IgG leakage may contribute to neuronal dysfunction in drug-refractory epilepsies with blood-brain barrier disruption

Journal of Neuropathology and Experimental Neurology

Volumn 71, Issue 9, 2012, Pages 826-838

  Michalak, Zuzanna ^a,b,e   Lebrun, Aurore ^a,b   Di Miceli, Mathieu ^a,b   Rousset, Marie Claude ^a,b   Crespel, Arielle ^a,b,d   Coubes, Philippe ^a,b,c   Henshall, David C ^e   Lerner Natoli, Mireille ^a,b   Rigau, Valérie ^a,b,c,f  

^a INSTITUT DE GÉNOMIQUE FONCTIONNELLE   (France)

^b UNIV MONTPELLIER   (France)

^c GUI DE CHAULIAC HOSPITAL   (France)

^d Epilepsy Unit   (France)

^e ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^f Centre des Collections Biologiques   (France)

Author keywords

Blood brain barrier; Immunoglobulin G; NeuN; Neurodegeneration; Pilocarpine model; Temporal lobe epilepsy

Indexed keywords

IMMUNOGLOBULIN G;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; BLOOD BRAIN BARRIER DISRUPTION; BRAIN TISSUE; CELL STRUCTURE; CENTRAL NERVOUS SYSTEM DISEASE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; ELECTRON MICROSCOPY; ENTORHINAL CORTEX; EOSINOPHILIA; EPILEPSY; EPILEPTOGENESIS; FEMALE; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; IMMUNOGLOBULIN G LEAKAGE; IMMUNOHISTOCHEMISTRY; IMMUNOPATHOLOGY; IN VIVO STUDY; MALE; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; SEIZURE; TEMPORAL LOBE EPILEPSY;

ADULT; ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; EPILEPSY; FEMALE; HUMANS; IMMUNOGLOBULIN G; LITHIUM CHLORIDE; MALE; MEMBRANE PROTEINS; MICROSCOPY, IMMUNOELECTRON; MIDDLE AGED; NEUROGLIA; NEURONS; PHOSPHOPROTEINS; PHOSPHOPYRUVATE HYDRATASE; RATS; RATS, SPRAGUE-DAWLEY; SYNDECAN-1; TIME FACTORS; YOUNG ADULT;

EID: 84865615453     PISSN: 00223069     EISSN: 15546578     Source Type: Journal    
DOI: 10.1097/NEN.0b013e31826809a6     Document Type: Article

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