Clavulanic acid: A competitive inhibitor of beta-lactamases with novel anxiolytic-like activity and minimal side effects

Pharmacology Biochemistry and Behavior

Volumn 93, Issue 2, 2009, Pages 112-120

  Kim, Deog J ^a   King, Jean A ^b   Zuccarelli, Lisa ^c   Ferris, Craig F ^d   Koppel, Gary A ^e   Snowdon, Charles T ^f   Ahn, Chang H ^a  

^a Rexahn Pharmaceuticals Inc   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^c SALVE REGINA UNIVERSITY   (United States)

^d NORTHEASTERN UNIVERSITY   (United States)

^e University of Wisconsin ^*  (United States)

^f UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Anxiety; Benzodiazepine; Learning and memory; Libido; Serotonin reuptake inhibitor; Sexual motivation

Indexed keywords

BETA LACTAMASE; CHLORDIAZEPOXIDE; CLAVULANIC ACID; STRESS HORMONE;

AMNESIA; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANTIBACTERIAL ACTIVITY; ANXIETY DISORDER; ARTICLE; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG POTENCY; ENZYME INHIBITION; FEMALE; HAMSTER; HORMONE RELEASE; LEARNING; MALE; MAZE TEST; MEMORY CONSOLIDATION; MONKEY; MOTOR ACTIVITY; MOTOR DYSFUNCTION; NEUROENDOCRINE DISEASE; NONHUMAN; OPEN FIELD TEST; PENIS ERECTION; PRIORITY JOURNAL; RAT; SEX DIFFERENCE; SEXUAL AROUSAL; SPECIES DIFFERENCE; TRANQUILIZING ACTIVITY;

ANIMALS; ANTI-ANXIETY AGENTS; BETA-LACTAMASES; CHLORDIAZEPOXIDE; CLAVULANIC ACID; CRICETINAE; ENZYME INHIBITORS; LEARNING; MALE; MAZE LEARNING; MEMORY; MESOCRICETUS; MOTOR ACTIVITY; NEUROSECRETORY SYSTEMS; PENILE ERECTION; RATS; RATS, WISTAR; SAGUINUS; STRESS, PSYCHOLOGICAL;

BACTERIA (MICROORGANISMS); CRICETINAE; MAMMALIA; RATTUS; RODENTIA; SAGUINUS IMPERATOR; SAGUINUS OEDIPUS;

EID: 67649268391     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2009.04.013     Document Type: Article

References (43)

1. Barros M., Mello E.L., Huston J.P., and Tomaz C. Behavioral effects of buspirone in the marmoset employing a predator confrontation test of fear and anxiety. Pharm Biochem Behav 68 (2001) 255-262
2. Bolton G.C., Allen G.D., Davies B.E., Filer C.W., and Jeffery D.J. The disposition of clavulanic acid in man. Xenobiotica 16 (1986) 853-863
3. Brown A.G., Butterworth D., Cole M., Hanscomb G., Hood J.D., Reading C., et al. Naturally-occurring beta lactamase inhibitors with bacterial activity. J Antibiot 29 (1976) 668-669
4. Charney D.S., and Bremner J.D. The neurobiology of anxiety disorder. In: Charney D.S., Nestler E.J., and Bunney B.S. (Eds). Neurobiology of Mental Illness (1999), Oxford University Press, New York 494-517
5. Cilia J., and Piper D.C. Marmoset conspecific confrontation: an ethologically-based model of anxiety. Pharm Biochem Behav 58 (1997) 85-91
6. Clapp N.K., Henke M.L., Lushbaugh C.C., Humason G.L., and Gangaware B.L. Effect of various biological factors on spontaneous marmoset and tamarin colitis: a retrospective histopathological study. Dig Dis Sci 33 (1988) 1013-1019
7. Coop C.F., McNaughton N., and Lambie I. Effects of GABAA and GABAB receptor agonists on reticular-elicited hippocampal rhythmical slow activity. Eur J Pharmacol 192 (1991) 103-108
8. Crosby M.A., and Gump D.W. Activity of cefoperazone and two ß-lactamase inhibitors, sulbactam and clavulanic acid against Bacteroides spp. correlated with ß-lactamase production. Antimicrob Agents Chemother 22 (1982) 398-405
9. Davies B.E., Coates P.E., Clarke J.G., Thawley A.R., and Sutton J.A. Bioavailability and pharmacokinetics of clavulanic acid in healthy subjects. Int J Clin Pharmacol Ther Toxicol 23 (1985) 70-73
10. Feighner J.P. Overview of antidepressants currently used to treat anxiety disorders. J Clin Psychiatry 60 (1999) 18-22
11. File S.E., and Aranko K. Sodium valproate and chlordiazepoxide in the elevated plus-maze test of anxiety in the rat. Neuropsychobiology 20 (1988) 82-86
12. Gram L.F., and Christensen P. Benzodiazepine suppression of cortisol secretion: a measure of anxiolytic activity. Pharmacopsychiatry 19 (1986) 19-22
13. Hommer D.W., Matsuo V., Wolkowitz O., Chrousos G., Greenblatt D.J., Weingarteer H., et al. Benzodiazepine sensitivity in normal human subjects. Arch Gen Psychiatry 43 (1986) 542-551
14. King J.A., Messenger T., and Ferris C.F. Seed finding in golden hamsters: a potential animal model of anxiety. Neuropsychobiology 45 (2002) 150-155
15. Kotler M., Cohen H., Aizenberg D., Matar M., Loewenthal U., Kaplan Z., et al. Sexual dysfunction in male posttraumatic stress disorder patients. Psychother Psychosom 69 (2000) 309-315
16. Kumar R., Mac D.S., Gabrielli Jr. W.F., and Goodwin D.W. Anxiolytics and memory: a comparison of lorazepam and alprazolam. J Clin Psychiatry 48 (1987) 158-160
17. Liebowitz M.R., Campeas R., Levin A., Sandberg D., Hollander E., and Papp L. Pharmacotherapy of social phobia. A condition distinct from panic attacks. Psychosomatics 28 (1987) 305-308
18. Lister R.G. The use of a plus-maze to measure anxiety in the mouse. Psychopharmacology 92 (1987) 180-185
19. McElroy J.F., Fleming R.L., and Feldman R.S. A comparison between chlordiazepoxide and CL 218,872 - a synthetic nonbenzodiazepine ligand for benzodiazepine receptors on spontaneous locomotor activity in rats. Psychpharmacology 85 (1985) 224-226
20. McKinney W.T. Basis of development of animal models in psychiatry: an overview. In: Koob G.F., Ehlers C.L., and Kupfer D.J. (Eds). Animal Models of Depression (1989) 3-17 Boston
21. Morris R.G.M. Developments of a water maze procedure for studying spatial learning in the rat. J Neurosci Methods 11 (1984) 47-60
22. Nakagawa H., Yamada M., Tokiyoshi K., Miyawaki Y., and Kanayama T. Penetration of potassium clavulanate/ticarcillin sodium into cerebrospinal fluid in neurosurgical patients. Jpn J Antibiot 47 (1994) 93-101
23. Payne D.J., Cramp R., Winstanley D.J., and Knowles D.J. Comparative activities of clavulanic acid, sulbactam, and tazobactam against clinically important beta-lactamases. Antimicrob Agents Chemother 38 (1994) 767-772
24. Pellow S., Chopin P., File S.E., and Briley M. Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J Neurosci Methods 14 (1985) 149-167
25. Petraglia F., Bakkalakis S., Facchinetti F., Volpe A., Mulleer E.E., and Genazzani A.R. Effects of sodium valproate and diazepam on beta-endorphin, beta-lipotropin and cortisol secretion induced by hypoglycemic stress in humans. Neuroendocrinology 44 (1986) 320-325
26. Reading C., and Cole M. Clavulanic acid: a beta-lactamase-inhibiting beta-lactam from Streptomyces clavuligerus. Antimicrob Agents Chemother 11 (1977) 852-857
27. Reading C., and Farmer T. The inhibition of B-lactamase from Gram-negative bacteria by clavulanic acid. Biochem J 199 (1981) 779-787
28. Rothschild A.J. Sexual side effects of antidepressants. J Clin Psychiatry 11 (2000) 28-36
29. Rothstein J.D., Patel S., Regan M.R., Haenggeli C., Huang Y.H., Bergles D.E., et al. β-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression. Nature 433 (2005) 73-77
30. Sachar E., Hellman L., and Roffwarg H.P. Disrupted 24-hr cortisol secretion in psychotic depression. Arch Gen Psychiatry 28 (1973) 19-24
31. Sato Y., Suzuki N., Horita H., Wada H., Shibuya A., Adachi H., et al. Effects of long-term psychological stress on sexual behavior and brain catecholamine levels. J Androl 17 (1996) 83-90
32. Sawaki M., Noda S., Muroi T., Mitoma H., Takakura S., Sakamoto S., et al. Evaluation of an in utero through lactational exposure protocol for detection of estrogenic effects of ethinyl estradiol on the offspring of rats: preliminary trial. Reprod Toxicol 17 (2003) 335-343
33. Shumsky J.S., and Lucki I. Differential regulation of the behavioral effects of chlordiazepoxide. Psychopharmacology 115 (1994) 37-45
34. Smith A.D. Psychologic factors in the multidisciplinary evaluation and treatment of erectile dysfunction. Urol Clin North Am 15 (1988) 41-51
35. Snowdon C.T., and Ziegler T.E. Growing up cooperatively: family processes and infant care in marmosets and tamarins. J Dev Processes 2 (2007) 40-66
36. Snowdon C.T., Savage A., and McConnell P.B. A breeding colony of cotton-top tamarins (Saguinus oedipus). Lab Anim Sci 35 (1985) 477-480
37. Thayer K.A., Ruhlen R.L., Howdeshell K.L., Buchanan D., Cooke P.S., Welshons W.V., et al. Altered reproductive organs in male mice exposed prenatally to sub-clinical doses of 17 alpha-ethinyl estradiol. Hum Reprod 16 (2001) 988-996
38. Weinberg J., and Wong R. Adrenocortical responsiveness to novelty in the hamster. Physiol Behav 37 (1986) 669-672
39. Wilde W.S. Chloride equilibrium in muscle. Am J Physiol 143 (1945) 666-676
40. Wood J.D., Peck O.C., Sharma H.M., Hernandez J.I., Rodriguez J.V., Rodriguez M.A., et al. Environmental stress as a factor in the etiology of colitis in the cotton-top tamarin. Gastroenterology 108 (1995) A943
41. Wood J.D., Peck O.C., Tefend K.S., Rodriguez M.A., Rodriguez J.V., Hernandez J.I., et al. Colitis and colon cancer in cotton-top tamarins (Saguinus oedipus oedipus) living wild in their natural habitat. Dig Dis Sci 43 (1998) 1443-1453
42. Wood J.D., Peck O.C., Tefend K.S., Stonerook M.J., Caniano D.A., Mutabagani K.H., et al. Evidence that colitis is initiated by environmental stress and sustained by fecal factors in the cotton-top tamarin (Saguinus oedipus). Dig Dis Sci 45 (2000) 385-393
43. Wüst J., and Wilkins T.D. Effect of clavulanic acid on anaerobic bacteria resistant to beta-lactam antibiotics. Antimicrob Agents Chemother 13 (1978) 130-133