Lithium protects against methamphetamine-induced neurotoxicity in PC12 cells via Akt/GSK3β/mTOR pathway

Biochemical and Biophysical Research Communications

Volumn 465, Issue 3, 2015, Pages 368-373

  Wu, Jintao ^a   Zhu, Dexiao ^a   Zhang, Jing ^a   Li, Guibao ^a   Liu, Zengxun ^a   Sun, Jinhao ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

Akt; GSK3 ; Lithium; Methamphetamine; mTOR; Neurotoxicity

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; GLYCOGEN SYNTHASE KINASE 3BETA; LITHIUM; MAMMALIAN TARGET OF RAPAMYCIN; METHAMPHETAMINE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; LITHIUM CHLORIDE; MTOR PROTEIN, RAT; NEUROPROTECTIVE AGENT; NEUROTOXIN; ONCOPROTEIN; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL VIABILITY; CLINICAL EFFECTIVENESS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG EXPOSURE; ENZYME INHIBITION; IN VITRO STUDY; MITOCHONDRIAL MEMBRANE POTENTIAL; NEURITE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PC12 CELL LINE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; ANIMAL; CELL SURVIVAL; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; NERVE CELL; PATHOLOGY; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GLYCOGEN SYNTHASE KINASE 3; LITHIUM CHLORIDE; METHAMPHETAMINE; NEURONS; NEUROPROTECTIVE AGENTS; NEUROTOXINS; ONCOGENE PROTEIN V-AKT; PC12 CELLS; PHOSPHORYLATION; RATS; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84940884250     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.08.005     Document Type: Article

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