Sevoflurane and Isoflurane induce structural changes in brain vascular endothelial cells and increase blood-brain barrier permeability: Possible link to postoperative delirium and cognitive decline

Brain Research

Volumn 1620, Issue , 2015, Pages 29-41

  Acharya, Nimish K ^a   Goldwaser, Eric L ^a,b   Forsberg, Martin M ^a   Godsey, George A ^a,b   Johnson, Cristina A ^a,b   Sarkar, Abhirup ^a,b   DeMarshall, Cassandra ^a,b   Kosciuk, Mary C ^a   Dash, Jacqueline M ^a,b   Hale, Caitlin P ^a   Leonard, Douglas M ^a   Appelt, Denah M ^c   Nagele, Robert G ^a  

^a UMDNJ School of Osteopathic Medicine   (United States)

^b ROWAN UNIVERSITY   (United States)

^c PHILADELPHIA COLLEGE OF OSTEOPATHIC MEDICINE   (United States)

Author keywords

Anesthesia; Blood brain barrier; Delirium; Isoflurane; Postoperative delirium; Sevoflurane

Indexed keywords

IMMUNOGLOBULIN G; ISOFLURANE; SEVOFLURANE; ETHER DERIVATIVE; INHALATION ANESTHETIC AGENT;

ADULT; AGED; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN BLOOD VESSEL; CELL MEMBRANE; COGNITIVE DEFECT; CONTROLLED STUDY; ENDOTHELIUM CELL; HOMEOSTASIS; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; NONHUMAN; PARENCHYMA; POSTOPERATIVE DELIRIUM; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; SCANNING ELECTRON MICROSCOPY; TIGHT JUNCTION; VASCULAR ENDOTHELIUM; ANIMAL; CAPILLARY PERMEABILITY; CHEMICALLY INDUCED; COGNITION DISORDERS; DELIRIUM; DRUG EFFECTS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; PATHOLOGY; PHYSIOLOGY; POSTOPERATIVE COMPLICATION; SPRAGUE DAWLEY RAT; TIME FACTOR;

AGING; ANESTHETICS, INHALATION; ANIMALS; BLOOD-BRAIN BARRIER; CAPILLARY PERMEABILITY; COGNITION DISORDERS; DELIRIUM; ENDOTHELIAL CELLS; IMMUNOGLOBULIN G; IMMUNOHISTOCHEMISTRY; ISOFLURANE; METHYL ETHERS; MICROSCOPY, ELECTRON, SCANNING; POSTOPERATIVE COMPLICATIONS; PYRAMIDAL CELLS; RATS, SPRAGUE-DAWLEY; TIME FACTORS;

EID: 84940891753     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2015.04.054     Document Type: Article

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