Reactivation of cocaine reward memory engages the Akt/GSK3/mTOR signaling pathway and can be disrupted by GSK3 inhibition

Psychopharmacology

Volumn 231, Issue 16, 2014, Pages 3109-3118

  Shi, Xiangdang ^a   Miller, Jonathan S ^a   Harper, Lauren J ^a   Poole, Rachel L ^b   Gould, Thomas J ^b   Unterwald, Ellen M ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TEMPLE UNIVERSITY   (United States)

Author keywords

Akt; Cocaine; Conditioned place preference; Fear conditioning; Glycogen synthase kinase 3; Hippocampus; Memory; Mouse; mTORC1; Nucleus accumbens; Protein kinase B; Reconsolidation; Reward

Indexed keywords

2 (2,4 DICHLOROPHENYL) 3 (1 METHYL 3 INDOLYL)MALEIMIDE; COCAINE; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3ALPHA; GLYCOGEN SYNTHASE KINASE 3BETA; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PROTEIN KINASE B; S6 KINASE; ENZYME INHIBITOR; INDOLE DERIVATIVE; MALEIMIDE DERIVATIVE; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; ONCOPROTEIN; TARGET OF RAPAMYCIN KINASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HIPPOCAMPUS; MALE; MEMORY; MEMORY CONSOLIDATION; MOUSE; NONHUMAN; NUCLEUS ACCUMBENS; PLACE PREFERENCE; PREFRONTAL CORTEX; PRIORITY JOURNAL; REWARD; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; ASSOCIATION; COCAINE DEPENDENCE; DRUG EFFECTS; FEAR; INSTRUMENTAL CONDITIONING; LIMBIC SYSTEM; METABOLISM; NEOSTRIATUM; PHOSPHORYLATION; PHYSIOLOGY; PSYCHOLOGY;

ANIMALS; COCAINE-RELATED DISORDERS; CONDITIONING, OPERANT; CUES; ENZYME INHIBITORS; FEAR; GLYCOGEN SYNTHASE KINASE 3; HIPPOCAMPUS; INDOLES; LIMBIC SYSTEM; MALE; MALEIMIDES; MEMORY; MICE; MULTIPROTEIN COMPLEXES; NEOSTRIATUM; ONCOGENE PROTEIN V-AKT; PHOSPHORYLATION; PREFRONTAL CORTEX; REWARD; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84905003157     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-014-3491-8     Document Type: Article

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