, J. W., Dissolution: Theory and Practice. in: Pharmaceutical Dosage Forms: Tablets, Eds: H. A. Lieberman, L. Lachman, J. B. Schwartz, Vol.2, pp. 393-403, 2nd Edition, Revised and Expanded, Marcel Dekker, Inc., New York, 1990.
15. Langenbucher, F., "Parametric represantation of dissolution rate curves by the RRSBW distribution" Pharm. Ind., 38(5), 472-477, 1976.
16. Antal, I., Zelko, R., Roczey, N., Plachy, J., Racz, I., "Dissolution and diffuse reflectance characteristics of coated theophylline particles" Int. J. Pharm., 155, 83-89, 1997. (Pubitemid 27368125)
17. Wieland-Berghausen, S., Schote, U., Frey, M., Schmidt, F., "Comparison of microencapsulation techniques for the water-soluble drugs nitenpyram and clomipramine HCl" J. Contr. Release, 85(1-3), 35-43, 2002. (Pubitemid 35476851)
18. Babay, D., Hoffman, A., Benita, S., "Design and release kinetic pattern evaluation of indomethacin microspheres intended for oral administration" Biomaterials, 9(6), 482-488, 1988. (Pubitemid 19001129)
19. Zessin, G., Dashevsky, A., The effect of viscosity on micromeritic properties of ethylcellulose-walled theophylline microspheres. Proc. 1st World Meeting APGI/APV, Budapest, pp. 443-444, May 9-11, 1995.
20. Canefe, K., Yüce, M., Indomethacin-loaded microspheres: preparation, characterization and in vitro evaluation regarding ethylcellulose wall material. EUFEPS Conference on Membrane Drug Transporters: Impact on Drug Discovery, Development, Regulation and Usage, Copenhagen, Denmark, September 25-27, 2006.