Introduction of human pharmaceuticals from wastewater treatment plants into the aquatic environment: A rural perspective

Environmental Science and Pollution Research

Volumn 22, Issue 14, 2015, Pages 10559-10568

  Nebot, Carolina ^a,b   Falcon, Raquel ^c   Boyd, Kenneth G ^a   Gibb, Stuart W ^a  

^a UNIVERSITY OF THE HIGHLANDS AND ISLANDS   (United Kingdom)

^b UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^c UNIVERSITY OF PORTSMOUTH   (United Kingdom)

Author keywords

Pharmaceuticals; River water; Ruralareas; Wastewater

Indexed keywords

AQUATIC ENVIRONMENT; DRUG; EFFLUENT; INDUSTRIAL EMISSION; RURAL AREA; WASTE FACILITY; WASTE TREATMENT; WASTEWATER; WATER POLLUTION; WATER QUALITY;

HIGHLAND; SCOTLAND; THURSO RIVER; UNITED KINGDOM;

DRUG; WASTE WATER; WATER POLLUTANT;

ANALYSIS; CHEMISTRY; ENVIRONMENTAL MONITORING; HUMAN; RIVER; RURAL POPULATION; UNITED KINGDOM; WASTE WATER; WATER POLLUTANT;

ENVIRONMENTAL MONITORING; HUMANS; PHARMACEUTICAL PREPARATIONS; RIVERS; RURAL POPULATION; SCOTLAND; WASTE WATER; WATER POLLUTANTS, CHEMICAL;

EID: 84940918385     PISSN: 09441344     EISSN: 16147499     Source Type: Journal    
DOI: 10.1007/s11356-015-4234-z     Document Type: Article

References (59)

1. Andreozzi R, Raffaele M, Nicklas P (2003) Pharmaceuticals in STP effluents and their solar photodegradation in aquatic environment. Chemosphere 50:1319-1330
2. Ashton D, Hilton M, Thomas KV (2004) Investigating the environmental transport of human pharmaceuticals to streams in the United Kingdom. Sci Total Environ 333:167-184
3. Baker DR, Kasprzyk-Hordern B (2013) Spatial and temporal occurrence of pharmaceuticals and illicit drugs in the aqueous environment and during wastewater treatment: new developments. Sci Total Environ 454-455:442-456
4. Barbara K, Dinsdale R, Guwy A (2008) The occurrence of pharmaceuticals, personal care products, endocrine disruptors and illicit drugs in surface water in South Wales, UK. Water Res 42:3498-3518
5. Bendz D, Paxeus NA, Ginn TR, Loge FJ (2005) Occurrence and fate of pharmaceutically active compounds in the environment, a case study: Hoje River in Sweden. J Hazard Mater 122:195-204
6. Bound JP, Voulvoulis N (2006) Predicted and measured concentrations for selected pharmaceuticals in UK rivers: implications for risk assessment. Water Res 40:2885-2892
7. Boxall AB, Fogg LA, Blackwell PA, Blackweel P, Kay P, Pemberton EJ, Croxford A (2004) Veterinary medicines in the environment. Rev Environ Contam Toxicol 180:1-91
8. Brown KD, Kulis J, Thomson B, Chapman TH, Mawhinney DB (2006) Occurrence of antibiotics in hospital, residential, and dairy effluent, municipalwastewater, and the Rio Grande in NewMexico. Sci Total Environ 366:772-783
9. Buser H, Müller MD (1998) Occurrence of the pharmaceutical drug clofibric acid and the herbicide mecoprop in various Swiss lakes and in the North Sea. Environ Sci Technol 32:188-192
10. Carballa M, Omil F, Lema JM, Llompart M, Garcia-Jares C, Rodriguez I, Gomez M, Ternes T (2004) Behavior of pharmaceuticals, cosmetics and hormones in a sewage treatment plant. Water Res 38:2918-2926
11. Carballa M, Omil F, Ternes T, Lema JM (2007) Fate of pharmaceutical and personal care products (PPCPs) during anaerobic digestion of sewage sludge. Water Res 41:2139-2150
12. Castiglioni S, Bagnati R, Fanelli R, Pomati F, Calamari D, Zuccato E (2006) Removal of pharmaceuticals in sewage treatment plants in Italy. Environ Sci Technol 40:357-363
13. Corcoran J, Winter MJ, Tyler CR (2010) Pharmaceuticals in the aquatic environment: a critical review of the evidence for health effects in fish. Crit Rev Toxicol 40:287-304
14. Dietrich DRE, Webb SFE, Petry TE (2002) Ed by Daniel R. Ed Dietrich. Hot spot pollutants: pharmaceuticals in the environment. Toxicol Lett 131:1-3
15. Farre M, Ferrer I, Ginebreda A, Figueras M, Olivella L, Tirapu L, Vilanova M, Barcelo D (2001) Determination of drugs in surface water andwastewater samples by liquid chromatography-mass spectrometry: methods and preliminary results including toxicity studies with Vibrio fischeri. J Chromatogr A 938:187-197
16. Ferreira da Silva B, Jelic A, López-Serna R, Mozeto AA, Petrovic M, Barceló D (2011) Occurrence and distribution of pharmaceuticals in surface water, suspended solids and sediments of the Ebro river basin, Spain. Chemosphere 85:1331-1339
17. Gagne F, Blaise C, Andre C (2006) Occurrence of pharmaceutical products in a municipal effluent and toxicity to rainbow trout (Oncorhynchus mykiss) hepatocytes. Ecotoxicol Environ Saf 64: 329-336
18. Garrison AW, Pope JD, Allen FR (1976) GC-MS analysis of organic compounds in domestic wastewater. In: Keith LH (ed) Identification and analysis of organic pollutants in water. Ann Arbor Science, Michigan, pp 517-556
19. Geddes G (2007) Effluent flows, Scottish Water [personal communication] to Carolina Nebot
20. Gomez MJ, Petrovic M, Fernandez-Alba AR, Barcelo D (2006) Determination of pharmaceuticals of various therapeutic classes by solid-phase extraction and liquid chromatography-tandem mass spectrometry analysis in hospital effluent wastewaters. J Chromatogr A 1114:224-233
21. Gros M, Petrovic M, Barcelo D (2006) Development of a multi-residue analytical methodology based on liquid chromatography-tandem mass spectrometry (LC-MS/MS) for screening and trace level determination of pharmaceuticals in surface and wastewaters. Talanta 70: 678-690
22. Heberer T, Fuhrmann B, Schmidt-Baumler K, Tsipi D, Koutsouba V, Hiskia A (2001) Occurrence of pharmaceutical residues in sewage, river, ground and drinking water in Greece and Germany. In: Pharmaceuticals and personal care products in the environment: scientific and regulatory issues. by Jones-Lepp, T. L., et al. Washington, D. C., American Chemical Society; Oxford University Press distributor
23. Hilton MJ, Thomas KV (2003) Determination of selected human pharmaceutical compounds in effluent and surface water samples by high-performance liquid chromatography-electrospray tandem mass spectrometry. J Chromatogr A 1015:129-141
24. Hilton MJ, Thomas KV, Ashton D (2003) Targeted Monitoring Programme for Pharmaceuticals in the Aquatic Environment R&D Technical Report P6-012/06/TR. Environment Agency, Bristol
25. Hoshina K, Horiyama S, Matsunaga H, Haginaka J (2011) Simultaneous determination of non-steroidal anti-inflammatory drugs in river water samples by liquid chromatography-tandem mass spectrometry using molecularly imprinted polymers as a pretreatment column. J Pharm Biomed Anal 55:916-922
26. Jones OAH, Voulvoulis N, Lester JN (2007) The occurrence and removal of selected pharmaceutical compounds in a sewage treatment works utilising activated sludge treatment. Environ Pollut 145:738-744
27. Kasprzyk-Hordern B, Dinsdale RM, Guwy AJ (2008) The occurrence of pharmaceuticals, personal care products, endocrine disruptors and illicit drugs in surface water in South Wales, UK. Water Res 42: 3498-3518
28. Kemper N (2008) Veterinary antibiotics in the aquatic and terrestrial environment. Ecol Indic 8:1-13
29. Kools SAE, Boxall ABA, Moltmann JF, Bryning G, Koschorreck J, Knacker T (2008) A ranking of European veterinary medicines based on environmental risks. Integr Environ Assess Manage 4: 399-408
30. Kümmerer K (2008) Pharmaceuticals in the environment: sources, fate, effects and risks, 3rd edn. Springer, Berlin
31. Kümmerer K (2009) The presence of pharmaceuticals in the environment due to human use-present knowledge and future challenges. J Environ Manage 90:2354-2366
32. Lindberg RH, Olofsson U, Rendahl P, Johansson MI, Tysklind M, Andersson BAV (2006) Behavior of fluoroquinolones and trimethoprim during mechanical, chemical, and active sludge treatment of sewage water and digestion of sludge. Environ Sci Technol 40: 1042-1048
33. Markager S, Vincent WR (2000) Spectral light attenuation and the absorption of UV and blue light in natural waters. Limnol Oceanogr 45 (3):642-650
34. Maurer M, Escher BI, Richle P, Schaffner C, Alder AC (2007) Elimination of β-blockers in sewage treatment plants. Water Res 41:1614-1622
35. Metcalfe CD, Koenig BG, Bennie DT, Servos M, Ternes TA, Hirsch R (2003) Occurrence of neutral and acidic drugs in the effluents of Canadian sewage treatment plants. Environ Toxicol Chem 22: 2872-2880
36. Miao X, Metcalfe CD (2003) Determination of pharmaceuticals in aqueous samples using positive and negative voltage switching microbore liquid chromatography/electrospray ionization tandem mass spectrometry. J Mass Spectrom 38:27-34
37. Moldovan Z (2006) Occurrences of pharmaceutical and personal care products as micropollutants in rivers from Romania. Chemosphere 64:1808-1817
38. Nakada N, Tanishima T, Shinohara H, Kiri K, Takada H (2006) Pharmaceutical chemicals and endocrine disrupters in municipal wastewater in Tokyo and their removal during activated sludge treatment. Water Res 40:3297-3303
39. Nakada N, Shinohara H, Murata A, Kiri K, Managaki S, Sato N, Takada H (2007) Removal of selected pharmaceuticals and personal care products (PPCPs) and endocrine-disrupting chemicals (EDCs) during sand filtration and ozonation at a municipal sewage treatment plant. Water Res 41:4373-4382
40. National Services Scotland (2014) Prescribing & Medicines: Prescription Cost Analysis Financial Year 2013/14. Publication date -24 June 2014. Information Services Division. NHS National Services Scotland. https://isdscotland.scot.nhs.uk/Health-Topics/Prescribingand-Medicines/Publications/2014-06-24/2014-06-24-Prescribing-PrescriptionCostAnalysis-Summary.pdf. Accessed June 2014
41. Nebot C, Gibb SW, Boyd KG (2007) Quantification of human pharmaceuticals in water samples by high performance liquid chromatography-tandem mass spectrometry. Anal Chim Acta 598:87-94
42. Öllers S, Singer HP, Fassler P, Muller SR (2001) Simultaneous quantification of neutral and acidic pharmaceuticals and pesticides at the low-ng/l level in surface and waste water. J Chromatogr A 911: 225-234
43. Rabiet M, Togola A, Brissaud F, Seidel JL, Budzinski H, Elbaz-Poulichet F (2006) Consequences of treated water recycling as regards pharmaceuticals and drugs in surface and ground waters of a mediumsizedMediterranean catchment. Environ Sci Technol 40:5282-5288
44. Roberts PH, Thomas KV (2006) The occurrence of selected pharmaceuticals in wastewater effluent and surface waters of the lower Tyne catchment. Sci Total Environ 356:143-153
45. Sanderson H, Laird B, Pope L, Brain R, Wilson C, Johnson D, Bryning G, Peregrine AS, Boxall A, Solomon K (2007) Assessment of the environmental fate and effects of ivermectin in aquatic mesocosms. Aquat Toxicol 85:229-240
46. Sarmah AK, Meyer MT, Boxall ABA (2006) A global perspective on the use, sales, exposure pathways, occurrence, fate and effects of veterinary antibiotics (VAs) in the environment. Chemosphere 65:725-759
47. SEPA (2007) Scottish Environment Protection Agency Thurso at Halkirk [Online] Date. http://www.nwl.ac.uk/ih/nrfa/station_summaries/097/002.html. Accessed 2008
48. Sui Q, Wang B, Zhao W, Huang J, Yu G, Deng S, Zhaofu Q, Lu S (2012) Identification of priority pharmaceuticals in the water environment of China. Chemosphere 89:280-286
49. Ternes TA (1998) Occurrence of drugs in German sewage treatment plants and rivers. Water Res 32:3245-3260
50. Ternes T, Bonerz M, Schmidt T (2001) Determination of neutral pharmaceuticals inwastewater and rivers by liquid chromatography electrospray tandem mass spectrometry. J Chromatogr A 938: 175-185
51. The Office for National Statistic (2013) Population Estimates for UK, England and Wales, Scotland and Northern Ireland, Mid-2013 [Online] Date. http://www.ons.gov.uk/ons/rel/pop-estimate/population-estimates-for-uk-england-and-wales-scotlandandnorthern-ireland/2013/index.html. Accessed August 2014
52. Thomas KV, Hilton MJ (2004) The occurrence of selected human pharmaceutical compounds in UK estuaries. Mar Pollut Bull 49:436-444
53. Weigel S, Kuhlmann J, Huhnerfuss H (2002) Drugs and personal care products as ubiquitous pollutants: occurrence and distribution of clofibric acid, caffeine and DEET in the North Sea. Sci Total Environ 295:131-141
54. Wheeler C (2007) River Thurso rainfall data, Scottish Environment Protection Agency [personal communication] to Carolina Nebot
55. Zhao X, Metcalfe CD (2008) Characterizing and compensating for matrix effects using atmospheric pressure chemical ionization liquid chromatography-tandem mass spectrometry: analysis of neutral pharmaceuticals in municipal wastewater. Anal Chem 80:2010-2017
56. Zhao JL, Ying GG, Liu YS, Chen F, Yang JF, Wang L (2010) Occurrence and risks of triclosan and triclocarban in the Pearl River system, South China: from source to the receiving environment. J Hazard Mater 179:215-222
57. Zuccato E, Castiglioni S, Fanelli R, Bagnati R, Reitano G, Calamari D (2004) Risk related to the discharge of pharmaceuticals in the environment: further research is needed. In pharmaceuticals in the Environmen Second edition edn. ed. by Springer-Verlag
58. Zuccato E, Castiglioni S, Fanelli R (2005) Identification of the pharmaceuticals for human use contaminating the Italian aquatic environment. J Hazard Mater 122:205-209
59. Zuccato E, Castiglioni S, Bagnati R, Chiabrando C, Grassi P, Fanelli R (2008) Illicit drugs, a novel group of environmental contaminants. Water Res 42:961-968