Erratum: Laboratory evidence of disseminated intravascular coagulation is associated with a fatal outcome in children with cerebral malaria despite an absence of clinically evident thrombosis or bleeding (Journal of Thrombosis and Haemostasis (2015) 13(9) (1653–1664), (S153878362203450X), (10.1111/jth.13060));Laboratory evidence of disseminated intravascular coagulation is associated with a fatal outcome in children with cerebral malaria despite an absence of clinically evident thrombosis or bleeding

Journal of Thrombosis and Haemostasis

Volumn 13, Issue 9, 2015, Pages 1653-1664

  Moxon, C A ^a,b   Chisala, N V ^b   Mzikamanda, R ^b   Maccormick, I ^b   Harding, S ^a   Downey, C ^c   Molyneux, M ^b,d   Seydel, K B ^b,e   Taylor, T E ^b,e   Heyderman, R S ^a,b   Toh, C H ^a,c  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b UNIVERSITY OF MALAWI   (Malawi)

^c ROYAL LIVERPOOL UNIVERSITY HOSPITAL   (United Kingdom)

^d LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

^e MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

Blood coagulation; Disseminated intravascular coagulation; Endothelial cell protein C receptor; Fibrin; Malaria, cerebral

Indexed keywords

ANTITHROMBIN; FIBRINOGEN; PROTEIN C; THROMBOMODULIN; BIOLOGICAL MARKER; FIBRIN; GLUCOSE BLOOD LEVEL; LACTIC ACID DERIVATIVE; THBD PROTEIN, HUMAN;

ARTICLE; BLEEDING; BRAIN MALARIA; CHILD; CHILDHOOD MORTALITY; COHORT ANALYSIS; CONTROLLED STUDY; DIC SCORE; DISEASE ASSOCIATION; DISSEMINATED INTRAVASCULAR CLOTTING; FATALITY; FEMALE; FETUS OUTCOME; FIBRINOLYSIS; HUMAN; MAJOR CLINICAL STUDY; MALAWIAN; MALE; OUTCOME ASSESSMENT; PREDICTIVE VALUE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RETINA HEMORRHAGE; RETINOPATHY; RISK ASSESSMENT; RISK FACTOR; SCORING SYSTEM; THROMBOCYTE COUNT; THROMBOSIS; ANALYSIS; BIOSYNTHESIS; BLOOD; BLOOD EXAMINATION; CEREBRAL MALARIA; COMA; DISSEMINATED INTRAVASCULAR COAGULATION; FEVER; GLUCOSE BLOOD LEVEL; INFANT; MALARIA FALCIPARUM; MALAWI; MORTALITY; PARASITEMIA; PARASITOLOGY; PRESCHOOL CHILD;

BIOMARKERS; BLOOD GLUCOSE; CHILD; CHILD, PRESCHOOL; COMA; DISSEMINATED INTRAVASCULAR COAGULATION; FEMALE; FEVER; FIBRIN; HEMATOLOGIC TESTS; HUMANS; INFANT; LACTATES; MALARIA, CEREBRAL; MALARIA, FALCIPARUM; MALAWI; MALE; PARASITEMIA; PROSPECTIVE STUDIES; RETINAL HEMORRHAGE; RISK FACTORS; THROMBOMODULIN;

EID: 84940900089     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/jth.13233     Document Type: Erratum

References (41)

1. Taylor TE, Fu WJ, Carr RA, Whitten RO, Mueller JS, Fosiko NG, Lewallen S, Liomba NG, Molyneux ME. Differentiating the pathologies of cerebral malaria by postmortem parasite counts. Nat Med 2004; 10: 143-5.
2. Murphy SC, Breman JG. Gaps in the childhood malaria burden in Africa: cerebral malaria, neurological sequelae, anemia, respiratory distress, hypoglycemia, and complications of pregnancy. Am J Trop Med Hyg 2001; 64: 57-67.
3. John CC, Kutamba E, Mugarura K, Opoka RO. Adjunctive therapy for cerebral malaria and other severe forms of Plasmodium falciparum malaria. Expert Rev Anti Infect Ther 2010; 8: 997-1008.
4. Turner L, Lavstsen T, Berger SS, Wang CW, Petersen JE, Avril M, Brazier AJ, Freeth J, Jespersen JS, Nielsen MA, Magistrado P, Lusingu J, Smith JD, Higgins MK, Theander TG. Severe malaria is associated with parasite binding to endothelial protein C receptor. Nature 2013; 498: 502-5.
5. Francischetti IM, Seydel KB, Monteiro RQ, Whitten RO, Erexson CR, Noronha AL, Ostera GR, Kamiza SB, Molyneux ME, Ward JM, Taylor TE. Plasmodium falciparum-infected erythrocytes induce tissue factor expression in endothelial cells and support the assembly of multimolecular coagulation complexes. J Thromb Haemost 2007; 5: 155-65.
6. Larkin D, de Laat B, Jenkins PV, Bunn J, Craig AG, Terraube V, Preston RJ, Donkor C, Grau GE, van Mourik JA, O'Donnell JS. Severe Plasmodium falciparum malaria is associated with circulating ultra-large von Willebrand multimers and ADAMTS13 inhibition. PLoS Pathog 2009; 5: e1000349.
7. Ndonwi M, Burlingame OO, Miller AS, Tollefsen DM, Broze GJ Jr, Goldberg DE. Inhibition of antithrombin by Plasmodium falciparum histidine-rich protein II. Blood 2011; 117: 6347-54.
8. Ghosh K, Shetty S. Blood coagulation in falciparum malaria - a review. Parasitol Res 2008; 102: 571-6.
9. Schwameis M, Schorgenhofer C, Assinger A, Steiner M, Jilma B. VWF excess and ADAMTS13 deficiency: a unifying pathomechanism linking inflammation to thrombosis in DIC, malaria, and TTP. Thromb Haemost 2014; 113: 708-18.
10. Connolly SJ, Ezekowitz MD, Yusuf S, Eikelboom J, Oldgren J, Parekh A, Pogue J, Reilly PA, Themeles E, Varrone J, Wang S, Alings M, Xavier D, Zhu J, Diaz R, Lewis BS, Darius H, Diener HC, Joyner CD, Wallentin L. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med 2009; 361: 1139-51.
11. Lassen MR, Ageno W, Borris LC, Lieberman JR, Rosencher N, Bandel TJ, Misselwitz F, Turpie AG. Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty. N Engl J Med 2008; 358: 2776-86.
12. Vincent JL, Ramesh MK, Ernest D, LaRosa SP, Pachl J, Aikawa N, Hoste E, Levy H, Hirman J, Levi M, Daga M, Kutsogiannis DJ, Crowther M, Bernard GR, Devriendt J, Puigserver JV, Blanzaco DU, Esmon CT, Parrillo JE, Guzzi L, et al. A randomized, double-blind, placebo-controlled, Phase 2b study to evaluate the safety and efficacy of recombinant human soluble thrombomodulin, ART-123, in patients with sepsis and suspected disseminated intravascular coagulation. Crit Care Med 2013; 41: 2069-79.
13. Lyden P, Levy H, Weymer S, Pryor K, Kramer W, Griffin JH, Davis TP, Zlokovic B. Phase 1 safety, tolerability and pharmacokinetics of 3K3A-APC in healthy adult volunteers. Curr Pharm Des 2013; 19: 7479-85.
14. van der Poll T. The endothelial protein C receptor and malaria. Blood 2013; 122: 624-5.
15. Aird WC, Mosnier LO, Fairhurst RM. Plasmodium falciparum picks (on) EPCR. Blood 2014; 123: 163-7.
16. Moxon CA, Wassmer SC, Milner DA Jr, Chisala NV, Taylor TE, Seydel KB, Molyneux ME, Faragher B, Esmon CT, Downey C, Toh CH, Craig AG, Heyderman RS. Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African children. Blood 2013; 122: 842-51.
17. Miller LH, Ackerman HC, Su XZ, Wellems TE. Malaria biology and disease pathogenesis: insights for new treatments. Nat Med 2013; 19: 156-67.
18. Sundaram J, Keshava S, Gopalakrishnan R, Esmon CT, Pendurthi UR, Rao LV. Factor VIIa binding to endothelial cell protein C receptor protects vascular barrier integrity in vivo. J Thromb Haemost 2014; 12: 690-700.
19. Clemens R, Pramoolsinsap C, Lorenz R, Pukrittayakamee S, Bock HL, White NJ. Activation of the coagulation cascade in severe falciparum malaria through the intrinsic pathway. Br J Haematol 1994; 87: 100-5.
20. Marsh K, Forster D, Waruiru C, Mwangi I, Winstanley M, Marsh V, Newton C, Winstanley P, Warn P, Peshu N. Indicators of life-threatening malaria in African children. N Engl J Med 1995; 332: 1399-404.
21. Moxon CA, Heyderman RS, Wassmer SC. Dysregulation of coagulation in cerebral malaria. Mol Biochem Parasitol 2009; 166: 99-108.
22. Moxon CA, Chisala NV, Wassmer SC, Taylor TE, Seydel KB, Molyneux ME, Faragher B, Kennedy N, Toh CH, Craig AG, Heyderman RS. Persistent endothelial activation and inflammation after Plasmodium falciparum infection in Malawian children. J Infect Dis 2014; 209: 610-15.
23. World Health Organization. WHO Expert Committee on Malaria. World Health Organ Tech Rep Ser 2000; 892: i-v, 1-74.
24. Harding SP, Lewallen S, Beare NA, Smith A, Taylor TE, Molyneux ME. Classifying and grading retinal signs in severe malaria. Trop Doct 2006; 36(Suppl. 1): 1-13.
25. White VA, Lewallen S, Beare NA, Molyneux ME, Taylor TE. Retinal pathology of pediatric cerebral malaria in Malawi. PLoS One 2009; 4: e4317.
26. Postels DG, Birbeck GL. Children with retinopathy-negative cerebral malaria: a pathophysiological puzzle. Pediatr Infect Dis J 2011; 30: 953-6.
27. Liaw PC, Esmon CT, Kahnamoui K, Schmidt S, Kahnamoui S, Ferrell G, Beaudin S, Julian JA, Weitz JI, Crowther M, Loeb M, Cook D. Patients with severe sepsis vary markedly in their ability to generate activated protein C. Blood 2004; 104: 3958-64.
28. Toh CH, Hoots WK. The scoring system of the Scientific and Standardisation Committee on Disseminated Intravascular Coagulation of the International Society on Thrombosis and Haemostasis: a 5-year overview. J Thromb Haemost 2007; 5: 604-6.
29. Taylor FB Jr, Toh CH, Hoots WK, Wada H, Levi M. Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation. Thromb Haemost 2001; 86: 1327-30.
30. Chimalizeni Y, Kawaza K, Taylor T, Molyneux M. The platelet count in cerebral malaria, is it useful to the clinician? Am J Trop Med Hyg 2010; 83: 48-50.
31. Toh JM, Ken-Dror G, Downey C, Abrams ST. The clinical utility of fibrin-related biomarkers in sepsis. Blood Coagul Fibrinolysis 2013; 24: 839-43.
32. Dempfle CE, Wurst M, Smolinski M, Lorenz S, Osika A, Olenik D, Fiedler F, Borggrefe M. Use of soluble fibrin antigen instead of D-dimer as fibrin-related marker may enhance the prognostic power of the ISTH overt DIC score. Thromb Haemost 2004; 91: 812-18.
33. Knower MT, Bowton DL, Owen J, Dunagan DP. Quinine-induced disseminated intravascular coagulation: case report and review of the literature. Intensive Care Med 2003; 29: 1007-11.
34. Reinhart K, Bayer O, Brunkhorst F, Meisner M. Markers of endothelial damage in organ dysfunction and sepsis. Crit Care Med 2002; 30: S302-12.
35. World Health Organization. WHO Case Definitions of HIV for Surveillance and Revised Clinical Staging and Immunological Classification of HIV-Related Disease in Adults and Children. Geneva: WHO Press, 2006.
36. White VA, Lewallen S, Beare N, Kayira K, Carr RA, Taylor TE. Correlation of retinal haemorrhages with brain haemorrhages in children dying of cerebral malaria in Malawi. Trans R Soc Trop Med Hyg 2001; 95: 618-21.
37. Grau GE, Mackenzie CD, Carr RA, Redard M, Pizzolato G, Allasia C, Cataldo C, Taylor TE, Molyneux ME. Platelet accumulation in brain microvessels in fatal pediatric cerebral malaria. J Infect Dis 2003; 187: 461-6.
38. Liechti ME, Zumsteg V, Hatz CF, Herren T. Plasmodium falciparum cerebral malaria complicated by disseminated intravascular coagulation and symmetrical peripheral gangrene: case report and review. Eur J Clin Microbiol Infect Dis 2003; 22: 551-4.
39. Nadel S, Goldstein B, Williams MD, Dalton H, Peters M, Macias WL, Abd-Allah SA, Levy H, Angle R, Wang D, Sundin DP, Giroir B. Drotrecogin alfa (activated) in children with severe sepsis: a multicentre phase III randomised controlled trial. Lancet 2007; 369: 836-43.
40. Moussiliou A, Alao MJ, Denoeud-Ndam L, Tahar R, Ezimegnon S, Sagbo G, Amoussou A, Luty AJ, Deloron P, Tuikue Ndam N. High plasma levels of soluble endothelial protein C receptor are associated with increased mortality among children with cerebral malaria in Benin. J Infect Dis 2015; 211: 1484-8.
41. Dorovini-Zis K, Schmidt K, Huynh H, Fu W, Whitten RO, Milner D, Kamiza S, Molyneux M, Taylor TE. The neuropathology of fatal cerebral malaria in Malawian children. Am J Pathol 2011; 178: 2146-58.