Ketamine-Induced Toxicity in Neurons Differentiated from Neural Stem Cells

Molecular Neurobiology

Volumn 52, Issue 2, 2015, Pages 959-969

  Slikker, William ^a   Liu, Fang ^a   Rainosek, Shuo W ^b   Patterson, Tucker A ^a   Sadovova, Natalya ^a   Hanig, Joseph P ^c   Paule, Merle G ^a   Wang, Cheng ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^c CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Development; Differentiation; Ketamine; N methyl D aspartate (NMDA) receptors; Neurodegeneration; Neurons

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN; KETAMINE; MARKER; O4 PROTEIN; POLYSIALIC ACID NEURAL CELL ADHESION MOLECULE; UNCLASSIFIED DRUG; CALCIUM; CULTURE MEDIUM; GLYCINE; N METHYLASPARTIC ACID; SIGNAL PEPTIDE;

ANIMAL CELL; ARTICLE; ASTROCYTE; CALCIUM CELL LEVEL; CELL PROLIFERATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; EMBRYO; GLIA CELL; NERVE CELL; NERVE CELL DIFFERENTIATION; NEURAL STEM CELL; NEUROTOXICITY; NONHUMAN; OLIGODENDROGLIA; RAT; ANIMAL; APOPTOSIS; BRAIN CORTEX; CELL CULTURE; CELL DIVISION; CHEMICALLY INDUCED; CULTURE MEDIUM; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; EMBRYOLOGY; EXTRACELLULAR FLUID; METABOLISM; MITOCHONDRION; NECROSIS; NERVE DEGENERATION; NERVOUS SYSTEM DEVELOPMENT; PATHOLOGY; PHARMACOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; APOPTOSIS; ASTROCYTES; CALCIUM; CELL DIVISION; CELLS, CULTURED; CEREBRAL CORTEX; CULTURE MEDIA; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRACELLULAR FLUID; GLYCINE; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; KETAMINE; MITOCHONDRIA; N-METHYLASPARTATE; NECROSIS; NERVE DEGENERATION; NEURAL STEM CELLS; NEUROGENESIS; NEURONS; OLIGODENDROGLIA; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84940795885     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-015-9248-5     Document Type: Article

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