Mutational dissection of telomeric DNA binding requirements of G4 Resolvase 1 shows that G4-structure and certain 3′-tail sequences are sufficient for tight and complete binding

PLoS ONE

Volumn 10, Issue 7, 2015, Pages

  Smaldino, Philip J ^a   Routh, Eric D ^a   Kim, Jung H ^a   Giri, Banabihari ^b   Creacy, Steven D ^a,c   Hantgan, Roy R ^a   Akman, Steven A ^d   Vaughn, James P ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b FURMAN UNIVERSITY   (United States)

^c Harmonyx Diagnostics   (United States)

^d Roper St Francis Health Care   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; DNA; G4 RESOLVASE; GUANINE; GUANINE QUADRUPLEX; HOLOENZYME; POTASSIUM ION; RESOLVASE; SODIUM ION; TELOMERASE; TELOMERIC DNA; UNCLASSIFIED DRUG; DEAD BOX PROTEIN; DHX36 PROTEIN, HUMAN; POTASSIUM; SODIUM;

ARTICLE; CIRCULAR DICHROISM; COMPLEX FORMATION; CONTROLLED STUDY; DNA FLANKING REGION; DNA SEQUENCE; G4R1 GENE; GENE INTERACTION; GENE MUTATION; PROTEIN DNA BINDING; TELOMERE; BINDING SITE; CHEMISTRY; GENETICS; HUMAN; KINETICS; METABOLISM; MOLECULAR MODEL; MUTATION; NUCLEOTIDE REPEAT; NUCLEOTIDE SEQUENCE;

BASE SEQUENCE; BINDING SITES; CIRCULAR DICHROISM; DEAD-BOX RNA HELICASES; DNA; G-QUADRUPLEXES; HUMANS; KINETICS; MODELS, MOLECULAR; MUTATION; POTASSIUM; REPETITIVE SEQUENCES, NUCLEIC ACID; SODIUM; TELOMERE;

EID: 84940784711     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0132668     Document Type: Article

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