Increased gray matter volume in lithium-treated bipolar disorder patients

Neuroscience Letters

Volumn 329, Issue 2, 2002, Pages 243-245

  Sassi, Roberto B ^a,b   Nicoletti, Mark ^a,c   Brambilla, Paolo ^a,c,d   Mallinger, Alan G ^a,e   Frank, Ellen ^a,e   Kupfer, David J ^a,e   Keshavan, Matcheri S ^a   Soares, Jair C ^a,c  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c Mays Cancer Center at UT Health San Antonio   (United States)

^d UNIVERSITY OF PAVIA   (Italy)

^e UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Bipolar disorder; Gray matter; Lithium; Magnetic resonance imaging; Mood disorders; Neuroimaging

Indexed keywords

LITHIUM; LITHIUM CHLORIDE;

ADULT; AGE; ARTICLE; BRAIN SIZE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFECT; FEMALE; GENDER; GRAY MATTER; HUMAN; MALE; MANIC DEPRESSIVE PSYCHOSIS; MULTIVARIATE ANALYSIS OF COVARIANCE; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; WHITE MATTER; ANALYSIS OF VARIANCE; BIPOLAR DISORDER; BRAIN; CHI SQUARE DISTRIBUTION; COMPARATIVE STUDY; CROSS-SECTIONAL STUDY; HISTOLOGY; MIDDLE AGED; MULTIVARIATE ANALYSIS; NONPARAMETRIC TEST; PATHOLOGY; STATISTICS;

ANALYSIS OF VARIANCE; BIPOLAR DISORDER; BRAIN; CHI-SQUARE DISTRIBUTION; COMPARATIVE STUDY; CROSS-SECTIONAL STUDIES; FEMALE; HUMAN; LITHIUM CHLORIDE; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGE; MULTIVARIATE ANALYSIS; STATISTICS, NONPARAMETRIC; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; HUMANS; MIDDLE AGED;

EID: 0037199676     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(02)00615-8     Document Type: Article

References (7)

1. Differential effects of age on brain gray matter in bipolar patients and healthy individuals
2. The mood-stabilizing agents lithium and valproate robustly increase the levels of the neuroprotective protein bcl-2 in the CNS
3. Overview of the mechanism of action of lithium in the brain: Fifty-year update
4. Clinical and preclinical evidence for the neurotrophic effects of mood stabilizers: Implications for the pathophysiology and treatment of manic-depressive illness
5. Lithium up-regulates the cytoprotective protein Bcl-2 in the CNS in vivo: A role for neurotrophic and neuroprotective effects in manic depressive illness
6. Lithium increases N-acetyl-aspartate in the human brain: In vivo evidence in support of bcl-2's neurotrophic effects?
7. Lithium-induced increase in human brain grey matter